Symbol:
Bace1
Name:
beta-secretase 1
RGD ID:
8704832
Description:
ENCODES a protein that exhibits amyloid-beta binding (ortholog); aspartic-type endopeptidase activity (ortholog); endopeptidase activity (ortholog); INVOLVED IN amyloid precursor protein catabolic process (ortholog); amyloid-beta formation (ortholog); amyloid-beta metabolic process (ortholog); ASSOCIATED WITH alcohol use disorder (ortholog); Alzheimer's disease (ortholog); CD3epsilon deficiency (ortholog); FOUND IN axon (ortholog); cell surface (ortholog); cytoplasmic vesicle (ortholog)
Type:
protein-coding
RefSeq Status:
MODEL
Previously known as:
beta-site APP-cleaving enzyme 1
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Latest Assembly:
ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 Ensembl NW_004955412 18,596,643 - 18,620,362 (-) Ensembl ChiLan1.0 ChiLan1.0 NW_004955412 18,596,643 - 18,620,089 (-) NCBI ChiLan1.0 ChiLan1.0
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Bace1 Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 Ensembl NW_004955412 18,596,643 - 18,620,362 (-) Ensembl ChiLan1.0 ChiLan1.0 NW_004955412 18,596,643 - 18,620,089 (-) NCBI ChiLan1.0 ChiLan1.0
BACE1 Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 11 117,285,698 - 117,316,256 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 11 117,285,232 - 117,316,259 (-) Ensembl GRCh38 hg38 GRCh38 GRCh37 11 117,156,414 - 117,186,972 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 11 116,661,624 - 116,692,182 (-) NCBI NCBI36 Build 36 hg18 NCBI36 Celera 11 114,314,074 - 114,344,631 (-) NCBI Celera Cytogenetic Map 11 q23.3 NCBI HuRef 11 113,090,543 - 113,121,018 (-) NCBI HuRef CHM1_1 11 117,041,502 - 117,072,072 (-) NCBI CHM1_1 T2T-CHM13v2.0 11 117,302,503 - 117,333,060 (-) NCBI T2T-CHM13v2.0
Bace1 Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 9 45,749,878 - 45,775,694 (+) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 9 45,749,878 - 45,775,697 (+) Ensembl GRCm39 Ensembl GRCm38 9 45,838,545 - 45,862,484 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 9 45,838,580 - 45,864,399 (+) Ensembl GRCm38 mm10 GRCm38 MGSCv37 9 45,646,612 - 45,670,567 (+) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 9 45,589,578 - 45,613,436 (+) NCBI MGSCv36 mm8 Celera 9 43,121,304 - 43,145,259 (+) NCBI Celera Cytogenetic Map 9 A5.2 NCBI cM Map 9 25.22 NCBI
Bace1 Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 8 55,038,842 - 55,061,138 (+) NCBI GRCr8 mRatBN7.2 8 46,142,060 - 46,166,268 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 8 46,142,116 - 46,165,876 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 8 51,643,201 - 51,665,458 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 8 49,921,966 - 49,944,223 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 8 47,786,230 - 47,808,489 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 8 50,140,092 - 50,162,388 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 8 50,139,997 - 50,162,361 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 8 48,766,005 - 48,788,272 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 8 48,817,824 - 48,839,681 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 8 48,826,589 - 48,848,447 (+) NCBI Celera 8 45,724,900 - 45,747,208 (+) NCBI Celera Cytogenetic Map 8 q22 NCBI
BACE1 Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 9 117,986,558 - 118,017,119 (-) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 11 119,095,929 - 119,123,152 (-) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 11 112,120,950 - 112,151,505 (-) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 11 116,054,303 - 116,084,813 (-) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl 11 116,054,303 - 116,084,812 (-) Ensembl panpan1.1 panPan2
BACE1 Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 5 16,308,953 - 16,319,100 (+) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 5 16,308,944 - 16,319,100 (+) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 5 16,347,976 - 16,371,490 (+) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 5 16,240,025 - 16,263,790 (+) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 5 16,239,793 - 16,264,160 (+) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 5 16,377,977 - 16,401,485 (+) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 5 16,280,937 - 16,304,419 (+) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 5 16,323,226 - 16,346,725 (+) NCBI UU_Cfam_GSD_1.0
Bace1 Squirrel Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl HiC_Itri_2 NW_024404947 99,590,774 - 99,617,699 (-) NCBI HiC_Itri_2 SpeTri2.0 Ensembl NW_004936542 2,514,300 - 2,539,135 (-) Ensembl SpeTri2.0 SpeTri2.0 Ensembl SpeTri2.0 NW_004936542 2,514,297 - 2,539,088 (-) NCBI SpeTri2.0 SpeTri2.0 SpeTri2.0
BACE1 Pig Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Sscrofa11.1 Ensembl 9 44,640,394 - 44,665,835 (-) Ensembl Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa11.1 9 44,640,389 - 44,665,863 (-) NCBI Sscrofa11.1 Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa10.2 9 49,716,271 - 49,738,860 (-) NCBI Sscrofa10.2 Sscrofa10.2 susScr3
BACE1 Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 1 108,659,723 - 108,689,879 (-) NCBI ChlSab1.1 ChlSab1.1 chlSab2 ChlSab1.1 Ensembl 1 108,657,584 - 108,689,843 (-) Ensembl ChlSab1.1 ChlSab1.1 Ensembl chlSab2 Vero_WHO_p1.0 NW_023666043 17,364,724 - 17,395,903 (+) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
Bace1
.
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
Ensembl Acc Id:
ENSCLAT00000019526 ⟹ ENSCLAP00000019337
Type:
CODING
Position:
Chinchilla Assembly Chr Position (strand) Source ChiLan1.0 Ensembl NW_004955412 18,596,643 - 18,620,362 (-) Ensembl
Ensembl Acc Id:
ENSCLAT00000019527 ⟹ ENSCLAP00000019338
Type:
CODING
Position:
Chinchilla Assembly Chr Position (strand) Source ChiLan1.0 Ensembl NW_004955412 18,598,341 - 18,619,567 (-) Ensembl
RefSeq Acc Id:
XM_005378205 ⟹ XP_005378262
Type:
CODING
Position:
Chinchilla Assembly Chr Position (strand) Source ChiLan1.0 NW_004955412 18,596,643 - 18,620,089 (-) NCBI
Sequence:
AAAAGCGAAAACCCTTTGGCTTTGACAGCCGCCACCACAGGTCTTTCCGCCTCCCCTGCTTGCTTGGGAGCTGGGAGCTGGGAGCTGAGAGCTGGGAGCTGGGAGCTGGGAGCTGGATTATGGTGGCC
hide sequence
RefSeq Acc Id:
XP_005378262 ⟸ XM_005378205
- UniProtKB:
A0A8C2YS60 (UniProtKB/TrEMBL), A0A8C2YS57 (UniProtKB/TrEMBL)
- Sequence:
MAPALPWLLLWVGSGVLPAHGTQHGIRLPLRSGLAGAPLGLRLPRETDEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQRSSTYRDLRKGVYVP
hide sequence
Ensembl Acc Id:
ENSCLAP00000019338 ⟸ ENSCLAT00000019527
Ensembl Acc Id:
ENSCLAP00000019337 ⟸ ENSCLAT00000019526
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2016-08-03
Bace1
beta-secretase 1
beta-site APP-cleaving enzyme 1
Symbol and/or name change
5135510 APPROVED
