Bace1 (beta-site APP cleaving enzyme 1) - Rat Genome Database

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Gene: Bace1 (beta-site APP cleaving enzyme 1) Mus musculus
Analyze
Symbol: Bace1
Name: beta-site APP cleaving enzyme 1
RGD ID: 1332039
MGI Page MGI
Description: Enables aspartic-type endopeptidase activity. Involved in amyloid precursor protein catabolic process; presynaptic modulation of chemical synaptic transmission; and proteolysis. Acts upstream of or within amyloid-beta metabolic process and proteolysis. Located in several cellular components, including cell surface; endosome; and trans-Golgi network. Is active in hippocampal mossy fiber to CA3 synapse and presynapse. Is expressed in several structures, including immune system; liver; nervous system; retina; and submandibular gland. Used to study schizophrenia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE1 (beta-secretase 1).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: APP beta-secretase; asp 2; ASP2; aspartyl protease 2; Bace; beta-secretase 1; beta-site amyloid precursor protein cleaving enzyme 1; C76936; memapsin-2; membrane-associated aspartic protease 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39945,749,878 - 45,775,694 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl945,749,878 - 45,775,697 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38945,838,545 - 45,862,484 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl945,838,580 - 45,864,399 (+)Ensemblmm10GRCm38
MGSCv37945,646,612 - 45,670,567 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36945,589,578 - 45,613,436 (+)NCBIMGSCv36mm8
Celera943,121,304 - 43,145,259 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map925.22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-naringenin  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2,2-tetramine  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
26-hydroxycholesterol  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
aminoguanidine  (ISO)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azure B  (ISO)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calycosin  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP)
ceftriaxone  (ISO)
CGP 52608  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
clofibrate  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cyprodinil  (EXP)
DDE  (ISO)
DDT  (EXP,ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
Didymin  (ISO)
diethyldithiocarbamic acid  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
donepezil hydrochloride  (EXP)
dorsomorphin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
fenthion  (EXP)
ferulic acid  (ISO)
folic acid  (EXP)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
ginsenoside Rg1  (ISO)
Goe 6976  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
hexadecanoic acid  (EXP)
hydrogen peroxide  (ISO)
hypochlorous acid  (EXP)
ibuprofen  (EXP,ISO)
icariin  (ISO)
indometacin  (EXP,ISO)
isoflurane  (ISO)
ketamine  (EXP,ISO)
ketoconazole  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
linuron  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
melatonin  (ISO)
mepanipyrim  (EXP)
methamphetamine  (ISO)
methylmercury chloride  (ISO)
minocycline  (ISO)
monensin A  (ISO)
naproxen  (EXP)
oleic acid  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
pentetrazol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
Pf-06840003  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
PhIP  (EXP)
phorbol 12,13-dibutanoate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (EXP,ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
prochloraz  (ISO)
procymidone  (ISO)
propiconazole  (EXP)
pyrimethanil  (EXP)
quercetin  (ISO)
rotenone  (ISO)
S-adenosyl-L-homocysteine  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
sevoflurane  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
tolfenamic acid  (EXP)
tolonium chloride  (EXP)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
uranium atom  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IDA,IEA,ISO)
cell projection  (IEA)
cell surface  (IDA,IEA,ISO)
