Dpysl2 (dihydropyrimidinase-like 2) - Rat Genome Database

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Gene: Dpysl2 (dihydropyrimidinase-like 2) Rattus norvegicus
Analyze
Symbol: Dpysl2
Name: dihydropyrimidinase-like 2
RGD ID: 2517
Description: Predicted to enable hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides; identical protein binding activity; and protein kinase binding activity. Involved in several processes, including central nervous system development; positive regulation of glutamate secretion; and regulation of postsynapse assembly. Located in several cellular components, including distal axon; myelin sheath; and neuronal cell body. Part of protein-containing complex. Is active in glutamatergic synapse and presynapse. Biomarker of brain ischemia; hypothyroidism; and status epilepticus. Orthologous to human DPYSL2 (dihydropyrimidinase like 2); INTERACTS WITH (+)-pilocarpine; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: collapsin response mediator protein 2; CRMP-2; Crmp2; dihydropyrimidinase-related protein 2; DRP-2; TOAD-64; turned on after division 64 kDa protein; turned on after division, 64 kDa protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81545,181,041 - 45,287,065 (-)NCBIGRCr8
mRatBN7.21541,005,551 - 41,111,724 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1541,005,551 - 41,111,829 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1542,870,932 - 42,938,358 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01544,021,144 - 44,088,568 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01542,465,839 - 42,533,150 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01543,475,640 - 43,581,725 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1543,477,629 - 43,542,939 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,014,263 - 48,120,298 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41546,346,413 - 46,413,786 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11546,363,561 - 46,429,519 (-)NCBI
Celera1540,673,435 - 40,740,421 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
1,2-dimethylhydrazine  (ISO)
1-benzylpiperazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,5-hexanedione  (EXP)
2-butoxyethanol  (ISO)
2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
albendazole  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
buspirone  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper(II) chloride  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
dexmedetomidine  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
diethyl maleate  (ISO)
diethyldithiocarbamic acid  (EXP)
dihydroartemisinin  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
etoposide  (ISO)
finasteride  (EXP)
folic acid  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
glyphosate  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
isoflavones  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lovastatin  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methylseleninic acid  (ISO)
miconazole  (ISO)
morphine  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
naphthalene  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
permethrin  (EXP)
piroxicam  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propofol  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 415286  (EXP)
SB 431542  (ISO)
sevoflurane  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sulfadimethoxine  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triticonazole  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)
warfarin  (ISO)
zaragozic acid A  (EXP,ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Signaling pathway adaptations and novel protein kinase A substrates related to behavioral sensitization to cocaine. Boudreau AC, etal., J Neurochem. 2009 Jul;110(1):363-77. Epub 2009 May 3.
2. An atypical role for collapsin response mediator protein 2 (CRMP-2) in neurotransmitter release via interaction with presynaptic voltage-gated calcium channels. Brittain JM, etal., J Biol Chem. 2009 Nov 6;284(45):31375-90. Epub 2009 Sep 15.
3. Novel cytosolic binding partners of the neural cell adhesion molecule: mapping the binding domains of PLC gamma, LANP, TOAD-64, syndapin, PP1, and PP2A. Buttner B, etal., Biochemistry. 2005 May 10;44(18):6938-47.
4. Regulation of N-type voltage-gated calcium channels (Cav2.2) and transmitter release by collapsin response mediator protein-2 (CRMP-2) in sensory neurons. Chi XX, etal., J Cell Sci. 2009 Dec 1;122(Pt 23):4351-62. doi: 10.1242/jcs.053280. Epub 2009 Nov 10.
5. Detection of TOAD-64 in adult rat brain as revealed by two-dimensional protein gel electrophoresis followed by MALDI mass spectrometry possible modulatory effect of chronic haloperidol treatment. Dahmen N, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2002 May;26(4):693-8.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Identification and characterization of novel developmentally regulated proteins in rat spinal cord. Geschwind DH, etal., Brain Res Dev Brain Res. 1996 Nov 22;97(1):62-75.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Upregulation of Dpysl2 and Spna2 gene expression in the rat brain after ischemic stroke. Indraswari F, etal., Neurochem Int. 2009 Sep;55(4):235-42. Epub 2009 Mar 18.
10. Methods in drug abuse neuroproteomics: methamphetamine psychoproteome. Kobeissy FH, etal., Methods Mol Biol. 2009;566:217-28.
11. Lovastatin modulates glycogen synthase kinase-3beta pathway and inhibits mossy fiber sprouting after pilocarpine-induced status epilepticus. Lee CY, etal., PLoS One. 2012;7(6):e38789. doi: 10.1371/journal.pone.0038789. Epub 2012 Jun 26.
