Igkc (immunoglobulin kappa constant) - Rat Genome Database

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Gene: Igkc (immunoglobulin kappa constant) Rattus norvegicus
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Symbol: Igkc
Name: immunoglobulin kappa constant
RGD ID: 1562743
Description: INVOLVED IN B cell differentiation (ortholog); retina homeostasis (ortholog); ASSOCIATED WITH COVID-19 (ortholog); dysgammaglobulinemia (ortholog); Hepatomegaly (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 3-chloropropane-1,2-diol; 4,4'-diaminodiphenylmethane
Type: protein-coding
Also known as: D4Mit8; Igk@; immunoglobulin kappa chain; LOC500183; MGC112745; MGC73014; similar to NGF-binding Ig light chain
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Genome Annotation Status: not in current annotation release
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
RGSC_v3.44102,208,006 - 102,208,502 (-)NCBIRGSC3.4rn4RGSC3.4
Celera417,127,845 - 17,128,341 (+)NCBICelera
Cytogenetic Map4q31NCBI


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:6273908   PMID:8080841   PMID:16502470   PMID:22516433   PMID:22664934   PMID:23376485   PMID:23533145   PMID:23580065  


Genomics

Comparative Map Data
Igkc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
RGSC_v3.44102,208,006 - 102,208,502 (-)NCBIRGSC3.4rn4RGSC3.4
Celera417,127,845 - 17,128,341 (+)NCBICelera
Cytogenetic Map4q31NCBI
IGKC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl288,857,161 - 88,857,683 (-)EnsemblGRCh38hg38GRCh38
GRCh38288,857,361 - 88,857,683 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37289,156,874 - 89,157,196 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36288,937,989 - 88,938,311 (-)NCBINCBI36hg18NCBI36
Celera287,632,104 - 87,632,426 (+)NCBI
Cytogenetic Map2p11.2NCBI
HuRef288,075,653 - 88,166,302 (-)NCBIHuRef
CHM1_1289,086,475 - 89,086,797 (-)NCBICHM1_1
Igkc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39670,703,419 - 70,703,738 (+)NCBIGRCm39mm39
GRCm39 Ensembl670,703,419 - 70,703,950 (+)Ensembl
GRCm38670,726,435 - 70,726,754 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl670,726,435 - 70,726,966 (+)EnsemblGRCm38mm10GRCm38
MGSCv37670,676,429 - 70,676,748 (+)NCBIGRCm37mm9NCBIm37
Celera672,811,869 - 72,812,188 (+)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.04NCBI

Position Markers
D4Mit8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24102,684,777 - 102,684,881 (+)MAPPERmRatBN7.2
Rnor_6.0498,542,003 - 98,542,106RGDRnor6.0
RH127636  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24102,688,085 - 102,688,280 (+)MAPPERmRatBN7.2
Rnor_6.0498,523,071 - 98,523,265NCBIRnor6.0
Rnor_5.04163,308,908 - 163,309,102UniSTSRnor5.0
Celera491,864,152 - 91,864,346UniSTS
RH 3.4 Map4633.8UniSTS
Cytogenetic Map4q32UniSTS
Cytogenetic Map4q31UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:33
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000074175
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
GenBank Nucleotide BC062802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L22655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Protein Sequences
GenBank Protein AAA91898 (Get FASTA)   NCBI Sequence Viewer  
  AAH62802 (Get FASTA)   NCBI Sequence Viewer  
  P01836 (Get FASTA)   NCBI Sequence Viewer  
Protein Domains
Ig-like


Additional Information

Database Acc Id Source(s)
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6890409 IMAGE-MGC_LOAD
  IMAGE:7388228 IMAGE-MGC_LOAD
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig/MHC_CS UniProtKB/Swiss-Prot
  Ig_C1-set UniProtKB/Swiss-Prot
MGC_CLONE MGC:112745 IMAGE-MGC_LOAD
  MGC:73014 IMAGE-MGC_LOAD
NCBI Gene 500183 ENTREZGENE
Pfam C1-set UniProtKB/Swiss-Prot
PhenoGen Igkc PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot
  IG_MHC UniProtKB/Swiss-Prot
SMART IGc1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt KACA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-14 Igkc  immunoglobulin kappa constant  LOC500183  similar to NGF-binding Ig light chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC500183  similar to NGF-binding Ig light chain      Symbol and Name status set to provisional 70820 PROVISIONAL