cytoplasmic vesicle  (IDA,IEA)
cytoplasmic vesicle membrane  (IEA)
dendrite  (IEA,ISO)
early endosome  (IDA,IEA,ISO)
endoplasmic reticulum  (IEA)
endosome  (IBA,IDA,IEA,ISO,ISS)
Golgi apparatus  (IEA,ISO,ISS)
hippocampal mossy fiber to CA3 synapse  (IDA,IMP)
late endosome  (IEA,ISO,ISS)
lysosome  (IEA,ISO,ISS)
membrane  (IDA,IEA)
membrane raft  (IEA)
multivesicular body  (IEA,ISO)
neuronal cell body  (IEA,ISO)
plasma membrane  (IBA,IDA,IEA,IMP,ISO)
presynapse  (IDA)
recycling endosome  (IDA,IEA,ISO,ISS)
synaptic vesicle  (IEA,ISO)
trans-Golgi network  (IBA,IDA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal anxiety-related response  (IAGP)
abnormal cell physiology  (IAGP)
abnormal channel response  (IAGP)
abnormal dendritic spine morphology  (IAGP)
abnormal dishabituation  (IAGP)
abnormal gait  (IAGP)
abnormal locomotor activation  (IAGP)
abnormal long-term depression  (IAGP)
abnormal muscle physiology  (IAGP)
abnormal muscle spindle morphology  (IAGP)
abnormal myelin sheath morphology  (IAGP)
abnormal myelination  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal response to novel object  (IAGP)
abnormal spatial learning  (IAGP)
abnormal spatial reference memory  (IAGP)
abnormal spatial working memory  (IAGP)
abnormal startle reflex  (IAGP)
amyloid beta deposits  (IAGP)
amyloidosis  (IAGP)
astrocytosis  (IAGP)
cachexia  (IAGP)
decreased anxiety-related response  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased brain weight  (IAGP)
decreased exploration in new environment  (IAGP)
decreased grip strength  (IAGP)
decreased muscle spindle number  (IAGP)
decreased prepulse inhibition  (IAGP)
decreased thermal nociceptive threshold  (IAGP)
demyelination  (IAGP)
enhanced behavioral response to xenobiotic  (IAGP)
enhanced paired-pulse facilitation  (IAGP)
hippocampal neuron degeneration  (IAGP)
hyperactivity  (IAGP)
impaired coordination  (IAGP)
impaired passive avoidance behavior  (IAGP)
improved righting response  (IAGP)
increased locomotor activity  (IAGP)
no abnormal phenotype detected  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Sleep deprivation accelerates the progression of alzheimer's disease by influencing Aß-related metabolism. Chen L, etal., Neurosci Lett. 2017 May 22;650:146-152. doi: 10.1016/j.neulet.2017.04.047. Epub 2017 Apr 25.
2. Plasma long non-coding RNA BACE1 as a novel biomarker for diagnosis of Alzheimer disease. Feng L, etal., BMC Neurol. 2018 Jan 9;18(1):4. doi: 10.1186/s12883-017-1008-x.
3. miR-15b mediates oxaliplatin-induced chronic neuropathic pain through BACE1 down-regulation. Ito N, etal., Br J Pharmacol. 2017 Mar;174(5):386-395. doi: 10.1111/bph.13698. Epub 2017 Jan 23.
4. The correlation between accumulation of amyloid beta with enhanced neuroinflammation and cognitive impairment after intraventricular hemorrhage. Jiang C, etal., J Neurosurg. 2018 Jul 20:1-10. doi: 10.3171/2018.1.JNS172938.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. Effects of chronic alcohol consumption on expression levels of APP and Aβ-producing enzymes. Kim SR, etal., BMB Rep. 2011 Feb;44(2):135-9. doi: 10.5483/BMBRep.2011.44.2.135.
7. Polymorphism in the BACE gene influences the risk for Alzheimer's disease. Kirschling CM, etal., Neuroreport 2003 Jul 1;14(9):1243-6.
8. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
9. Flavonoid-rich ethanol extract from the leaves of Diospyros kaki attenuates cognitive deficits, amyloid-beta production, oxidative stress, and neuroinflammation in APP/PS1 transgenic mice. Ma Y, etal., Brain Res. 2018 Jan 1;1678:85-93. doi: 10.1016/j.brainres.2017.10.001. Epub 2017 Oct 14.
10. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. MGD IEA MGD IEA
13. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics. Roberds SL, etal., Hum Mol Genet 2001 Jun 1;10(12):1317-24.
17. BACE1 Mediates HIV-Associated and Excitotoxic Neuronal Damage Through an APP-Dependent Mechanism. Stern AL, etal., J Neurosci. 2018 May 2;38(18):4288-4300. doi: 10.1523/JNEUROSCI.1280-17.2018. Epub 2018 Apr 9.
18. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Vassar R, etal., Science 1999 Oct 22;286(5440):735-41.
