Map4k5 (mitogen-activated protein kinase kinase kinase kinase 5) - Rat Genome Database

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Gene: Map4k5 (mitogen-activated protein kinase kinase kinase kinase 5) Rattus norvegicus
Analyze
Symbol: Map4k5
Name: mitogen-activated protein kinase kinase kinase kinase 5
RGD ID: 1562028
Description: Predicted to enable ATP binding activity and MAP kinase kinase kinase kinase activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC503027; RGD1562028; similar to mitogen-activated protein kinase kinase kinase kinase 5 isoform 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2688,284,094 - 88,377,118 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl688,284,094 - 88,376,799 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx688,682,790 - 88,775,999 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0688,982,254 - 89,075,463 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0688,421,994 - 88,514,988 (-)NCBIRnor_WKY
Rnor_6.0692,136,242 - 92,229,578 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl692,136,992 - 92,229,260 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06101,585,538 - 101,678,657 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4691,885,447 - 91,978,735 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera686,779,691 - 86,871,808 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (ISO)
plasma membrane  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9038372  


Genomics

Comparative Map Data
Map4k5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2688,284,094 - 88,377,118 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl688,284,094 - 88,376,799 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx688,682,790 - 88,775,999 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0688,982,254 - 89,075,463 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0688,421,994 - 88,514,988 (-)NCBIRnor_WKY
Rnor_6.0692,136,242 - 92,229,578 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl692,136,992 - 92,229,260 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06101,585,538 - 101,678,657 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4691,885,447 - 91,978,735 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera686,779,691 - 86,871,808 (-)NCBICelera
Cytogenetic Map6q24NCBI
MAP4K5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381450,418,521 - 50,561,126 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1450,418,501 - 50,561,126 (-)EnsemblGRCh38hg38GRCh38
GRCh371450,885,239 - 50,999,287 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361449,954,993 - 50,069,126 (-)NCBINCBI36Build 36hg18NCBI36
Build 341449,954,992 - 50,069,126NCBI
Celera1430,752,350 - 30,866,424 (-)NCBICelera
Cytogenetic Map14q22.1NCBI
HuRef1431,010,380 - 31,124,579 (-)NCBIHuRef
CHM1_11450,823,813 - 50,937,937 (-)NCBICHM1_1
T2T-CHM13v2.01444,624,744 - 44,767,297 (-)NCBIT2T-CHM13v2.0
Map4k5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391269,850,531 - 69,939,937 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1269,850,524 - 69,939,974 (-)EnsemblGRCm39 Ensembl
GRCm381269,803,757 - 69,893,163 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1269,803,750 - 69,893,200 (-)EnsemblGRCm38mm10GRCm38
MGSCv371270,904,744 - 70,994,150 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361270,722,362 - 70,811,768 (-)NCBIMGSCv36mm8
Celera1270,899,904 - 70,995,304 (-)NCBICelera
Cytogenetic Map12C2NCBI
Map4k5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540912,315,321 - 12,396,136 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540912,319,806 - 12,396,136 (+)NCBIChiLan1.0ChiLan1.0
MAP4K5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11450,771,324 - 50,888,105 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01431,008,177 - 31,122,127 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11449,311,733 - 49,425,529 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1449,311,733 - 49,425,520 (-)Ensemblpanpan1.1panPan2
MAP4K5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1826,851,143 - 26,960,144 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl826,852,689 - 26,959,980 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha826,604,503 - 26,713,962 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0827,028,723 - 27,137,853 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl827,028,741 - 27,137,036 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1826,683,589 - 26,792,878 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0826,756,060 - 26,866,857 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0827,074,892 - 27,184,205 (-)NCBIUU_Cfam_GSD_1.0
