Hsp90ab1 (heat shock protein 90 alpha family class B member 1) - Rat Genome Database

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Gene: Hsp90ab1 (heat shock protein 90 alpha family class B member 1) Rattus norvegicus
Analyze
Symbol: Hsp90ab1
Name: heat shock protein 90 alpha family class B member 1
RGD ID: 1303075
Description: Exhibits ion channel binding activity; nucleotide binding activity; and sulfonylurea receptor binding activity. Is predicted to contribute to protein kinase regulator activity. Involved in several processes, including negative regulation of complement-dependent cytotoxicity; positive regulation of protein import into nucleus; and regulation of cellular protein metabolic process. Localizes to several cellular components, including basolateral plasma membrane; brush border membrane; and ooplasm. Predicted to colocalize with COP9 signalosome. Biomarker of muscular atrophy; pancreatitis; and pulmonary fibrosis. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human HSP90AB1 (heat shock protein 90 alpha family class B member 1); PARTICIPATES IN aldosterone signaling pathway; androgen signaling pathway; cortisol signaling pathway; INTERACTS WITH (R)-adrenaline; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: heat shock 84 kDa; heat shock 90kDa protein 1, beta; heat shock protein 90 alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha family class B member 1; heat shock protein HSP 90-beta; HSP 84; HSP84; HSP90-BETA; HSP90B; HSPC2; Hspcb; MGC94263
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2915,432,986 - 15,438,358 (+)NCBI
Rnor_6.0 Ensembl917,817,721 - 17,823,243 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0917,817,791 - 17,823,163 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0916,706,512 - 16,711,884 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4911,033,496 - 11,038,868 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1911,030,786 - 11,036,319 (+)NCBI
Celera913,176,225 - 13,181,597 (+)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (EXP)
(Z)-3-butylidenephthalide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (EXP)
2-amino-4,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dihydrocoumarin  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (EXP)
4-vinylcyclohexene dioxide  (ISO)
6-anilino-5,8-quinolinedione  (EXP)
7,12-dimethyltetraphene  (EXP)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acrylamide  (EXP,ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
albendazole  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
aniline  (ISO)
arachidonic acid  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
astemizole  (EXP)
atrazine  (ISO)
BAPTA  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
calcidiol  (EXP)
carbon nanotube  (ISO)
celastrol  (EXP)
chloropicrin  (ISO)
chloroprene  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (EXP)
curcumin  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
DDT  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP)
disodium selenite  (ISO)
disulfiram  (ISO)
dopamine  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
fenofibrate  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
geldanamycin  (EXP,ISO)
genistein  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hexachlorobenzene  (EXP)
indometacin  (ISO)
isoflavones  (EXP)
ivermectin  (ISO)
kojic acid  (EXP)
L-ascorbic acid  (ISO)
lead nitrate  (ISO)
leflunomide  (EXP)
limonene  (EXP)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
methyl methanesulfonate  (ISO)
Methylazoxymethanol acetate  (EXP)
methylisothiazolinone  (ISO)
miconazole  (ISO)
morphine  (EXP)
motexafin gadolinium  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nickel dichloride  (ISO)
nimesulide  (EXP)
nonanoic acid  (ISO)
ochratoxin A  (EXP)
oxidopamine  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraoxon  (ISO)
PCB138  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
PhIP  (EXP)
phlorizin  (ISO)
pinosylvin  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
prostaglandin A1  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
resveratrol  (EXP)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
sulfasalazine  (ISO)
T-2 toxin  (EXP)
tamibarotene  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thiostrepton  (ISO)
toluene 2,4-diisocyanate  (ISO)
trans-pinosylvin  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