19. Insulin-like growth factor-1 improves postoperative cognitive dysfunction following splenectomy in aged rats. Wang B, etal., Exp Ther Med. 2021 Mar;21(3):215. doi: 10.3892/etm.2021.9647. Epub 2021 Jan 15.
20. BACE1 gene silencing alleviates isoflurane anesthesia‑induced postoperative cognitive dysfunction in immature rats by activating the PI3K/Akt signaling pathway. Wang YB, etal., Mol Med Rep. 2018 Nov;18(5):4259-4270. doi: 10.3892/mmr.2018.9453. Epub 2018 Sep 4.
21. Increased beta-secretase activity and expression in rats following transient cerebral ischemia. Wen Y, etal., Brain Res. 2004 May 29;1009(1-2):1-8. doi: 10.1016/j.brainres.2003.09.086.
22. BACE1 inhibition by microdose lithium formulation NP03 rescues memory loss and early stage amyloid neuropathology. Wilson EN, etal., Transl Psychiatry. 2017 Aug 1;7(8):e1190. doi: 10.1038/tp.2017.169.
23. MiR-9 Regulates the Expression of BACE1 in Dementia Induced by Chronic Brain Hypoperfusion in Rats. Xie H, etal., Cell Physiol Biochem. 2017;42(3):1213-1226. doi: 10.1159/000478919. Epub 2017 Jul 3.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10591213   PMID:10922068   PMID:11032903   PMID:11042159   PMID:11076861   PMID:11224535   PMID:11224536   PMID:11740561   PMID:12477932   PMID:12509807  
PMID:12904583   PMID:13678669   PMID:14664815   PMID:14715132   PMID:14717705   PMID:15034149   PMID:15080893   PMID:15123597   PMID:15364953   PMID:15368895   PMID:15466887   PMID:15485862  
PMID:15489334   PMID:15509532   PMID:15522224   PMID:15583033   PMID:15584902   PMID:15606899   PMID:15745965   PMID:15782199   PMID:15824102   PMID:15886206   PMID:15917100   PMID:15951428  
PMID:15987683   PMID:16027115   PMID:16141072   PMID:16141073   PMID:16267225   PMID:16354928   PMID:16407538   PMID:16420434   PMID:16990514   PMID:17091494   PMID:17099708   PMID:17157415  
PMID:17258906   PMID:17303576   PMID:17307738   PMID:17409228   PMID:17470798   PMID:17494994   PMID:17573534   PMID:17576410   PMID:17616527   PMID:17644063   PMID:17897958   PMID:17920016  
PMID:17980964   PMID:18081741   PMID:18263584   PMID:18341989   PMID:18385378   PMID:18413858   PMID:18434550   PMID:18587408   PMID:18650431   PMID:18660751   PMID:18680556   PMID:18753368  
PMID:18845544   PMID:18945886   PMID:18986979   PMID:19074428   PMID:19118188   PMID:19196715   PMID:19214738   PMID:19251705   PMID:19287391   PMID:19332646   PMID:19357271   PMID:19632177  
PMID:19683527   PMID:19737556   PMID:19809370   PMID:19907078   PMID:19920078   PMID:19935654   PMID:20092558   PMID:20092570   PMID:20097169   PMID:20163459   PMID:20212127   PMID:20453200  
PMID:20484053   PMID:20505099   PMID:20592204   PMID:20595388   PMID:20704561   PMID:20724034   PMID:20731874   PMID:20833873   PMID:20854419   PMID:20886088   PMID:20943921   PMID:21146496  
PMID:21190943   PMID:21209097   PMID:21246381   PMID:21423189   PMID:21490216   PMID:21542009   PMID:21630010   PMID:21642424   PMID:21695060   PMID:21795680   PMID:21812781   PMID:21825135  
PMID:21873635   PMID:21880018   PMID:21907142   PMID:21933711   PMID:22008266   PMID:22042227   PMID:22049418   PMID:22052506   PMID:22166205   PMID:22170863   PMID:22204380   PMID:22205609  
PMID:22223639   PMID:22249458   PMID:22267734   PMID:22355745   PMID:22490838   PMID:22692213   PMID:22721728   PMID:22728099   PMID:22728825   PMID:22836275   PMID:22843498   PMID:22895721  
PMID:22903875   PMID:22912719   PMID:22988240   PMID:23048024   PMID:23202730   PMID:23274884   PMID:23335052   PMID:23430253   PMID:23504710   PMID:23507144   PMID:23541064   PMID:23596049  
PMID:23613819   PMID:23663737   PMID:23713656   PMID:23750206   PMID:23754390   PMID:23792428   PMID:23820808   PMID:23825420   PMID:23831026   PMID:23931995   PMID:24005676   PMID:24368770  
PMID:24373286   PMID:24386896   PMID:24405708   PMID:24630972   PMID:24637500   PMID:24797530   PMID:24806669   PMID:24827165   PMID:24889041   PMID:24893886   PMID:24907271   PMID:24963413  
PMID:25051175   PMID:25156639   PMID:25384422   PMID:25457554   PMID:25481013   PMID:25567526   PMID:25592972   PMID:25599931   PMID:25663301   PMID:25716831   PMID:25740511   PMID:25884928  