12. Collapsin response mediator protein-2 inhibits neuronal phospholipase D(2) activity by direct interaction. Lee S, etal., J Biol Chem. 2002 Feb 22;277(8):6542-9. Epub 2001 Dec 10.
13. Neurofibromin interacts with CRMP-2 and CRMP-4 in rat brain. Lin YL and Hsueh YP, Biochem Biophys Res Commun. 2008 May 2;369(2):747-52. Epub 2008 Feb 29.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. TOAD-64, a gene expressed early in neuronal differentiation in the rat, is related to unc-33, a C. elegans gene involved in axon outgrowth. Minturn JE, etal., J Neurosci 1995 Oct;15(10):6757-66.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2. Nishimura T, etal., Mol Biol Cell. 2006 Mar;17(3):1273-85. Epub 2006 Jan 4.
18. Neurofibromatosis type 1 (NF1) tumor suppressor, neurofibromin, regulates the neuronal differentiation of PC12 cells via its associating protein, CRMP-2. Patrakitkomjorn S, etal., J Biol Chem. 2008 Apr 4;283(14):9399-413. Epub 2008 Jan 23.
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Expression of axon guidance molecules and their related genes during development and sexual differentiation of the olfactory bulb in rats. Tsim TY, etal., Neuroscience. 2004;123(4):951-65.
23. Brain CRMP forms heterotetramers similar to liver dihydropyrimidinase. Wang LH and Strittmatter SM, J Neurochem. 1997 Dec;69(6):2261-9.
24. Effects of neonatal hypothyroidism on the expressions of growth cone proteins and axon guidance molecules related genes in the hippocampus. Wong CC and Leung MS, Mol Cell Endocrinol. 2001 Nov 26;184(1-2):143-50.
25. Two-dimensional electrophoresis with cationic detergents: a powerful tool for the proteomic analysis of myelin proteins. Part 2: analytical aspects. Yamaguchi Y, etal., J Neurosci Res. 2008 Mar;86(4):766-75.
26. Identification of protein substrates of Ca(2+)/calmodulin-dependent protein kinase II in the postsynaptic density by protein sequencing and mass spectrometry. Yoshimura Y, etal., Biochem Biophys Res Commun 2002 Jan 25;290(3):948-54.
27. Phosphorylation and SUMOylation of CRMP2 regulate the formation and maturation of dendritic spines. Zhang J, etal., Brain Res Bull. 2018 May;139:21-30. doi: 10.1016/j.brainresbull.2018.02.004. Epub 2018 Feb 6.
28. Calpain-mediated collapsin response mediator protein-1, -2, and -4 proteolysis after neurotoxic and traumatic brain injury. Zhang Z, etal., J Neurotrauma. 2007 Mar;24(3):460-72.
29. Protein phosphatase 2A facilitates axonogenesis by dephosphorylating CRMP2. Zhu LQ, etal., J Neurosci. 2010 Mar 10;30(10):3839-48. doi: 10.1523/JNEUROSCI.5174-09.2010.
Additional References at PubMed
PMID:8889548   PMID:10757975   PMID:12134159   PMID:12887701   PMID:12942088   PMID:14651853   PMID:15834957   PMID:15935053   PMID:16189471   PMID:16260607   PMID:16343426   PMID:16418269  
PMID:16854843   PMID:17051644   PMID:17634366   PMID:17670980   PMID:18332147   PMID:18460467   PMID:19151921   PMID:19648118   PMID:19652227   PMID:20131911   PMID:20453694   PMID:20458337  
PMID:20538611   PMID:20801876   PMID:20926379   PMID:21333637   PMID:21516116   PMID:21550974   PMID:21829088   PMID:21832084   PMID:22057101   PMID:22373559   PMID:22431514   PMID:22433297  
PMID:22443207   PMID:22542739   PMID:22554777   PMID:22871113   PMID:23022559   PMID:23275173   PMID:23276635   PMID:23459330   PMID:23510938   PMID:23904609   PMID:24036111   PMID:24227739  
PMID:24474686   PMID:25416956   PMID:25847191   PMID:26064693   PMID:27765673   PMID:27845394   PMID:27940916   PMID:28259758   PMID:28445771   PMID:28677754   PMID:28809766   PMID:28837387  
PMID:29476059   PMID:29749502   PMID:29892012   PMID:30315937   PMID:30537069   PMID:31025580   PMID:31278888   PMID:31359322   PMID:31515488   PMID:31561361   PMID:31888677   PMID:32357304  
PMID:32571373   PMID:32645362   PMID:33559827   PMID:34975828   PMID:35334412   PMID:36044155   PMID:37175950  


Genomics

Comparative Map Data
Dpysl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81545,181,041 - 45,287,065 (-)NCBIGRCr8
mRatBN7.21541,005,551 - 41,111,724 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1541,005,551 - 41,111,829 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1542,870,932 - 42,938,358 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01544,021,144 - 44,088,568 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01542,465,839 - 42,533,150 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01543,475,640 - 43,581,725 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1543,477,629 - 43,542,939 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,014,263 - 48,120,298 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41546,346,413 - 46,413,786 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11546,363,561 - 46,429,519 (-)NCBI
Celera1540,673,435 - 40,740,421 (-)NCBICelera
Cytogenetic Map15p12NCBI
