BACE1 (beta-secretase 1) - Rat Genome Database

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Gene: BACE1 (beta-secretase 1) Pan paniscus
Analyze
Symbol: BACE1
Name: beta-secretase 1
RGD ID: 11834513
Description: ENCODES a protein that exhibits peptidase activity (ortholog); INVOLVED IN amyloid-beta metabolic process (ortholog); cellular response to amyloid-beta (ortholog); cellular response to copper ion (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); CD3epsilon deficiency (ortholog); chromosome 11 partial duplication syndrome (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); endosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29117,986,558 - 118,017,119 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111119,095,929 - 119,123,152 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011112,120,950 - 112,151,505 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111116,054,303 - 116,084,813 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11116,054,303 - 116,084,812 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
BACE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29117,986,558 - 118,017,119 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111119,095,929 - 119,123,152 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011112,120,950 - 112,151,505 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111116,054,303 - 116,084,813 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11116,054,303 - 116,084,812 (-)Ensemblpanpan1.1panPan2
BACE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811117,285,698 - 117,316,256 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11117,285,232 - 117,316,259 (-)EnsemblGRCh38hg38GRCh38
GRCh3711117,156,414 - 117,186,972 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611116,661,624 - 116,692,182 (-)NCBINCBI36Build 36hg18NCBI36
Celera11114,314,074 - 114,344,631 (-)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11113,090,543 - 113,121,018 (-)NCBIHuRef
CHM1_111117,041,502 - 117,072,072 (-)NCBICHM1_1
T2T-CHM13v2.011117,302,503 - 117,333,060 (-)NCBIT2T-CHM13v2.0
Bace1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39945,749,878 - 45,775,694 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl945,749,878 - 45,775,697 (+)EnsemblGRCm39 Ensembl
GRCm38945,838,545 - 45,862,484 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl945,838,580 - 45,864,399 (+)EnsemblGRCm38mm10GRCm38
MGSCv37945,646,612 - 45,670,567 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36945,589,578 - 45,613,436 (+)NCBIMGSCv36mm8
Celera943,121,304 - 43,145,259 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map925.22NCBI
Bace1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8855,038,842 - 55,061,138 (+)NCBIGRCr8
mRatBN7.2846,142,060 - 46,166,268 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl846,142,116 - 46,165,876 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx851,643,201 - 51,665,458 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0849,921,966 - 49,944,223 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0847,786,230 - 47,808,489 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0850,140,092 - 50,162,388 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl850,139,997 - 50,162,361 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0848,766,005 - 48,788,272 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4848,817,824 - 48,839,681 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1848,826,589 - 48,848,447 (+)NCBI
Celera845,724,900 - 45,747,208 (+)NCBICelera
Cytogenetic Map8q22NCBI
Bace1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541218,596,643 - 18,620,362 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541218,596,643 - 18,620,089 (-)NCBIChiLan1.0ChiLan1.0
BACE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1516,308,953 - 16,319,100 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl516,308,944 - 16,319,100 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha516,347,976 - 16,371,490 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0516,240,025 - 16,263,790 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl516,239,793 - 16,264,160 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1516,377,977 - 16,401,485 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0516,280,937 - 16,304,419 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0516,323,226 - 16,346,725 (+)NCBIUU_Cfam_GSD_1.0