triphenylstannane  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
uranium atom  (ISO)
usnic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
warfarin  (ISO)
zinc acetate  (ISO)
zinc pyrithione  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axon extension  (ISO)
cellular response to heat  (IBA,ISO)
cellular response to interleukin-4  (ISO)
cellular response to organic cyclic compound  (IEP)
central nervous system neuron axonogenesis  (ISO)
chaperone-mediated autophagy  (NAS)
chaperone-mediated protein complex assembly  (ISO)
establishment of cell polarity  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of complement-dependent cytotoxicity  (IMP)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of proteasomal protein catabolic process  (IMP,ISO)
negative regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO,ISS)
negative regulation of protein metabolic process  (IMP)
negative regulation of transforming growth factor beta activation  (ISO,ISS)
placenta development  (ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of cell size  (IMP)
positive regulation of cyclin-dependent protein kinase activity  (IMP,ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of phosphoprotein phosphatase activity  (ISO)
positive regulation of protein binding  (IMP)
positive regulation of protein import into nucleus  (IMP)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein localization to cell surface  (ISO)
positive regulation of protein serine/threonine kinase activity  (IMP)
positive regulation of telomerase activity  (ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (ISO,ISS)
protein folding  (IBA,IEA,ISO,TAS)
protein stabilization  (IBA)
regulation of cell cycle  (ISO,ISS)
regulation of cellular protein localization  (ISO)
regulation of interferon-gamma-mediated signaling pathway  (ISO)
regulation of protein complex stability  (NAS)
regulation of protein ubiquitination  (ISO)
regulation of type I interferon-mediated signaling pathway  (ISO)
response to cocaine  (IEP)
response to drug  (IEP)
response to organic substance  (ISO)
response to salt stress  (IEP)
response to unfolded protein  (TAS)
supramolecular fiber organization  (ISO)
telomerase holoenzyme complex assembly  (ISO)
telomere maintenance via telomerase  (ISO)
virion attachment to host cell  (ISO)

References

References - curated
1. Bandyopadhyay U, etal., Mol Cell Biol. 2008 Sep;28(18):5747-63. doi: 10.1128/MCB.02070-07. Epub 2008 Jul 21.
2. Cid C and Alcazar A, Exp Neurol. 2010 Sep;225(1):29-33. Epub 2009 Dec 4.
3. Cid C, etal., FASEB J. 2004 Feb;18(2):409-11. Epub 2003 Dec 19.
4. Cid C, etal., J Neurochem. 2005 Oct;95(2):349-60. Epub 2005 Aug 31.
5. Erazo T, etal., Mol Cell Biol. 2013 Apr;33(8):1671-86. doi: 10.1128/MCB.01246-12. Epub 2013 Feb 19.
6. Forner F, etal., Biochim Biophys Acta. 2010 Jun;1804(6):1334-41. Epub 2010 Feb 25.
7. Fukushima T, etal., Mol Cell Endocrinol. 2011 Sep 15;344(1-2):81-9. Epub 2011 Jul 1.
8. Garcia-Fuster MJ, etal., PLoS One. 2012;7(7):e42092. doi: 10.1371/journal.pone.0042092. Epub 2012 Jul 30.
9. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Gotoh K, etal., FEBS Lett 2004 Feb 27;560(1-3):19-24.
11. Haase MG, etal., J Histochem Cytochem. 2014 May;62(5):355-68. doi: 10.1369/0022155414529133. Epub 2014 Mar 26.
12. Kim YH, etal., Diabetes. 2008 Aug;57(8):2181-90. Epub 2008 Apr 28.
13. Krzemień-Ojak Ł, etal., J Cell Biochem. 2017 Feb;118(2):420-429. doi: 10.1002/jcb.25669. Epub 2016 Oct 17.
14. Lee KH, etal., Exp Mol Med. 2010 Oct 31;42(10):703-11.
15. Lee KJ, etal., Cell Stress Chaperones. 2004 Mar;9(1):58-68.
16. Liao DF, etal., J Biol Chem 2000 Jan 7;275(1):189-96.
17. Lomonosova YN, etal., Biochemistry (Mosc). 2011 May;76(5):571-80. doi: 10.1134/S0006297911050075.
18. Luo W, etal., Proc Natl Acad Sci U S A. 2007 May 29;104(22):9511-6. doi: 10.1073/pnas.0701055104. Epub 2007 May 21.
19. Maselli J, etal., Andrology. 2014 Mar;2(2):259-66. doi: 10.1111/j.2047-2927.2014.00185.x. Epub 2014 Jan 29.
20. McGuire JA, etal., J Steroid Biochem Mol Biol 1992 Sep;42(8):813-22.
21. MGD data from the GO Consortium
22. Moretti AI, etal., Pancreas. 2009 Jul;38(5):507-14.
23. Pipeline to import KEGG annotations from KEGG into RGD
24. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
25. Pires ES and Khole VV, Fertil Steril. 2009 Oct;92(4):1395-409. doi: 10.1016/j.fertnstert.2008.08.068. Epub 2008 Nov 19.
