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Gene: Bace1 (beta-secretase 1) Rattus norvegicus
Symbol: Bace1
Name: beta-secretase 1
Description: Exhibits peptidase activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to metal ion; and detection of mechanical stimulus involved in sensory perception of pain. Localizes to several cellular components, including Golgi apparatus; cytoplasmic vesicle; and neuronal cell body. Used to study dementia. Biomarker of Alzheimer's disease; sensory peripheral neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE1 (beta-secretase 1); PARTICIPATES IN Alzheimer's disease pathway; INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; acrolein.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: asp 2; ASP2; aspartyl protease 2; Bace; beta-site amyloid precursor protein cleaving enzyme 1; beta-site APP cleaving enzyme; beta-site APP cleaving enzyme 1; memapsin-2; membrane-associated aspartic protease 2
Homo sapiens (human) : BACE1 (beta-secretase 1)  HGNC  Alliance
Mus musculus (house mouse) : Bace1 (beta-site APP cleaving enzyme 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bace1 (beta-secretase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : BACE1 (beta-secretase 1)
Canis lupus familiaris (dog) : BACE1 (beta-secretase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bace1 (beta-secretase 1)
Sus scrofa (pig) : BACE1 (beta-secretase 1)
Chlorocebus sabaeus (African green monkey) : BACE1 (beta-secretase 1)
Heterocephalus glaber (naked mole-rat) : Bace1 (beta-secretase 1)
more info ...
Allele / Splice: Bace1em1Sage  
Genetic Models: SD-Bace1em1Sage-/- SD-Bace1em1Sage+/- SD-Bace1em1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0850,140,092 - 50,162,388 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl850,139,997 - 50,162,361 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0848,766,005 - 48,788,272 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4848,817,824 - 48,839,681 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1848,826,589 - 48,848,447 (+)NCBI
Celera845,724,900 - 45,747,208 (+)NCBICelera
Cytogenetic Map8q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Bace1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2191
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.