Plag1 (PLAG1 zinc finger) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Plag1 (PLAG1 zinc finger) Rattus norvegicus
Analyze
Symbol: Plag1
Name: PLAG1 zinc finger
RGD ID: 1305286
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of glial cell proliferation and regulation of gene expression. Predicted to act upstream of or within gland morphogenesis and prostate gland growth. Predicted to be located in centrosome; cytosol; and nuclear speck. Human ortholog(s) of this gene implicated in Silver-Russell syndrome and pleomorphic adenoma. Orthologous to human PLAG1 (PLAG1 zinc finger); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC297804; MGC94626; pleiomorphic adenoma gene 1; pleiomorphic adenoma gene 1 protein; zinc finger protein PLAG1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2516,902,057 - 16,956,727 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl516,905,394 - 16,913,647 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx519,156,087 - 19,164,167 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0520,754,576 - 20,762,656 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0520,506,071 - 20,514,151 (-)NCBIRnor_WKY
Rnor_6.0516,788,186 - 16,842,827 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl516,791,523 - 16,799,776 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0521,565,875 - 21,584,631 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4517,214,930 - 17,223,197 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1517,214,938 - 17,223,197 (-)NCBI
Celera516,279,969 - 16,288,236 (-)NCBICelera
Cytogenetic Map5q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene. Astrom AK, etal., Cancer Res. 1999 Feb 15;59(4):918-23.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:10646861   PMID:12477932   PMID:15606491   PMID:19808959   PMID:36201855  


Genomics

Comparative Map Data
Plag1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2516,902,057 - 16,956,727 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl516,905,394 - 16,913,647 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx519,156,087 - 19,164,167 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0520,754,576 - 20,762,656 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0520,506,071 - 20,514,151 (-)NCBIRnor_WKY
Rnor_6.0516,788,186 - 16,842,827 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl516,791,523 - 16,799,776 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0521,565,875 - 21,584,631 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4517,214,930 - 17,223,197 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1517,214,938 - 17,223,197 (-)NCBI
Celera516,279,969 - 16,288,236 (-)NCBICelera
Cytogenetic Map5q12NCBI
PLAG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38856,160,909 - 56,211,273 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl856,160,909 - 56,211,324 (-)EnsemblGRCh38hg38GRCh38
GRCh37857,073,468 - 57,123,832 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36857,236,037 - 57,286,392 (-)NCBINCBI36Build 36hg18NCBI36
Build 34857,236,036 - 57,286,392NCBI
Celera853,064,260 - 53,082,827 (-)NCBICelera
Cytogenetic Map8q12.1NCBI
HuRef852,540,946 - 52,591,254 (-)NCBIHuRef
CHM1_1857,125,297 - 57,175,697 (-)NCBICHM1_1
T2T-CHM13v2.0856,537,883 - 56,588,262 (-)NCBIT2T-CHM13v2.0
Plag1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3943,895,209 - 3,938,429 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl43,900,996 - 3,938,423 (-)EnsemblGRCm39 Ensembl
GRCm3843,898,769 - 3,938,430 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl43,900,996 - 3,938,423 (-)EnsemblGRCm38mm10GRCm38
MGSCv3743,828,305 - 3,865,552 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3643,829,756 - 3,865,529 (-)NCBIMGSCv36mm8
Celera43,857,688 - 3,895,036 (-)NCBICelera
Cytogenetic Map4A1NCBI
Plag1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545415,239,042 - 15,281,669 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545415,239,042 - 15,281,669 (-)NCBIChiLan1.0ChiLan1.0
PLAG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1849,978,292 - 50,028,591 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl849,983,627 - 50,028,591 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0852,607,398 - 52,657,808 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PLAG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1297,563,804 - 7,608,819 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl297,564,596 - 7,608,902 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha297,871,731 - 7,921,444 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0297,633,248 - 7,683,215 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl297,636,479 - 7,683,212 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1297,647,839 - 7,697,595 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0297,779,563 - 7,829,280 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0298,056,328 - 8,106,311 (-)NCBIUU_Cfam_GSD_1.0
