Kctd12b (potassium channel tetramerisation domain containing 12b) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Kctd12b (potassium channel tetramerisation domain containing 12b) Rattus norvegicus
Analyze
Symbol: Kctd12b (Ensembl: LOC681355)
Name: potassium channel tetramerisation domain containing 12b (Ensembl:similar to potassium channel tetramerisation domain containing 12b)
RGD ID: 1596735
Description: Predicted to be involved in regulation of G protein-coupled receptor signaling pathway. Predicted to be part of receptor complex. Orthologous to human KCTD12 (potassium channel tetramerization domain containing 12); INTERACTS WITH diethylstilbestrol; ketoconazole; 1,2-dichloroethane (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: BTB/POZ domain-containing protein KCTD12-like; LOC681355; similar to potassium channel tetramerisation domain containing 12b
RGD Orthologs
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X20,989,053 - 21,000,208 (+)NCBIGRCr8
mRatBN7.2X17,643,707 - 17,654,820 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX17,643,615 - 17,654,820 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X18,483,254 - 18,494,403 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX18,489,597 - 18,490,475 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X19,253,518 - 19,264,584 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X37,754,921 - 37,758,339 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX17,898,347 - 17,901,746 (+)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Kctd12b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X20,989,053 - 21,000,208 (+)NCBIGRCr8
mRatBN7.2X17,643,707 - 17,654,820 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX17,643,615 - 17,654,820 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X18,483,254 - 18,494,403 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX18,489,597 - 18,490,475 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X19,253,518 - 19,264,584 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X37,754,921 - 37,758,339 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX17,898,347 - 17,901,746 (+)NCBICelera
Cytogenetic MapXq12NCBI
Kctd12b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X152,468,150 - 152,479,382 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX152,468,150 - 152,479,387 (-)EnsemblGRCm39 Ensembl
GRCm38X153,685,154 - 153,696,386 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX153,685,154 - 153,696,391 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X150,119,697 - 150,130,823 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X149,025,870 - 149,036,996 (-)NCBIMGSCv36mm8
CeleraX135,546,787 - 135,557,897 (+)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX71.79NCBI

Variants

.
Variants in Kctd12b
36 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:21
Count of miRNA genes:20
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000059744
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 4 1 1 6 16 8 2 1
Low 2 32 53 37 15 37 7 9 68 19 28 9 7
Below cutoff 1 3 4 4 4 1 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000059744   ⟹   ENSRNOP00000056498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX18,489,597 - 18,490,475 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097922   ⟹   ENSRNOP00000084368
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX17,643,667 - 17,654,820 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102567   ⟹   ENSRNOP00000078700
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX17,643,615 - 17,654,820 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106593   ⟹   ENSRNOP00000088862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX17,643,667 - 17,654,820 (+)Ensembl
RefSeq Acc Id: XM_003752020   ⟹   XP_003752068
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X20,989,053 - 21,000,208 (+)NCBI
mRatBN7.2X17,643,708 - 17,654,820 (+)NCBI
Rnor_6.0X18,483,254 - 18,494,403 (+)NCBI
Rnor_5.0X19,253,518 - 19,264,584 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256771   ⟹   XP_006256833
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X20,989,053 - 21,000,208 (+)NCBI
mRatBN7.2X17,643,707 - 17,654,820 (+)NCBI
Rnor_6.0X18,483,254 - 18,494,403 (+)NCBI
Rnor_5.0X19,253,518 - 19,264,584 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256772   ⟹   XP_006256834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X20,989,100 - 21,000,208 (+)NCBI
mRatBN7.2X17,643,707 - 17,654,820 (+)NCBI
Rnor_6.0X18,483,254 - 18,494,403 (+)NCBI
Rnor_5.0X19,253,518 - 19,264,584 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256773   ⟹   XP_006256835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X20,989,100 - 21,000,208 (+)NCBI
mRatBN7.2X17,643,707 - 17,654,820 (+)NCBI
Rnor_6.0X18,483,254 - 18,494,403 (+)NCBI
Rnor_5.0X19,253,518 - 19,264,584 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_003752068   ⟸   XM_003752020
- UniProtKB: A0A8I6A7D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256834   ⟸   XM_006256772
- UniProtKB: A0A8I6A7D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256833   ⟸   XM_006256771
- UniProtKB: A0A8I6A7D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256835   ⟸   XM_006256773
- UniProtKB: A0A8I6A7D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000056498   ⟸   ENSRNOT00000059744
RefSeq Acc Id: ENSRNOP00000078700   ⟸   ENSRNOT00000102567
RefSeq Acc Id: ENSRNOP00000084368   ⟸   ENSRNOT00000097922
RefSeq Acc Id: ENSRNOP00000088862   ⟸   ENSRNOT00000106593
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M1A6-F1-model_v2 AlphaFold F1M1A6 1-292 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1596735 AgrOrtholog
BioCyc Gene G2FUF-2835 BioCyc
Ensembl Genes ENSRNOG00000039063 Ensembl
  ENSRNOG00000069375 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000097922.1 UniProtKB/TrEMBL
  ENSRNOT00000102567.1 UniProtKB/TrEMBL
  ENSRNOT00000106593.1 UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/TrEMBL
KEGG Report rno:681355 UniProtKB/TrEMBL
NCBI Gene 681355 ENTREZGENE
PANTHER POTASSIUM CHANNEL TETRAMERISATION DOMAIN-CONTAINING 12B UniProtKB/TrEMBL
  POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/TrEMBL
PhenoGen Kctd12b PhenoGen
RatGTEx ENSRNOG00000039063 RatGTEx
  ENSRNOG00000069375 RatGTEx
SMART BTB UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/TrEMBL
UniProt A0A8I6A7D3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-11 Kctd12b  potassium channel tetramerisation domain containing 12b  LOC681355  similar to potassium channel tetramerisation domain containing 12b  Name and Symbol changed 629549 APPROVED
2006-11-20 LOC681355  similar to potassium channel tetramerisation domain containing 12b      Symbol and Name status set to provisional 70820 PROVISIONAL