Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Ssbp4 | Rat | (+)-catechin | multiple interactions | ISO | SSBP4 (Homo sapiens) | 6480464 | [Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SSBP4 mRNA | CTD | PMID:24763279 | Ssbp4 | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Ssbp4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SSBP4 mRNA | CTD | PMID:36331819 | Ssbp4 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Ssbp4 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SSBP4 mRNA | CTD | PMID:22206623 | Ssbp4 | Rat | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of SSBP4 mRNA | CTD | PMID:32145629 | Ssbp4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Ssbp4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SSBP4 mRNA | CTD | PMID:21570461 | Ssbp4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SSBP4 mRNA | CTD | PMID:34747641 | Ssbp4 | Rat | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Ssbp4 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of SSBP4 mRNA | CTD | PMID:20188158 | Ssbp4 | Rat | 4,4'-sulfonyldiphenol | increases methylation | ISO | Ssbp4 (Mus musculus) | 6480464 | bisphenol S results in increased methylation of SSBP4 exon | CTD | PMID:33297965 | Ssbp4 | Rat | 4,4'-sulfonyldiphenol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of SSBP4 mRNA | CTD | PMID:36041667 | Ssbp4 | Rat | 4,4'-sulfonyldiphenol | affects methylation | ISO | Ssbp4 (Mus musculus) | 6480464 | bisphenol S affects the methylation of SSBP4 gene | CTD | PMID:31683443 | Ssbp4 | Rat | 4-hydroxyphenyl retinamide | decreases expression | ISO | SSBP4 (Homo sapiens) | 6480464 | Fenretinide results in decreased expression of SSBP4 mRNA | CTD | PMID:16671099 | Ssbp4 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of SSBP4 mRNA | CTD | PMID:30047161 | Ssbp4 | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of SSBP4 mRNA | CTD | PMID:31881176 | Ssbp4 | Rat | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of SSBP4 mRNA | CTD | PMID:28959563 | Ssbp4 | Rat | acrylamide | decreases expression | ISO | SSBP4 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of SSBP4 mRNA | CTD | PMID:32763439 | Ssbp4 | Rat | aflatoxin B1 | increases methylation | ISO | SSBP4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of SSBP4 polyA tail | CTD | PMID:30157460 | Ssbp4 | Rat | Aflatoxin B2 alpha | decreases methylation | ISO | SSBP4 (Homo sapiens) | 6480464 | aflatoxin B2 results in decreased methylation of SSBP4 polyA tail | CTD | PMID:30157460 | Ssbp4 | Rat | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of SSBP4 mRNA | CTD | PMID:30047161 | Ssbp4 | Rat | antirheumatic drug | increases expression | ISO | SSBP4 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of SSBP4 mRNA | CTD | PMID:24449571 | Ssbp4 | Rat | arsenite(3-) | decreases expression | ISO | Ssbp4 (Mus musculus) | 6480464 | arsenite results in decreased expression of SSBP4 mRNA | CTD | PMID:18929588 | Ssbp4 | Rat | arsenite(3-) | multiple interactions | ISO | Ssbp4 (Mus musculus) | 6480464 | TRP53 protein affects the reaction [arsenite results in decreased expression of SSBP4 mRNA] | CTD | PMID:18929588 | Ssbp4 | Rat | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of SSBP4 mRNA | CTD | PMID:21839799 | Ssbp4 | Rat | benzo[a]pyrene | increases methylation | ISO | SSBP4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of SSBP4 promoter | CTD | PMID:27901495 | Ssbp4 | Rat | benzo[a]pyrene | increases expression | ISO | Ssbp4 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of SSBP4 mRNA | CTD | PMID:22228805 | Ssbp4 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SSBP4 mRNA | CTD | PMID:25181051 and PMID:32145629 | Ssbp4 | Rat | bisphenol A | increases expression | ISO | Ssbp4 (Mus musculus) | 6480464 | bisphenol A results in increased expression of SSBP4 mRNA | CTD | PMID:32156529 | Ssbp4 | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of SSBP4 mRNA | CTD | PMID:36041667 | Ssbp4 | Rat | bisphenol A | decreases expression | ISO | Ssbp4 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of SSBP4 mRNA | CTD | PMID:35598803 | Ssbp4 | Rat | bisphenol F | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of SSBP4 mRNA | CTD | PMID:36041667 | Ssbp4 | Rat | cadmium atom | increases expression | ISO | SSBP4 (Homo sapiens) | 6480464 | Cadmium results in increased expression of SSBP4 mRNA | CTD | PMID:24376830 | Ssbp4 | Rat | cadmium atom | multiple interactions | ISO | Ssbp4 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SSBP4 mRNA | CTD | PMID:37325564 | Ssbp4 | Rat | cadmium dichloride | decreases expression | ISO | SSBP4 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of SSBP4 mRNA | CTD | PMID:38568856 | Ssbp4 | Rat | cadmium dichloride | multiple interactions | ISO | Ssbp4 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SSBP4 mRNA | CTD | PMID:37325564 | Ssbp4 | Rat | carbon nanotube | increases expression | ISO | Ssbp4 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 and PMID:25620056 | Ssbp4 | Rat | chlorpyrifos | increases expression | ISO | Ssbp4 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of SSBP4 mRNA | CTD | PMID:37019170 | Ssbp4 | Rat | choline | multiple interactions | ISO | Ssbp4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of SSBP4 more ... | CTD | PMID:20938992 | Ssbp4 | Rat | clofibrate | multiple interactions | ISO | Ssbp4 (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of SSBP4 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SSBP4 mRNA] | CTD | PMID:17585979 | Ssbp4 | Rat | copper atom | multiple interactions | ISO | SSBP4 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of SSBP4 mRNA | CTD | PMID:20971185 | Ssbp4 | Rat | copper(0) | multiple interactions | ISO | SSBP4 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of SSBP4 mRNA | CTD | PMID:20971185 | Ssbp4 | Rat | copper(II) sulfate | decreases expression | ISO | SSBP4 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of SSBP4 mRNA | CTD | PMID:19549813 | Ssbp4 | Rat | Dibutyl phosphate | affects expression | ISO | SSBP4 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of SSBP4 mRNA | CTD | PMID:37042841 | Ssbp4 | Rat | dibutyl phthalate | decreases expression | ISO | Ssbp4 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of SSBP4 mRNA | CTD | PMID:21266533 | Ssbp4 | Rat | ethanol | affects splicing | ISO | Ssbp4 (Mus musculus) | 6480464 | Ethanol affects the splicing of SSBP4 mRNA | CTD | PMID:30319688 | Ssbp4 | Rat | folic acid | multiple interactions | ISO | Ssbp4 (Mus musculus) | 6480464 | [1 more ... | CTD | PMID:20938992 and PMID:22206623 | Ssbp4 | Rat | FR900359 | increases phosphorylation | ISO | SSBP4 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of SSBP4 protein | CTD | PMID:37730182 | Ssbp4 | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of SSBP4 mRNA | CTD | PMID:33387578 | Ssbp4 | Rat | hydralazine | multiple interactions | ISO | SSBP4 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of SSBP4 mRNA | CTD | PMID:17183730 | Ssbp4 | Rat | L-methionine | multiple interactions | ISO | Ssbp4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of SSBP4 more ... | CTD | PMID:20938992 | Ssbp4 | Rat | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of SSBP4 mRNA | CTD | PMID:30047161 | Ssbp4 | Rat | methylmercury chloride | decreases expression | ISO | SSBP4 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of SSBP4 mRNA | CTD | PMID:28001369 | Ssbp4 | Rat | miconazole | decreases expression | ISO | Ssbp4 (Mus musculus) | 6480464 | Miconazole results in decreased expression of SSBP4 mRNA | CTD | PMID:27462272 | Ssbp4 | Rat | paracetamol | multiple interactions | ISO | Ssbp4 (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of SSBP4 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SSBP4 mRNA] | CTD | PMID:17585979 | Ssbp4 | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of SSBP4 mRNA | CTD | PMID:33387578 | Ssbp4 | Rat | paracetamol | affects expression | ISO | Ssbp4 (Mus musculus) | 6480464 | Acetaminophen affects the expression of SSBP4 mRNA | CTD | PMID:17562736 | Ssbp4 | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Ssbp4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SSBP4 mRNA | CTD | PMID:36331819 | Ssbp4 | Rat | perfluorooctanoic acid | decreases expression | ISO | SSBP4 (Homo sapiens) | 6480464 | perfluorooctanoic acid results in decreased expression of SSBP4 mRNA | CTD | PMID:36326898 | Ssbp4 | Rat | resveratrol | multiple interactions | ISO | SSBP4 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of SSBP4 mRNA | CTD | PMID:23557933 | Ssbp4 | Rat | sodium arsenite | decreases expression | ISO | SSBP4 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of SSBP4 mRNA | CTD | PMID:38568856 | Ssbp4 | Rat | sodium arsenite | increases expression | ISO | Ssbp4 (Mus musculus) | 6480464 | sodium arsenite results in increased expression of SSBP4 mRNA | CTD | PMID:37682722 | Ssbp4 | Rat | sodium arsenite | increases expression | ISO | SSBP4 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of SSBP4 mRNA | CTD | PMID:34032870 | Ssbp4 | Rat | sunitinib | increases expression | ISO | SSBP4 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of SSBP4 mRNA | CTD | PMID:31533062 | Ssbp4 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of SSBP4 mRNA | CTD | PMID:34492290 | Ssbp4 | Rat | trovafloxacin | decreases expression | ISO | Ssbp4 (Mus musculus) | 6480464 | trovafloxacin results in decreased expression of SSBP4 mRNA | CTD | PMID:35537566 | Ssbp4 | Rat | valproic acid | multiple interactions | ISO | SSBP4 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of SSBP4 mRNA | CTD | PMID:17183730 | Ssbp4 | Rat | valproic acid | increases expression | ISO | SSBP4 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of SSBP4 mRNA | CTD | PMID:23179753 and PMID:27188386 | Ssbp4 | Rat | valproic acid | affects expression | ISO | SSBP4 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SSBP4 mRNA | CTD | PMID:25979313 | Ssbp4 | Rat | valproic acid | increases methylation | ISO | SSBP4 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of SSBP4 gene | CTD | PMID:29154799 | Ssbp4 | Rat | vancomycin | decreases expression | ISO | Ssbp4 (Mus musculus) | 6480464 | Vancomycin results in decreased expression of SSBP4 mRNA | CTD | PMID:18930951 | |