PMID:25912880   PMID:25955795   PMID:25957769   PMID:25961820   PMID:26062786   PMID:26091071   PMID:26139848   PMID:26240147   PMID:26283960   PMID:26296617   PMID:26299962   PMID:26314636  
PMID:26317805   PMID:26322584   PMID:26336937   PMID:26378740   PMID:26404616   PMID:26414661   PMID:26454161   PMID:26467158   PMID:26497029   PMID:26563932   PMID:26642089   PMID:26661166  
PMID:26663083   PMID:26710318   PMID:26755586   PMID:26833257   PMID:26900752   PMID:26923405   PMID:26987953   PMID:26993139   PMID:27080468   PMID:27084579   PMID:27179792   PMID:27294139  
PMID:27372924   PMID:27404286   PMID:27517085   PMID:27565738   PMID:27576688   PMID:27687728   PMID:27707970   PMID:27716410   PMID:27791018   PMID:27853315   PMID:28004339   PMID:28028177  
PMID:28109317   PMID:28159908   PMID:28191691   PMID:28281673   PMID:28502705   PMID:28626014   PMID:28669600   PMID:28696204   PMID:28739891   PMID:28855330   PMID:28869759   PMID:29311632  
PMID:29325091   PMID:29444819   PMID:29507146   PMID:29610518   PMID:29702127   PMID:29716987   PMID:29979789   PMID:30079376   PMID:30120949   PMID:30232227   PMID:30315100   PMID:30456346  
PMID:30626721   PMID:30647119   PMID:30701309   PMID:30756113   PMID:30776900   PMID:30784815   PMID:30837353   PMID:31014193   PMID:31110178   PMID:31164420   PMID:31209103   PMID:31303501  
PMID:31442405   PMID:31513457   PMID:31527119   PMID:31741224   PMID:31743528   PMID:31882662   PMID:31915042   PMID:31992816   PMID:32290105   PMID:32407295   PMID:32408680   PMID:32444547  
PMID:32507599   PMID:32668504   PMID:32913125   PMID:32921309   PMID:33052800   PMID:33074142   PMID:33208500   PMID:33311478   PMID:33548223   PMID:34158621   PMID:34302009   PMID:34321999  
PMID:34349120   PMID:34375641   PMID:34500034   PMID:34613632   PMID:34951366   PMID:34956559   PMID:35119166   PMID:35353937   PMID:35382554   PMID:35857844   PMID:35883144   PMID:36251052  
PMID:36370042   PMID:36555791   PMID:36716914   PMID:36750595   PMID:36765071   PMID:36810097   PMID:37016576   PMID:37137417   PMID:37143090   PMID:37216506   PMID:37286480   PMID:37452089  
PMID:37522285   PMID:37536983   PMID:37819761   PMID:38110001   PMID:38142018   PMID:38311982   PMID:38630369   PMID:38888964   PMID:39042667   PMID:39548583   PMID:40015276  


Genomics

Comparative Map Data
Bace1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39945,749,878 - 45,775,694 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl945,749,878 - 45,775,697 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38945,838,545 - 45,862,484 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl945,838,580 - 45,864,399 (+)Ensemblmm10GRCm38
MGSCv37945,646,612 - 45,670,567 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36945,589,578 - 45,613,436 (+)NCBIMGSCv36mm8
Celera943,121,304 - 43,145,259 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map925.22NCBI
BACE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811117,285,698 - 117,316,256 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11117,285,232 - 117,316,259 (-)Ensemblhg38GRCh38
GRCh3711117,156,414 - 117,186,972 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611116,661,624 - 116,692,182 (-)NCBIBuild 36Build 36hg18NCBI36
Celera11114,314,074 - 114,344,631 (-)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11113,090,543 - 113,121,018 (-)NCBIHuRef
CHM1_111117,041,502 - 117,072,072 (-)NCBICHM1_1
T2T-CHM13v2.011117,302,503 - 117,333,060 (-)NCBIT2T-CHM13v2.0
Bace1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8855,038,842 - 55,061,138 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl855,038,823 - 55,064,918 (+)EnsemblGRCr8
mRatBN7.2846,142,060 - 46,166,268 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl846,142,116 - 46,165,876 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx851,643,201 - 51,665,458 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0849,921,966 - 49,944,223 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0847,786,230 - 47,808,489 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0850,140,092 - 50,162,388 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl850,139,997 - 50,162,361 (+)Ensemblrn6Rnor6.0
