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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2191
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bace1
Name: beta-secretase 1
Acc ID: CHEBI:27889
Term: lead(0)
Definition: An elemental lead that has formula Pb.
Chemical ID: MESH:D007854
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bace1multiple interactionsEXP 6480464CTD[Arsenic co-treated with Cadmium co-treated with Lead] promotes the reaction [BACE1 protein results in increased metabolism of APP protein]PMID:25288670
Bace1increases expressionISOBace1 (Mus musculus)6480464CTDLead results in increased expression of BACE1 mRNA; Lead results in increased expression of BACE1 proteinPMID:35426476
Bace1increases expressionISOBACE1 (Homo sapiens)6480464CTDLead results in increased expression of BACE1 proteinPMID:22272629
Bace1multiple interactionsISOBace1 (Mus musculus)6480464CTD[lead acetate results in increased abundance of Lead] which results in increased expression of BACE1 mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of BACE1 proteinPMID:31730887 PMID:32058320
Bace1multiple interactionsISOBACE1 (Homo sapiens)6480464CTD[lead acetate results in increased abundance of Lead] promotes the reaction [APP protein modified form results in increased expression of BACE1 protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein results in increased expression of BACE1 protein]; [lead acetate results in increased abundance of Lead] which results in increased expression of BACE1 protein; [Lead co-treated with APP protein co-treated with APP protein modified form] results in increased expression of BACE1 protein; MIR124-1 inhibits the reaction [Lead results in increased expression of BACE1 mRNA]; MIR124-1 inhibits the reaction [Lead results in increased expression of BACE1 protein]PMID:31843630 PMID:35426476
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