DPYSL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38826,514,031 - 26,658,175 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl826,514,031 - 26,658,178 (+)EnsemblGRCh38hg38GRCh38
GRCh37826,371,547 - 26,515,691 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36826,491,338 - 26,571,610 (+)NCBINCBI36Build 36hg18NCBI36
Build 34826,491,337 - 26,571,610NCBI
Celera825,397,861 - 25,478,105 (+)NCBICelera
Cytogenetic Map8p21.2NCBI
HuRef824,916,540 - 25,060,679 (+)NCBIHuRef
CHM1_1826,573,316 - 26,717,422 (+)NCBICHM1_1
T2T-CHM13v2.0826,790,610 - 26,934,895 (+)NCBIT2T-CHM13v2.0
Dpysl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391467,040,313 - 67,148,490 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1467,040,313 - 67,148,410 (-)EnsemblGRCm39 Ensembl
GRCm381466,802,864 - 66,911,041 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1466,802,864 - 66,868,688 (-)EnsemblGRCm38mm10GRCm38
MGSCv371467,421,701 - 67,487,437 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361465,756,974 - 65,822,710 (-)NCBIMGSCv36mm8
Celera1464,556,867 - 64,622,100 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.6NCBI
Dpysl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540349,188,205 - 49,307,810 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540349,188,259 - 49,306,916 (+)NCBIChiLan1.0ChiLan1.0
DPYSL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2745,047,458 - 45,188,188 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1820,761,563 - 20,902,380 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0825,786,950 - 25,927,782 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1822,693,863 - 22,834,080 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl822,693,863 - 22,834,080 (+)Ensemblpanpan1.1panPan2
DPYSL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12530,900,347 - 31,038,256 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2530,903,253 - 31,038,144 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2531,488,825 - 31,626,366 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02531,099,660 - 31,237,832 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2531,099,705 - 31,238,131 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12531,034,380 - 31,172,517 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02530,904,994 - 31,043,606 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02531,072,136 - 31,210,060 (-)NCBIUU_Cfam_GSD_1.0
Dpysl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049439,058,904 - 9,170,248 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936757309,022 - 422,955 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936757311,317 - 422,870 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DPYSL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1410,427,957 - 10,545,704 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11410,428,598 - 10,545,705 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21411,593,761 - 11,711,007 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DPYSL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1824,625,961 - 24,772,047 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl824,690,856 - 24,772,087 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605217,387,238 - 17,533,529 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dpysl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475821,355,872 - 21,475,788 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475821,355,816 - 21,475,662 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dpysl2
650 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:939
Count of miRNA genes:323
Interacting mature miRNAs:457
Transcripts:ENSRNOT00000012996
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154028990149308583Rat
2306968Anxrr23Anxiety related response QTL 234.83reflex trait (VT:0001961)amplitude of the acoustic startle response (CMO:0001520)154063126846187442Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat

Markers in Region
D15Uwm1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21541,010,879 - 41,011,035 (+)MAPPERmRatBN7.2
Rnor_6.01543,480,969 - 43,481,124NCBIRnor6.0
Rnor_5.01548,114,814 - 48,114,969UniSTSRnor5.0
RGSC_v3.41546,351,742 - 46,351,897UniSTSRGSC3.4
Celera1540,678,693 - 40,678,848UniSTS
Cytogenetic Map15p12UniSTS
BI284489  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21541,006,395 - 41,006,572 (+)MAPPERmRatBN7.2
Rnor_6.01543,476,485 - 43,476,661NCBIRnor6.0
Rnor_5.01548,119,277 - 48,119,453UniSTSRnor5.0
RGSC_v3.41546,347,258 - 46,347,434UniSTSRGSC3.4
Celera1540,674,278 - 40,674,454UniSTS
RH 3.4 Map15323.3UniSTS
Cytogenetic Map15p12UniSTS
RH139185  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21541,005,910 - 41,006,064 (+)MAPPERmRatBN7.2
Rnor_6.01543,476,000 - 43,476,153NCBIRnor6.0
Rnor_5.01548,119,785 - 48,119,938UniSTSRnor5.0