26. Pratt WB, etal., Handb Exp Pharmacol. 2006;(172):111-38.
27. Prescott J and Coetzee GA, Cancer Lett. 2006 Jan 8;231(1):12-9.
28. Ramirez V, etal., Cell Stress Chaperones. 2004 Summer;9(2):198-206.
29. RGD automated data pipeline
30. RGD automated import pipeline for gene-chemical interactions
31. Seguin-Py S, etal., Biochimie. 2011 Nov 20.
32. Smith DF and Toft DO, Mol Endocrinol. 2008 Oct;22(10):2229-40. Epub 2008 May 1.
33. Soti C, etal., Eur J Biochem 2003 Jun;270(11):2421-8.
34. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
35. Tash JS, etal., Biol Reprod. 2008 Jun;78(6):1139-52. doi: 10.1095/biolreprod.107.062679. Epub 2008 Jan 23.
36. Vanhecke D, etal., J Microsc. 2008 May;230(Pt 2):253-62.
37. Yan FF, etal., Mol Biol Cell. 2010 Jun 15;21(12):1945-54. Epub 2010 Apr 28.
38. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
39. Zhou Y, etal., Eur Spine J. 2014 Jul;23(7):1480-90. doi: 10.1007/s00586-014-3214-1. Epub 2014 Feb 6.
Additional References at PubMed
PMID:3189818   PMID:7588731   PMID:8663025   PMID:9122205   PMID:9798653   PMID:10197982   PMID:10543959   PMID:10654595   PMID:10791971   PMID:10811660   PMID:11732320   PMID:11785981  
PMID:14651853   PMID:15489334   PMID:15581363   PMID:15713458   PMID:15808839   PMID:16166581   PMID:16207813   PMID:16280321   PMID:16396499   PMID:16580629   PMID:16641100   PMID:16809764  
PMID:16854843   PMID:17475835   PMID:17562399   PMID:17908927   PMID:18239673   PMID:18320580   PMID:18845059   PMID:18850735   PMID:19292454   PMID:19751963   PMID:19946888   PMID:20353823  
PMID:20458337   PMID:20599762   PMID:20833797   PMID:21063103   PMID:21183720   PMID:21266579   PMID:21855797   PMID:22082260   PMID:22658674   PMID:22681889   PMID:22843495   PMID:22871113  
PMID:22939624   PMID:23106098   PMID:23349634   PMID:23431407   PMID:23484111   PMID:23533145   PMID:23904609   PMID:24098578   PMID:24286867   PMID:24466266   PMID:24613385   PMID:24625528  
PMID:24880080   PMID:25468996   PMID:26316108   PMID:26593036   PMID:27248656   PMID:27686098   PMID:29476059   PMID:30382094  


Genomics

Comparative Map Data
Hsp90ab1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2915,432,986 - 15,438,358 (+)NCBI
Rnor_6.0 Ensembl917,817,721 - 17,823,243 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0917,817,791 - 17,823,163 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0916,706,512 - 16,711,884 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4911,033,496 - 11,038,868 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1911,030,786 - 11,036,319 (+)NCBI
Celera913,176,225 - 13,181,597 (+)NCBICelera
Cytogenetic Map9q12NCBI
HSP90AB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl644,246,166 - 44,253,888 (+)EnsemblGRCh38hg38GRCh38
GRCh38644,246,194 - 44,253,883 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37644,213,931 - 44,221,620 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36644,322,827 - 44,329,592 (+)NCBINCBI36hg18NCBI36
Build 34644,322,826 - 44,329,592NCBI
Celera645,767,994 - 45,774,759 (+)NCBI
Cytogenetic Map6p21.1NCBI
HuRef643,935,917 - 43,943,640 (+)NCBIHuRef
CHM1_1644,217,626 - 44,225,330 (+)NCBICHM1_1
Hsp90ab1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391745,878,704 - 45,884,187 (-)NCBIGRCm39mm39
GRCm39 Ensembl1745,878,701 - 45,884,197 (-)Ensembl
GRCm381745,567,778 - 45,573,261 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1745,567,775 - 45,573,271 (-)EnsemblGRCm38mm10GRCm38
MGSCv371745,704,727 - 45,710,210 (-)NCBIGRCm37mm9NCBIm37
MGSCv361745,031,359 - 45,036,842 (-)NCBImm8
Celera1749,000,428 - 49,005,921 (-)NCBICelera
Cytogenetic Map17B3NCBI
cM Map1722.59NCBI
Hsp90ab1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554379,873,908 - 9,878,459 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554379,872,649 - 9,878,459 (+)NCBIChiLan1.0ChiLan1.0
HSP90AB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1645,126,060 - 45,132,972 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl645,125,773 - 45,133,872 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0643,842,796 - 43,849,637 (+)NCBIMhudiblu_PPA_v0panPan3
HSP90AB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11212,658,415 - 12,664,945 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1212,660,008 - 12,664,940 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1212,682,075 - 12,689,685 (+)NCBI
ROS_Cfam_1.01213,139,324 - 13,147,144 (+)NCBI
UMICH_Zoey_3.11212,665,005 - 12,672,579 (+)NCBI
