Map4k5 (mitogen-activated protein kinase kinase kinase kinase 5) - Rat Genome Database

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Gene: Map4k5 (mitogen-activated protein kinase kinase kinase kinase 5) Chinchilla lanigera
Analyze
Symbol: Map4k5
Name: mitogen-activated protein kinase kinase kinase kinase 5
RGD ID: 8873158
Description: ENCODES a protein that exhibits ATP binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN intracellular signal transduction (ortholog); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; ASSOCIATED WITH genetic disease (ortholog); hereditary sensory neuropathy type 1D (ortholog); hereditary spastic paraplegia 3A (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540912,315,321 - 12,396,136 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540912,319,806 - 12,396,136 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
cytosol  (ISO)
plasma membrane  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Map4k5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540912,315,321 - 12,396,136 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540912,319,806 - 12,396,136 (+)NCBIChiLan1.0ChiLan1.0
MAP4K5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381450,418,521 - 50,561,126 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1450,418,501 - 50,561,126 (-)EnsemblGRCh38hg38GRCh38
GRCh371450,885,239 - 50,999,287 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361449,954,993 - 50,069,126 (-)NCBINCBI36Build 36hg18NCBI36
Build 341449,954,992 - 50,069,126NCBI
Celera1430,752,350 - 30,866,424 (-)NCBICelera
Cytogenetic Map14q22.1NCBI
HuRef1431,010,380 - 31,124,579 (-)NCBIHuRef
CHM1_11450,823,813 - 50,937,937 (-)NCBICHM1_1
T2T-CHM13v2.01444,624,744 - 44,767,297 (-)NCBIT2T-CHM13v2.0
Map4k5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391269,850,531 - 69,939,937 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1269,850,524 - 69,939,974 (-)EnsemblGRCm39 Ensembl
GRCm381269,803,757 - 69,893,163 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1269,803,750 - 69,893,200 (-)EnsemblGRCm38mm10GRCm38
MGSCv371270,904,744 - 70,994,150 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361270,722,362 - 70,811,768 (-)NCBIMGSCv36mm8
Celera1270,899,904 - 70,995,304 (-)NCBICelera
Cytogenetic Map12C2NCBI
cM Map1228.94NCBI
Map4k5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8694,020,079 - 94,112,943 (-)NCBIGRCr8
mRatBN7.2688,284,087 - 88,377,118 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl688,284,094 - 88,376,799 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx688,682,790 - 88,775,999 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0688,982,254 - 89,075,463 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0688,421,994 - 88,514,988 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0692,136,242 - 92,229,578 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl692,136,992 - 92,229,260 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06101,585,538 - 101,678,657 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4691,885,447 - 91,978,735 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera686,779,691 - 86,871,808 (-)NCBICelera
Cytogenetic Map6q24NCBI
MAP4K5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21551,554,822 - 51,671,662 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11450,771,324 - 50,888,105 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01431,008,177 - 31,122,127 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11449,311,733 - 49,425,529 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1449,311,733 - 49,425,520 (-)Ensemblpanpan1.1panPan2
MAP4K5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1826,851,143 - 26,960,144 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl826,852,689 - 26,959,980 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha826,604,503 - 26,713,962 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0827,028,723 - 27,137,853 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl827,028,741 - 27,137,036 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1826,683,589 - 26,792,878 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0826,756,060 - 26,866,857 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0827,074,892 - 27,184,205 (-)NCBIUU_Cfam_GSD_1.0
Map4k5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864059,032,682 - 59,138,318 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649515,053,275 - 15,159,011 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649515,053,275 - 15,159,011 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP4K5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1180,164,458 - 180,299,496 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11180,164,427 - 180,299,491 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21200,523,478 - 200,568,182 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP4K5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12427,496,269 - 27,604,726 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2427,493,322 - 27,604,295 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605315,814,474 - 15,921,001 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map4k5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473118,362,856 - 18,460,761 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000018220   ⟹   ENSCLAP00000018042
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540912,315,321 - 12,394,969 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000018221   ⟹   ENSCLAP00000018043
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540912,319,092 - 12,394,969 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000018222   ⟹   ENSCLAP00000018044
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540912,319,806 - 12,396,136 (+)Ensembl
RefSeq Acc Id: XM_005376823   ⟹   XP_005376880
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540912,319,806 - 12,396,136 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013510334   ⟹   XP_013365788
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540912,319,806 - 12,396,136 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005376880 (Get FASTA)   NCBI Sequence Viewer  
  XP_013365788 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000018042.1
  ENSCLAP00000018043.1
  ENSCLAP00000018044
  ENSCLAP00000018044.1
Reference Protein Sequences
RefSeq Acc Id: XP_005376880   ⟸   XM_005376823
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VQA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013365788   ⟸   XM_013510334
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VQA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000018043   ⟸   ENSCLAT00000018221
RefSeq Acc Id: ENSCLAP00000018044   ⟸   ENSCLAT00000018222
RefSeq Acc Id: ENSCLAP00000018042   ⟸   ENSCLAT00000018220
Protein Domains
CNH   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000012379 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000018220.1 UniProtKB/TrEMBL
  ENSCLAT00000018221.1 UniProtKB/TrEMBL
  ENSCLAT00000018222 ENTREZGENE
  ENSCLAT00000018222.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro CNH_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  MAPKKKK UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
NCBI Gene Map4k5 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 5 UniProtKB/TrEMBL
  STERILE20-LIKE KINASE, ISOFORM B-RELATED UniProtKB/TrEMBL
Pfam CNH UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PIRSF MAPKKKK UniProtKB/TrEMBL
PROSITE CNH UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART CNH UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2VN50_CHILA UniProtKB/TrEMBL
  A0A8C2VQA4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VVD0_CHILA UniProtKB/TrEMBL