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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2517
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dpysl2
Name: dihydropyrimidinase-like 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dpysl2affects methylationISODPYSL2 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of DPYSL2 intron; Benzo(a)pyrene affects the methylation of DPYSL2 polyA tailPMID:30157460
Dpysl2decreases expressionISODPYSL2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of DPYSL2 mRNAPMID:21632981 PMID:26238291
Dpysl2decreases expressionISODpysl2 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of DPYSL2 mRNAPMID:19770486
Dpysl2increases expressionISODpysl2 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of DPYSL2 mRNAPMID:22228805 PMID:32417428
Dpysl2multiple interactionsISODpysl2 (Mus musculus)6480464CTDAHR protein affects the reaction [Benzo(a)pyrene affects the expression of DPYSL2 mRNA]PMID:22228805
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