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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2191
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bace1
Name: beta-secretase 1
Acc ID: CHEBI:27617
Term: monensin A
Definition: A spiroketal, monensin A is the major component of monensin, a mixture of antibiotic substances produced by Streptomyces cinnamonensis. An antiprotozoal, it is used as the sodium salt as a feed additive for the prevention of coccidiosis in poultry and as a growth promoter in cattle.
Chemical ID: MESH:D008985
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bace1multiple interactionsISOBACE1 (Homo sapiens)6480464CTDMonensin inhibits the reaction [Ketamine results in increased expression of and affects the localization of BACE1 protein]PMID:35378374
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