Rnor_5.0848,766,005 - 48,788,272 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4848,817,824 - 48,839,681 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera845,724,900 - 45,747,208 (+)NCBICelera
RGSC_v3.1848,826,589 - 48,848,447 (+)NCBI
Cytogenetic Map8q22NCBI
Bace1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541218,596,643 - 18,620,362 (-)Ensembl
ChiLan1.0NW_00495541218,596,643 - 18,620,089 (-)NCBIChiLan1.0ChiLan1.0
BACE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29117,986,558 - 118,017,119 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111119,095,929 - 119,123,152 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011112,120,950 - 112,151,505 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111116,054,303 - 116,084,813 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11116,054,303 - 116,084,812 (-)EnsemblpanPan2panpan1.1
BACE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1516,308,953 - 16,319,100 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl516,308,944 - 16,319,100 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha516,347,976 - 16,371,490 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0516,240,025 - 16,263,790 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl516,239,793 - 16,264,160 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1516,377,977 - 16,401,485 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0516,280,937 - 16,304,419 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0516,323,226 - 16,346,725 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bace1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494799,590,774 - 99,617,699 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365422,514,300 - 2,539,135 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365422,514,297 - 2,539,088 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BACE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl944,640,394 - 44,665,835 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1944,640,389 - 44,665,863 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2949,716,271 - 49,738,860 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BACE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11108,659,723 - 108,689,879 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1108,657,584 - 108,689,843 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604317,364,724 - 17,395,903 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bace1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478412,725,063 - 12,759,637 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478412,725,419 - 12,759,530 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Bace1
809 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:3317
Count of miRNA genes:827
Interacting mature miRNAs:1129
Transcripts:ENSMUST00000034591, ENSMUST00000078111, ENSMUST00000159499, ENSMUST00000159970, ENSMUST00000162559, ENSMUST00000162587
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93809957572099575Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91670964150709641Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91697884050978943Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91574962749749627Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93809957572099575Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91339117547391175Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91574962749749627Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93809957572099575Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94348071477480860Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91236997046370114Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94442817478428262Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91541175149411890Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined91994340653943525Mouse
13432191Actrse4_mactivity response to saline/ethanol 4 (mouse)94370321448603195Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
10045613Rapop7_mradiation-induced apoptosis 6 (mouse)Not determined93673624349420511Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91541175149411890Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
11532693Sluc39_msusceptibility to lung cancer 39 (mouse)94064537448351476Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91541175149411890Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
1558993Tdmq1_mtype 2 diabetes modifying QTL 1 (mouse)Not determined94041959451808670Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91541175149411890Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94080504774805204Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93781952871819528Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91601129650011296Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94348071477480860Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91601129650011296Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91574962749749627Mouse
1301501Lmr2_mleishmaniasis resistance 2 (mouse)Not determined93694340650111140Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse

Markers in Region
AI842136  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38945,856,855 - 45,856,954UniSTSGRCm38
MGSCv37945,664,938 - 45,665,037UniSTSGRCm37
Celera943,139,630 - 43,139,729UniSTS
Cytogenetic Map9A5.2UniSTS
Bace1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A5.2UniSTS
cM Map9 UniSTS
UniSTS:236114  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38945,858,635 - 45,858,899UniSTSGRCm38
MGSCv37945,666,718 - 45,666,982UniSTSGRCm37
Celera943,141,410 - 43,141,674UniSTS
Cytogenetic Map9A5.2UniSTS
RH126063  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38945,861,901 - 45,862,127UniSTSGRCm38
MGSCv37945,669,984 - 45,670,210UniSTSGRCm37
Celera943,144,676 - 43,144,902UniSTS
Cytogenetic Map9A5.2UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001145947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001410455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001410456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001410457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC126804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF190726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF200346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK014390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK014464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK033112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK046175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK048909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK082230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK082317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK173112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC048189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY724111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000034591   ⟹   ENSMUSP00000034591
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl945,749,878 - 45,775,697 (+)Ensembl
GRCm38.p6 Ensembl945,838,580 - 45,864,399 (+)Ensembl
Ensembl Acc Id: ENSMUST00000078111   ⟹   ENSMUSP00000077249
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl945,749,878 - 45,773,782 (+)Ensembl
GRCm38.p6 Ensembl945,838,580 - 45,862,484 (+)Ensembl
Ensembl Acc Id: ENSMUST00000159499   ⟹   ENSMUSP00000124773
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl945,750,538 - 45,768,471 (+)Ensembl
GRCm38.p6 Ensembl945,839,240 - 45,857,173 (+)Ensembl
Ensembl Acc Id: ENSMUST00000159970
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl945,764,021 - 45,773,517 (+)Ensembl
GRCm38.p6 Ensembl945,852,723 - 45,862,219 (+)Ensembl
Ensembl Acc Id: ENSMUST00000162559
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl945,751,216 - 45,766,005 (+)Ensembl
GRCm38.p6 Ensembl945,839,918 - 45,854,707 (+)Ensembl
Ensembl Acc Id: ENSMUST00000162587   ⟹   ENSMUSP00000124960
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl945,765,925 - 45,771,660 (+)Ensembl
GRCm38.p6 Ensembl945,854,627 - 45,860,362 (+)Ensembl
RefSeq Acc Id: NM_001145947   ⟹   NP_001139419
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39945,749,878 - 45,775,694 (+)NCBI
GRCm38945,838,545 - 45,862,484 (+)NCBI
