Impdh2 (inosine monophosphate dehydrogenase 2) - Rat Genome Database

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Gene: Impdh2 (inosine monophosphate dehydrogenase 2) Rattus norvegicus
Analyze
Symbol: Impdh2
Name: inosine monophosphate dehydrogenase 2
RGD ID: 735092
Description: Enables IMP dehydrogenase activity and identical protein binding activity. Involved in retina development in camera-type eye. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Orthologous to human IMPDH2 (inosine monophosphate dehydrogenase 2); PARTICIPATES IN mycophenolic acid pharmacokinetics pathway; de novo purine biosynthetic pathway; purine metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IMP (inosine 5'-monophosphate) dehydrogenase 2; IMP (inosine monophosphate) dehydrogenase 2; IMP dehydrogenase 2; IMPD 2; IMPDH 2; inosine 5'-phosphate dehydrogenase 2; inosine 5-monophosphate dehydrogenase 2; inosine-5'-monophosphate dehydrogenase 2; MGC72938
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,135,204 - 118,139,892 (+)NCBIGRCr8
mRatBN7.28109,256,705 - 109,261,365 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,256,728 - 109,261,359 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,874,980 - 114,879,615 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08113,074,314 - 113,078,949 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,916,954 - 110,921,589 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,346,983 - 117,351,619 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,347,029 - 117,351,610 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,691,495 - 116,696,122 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,607,025 - 113,611,613 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18113,626,482 - 113,631,068 (+)NCBI
Celera8108,552,537 - 108,557,125 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,7-dihydropurine-6-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-fluorouracil  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
aminoglutethimide  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
Berberrubine  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorophyllin  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyproconazole  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
fenthion  (ISO)
flusilazole  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
genistein  (ISO)
gentamycin  (EXP)
guanosine  (EXP)
hexaconazole  (ISO)
IMP  (ISO)
ivermectin  (ISO)
Maleic hydrazide  (ISO)
mercaptopurine  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
miconazole  (ISO)
microcystin RR  (ISO)
Mizoribine  (EXP)
mycophenolic acid  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
nitrates  (ISO)
Nutlin-3  (ISO)
oridonin  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
pirinixic acid  (ISO)
propiconazole  (ISO)
purine-6-thiol  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
senecionine  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sunitinib  (ISO)
Tanshinone I  (ISO)
thioacetamide  (EXP)
tioguanine  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tungsten  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA,ISO,ISS)
nucleus  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Targeted disruption of the inosine 5'-monophosphate dehydrogenase type I gene in mice. Gu JJ, etal., Mol Cell Biol 2003 Sep;23(18):6702-12.
3. Characterisation of inosine monophosphate dehydrogenase expression during retinal development: differences between variants and isoforms. Gunter JH, etal., Int J Biochem Cell Biol. 2008;40(9):1716-28. Epub 2008 Jan 18.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12. Action of the active metabolites of tiazofurin and ribavirin on purified IMP dehydrogenase. Yamada Y, etal., Biochemistry. 1988 Mar 22;27(6):2193-6.
