Gene: Bace1 (beta-secretase 1) Rattus norvegicus
Symbol: Bace1
Name: beta-secretase 1
Description: ENCODES a protein that exhibits peptidase activity; amyloid-beta binding (ortholog); aspartic-type endopeptidase activity (ortholog); INVOLVED IN amyloid-beta metabolic process; membrane protein ectodomain proteolysis (ortholog); modulation of chemical synaptic transmission (ortholog); PARTICIPATES IN Alzheimer disease pathway; ASSOCIATED WITH Alzheimer Disease (ortholog); FOUND IN endosome; Golgi apparatus; axon (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; acrolein
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: asp 2; ASP2; aspartyl protease 2; Bace; beta-site amyloid precursor protein cleaving enzyme 1; beta-site APP cleaving enzyme; beta-site APP cleaving enzyme 1; memapsin-2; membrane-associated aspartic protease 2
Homo sapiens (human) : BACE1 (beta-secretase 1)  HGNC  Alliance
Mus musculus (house mouse) : Bace1 (beta-site APP cleaving enzyme 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bace1 (beta-secretase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : BACE1 (beta-secretase 1)
Canis lupus familiaris (dog) : BACE1 (beta-secretase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bace1 (beta-secretase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0850,140,092 - 50,162,388 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0848,766,005 - 48,788,272 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4848,817,824 - 48,839,681 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1848,826,589 - 48,848,447 (+)NCBI
Celera845,724,900 - 45,747,208 (+)NCBICelera
Cytogenetic Map8q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Bace1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2191
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2018-03-13
Status: ACTIVE