Cox18 (cytochrome c oxidase assembly factor COX18) - Rat Genome Database

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Gene: Cox18 (cytochrome c oxidase assembly factor COX18) Rattus norvegicus
Analyze
Symbol: Cox18
Name: cytochrome c oxidase assembly factor COX18
RGD ID: 1559547
Description: Predicted to enable membrane insertase activity. Predicted to be involved in mitochondrial cytochrome c oxidase assembly and protein insertion into mitochondrial inner membrane from matrix. Predicted to be active in mitochondrial inner membrane. Orthologous to human COX18 (cytochrome c oxidase assembly factor COX18); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: COX18 cytochrome c oxidase assembly homolog; COX18 cytochrome c oxidase assembly homolog (S. cerevisiae); COX18, cytochrome c oxidase assembly factor; cytochrome c oxidase assembly homolog 18; cytochrome c oxidase assembly homolog 18 (yeast); cytochrome c oxidase assembly protein 18; LOC289522; mitochondrial inner membrane protein COX18; RGD1559547; similar to hypothetical protein FLJ38991
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81418,147,558 - 18,161,622 (+)NCBIGRCr8
mRatBN7.21417,864,581 - 17,877,483 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,865,857 - 17,877,480 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,850,483 - 17,862,114 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01419,169,393 - 19,181,024 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,869,278 - 17,880,900 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01419,434,728 - 19,446,379 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1419,434,753 - 19,446,376 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01419,340,296 - 19,352,710 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41419,390,299 - 19,401,922 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1417,231,119 - 17,242,742 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16212937   PMID:16911509   PMID:18614015   PMID:28330871  


Genomics

Comparative Map Data
Cox18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81418,147,558 - 18,161,622 (+)NCBIGRCr8
mRatBN7.21417,864,581 - 17,877,483 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,865,857 - 17,877,480 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,850,483 - 17,862,114 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01419,169,393 - 19,181,024 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,869,278 - 17,880,900 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01419,434,728 - 19,446,379 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1419,434,753 - 19,446,376 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01419,340,296 - 19,352,710 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41419,390,299 - 19,401,922 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1417,231,119 - 17,242,742 (+)NCBICelera
Cytogenetic Map14p22NCBI
COX18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38473,052,362 - 73,069,759 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl473,052,362 - 73,069,755 (-)EnsemblGRCh38hg38GRCh38
GRCh37473,918,079 - 73,935,476 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36474,139,280 - 74,154,336 (-)NCBINCBI36Build 36hg18NCBI36
Celera471,276,493 - 71,291,542 (-)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef469,726,856 - 69,741,911 (-)NCBIHuRef
CHM1_1473,956,246 - 73,971,331 (-)NCBICHM1_1
T2T-CHM13v2.0476,395,977 - 76,413,374 (-)NCBIT2T-CHM13v2.0
Cox18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39590,362,583 - 90,371,828 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl590,362,583 - 90,371,860 (-)EnsemblGRCm39 Ensembl
GRCm38590,214,724 - 90,224,595 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,214,724 - 90,224,001 (-)EnsemblGRCm38mm10GRCm38
MGSCv37590,643,749 - 90,653,021 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36591,289,927 - 91,299,163 (-)NCBIMGSCv36mm8
Celera588,372,990 - 88,382,260 (-)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.32NCBI
LOC102025739
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955447382,679 - 390,037 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955447382,631 - 390,399 (+)NCBIChiLan1.0ChiLan1.0
LOC100993710
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2356,996,709 - 57,019,325 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1457,185,224 - 57,198,554 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0451,128,391 - 51,142,068 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1457,445,821 - 57,459,207 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl457,445,838 - 57,459,207 (+)Ensemblpanpan1.1panPan2
COX18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11361,875,507 - 61,888,068 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1361,877,194 - 61,888,387 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1361,544,008 - 61,557,463 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01362,684,228 - 62,697,511 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1362,686,601 - 62,697,847 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11362,293,197 - 62,306,657 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01361,782,057 - 61,795,539 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01362,934,159 - 62,947,369 (-)NCBIUU_Cfam_GSD_1.0
LOC101967120
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528513,891,694 - 13,904,530 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365982,343,574 - 2,357,019 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365982,343,103 - 2,354,226 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COX18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl869,341,198 - 69,354,894 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1869,274,420 - 69,354,969 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2873,274,303 - 73,356,361 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103235773
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1721,518,962 - 21,531,585 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl721,517,527 - 21,531,661 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660841,266,757 - 1,279,735 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101726570
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473534,532,847 - 34,541,511 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473534,532,911 - 34,542,833 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cox18
32 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:23
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000004074
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141757341219726296Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
61413Eae10Experimental allergic encephalomyelitis QTL 103.5nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)141762268518274498Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat

Markers in Region
RH132577  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21417,877,286 - 17,877,468 (+)MAPPERmRatBN7.2
Rnor_6.01419,446,183 - 19,446,364NCBIRnor6.0
Rnor_5.01419,352,514 - 19,352,695UniSTSRnor5.0
RGSC_v3.41419,401,729 - 19,401,910UniSTSRGSC3.4
Celera1417,242,549 - 17,242,730UniSTS
RH 3.4 Map14243.6UniSTS
Cytogenetic Map14p22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 29 22 12 22 66 24 30 3
Low 8 28 19 7 19 8 11 8 11 11 8 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000004074   ⟹   ENSRNOP00000004074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1417,865,857 - 17,877,480 (+)Ensembl
Rnor_6.0 Ensembl1419,434,753 - 19,446,376 (+)Ensembl
RefSeq Acc Id: NM_001106000   ⟹   NP_001099470
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81418,149,996 - 18,161,619 (+)NCBI
mRatBN7.21417,865,857 - 17,877,480 (+)NCBI
Rnor_6.01419,434,753 - 19,446,376 (+)NCBI
Rnor_5.01419,340,296 - 19,352,710 (+)NCBI
RGSC_v3.41419,390,299 - 19,401,922 (+)RGD
Celera1417,231,119 - 17,242,742 (+)RGD
Sequence:
RefSeq Acc Id: XM_006250771   ⟹   XP_006250833
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81418,147,558 - 18,161,622 (+)NCBI
mRatBN7.21417,864,588 - 17,877,483 (+)NCBI
Rnor_6.01419,434,728 - 19,446,379 (+)NCBI
Rnor_5.01419,340,296 - 19,352,710 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006250772   ⟹   XP_006250834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81418,147,558 - 18,161,622 (+)NCBI
mRatBN7.21417,864,585 - 17,877,483 (+)NCBI
Rnor_6.01419,434,728 - 19,446,379 (+)NCBI
Rnor_5.01419,340,296 - 19,352,710 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005492906
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81418,147,558 - 18,158,818 (+)NCBI
mRatBN7.21417,864,581 - 17,874,681 (+)NCBI
RefSeq Acc Id: NP_001099470   ⟸   NM_001106000
- UniProtKB: A6KKG4 (UniProtKB/TrEMBL),   A6KKG5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250834   ⟸   XM_006250772
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006250833   ⟸   XM_006250771
- Peptide Label: isoform X1
- UniProtKB: D4A568 (UniProtKB/TrEMBL),   A6KKG5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004074   ⟸   ENSRNOT00000004074
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A568-F1-model_v2 AlphaFold D4A568 1-331 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699235
Promoter ID:EPDNEW_R9759
Type:initiation region
Name:Cox18_1
Description:COX18, cytochrome c oxidase assembly factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01419,434,751 - 19,434,811EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559547 AgrOrtholog
BioCyc Gene G2FUF-16183 BioCyc
Ensembl Genes ENSRNOG00000003052 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004074.6 UniProtKB/TrEMBL
InterPro Membrane_insertion_OxaA/YidC UniProtKB/TrEMBL
  YidC/Oxa/ALB_C UniProtKB/TrEMBL
KEGG Report rno:289522 UniProtKB/TrEMBL
NCBI Gene 289522 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL UniProtKB/TrEMBL
  Innermemb_insert UniProtKB/TrEMBL
Pfam 60KD_IMP UniProtKB/TrEMBL
PhenoGen Cox18 PhenoGen
RatGTEx ENSRNOG00000003052 RatGTEx
UniProt A6KKG4 ENTREZGENE, UniProtKB/TrEMBL
  A6KKG5 ENTREZGENE, UniProtKB/TrEMBL
  D4A568 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-07-20 Cox18  cytochrome c oxidase assembly factor COX18  Cox18  COX18, cytochrome c oxidase assembly factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-07-21 Cox18  COX18, cytochrome c oxidase assembly factor  Cox18  cytochrome c oxidase assembly protein 18  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-09 Cox18  cytochrome c oxidase assembly protein 18  Cox18  cytochrome c oxidase assembly homolog 18 (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-24 Cox18  cytochrome c oxidase assembly homolog 18 (yeast)  Cox18  COX18 cytochrome c oxidase assembly homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Cox18  COX18 cytochrome c oxidase assembly homolog (S. cerevisiae)  RGD1559547_predicted  similar to hypothetical protein FLJ38991 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1559547_predicted  similar to hypothetical protein FLJ38991 (predicted)  LOC289522  similar to hypothetical protein FLJ38991  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC289522  similar to hypothetical protein FLJ38991      Symbol and Name status set to provisional 70820 PROVISIONAL