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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2191
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bace1
Name: beta-secretase 1
Acc ID: CHEBI:30052
Term: copper(0)
Definition: An elemental copper that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bace1increases expressionISOBACE1 (Homo sapiens)6480464CTDCopper results in increased expression of BACE1 mRNAPMID:18583042
Bace1multiple interactionsISOBACE1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Copper results in increased expression of BACE1 mRNA]; CEP-11004 inhibits the reaction [Copper results in increased expression of BACE1 mRNA]; Curcumin inhibits the reaction [Copper results in increased expression of BACE1 mRNA]; ferulic acid inhibits the reaction [Copper results in increased expression of BACE1 mRNA]; Minocycline inhibits the reaction [Copper results in increased expression of BACE1 mRNA]; SB 203580 inhibits the reaction [Copper results in increased expression of BACE1 mRNA]PMID:18583042
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