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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2191
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bace1
Name: beta-secretase 1
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bace1increases expressionISOBACE1 (Homo sapiens)6480464CTDHydrogen Peroxide results in increased expression of BACE1 mRNAPMID:31521693
Bace1multiple interactionsISOBACE1 (Homo sapiens)6480464CTD4-((alpha-L-rhamnosyloxy)benzyl)isothiocyanate inhibits the reaction [Hydrogen Peroxide results in increased expression of BACE1 mRNA]; Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of BACE1 mRNA]PMID:31521693
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