Gabrq (gamma-aminobutyric acid type A receptor subunit theta) - Rat Genome Database

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Gene: Gabrq (gamma-aminobutyric acid type A receptor subunit theta) Rattus norvegicus
Analyze
Symbol: Gabrq
Name: gamma-aminobutyric acid type A receptor subunit theta
RGD ID: 68331
Description: Predicted to enable neurotransmitter receptor activity. Predicted to contribute to GABA-A receptor activity and chloride channel activity. Predicted to be involved in several processes, including chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to be located in postsynaptic membrane. Predicted to be part of GABA-A receptor complex. Predicted to be active in neuron projection and synapse. Orthologous to human GABRQ (gamma-aminobutyric acid type A receptor subunit theta); INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: gamma-aminobutyric acid (GABA) A receptor theta; gamma-aminobutyric acid (GABA) A receptor, theta; gamma-aminobutyric acid (GABA) receptor, theta; gamma-aminobutyric acid (GABA-A) receptor, subunit theta; gamma-aminobutyric acid A receptor, theta; gamma-aminobutyric acid receptor subunit theta; gamma-aminobutyric acid type A receptor theta subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X150,696,174 - 150,712,950 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX150,696,427 - 150,709,919 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX152,888,448 - 152,900,925 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X156,420,788 - 156,433,265 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X153,963,894 - 153,976,377 (+)NCBIRnor_WKY
Rnor_6.0X152,852,230 - 152,869,012 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX152,852,506 - 152,864,975 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01148,583,050 - 148,599,817 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X158,843,492 - 158,855,961 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X158,916,924 - 158,929,394 (+)NCBI
Celera1131,660,367 - 131,672,836 (+)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus. Sinkkonen ST, etal., J Neurosci 2000 May 15;20(10):3588-95.
Additional References at PubMed
PMID:19249336   PMID:23382219  


Genomics

Comparative Map Data
Gabrq
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X150,696,174 - 150,712,950 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX150,696,427 - 150,709,919 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX152,888,448 - 152,900,925 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X156,420,788 - 156,433,265 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X153,963,894 - 153,976,377 (+)NCBIRnor_WKY
Rnor_6.0X152,852,230 - 152,869,012 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX152,852,506 - 152,864,975 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01148,583,050 - 148,599,817 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X158,843,492 - 158,855,961 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X158,916,924 - 158,929,394 (+)NCBI
Celera1131,660,367 - 131,672,836 (+)NCBICelera
Cytogenetic MapXq37NCBI
GABRQ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X152,637,895 - 152,658,965 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX152,637,895 - 152,657,542 (+)EnsemblGRCh38hg38GRCh38
GRCh37X151,806,349 - 151,826,007 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X151,557,293 - 151,572,481 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X151,477,204 - 151,492,393NCBI
CeleraX152,051,839 - 152,067,018 (+)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX140,659,584 - 140,674,760 (+)NCBIHuRef
CHM1_1X151,681,317 - 151,696,496 (+)NCBICHM1_1
T2T-CHM13v2.0X150,904,491 - 150,933,803 (+)NCBIT2T-CHM13v2.0
Gabrq
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X71,868,769 - 71,886,213 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX71,868,784 - 71,886,208 (+)EnsemblGRCm39 Ensembl
GRCm38X72,825,163 - 72,842,607 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX72,825,178 - 72,842,602 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X70,070,775 - 70,083,883 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X69,078,156 - 69,091,264 (+)NCBIMGSCv36mm8
CeleraX63,768,918 - 63,782,292 (+)NCBICelera
Cytogenetic MapXA7.3NCBI
Gabrq
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554988,048,265 - 8,064,239 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554988,048,012 - 8,064,239 (+)NCBIChiLan1.0ChiLan1.0
GABRQ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1X152,699,409 - 152,719,101 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X142,205,996 - 142,225,571 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X152,160,173 - 152,179,774 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX152,159,961 - 152,179,774 (+)Ensemblpanpan1.1panPan2
GABRQ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X120,607,815 - 120,630,251 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX120,607,686 - 120,628,343 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX105,986,731 - 106,009,002 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X122,830,162 - 122,852,448 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X119,549,100 - 119,571,365 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X122,039,877 - 122,062,152 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X121,914,807 - 121,937,084 (+)NCBIUU_Cfam_GSD_1.0
Gabrq
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X117,923,763 - 117,940,883 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936714318,676 - 332,357 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936714315,585 - 332,629 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GABRQ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX123,834,997 - 123,850,278 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X123,834,884 - 123,855,187 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X141,305,459 - 141,323,254 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GABRQ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X127,201,371 - 127,217,964 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX127,210,446 - 127,219,804 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606565,060,292 - 65,079,959 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gabrq
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248833,903,661 - 3,918,836 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248833,903,389 - 3,922,736 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gabrq
3 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:17
Count of miRNA genes:17
Interacting mature miRNAs:17
Transcripts:ENSRNOT00000022880
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat

Markers in Region
UniSTS:496008  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X150,707,366 - 150,707,457 (+)MAPPERmRatBN7.2
Rnor_6.0X152,863,431 - 152,863,521NCBIRnor6.0
Rnor_5.01148,594,236 - 148,594,326UniSTSRnor5.0
RGSC_v3.4X158,854,417 - 158,854,507UniSTSRGSC3.4
Celera1131,671,292 - 131,671,382UniSTS
Cytogenetic MapXq37UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 12 4 4 72 6 22 2
Below cutoff 26 23 15 6 15 5 6 2 14 11 9 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000078419   ⟹   ENSRNOP00000068820
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX150,696,427 - 150,708,911 (+)Ensembl
Rnor_6.0 EnsemblX152,852,506 - 152,864,975 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107625   ⟹   ENSRNOP00000089871
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX150,696,427 - 150,709,919 (+)Ensembl
RefSeq Acc Id: NM_031733   ⟹   NP_113921
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X150,696,442 - 150,708,911 (+)NCBI
Rnor_6.0X152,852,506 - 152,864,975 (+)NCBI
Rnor_5.01148,583,050 - 148,599,817 (+)NCBI
RGSC_v3.4X158,843,492 - 158,855,961 (+)RGD
Celera1131,660,367 - 131,672,836 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229516   ⟹   XP_006229578
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X150,696,174 - 150,712,950 (+)NCBI
Rnor_6.0X152,852,230 - 152,869,012 (+)NCBI
Rnor_5.01148,583,050 - 148,599,817 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_113921 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229578 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF70382 (Get FASTA)   NCBI Sequence Viewer  
  AAL15939 (Get FASTA)   NCBI Sequence Viewer  
  EDL82834 (Get FASTA)   NCBI Sequence Viewer  
  EDL82835 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_113921   ⟸   NM_031733
- Peptide Label: precursor
- UniProtKB: G3V875 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229578   ⟸   XM_006229516
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000068820   ⟸   ENSRNOT00000078419
RefSeq Acc Id: ENSRNOP00000089871   ⟸   ENSRNOT00000107625
Protein Domains
Neurotransmitter-gated ion-channel ligand-binding   Neurotransmitter-gated ion-channel transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V875-F1-model_v2 AlphaFold G3V875 1-635 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68331 AgrOrtholog
BioCyc Gene G2FUF-696 BioCyc
Ensembl Genes ENSRNOG00000053402 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000068820 ENTREZGENE
  ENSRNOP00000068820.2 UniProtKB/TrEMBL
  ENSRNOP00000089871.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078419 ENTREZGENE
  ENSRNOT00000078419.2 UniProtKB/TrEMBL
  ENSRNOT00000107625.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.390 UniProtKB/TrEMBL
  2.70.170.10 UniProtKB/TrEMBL
InterPro GABAA_rcpt UniProtKB/TrEMBL
  GABAAt_rcpt UniProtKB/TrEMBL
  Neur_chan_lig-bd UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/TrEMBL
  Neur_channel UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/TrEMBL
  Neuro_actylchol_rec UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/TrEMBL
KEGG Report rno:65187 UniProtKB/TrEMBL
NCBI Gene 65187 ENTREZGENE
PANTHER GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT THETA UniProtKB/TrEMBL
  PTHR18945 UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/TrEMBL
PhenoGen Gabrq PhenoGen
PRINTS GABAARECEPTR UniProtKB/TrEMBL
  GABAARTHETA UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/TrEMBL
Superfamily-SCOP Neu_channel_TM UniProtKB/TrEMBL
  Neur_chan_LBD UniProtKB/TrEMBL
TIGRFAMs LIC UniProtKB/TrEMBL
UniProt A0A8I6GHR1_RAT UniProtKB/TrEMBL
  G3V875 ENTREZGENE, UniProtKB/TrEMBL
  Q91ZM7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-06 Gabrq  gamma-aminobutyric acid type A receptor subunit theta  Gabrq  gamma-aminobutyric acid type A receptor theta subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Gabrq  gamma-aminobutyric acid type A receptor theta subunit  Gabrq  gamma-aminobutyric acid (GABA) A receptor, theta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-16 Gabrq  gamma-aminobutyric acid (GABA) A receptor, theta  Gabrq  gamma-aminobutyric acid (GABA) receptor, theta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-17 Gabrq  gamma-aminobutyric acid (GABA) receptor, theta  Gabrq  gamma-aminobutyric acid (GABA-A) receptor, subunit theta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-11 Gabrq  gamma-aminobutyric acid (GABA-A) receptor, subunit theta  Gabrq  gamma-aminobutyric acid (GABA) receptor, theta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Gabrq  gamma-aminobutyric acid (GABA) receptor, theta  Gabrq  gamma-aminobutyric acid A receptor, theta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gabrq  gamma-aminobutyric acid A receptor, theta      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA localized in the rat locus ceruleus and the hypothalamus 68250
gene_homology has low sequence conservation with human protein and may have significantly different functions 68250