Bace1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494799,590,774 - 99,617,699 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365422,514,300 - 2,539,135 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365422,514,297 - 2,539,088 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BACE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl944,640,394 - 44,665,835 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1944,640,389 - 44,665,863 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2949,716,271 - 49,738,860 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BACE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11108,659,723 - 108,689,879 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1108,657,584 - 108,689,843 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604317,364,724 - 17,395,903 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bace1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478412,725,063 - 12,759,637 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478412,725,419 - 12,759,530 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000052684   ⟹   ENSPPAP00000029832
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl11116,054,303 - 116,084,812 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000052692   ⟹   ENSPPAP00000029840
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl11116,055,197 - 116,061,778 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000052728   ⟹   ENSPPAP00000029876
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl11116,058,171 - 116,084,352 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000052736   ⟹   ENSPPAP00000029883
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl11116,058,171 - 116,084,352 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000052741   ⟹   ENSPPAP00000029888
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl11116,058,171 - 116,064,136 (-)Ensembl
RefSeq Acc Id: XM_003820071   ⟹   XP_003820119
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v29117,986,558 - 118,017,119 (-)NCBI
NHGRI_mPanPan111119,095,929 - 119,123,144 (-)NCBI
Mhudiblu_PPA_v011112,120,950 - 112,151,504 (-)NCBI
PanPan1.111116,054,303 - 116,084,811 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003820072   ⟹   XP_003820120
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v29117,986,558 - 118,017,095 (-)NCBI
NHGRI_mPanPan111119,095,929 - 119,123,152 (-)NCBI
Mhudiblu_PPA_v011112,120,950 - 112,151,505 (-)NCBI
PanPan1.111116,054,303 - 116,084,813 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034933794   ⟹   XP_034789685
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v29117,986,558 - 117,996,493 (-)NCBI
NHGRI_mPanPan111119,095,929 - 119,102,545 (-)NCBI
Mhudiblu_PPA_v011112,120,950 - 112,130,883 (-)NCBI
RefSeq Acc Id: XM_034933795   ⟹   XP_034789686
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v29117,986,558 - 117,996,496 (-)NCBI
NHGRI_mPanPan111119,095,929 - 119,102,548 (-)NCBI
Mhudiblu_PPA_v011112,120,950 - 112,130,885 (-)NCBI
RefSeq Acc Id: XP_003820120   ⟸   XM_003820072
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BN30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003820119   ⟸   XM_003820071
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BN30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034789686   ⟸   XM_034933795
- Peptide Label: isoform X4
- UniProtKB: A0A2R9BKH7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034789685   ⟸   XM_034933794
- Peptide Label: isoform X3
- UniProtKB: A0A2R9BKH7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000029832   ⟸   ENSPPAT00000052684
Ensembl Acc Id: ENSPPAP00000029840   ⟸   ENSPPAT00000052692
Ensembl Acc Id: ENSPPAP00000029876   ⟸   ENSPPAT00000052728
Ensembl Acc Id: ENSPPAP00000029888   ⟸   ENSPPAT00000052741
Ensembl Acc Id: ENSPPAP00000029883   ⟸   ENSPPAT00000052736
Protein Domains
Peptidase A1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037875 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000052684.1 UniProtKB/TrEMBL
  ENSPPAT00000052692.1 UniProtKB/TrEMBL
  ENSPPAT00000052728.1 UniProtKB/TrEMBL
  ENSPPAT00000052736.1 UniProtKB/TrEMBL
  ENSPPAT00000052741.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.70.10 UniProtKB/TrEMBL
InterPro Aspartic_peptidase_A1 UniProtKB/TrEMBL
  Aspartic_peptidase_AS UniProtKB/TrEMBL
  BACE UniProtKB/TrEMBL
  BACE1 UniProtKB/TrEMBL
  Memapsin-like UniProtKB/TrEMBL
  PEPTIDASE_A1 UniProtKB/TrEMBL
  Peptidase_aspartic_dom_sf UniProtKB/TrEMBL
KEGG Report pps:100986447 UniProtKB/TrEMBL
NCBI Gene BACE1 ENTREZGENE
PANTHER PTHR47965 UniProtKB/TrEMBL
  PTHR47965:SF69 UniProtKB/TrEMBL
Pfam Asp UniProtKB/TrEMBL
PRINTS BACE1 UniProtKB/TrEMBL
  BACEFAMILY UniProtKB/TrEMBL
  PEPSIN UniProtKB/TrEMBL
PROSITE ASP_PROTEASE UniProtKB/TrEMBL
  PEPTIDASE_A1 UniProtKB/TrEMBL
Superfamily-SCOP SSF50630 UniProtKB/TrEMBL
UniProt A0A2R9BJJ4_PANPA UniProtKB/TrEMBL
  A0A2R9BKH3_PANPA UniProtKB/TrEMBL
  A0A2R9BKH7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BN30 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BTH2_PANPA UniProtKB/TrEMBL