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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2191
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bace1
Name: beta-secretase 1
Acc ID: CHEBI:31767
Term: lead diacetate
Definition: A lead coordination entity in which a central lead(2+) atom is coordinated to two acetate ions.
Chemical ID: MESH:C008261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bace1increases expressionEXP 6480464CTDlead acetate results in increased expression of BACE1 proteinPMID:29908845
Bace1increases expressionISOBace1 (Mus musculus)6480464CTDlead acetate results in increased expression of BACE1 mRNA; lead acetate results in increased expression of BACE1 proteinPMID:23867794
Bace1multiple interactionsISOBace1 (Mus musculus)6480464CTD[lead acetate results in increased abundance of Lead] which results in increased expression of BACE1 mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of BACE1 proteinPMID:31730887 PMID:32058320
Bace1multiple interactionsISOBACE1 (Homo sapiens)6480464CTD[lead acetate results in increased abundance of Lead] promotes the reaction [APP protein modified form results in increased expression of BACE1 protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein results in increased expression of BACE1 protein]; [lead acetate results in increased abundance of Lead] which results in increased expression of BACE1 proteinPMID:31843630
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