Additional References at PubMed
PMID:7763314   PMID:9798653   PMID:14766016   PMID:19946888   PMID:20458337   PMID:21525035   PMID:28985504  


Genomics

Comparative Map Data
Impdh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,135,204 - 118,139,892 (+)NCBIGRCr8
mRatBN7.28109,256,705 - 109,261,365 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,256,728 - 109,261,359 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,874,980 - 114,879,615 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08113,074,314 - 113,078,949 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,916,954 - 110,921,589 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,346,983 - 117,351,619 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,347,029 - 117,351,610 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,691,495 - 116,696,122 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,607,025 - 113,611,613 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18113,626,482 - 113,631,068 (+)NCBI
Celera8108,552,537 - 108,557,125 (+)NCBICelera
Cytogenetic Map8q32NCBI
IMPDH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38349,024,325 - 49,029,398 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl349,024,325 - 49,029,447 (-)EnsemblGRCh38hg38GRCh38
GRCh37349,061,758 - 49,066,831 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,036,762 - 49,041,879 (-)NCBINCBI36Build 36hg18NCBI36
Build 34349,036,766 - 49,041,826NCBI
Celera349,018,480 - 49,023,597 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef349,119,623 - 49,124,740 (-)NCBIHuRef
CHM1_1349,014,319 - 49,019,436 (-)NCBICHM1_1
T2T-CHM13v2.0349,052,365 - 49,057,438 (-)NCBIT2T-CHM13v2.0
Impdh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,437,635 - 108,442,776 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9108,437,485 - 108,442,783 (+)EnsemblGRCm39 Ensembl
GRCm389108,560,436 - 108,565,577 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,560,286 - 108,565,584 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,462,832 - 108,467,904 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369108,418,604 - 108,423,676 (+)NCBIMGSCv36mm8
Celera9108,171,703 - 108,176,814 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.5NCBI
Impdh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,045,833 - 1,051,978 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,047,138 - 1,051,980 (-)NCBIChiLan1.0ChiLan1.0
IMPDH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2249,002,115 - 49,008,297 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1349,007,028 - 49,013,216 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0348,948,965 - 48,954,276 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1350,030,291 - 50,035,676 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,030,303 - 50,035,676 (-)Ensemblpanpan1.1panPan2
IMPDH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12040,136,106 - 40,140,983 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2040,136,154 - 40,140,972 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2040,054,292 - 40,059,168 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02040,493,283 - 40,498,161 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2040,493,262 - 40,498,161 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12039,859,889 - 39,864,764 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,263,666 - 40,268,542 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02040,543,176 - 40,548,052 (+)NCBIUU_Cfam_GSD_1.0
Impdh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560263,988,280 - 63,993,092 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936529745,511 - 753,581 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936529748,777 - 753,582 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IMPDH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,658,650 - 31,663,552 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,658,642 - 31,663,660 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21334,901,646 - 34,906,719 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IMPDH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,424,646 - 10,429,917 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2210,421,996 - 10,429,662 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041156,652,325 - 156,657,621 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Impdh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247303,071,141 - 3,075,882 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247303,071,132 - 3,075,870 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Impdh2
6 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:41
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000047717
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat

Markers in Region
RH134444  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,260,746 - 109,261,127 (+)MAPPERmRatBN7.2
Rnor_6.08117,351,013 - 117,351,393NCBIRnor6.0
Rnor_5.08116,695,516 - 116,695,896UniSTSRnor5.0
RGSC_v3.48113,611,009 - 113,611,389UniSTSRGSC3.4
Celera8108,556,521 - 108,556,901UniSTS
Cytogenetic Map8q32UniSTS
AI171562  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,261,412 - 109,261,574 (+)MAPPERmRatBN7.2
Rnor_6.08117,351,679 - 117,351,840NCBIRnor6.0
Rnor_5.08116,696,182 - 116,696,343UniSTSRnor5.0
RGSC_v3.48113,611,675 - 113,611,836UniSTSRGSC3.4
Celera8108,557,187 - 108,557,348UniSTS
RH 3.4 Map81116.8UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000047717   ⟹   ENSRNOP00000040635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,256,728 - 109,261,359 (+)Ensembl
Rnor_6.0 Ensembl8117,347,029 - 117,351,610 (+)Ensembl
RefSeq Acc Id: NM_199099   ⟹   NP_954530
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,135,257 - 118,139,892 (+)NCBI
mRatBN7.28109,256,728 - 109,261,363 (+)NCBI
Rnor_6.08117,347,029 - 117,351,617 (+)NCBI
Rnor_5.08116,691,495 - 116,696,122 (+)NCBI
RGSC_v3.48113,607,025 - 113,611,613 (+)RGD
Celera8108,552,537 - 108,557,125 (+)RGD
Sequence:
RefSeq Acc Id: XM_006243751   ⟹   XP_006243813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,135,204 - 118,139,882 (+)NCBI
mRatBN7.28109,256,705 - 109,261,365 (+)NCBI
Rnor_6.08117,346,983 - 117,351,619 (+)NCBI
Rnor_5.08116,691,495 - 116,696,122 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_954530 (Get FASTA)   NCBI Sequence Viewer  
  XP_006243813 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH60585 (Get FASTA)   NCBI Sequence Viewer  
  E9PU28 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000040635
  ENSRNOP00000108718
RefSeq Acc Id: NP_954530   ⟸   NM_199099
- UniProtKB: E9PU28 (UniProtKB/Swiss-Prot),   Q6P9U9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243813   ⟸   XM_006243751
- Peptide Label: isoform X1
- UniProtKB: Q6P9U9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000040635   ⟸   ENSRNOT00000047717
Protein Domains
CBS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PU28-F1-model_v2 AlphaFold E9PU28 1-514 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696308
Promoter ID:EPDNEW_R6832
Type:initiation region
Name:Impdh2_1
Description:inosine monophosphate dehydrogenase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08117,347,032 - 117,347,092EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735092 AgrOrtholog
BioCyc Gene G2FUF-29135 BioCyc
BioCyc Pathway PWY-5695 [inosine 5'-phosphate degradation] BioCyc
  PWY-7221 [guanosine ribonucleotides de novo biosynthesis] BioCyc
BioCyc Pathway Image PWY-5695 BioCyc
  PWY-7221 BioCyc
Ensembl Genes ENSRNOG00000031965 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000047717 ENTREZGENE
  ENSRNOT00000166384 ENTREZGENE
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6891123 IMAGE-MGC_LOAD
InterPro Aldolase_TIM UniProtKB/Swiss-Prot
  CBS_dom UniProtKB/Swiss-Prot
  IMP_DH UniProtKB/Swiss-Prot
  IMP_DH/GMP_Rdtase_CS UniProtKB/Swiss-Prot
  IMP_DH_GMPRt UniProtKB/Swiss-Prot
MGC_CLONE MGC:72938 IMAGE-MGC_LOAD
NCBI Gene 301005 ENTREZGENE
PANTHER INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2 UniProtKB/Swiss-Prot
  PTHR11911 UniProtKB/Swiss-Prot
Pfam CBS UniProtKB/Swiss-Prot
  IMPDH UniProtKB/Swiss-Prot
PharmGKB IMPDH2 RGD
PhenoGen Impdh2 PhenoGen
PIRSF IMPDH UniProtKB/Swiss-Prot
PROSITE CBS UniProtKB/Swiss-Prot
  IMP_DH_GMP_RED UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000031965 RatGTEx
SMART CBS UniProtKB/Swiss-Prot
  IMPDH UniProtKB/Swiss-Prot
Superfamily-SCOP Inosine monophosphate dehydrogenase (IMPDH) UniProtKB/Swiss-Prot
UniProt A0A8L2QJV6_RAT UniProtKB/TrEMBL
  E9PU28 ENTREZGENE, UniProtKB/Swiss-Prot
  Q6P9U9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Impdh2  inosine monophosphate dehydrogenase 2  Impdh2  IMP (inosine 5'-monophosphate) dehydrogenase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Impdh2  IMP (inosine 5'-monophosphate) dehydrogenase 2  Impdh2  IMP (inosine monophosphate) dehydrogenase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-06 Impdh2  IMP (inosine monophosphate) dehydrogenase 2  Impdh2  inosine 5'-phosphate dehydrogenase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Impdh2  inosine 5'-phosphate dehydrogenase 2  Impdh2  inosine 5-monophosphate dehydrogenase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Impdh2  inosine 5-monophosphate dehydrogenase 2    IMP (inosine monophosphate) dehydrogenase 2  Name updated 1299863 APPROVED