RGSC_v3.41546,346,773 - 46,346,926UniSTSRGSC3.4
Celera1540,673,795 - 40,673,948UniSTS
Cytogenetic Map15p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 4
Medium 3 42 38 22 19 22 8 9 70 35 37 11 8
Low 1 19 19 19 2 4
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000012996   ⟹   ENSRNOP00000012996
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1541,005,551 - 41,072,852 (-)Ensembl
Rnor_6.0 Ensembl1543,477,629 - 43,542,939 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103229   ⟹   ENSRNOP00000088353
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1541,005,551 - 41,069,672 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111164   ⟹   ENSRNOP00000097378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1541,005,551 - 41,111,829 (-)Ensembl
RefSeq Acc Id: NM_001105717   ⟹   NP_001099187
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81545,181,041 - 45,248,353 (-)NCBI
mRatBN7.21541,005,551 - 41,072,857 (-)NCBI
Rnor_6.01543,475,640 - 43,542,893 (-)NCBI
Rnor_5.01548,014,263 - 48,120,298 (+)NCBI
RGSC_v3.41546,346,413 - 46,413,786 (-)RGD
Celera1540,673,435 - 40,740,421 (-)RGD
Sequence:
RefSeq Acc Id: XM_006252097   ⟹   XP_006252159
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81545,181,043 - 45,287,065 (-)NCBI
mRatBN7.21541,005,551 - 41,111,724 (-)NCBI
Rnor_6.01543,475,640 - 43,581,725 (-)NCBI
Rnor_5.01548,014,263 - 48,120,298 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001099187   ⟸   NM_001105717
- UniProtKB: P47942 (UniProtKB/Swiss-Prot),   A6K6N4 (UniProtKB/TrEMBL),   A0A8I6AAN6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252159   ⟸   XM_006252097
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ANE0 (UniProtKB/TrEMBL),   A0A8I6AAN6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012996   ⟸   ENSRNOT00000012996
RefSeq Acc Id: ENSRNOP00000097378   ⟸   ENSRNOT00000111164
RefSeq Acc Id: ENSRNOP00000088353   ⟸   ENSRNOT00000103229
Protein Domains
Amidohydrolase-related

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47942-F1-model_v2 AlphaFold P47942 1-572 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699759
Promoter ID:EPDNEW_R10282
Type:initiation region
Name:Dpysl2_1
Description:dihydropyrimidinase-like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01543,542,948 - 43,543,008EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2517 AgrOrtholog
BioCyc Gene G2FUF-13319 BioCyc
BioCyc Pathway PWY-3982 [uracil degradation I (reductive)] BioCyc
  PWY-6430 [thymine degradation] BioCyc
BioCyc Pathway Image PWY-3982 BioCyc
  PWY-6430 BioCyc
Ensembl Genes ENSRNOG00000009625 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055006785 UniProtKB/Swiss-Prot
  ENSRNOG00060011761 UniProtKB/Swiss-Prot
  ENSRNOG00065017984 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012996 ENTREZGENE
  ENSRNOT00000012996.7 UniProtKB/Swiss-Prot
  ENSRNOT00000103229.1 UniProtKB/TrEMBL
  ENSRNOT00000111164.1 UniProtKB/TrEMBL
  ENSRNOT00055011125 UniProtKB/Swiss-Prot
  ENSRNOT00060019934 UniProtKB/Swiss-Prot
  ENSRNOT00065030193 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metal-dependent hydrolases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Amidohydro-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hydantoinase/dihydroPyrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metal-dep_hydrolase_composite UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metal_Hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25416 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25416 ENTREZGENE
PANTHER HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11647:SF56 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Amidohydro_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB DPYSL2 RGD
PhenoGen Dpysl2 PhenoGen
RatGTEx ENSRNOG00000009625 RatGTEx
  ENSRNOG00055006785 RatGTEx
  ENSRNOG00060011761 RatGTEx
  ENSRNOG00065017984 RatGTEx
Superfamily-SCOP SSF51338 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51556 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AAN6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ANE0 ENTREZGENE, UniProtKB/TrEMBL
  A6K6N4 ENTREZGENE, UniProtKB/TrEMBL
  DPYL2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2001-06-12 Dpysl2  Dihydropyrimidinase-like 2      Name updated 62408 APPROVED
2001-06-12 Crmp2  Collapsin response mediator protein 2      Symbol withdrawn, duplicate of Dpysl2 (RGD:2517) 62408 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization expressed in the postsynaptic density (PSD), a small amorphous structure located beneath the postsynaptic membrane of synapses 70740
gene_expression expressed immediately after neuronal birth and down-regulated in the adult 70740
gene_process a critical element for axonal outgrowth and pathfinding 70740
gene_regulation phosphorylated by CaM kinase II 70740