Plag1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530371,929,956 - 71,975,601 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364962,814,583 - 2,855,527 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364962,809,878 - 2,855,515 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLAG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl475,646,584 - 75,694,117 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1475,646,585 - 75,696,718 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2482,594,992 - 82,612,789 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLAG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1852,200,365 - 52,250,938 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl852,203,467 - 52,250,918 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603989,546,317 - 89,596,893 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plag1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248863,827,937 - 3,868,179 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248863,827,944 - 3,873,124 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Plag1
280 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:576
Count of miRNA genes:272
Interacting mature miRNAs:346
Transcripts:ENSRNOT00000011721
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5384401826141981Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
631827Alc4Alcohol consumption QTL 43.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)5818750118616199Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 7 2 5 2 20 10 24
Low 2 38 41 30 14 30 8 8 54 23 15 11 8
Below cutoff 1 1 9 9 9 1 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000011721   ⟹   ENSRNOP00000011721
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl516,905,394 - 16,913,647 (-)Ensembl
Rnor_6.0 Ensembl516,791,523 - 16,799,776 (-)Ensembl
RefSeq Acc Id: NM_001008316   ⟹   NP_001008317
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2516,905,380 - 16,913,647 (-)NCBI
Rnor_6.0516,791,509 - 16,799,776 (-)NCBI
Rnor_5.0521,565,875 - 21,584,631 (-)NCBI
RGSC_v3.4517,214,930 - 17,223,197 (-)RGD
Celera516,279,969 - 16,288,236 (-)RGD
Sequence:
RefSeq Acc Id: XM_008763525   ⟹   XP_008761747
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2516,902,057 - 16,956,727 (-)NCBI
Rnor_6.0516,788,186 - 16,842,827 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008763526   ⟹   XP_008761748
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2516,902,057 - 16,956,727 (-)NCBI
Rnor_6.0516,788,186 - 16,842,827 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593221   ⟹   XP_017448710
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2516,902,057 - 16,955,771 (-)NCBI
Rnor_6.0516,788,186 - 16,828,967 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593224   ⟹   XP_017448713
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2516,902,057 - 16,956,727 (-)NCBI
Rnor_6.0516,788,186 - 16,842,827 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109399   ⟹   XP_038965327
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2516,902,057 - 16,955,771 (-)NCBI
RefSeq Acc Id: XM_039109400   ⟹   XP_038965328
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2516,902,057 - 16,956,727 (-)NCBI
RefSeq Acc Id: XM_039109401   ⟹   XP_038965329
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2516,902,057 - 16,956,727 (-)NCBI
RefSeq Acc Id: XM_039109402   ⟹   XP_038965330
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2516,902,057 - 16,956,727 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001008317   ⟸   NM_001008316
- UniProtKB: Q5U2T6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008761747   ⟸   XM_008763525
- Peptide Label: isoform X1
- UniProtKB: Q5U2T6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008761748   ⟸   XM_008763526
- Peptide Label: isoform X1
- UniProtKB: Q5U2T6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017448713   ⟸   XM_017593224
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017448710   ⟸   XM_017593221
- Peptide Label: isoform X1
- UniProtKB: Q5U2T6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011721   ⟸   ENSRNOT00000011721
RefSeq Acc Id: XP_038965330   ⟸   XM_039109402
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038965329   ⟸   XM_039109401
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038965328   ⟸   XM_039109400
- Peptide Label: isoform X1
- UniProtKB: Q5U2T6 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038965327   ⟸   XM_039109399
- Peptide Label: isoform X1
- UniProtKB: Q5U2T6 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U2T6-F1-model_v2 AlphaFold Q5U2T6 1-499 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305286 AgrOrtholog
BioCyc Gene G2FUF-42112 BioCyc
Ensembl Genes ENSRNOG00000008846 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000011721 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000011721 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7191202 IMAGE-MGC_LOAD
InterPro PLAG1/PLAGL2 UniProtKB/Swiss-Prot
  Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report rno:297804 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94626 IMAGE-MGC_LOAD
NCBI Gene 297804 ENTREZGENE
PANTHER PTHR24390:SF64 UniProtKB/Swiss-Prot
Pfam zf-C2H2 UniProtKB/Swiss-Prot
PhenoGen Plag1 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
SMART ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot
UniProt PLAG1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Plag1  PLAG1 zinc finger  Plag1  pleiomorphic adenoma gene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Plag1  pleiomorphic adenoma gene 1  Plag1_predicted  pleiomorphic adenoma gene 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Plag1_predicted  pleiomorphic adenoma gene 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED