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Gene: Pde3b (phosphodiesterase 3B) Rattus norvegicus
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Symbol: Pde3b
Name: phosphodiesterase 3B
Description: Exhibits 3',5'-cyclic-AMP phosphodiesterase activity and phosphoprotein binding activity. Involved in negative regulation of cAMP-mediated signaling and negative regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to localize to several cellular components, including the Golgi apparatus; endoplasmic reticulum; and guanyl-nucleotide exchange factor complex. Orthologous to human PDE3B (phosphodiesterase 3B); PARTICIPATES IN protein kinase A (PKA) signaling pathway; insulin signaling pathway; purine metabolic pathway; INTERACTS WITH (+)-schisandrin B; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CGI-PDE B; CGIPDE1; cGMP-inhibited 3',5'-cyclic phosphodiesterase B; cyclic GMP-inhibited phosphodiesterase B; phosphodiesterase 3B cGMP inhibited; phosphodiesterase 3B cGMP-inhibited; phosphodiesterase 3B, cGMP inhibited ; phosphodiesterase 3B, cGMP-inhibited
Orthologs:
Homo sapiens (human) : PDE3B (phosphodiesterase 3B)  HGNC  Alliance
Mus musculus (house mouse) : Pde3b (phosphodiesterase 3B, cGMP-inhibited)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pde3b (phosphodiesterase 3B)
Pan paniscus (bonobo/pygmy chimpanzee) : PDE3B (phosphodiesterase 3B)
Canis lupus familiaris (dog) : PDE3B (phosphodiesterase 3B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pde3b (phosphodiesterase 3B)
Sus scrofa (pig) : PDE3B (phosphodiesterase 3B)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01183,892,841 - 184,078,071 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01190,865,614 - 191,050,207 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41172,409,282 - 172,577,108 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11172,545,390 - 172,713,217 (+)NCBI
Celera1166,458,524 - 166,609,913 (+)NCBICelera
Cytogenetic Map1q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Pde3b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 61943
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.