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Gene: Bace1 (beta-site APP cleaving enzyme 1) Mus musculus
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Symbol: Bace1
Name: beta-site APP cleaving enzyme 1
Description: Exhibits aspartic-type endopeptidase activity. Involved in several processes, including amyloid precursor protein catabolic process; amyloid-beta metabolic process; and membrane protein ectodomain proteolysis. Localizes to several cellular components, including the endosome; hippocampal mossy fiber to CA3 synapse; and trans-Golgi network. Used to study schizophrenia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is expressed in brain; liver; and metanephros. Orthologous to human BACE1 (beta-secretase 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: APP beta-secretase; asp 2; ASP2; aspartyl protease 2; Bace; beta-secretase 1; beta-site amyloid precursor protein cleaving enzyme 1; C76936; memapsin-2; membrane-associated aspartic protease 2
Orthologs:
Homo sapiens (human) : BACE1 (beta-secretase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Bace1 (beta-secretase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bace1 (beta-secretase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : BACE1 (beta-secretase 1)
Canis lupus familiaris (dog) : BACE1 (beta-secretase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bace1 (beta-secretase 1)
Sus scrofa (pig) : BACE1 (beta-secretase 1)
Chlorocebus sabaeus (green monkey) : BACE1 (beta-secretase 1)
Heterocephalus glaber (naked mole-rat) : Bace1 (beta-secretase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl945,838,580 - 45,864,399 (+)Ensembl
GRCm38945,838,545 - 45,862,484 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37945,646,612 - 45,670,567 (+)NCBIGRCm37mm9NCBIm37
MGSCv36945,589,578 - 45,613,436 (+)NCBImm8
Celera943,121,304 - 43,145,259 (+)NCBICelera
Cytogenetic Map9 A5.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Bace1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1332039
Created: 2005-02-01
Species: Mus musculus
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.