Map4k5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864059,032,682 - 59,138,318 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649515,053,275 - 15,159,011 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493649515,053,275 - 15,159,011 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP4K5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1180,164,458 - 180,299,496 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11180,164,427 - 180,299,491 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21200,523,478 - 200,568,182 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP4K5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12427,496,269 - 27,604,726 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2427,493,322 - 27,604,295 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605315,814,474 - 15,921,001 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map4k5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473118,362,856 - 18,460,761 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Map4k5
437 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:437
Count of miRNA genes:253
Interacting mature miRNAs:312
Transcripts:ENSRNOT00000006705
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)65672856290198260Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 48 37 14 37 8 10 74 35 35 11 8
Low 2 9 4 5 4 1 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006705   ⟹   ENSRNOP00000006705
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl688,284,094 - 88,376,799 (-)Ensembl
Rnor_6.0 Ensembl692,136,992 - 92,229,260 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105643   ⟹   ENSRNOP00000091112
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl688,284,094 - 88,376,799 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106217   ⟹   ENSRNOP00000092920
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl688,284,094 - 88,376,799 (-)Ensembl
RefSeq Acc Id: NM_001192016   ⟹   NP_001178945
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2688,284,834 - 88,376,714 (-)NCBI
Rnor_6.0692,136,982 - 92,229,260 (-)NCBI
Rnor_5.06101,585,538 - 101,678,657 (-)NCBI
Celera686,779,691 - 86,871,808 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240179   ⟹   XP_006240241
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2688,284,094 - 88,377,116 (-)NCBI
Rnor_6.0692,136,242 - 92,229,574 (-)NCBI
Rnor_5.06101,585,538 - 101,678,657 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240180   ⟹   XP_006240242
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2688,284,094 - 88,377,118 (-)NCBI
Rnor_6.0692,136,242 - 92,229,578 (-)NCBI
Rnor_5.06101,585,538 - 101,678,657 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001178945 (Get FASTA)   NCBI Sequence Viewer  
  XP_006240241 (Get FASTA)   NCBI Sequence Viewer  
  XP_006240242 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM03533 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001178945   ⟸   NM_001192016
- UniProtKB: D3ZHL6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240242   ⟸   XM_006240180
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006240241   ⟸   XM_006240179
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000006705   ⟸   ENSRNOT00000006705
RefSeq Acc Id: ENSRNOP00000092920   ⟸   ENSRNOT00000106217
RefSeq Acc Id: ENSRNOP00000091112   ⟸   ENSRNOT00000105643
Protein Domains
CNH   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZHL6-F1-model_v2 AlphaFold D3ZHL6 1-846 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562028 AgrOrtholog
BioCyc Gene G2FUF-37221 BioCyc
Ensembl Genes ENSRNOG00000004923 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000006705 ENTREZGENE
  ENSRNOP00000006705.6 UniProtKB/TrEMBL
  ENSRNOP00000091112.1 UniProtKB/TrEMBL
  ENSRNOP00000092920 ENTREZGENE
  ENSRNOP00000092920.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006705 ENTREZGENE
  ENSRNOT00000006705.6 UniProtKB/TrEMBL
  ENSRNOT00000105643.1 UniProtKB/TrEMBL
  ENSRNOT00000106217 ENTREZGENE
  ENSRNOT00000106217.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Citron UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  MAPKKKK UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
KEGG Report rno:503027 UniProtKB/TrEMBL
NCBI Gene 503027 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 5 UniProtKB/TrEMBL
  STERILE20-LIKE KINASE, ISOFORM B-RELATED UniProtKB/TrEMBL
Pfam CNH UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Map4k5 PhenoGen
PIRSF MAPKKKK UniProtKB/TrEMBL
PROSITE CNH UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART CNH UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I6AJ75_RAT UniProtKB/TrEMBL
  A0A8I6GJD3_RAT UniProtKB/TrEMBL
  D3ZHL6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-29 Map4k5  mitogen-activated protein kinase kinase kinase kinase 5  RGD1562028_predicted  similar to mitogen-activated protein kinase kinase kinase kinase 5 isoform 2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562028_predicted  similar to mitogen-activated protein kinase kinase kinase kinase 5 isoform 2 (predicted)  LOC503027  similar to mitogen-activated protein kinase kinase kinase kinase 5 isoform 2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC503027  similar to mitogen-activated protein kinase kinase kinase kinase 5 isoform 2      Symbol and Name status set to provisional 70820 PROVISIONAL