MGSCv37945,646,612 - 45,670,567 (+)RGD
Celera943,121,304 - 43,145,259 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001410455   ⟹   NP_001397384
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39945,749,878 - 45,775,694 (+)NCBI
RefSeq Acc Id: NM_001410456   ⟹   NP_001397385
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39945,751,189 - 45,775,694 (+)NCBI
RefSeq Acc Id: NM_001410457   ⟹   NP_001397386
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39945,749,878 - 45,775,694 (+)NCBI
RefSeq Acc Id: NM_011792   ⟹   NP_035922
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39945,749,878 - 45,775,694 (+)NCBI
GRCm38945,838,545 - 45,862,484 (+)NCBI
MGSCv37945,646,612 - 45,670,567 (+)RGD
Celera943,121,304 - 43,145,259 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035922   ⟸   NM_011792
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q544D0 (UniProtKB/Swiss-Prot),   P56818 (UniProtKB/Swiss-Prot),   Q8BQY4 (UniProtKB/TrEMBL),   Q8C7R1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001139419   ⟸   NM_001145947
- Peptide Label: isoform 2 precursor
- UniProtKB: Q8C4F4 (UniProtKB/TrEMBL),   Q8BQY4 (UniProtKB/TrEMBL),   Q8C7R1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000124773   ⟸   ENSMUST00000159499
Ensembl Acc Id: ENSMUSP00000034591   ⟸   ENSMUST00000034591
Ensembl Acc Id: ENSMUSP00000124960   ⟸   ENSMUST00000162587
Ensembl Acc Id: ENSMUSP00000077249   ⟸   ENSMUST00000078111
RefSeq Acc Id: NP_001397384   ⟸   NM_001410455
- Peptide Label: isoform 3 precursor
- UniProtKB: Q8BQY4 (UniProtKB/TrEMBL),   Q8C7R1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001397386   ⟸   NM_001410457
- Peptide Label: isoform 5
- UniProtKB: Q9CUU5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001397385   ⟸   NM_001410456
- Peptide Label: isoform 4
- UniProtKB: Q69ZQ6 (UniProtKB/TrEMBL)
Protein Domains
Peptidase A1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P56818-F1-model_v2 AlphaFold P56818 1-501 view protein structure

Promoters
RGD ID:6844227
Promoter ID:MM_KWN:57199
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_001145947,   NM_011792,   UC009PGG.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36945,646,484 - 45,646,984 (+)MPROMDB
RGD ID:6848381
Promoter ID:MM_ACW:50388
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:MEF_B6
Transcripts:BACE1.FSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36945,666,246 - 45,666,746 (+)MPROMDB
RGD ID:8669460
Promoter ID:EPDNEW_M12761
Type:multiple initiation site
Name:Bace1_1
Description:Mus musculus beta-site APP cleaving enzyme 1 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38945,838,580 - 45,838,640EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1346542 AgrOrtholog
Ensembl Genes ENSMUSG00000032086 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034591 ENTREZGENE
  ENSMUST00000034591.11 UniProtKB/Swiss-Prot
  ENSMUST00000078111 ENTREZGENE
  ENSMUST00000162587 ENTREZGENE
Gene3D-CATH 2.40.70.10 UniProtKB/Swiss-Prot
InterPro Aspartic_peptidase_A1 UniProtKB/Swiss-Prot
  Aspartic_peptidase_AS UniProtKB/Swiss-Prot
  BACE UniProtKB/Swiss-Prot
  BACE1 UniProtKB/Swiss-Prot
  Memapsin-like UniProtKB/Swiss-Prot
  PEPTIDASE_A1 UniProtKB/Swiss-Prot
  Peptidase_aspartic_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:23821 UniProtKB/Swiss-Prot
MGD MGI:1346542 ENTREZGENE
NCBI Gene 23821 ENTREZGENE
PANTHER PTHR47965 UniProtKB/Swiss-Prot
  PTHR47965:SF69 UniProtKB/Swiss-Prot
Pfam Asp UniProtKB/Swiss-Prot
PharmGKB BACE1 RGD
PhenoGen Bace1 PhenoGen
PRINTS BACE1 UniProtKB/Swiss-Prot
  BACEFAMILY UniProtKB/Swiss-Prot
  PEPSIN UniProtKB/Swiss-Prot
PROSITE ASP_PROTEASE UniProtKB/Swiss-Prot
  PEPTIDASE_A1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50630 UniProtKB/Swiss-Prot
UniProt BACE1_MOUSE UniProtKB/Swiss-Prot
  F6TV37_MOUSE UniProtKB/TrEMBL
  F6UH57_MOUSE UniProtKB/TrEMBL
  P56818 ENTREZGENE
  Q544D0 ENTREZGENE
  Q69ZQ6 ENTREZGENE, UniProtKB/TrEMBL
  Q8BQY4 ENTREZGENE, UniProtKB/TrEMBL
  Q8C4F4 ENTREZGENE, UniProtKB/TrEMBL
  Q8C7R1 ENTREZGENE, UniProtKB/TrEMBL
  Q9CUU5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q544D0 UniProtKB/Swiss-Prot