UNSW_CanFamBas_1.01212,752,685 - 12,760,264 (+)NCBI
UU_Cfam_GSD_1.01212,846,448 - 12,854,258 (+)NCBI
Hsp90ab1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494648,123,181 - 48,129,743 (+)NCBI
SpeTri2.0NW_00493647615,830,459 - 15,836,994 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSP90AB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl739,244,458 - 39,254,002 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1739,237,299 - 39,250,479 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2745,106,779 - 45,119,936 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HSP90AB1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11727,914,261 - 27,921,666 (-)NCBI
ChlSab1.1 Ensembl1727,911,013 - 27,921,251 (-)Ensembl
Hsp90ab1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475415,609,932 - 15,615,580 (-)NCBI

Position Markers
RH127542  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2915,438,717 - 15,438,913 (+)MAPPER
Rnor_6.0917,823,523 - 17,823,718NCBIRnor6.0
Rnor_5.0916,712,244 - 16,712,439UniSTSRnor5.0
RGSC_v3.4911,039,228 - 11,039,424UniSTSRGSC3.4
Celera913,181,957 - 13,182,152UniSTS
RH 3.4 Map978.5UniSTS
Cytogenetic Map9q12UniSTS
RH129394  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2915,438,604 - 15,438,786 (+)MAPPER
Rnor_6.0917,823,410 - 17,823,591NCBIRnor6.0
Rnor_5.0916,712,131 - 16,712,312UniSTSRnor5.0
RGSC_v3.4911,039,115 - 11,039,296UniSTSRGSC3.4
Celera913,181,844 - 13,182,025UniSTS
RH 3.4 Map21089.99UniSTS
Cytogenetic Map9q12UniSTS
RH140045  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.02196,981,799 - 196,982,006NCBIRnor5.0
Rnor_5.02249,154,349 - 249,154,557NCBIRnor5.0
RGSC_v3.42223,131,022 - 223,131,229UniSTSRGSC3.4
RGSC_v3.42170,299,880 - 170,300,086UniSTSRGSC3.4
Celera2206,759,298 - 206,759,505UniSTS
Celera2158,132,772 - 158,132,978UniSTS
RH 3.4 Map979.0UniSTS
Cytogenetic Map9q12UniSTS
Cytogenetic Map2q42UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9129467098Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9140383872Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9140383872Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9140383872Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9145029794Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9105522293442944Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9235572247355722Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9235572247355722Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9288097747375681Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9288097747880977Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9498609549986095Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9498609549986095Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9572425425692342Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)91221677157216771Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)91242546357425463Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)91242546357425463Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91555490147249201Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:292
Count of miRNA genes:191
Interacting mature miRNAs:214
Transcripts:ENSRNOT00000026920
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2 22 12 12 2 12 64 18 29 2
Medium 1 21 45 29 17 29 8 11 10 17 12 9 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001004082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC096454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY695392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY695393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY724481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC082009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ022068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S45392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000026920   ⟹   ENSRNOP00000026920
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl917,817,791 - 17,823,163 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086986   ⟹   ENSRNOP00000074112
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl917,817,721 - 17,823,243 (+)Ensembl
RefSeq Acc Id: NM_001004082   ⟹   NP_001004082
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2915,432,986 - 15,438,358 (+)NCBI
Rnor_6.0917,817,791 - 17,823,163 (+)NCBI
Rnor_5.0916,706,512 - 16,711,884 (+)NCBI
RGSC_v3.4911,033,496 - 11,038,868 (+)RGD
Celera913,176,225 - 13,181,597 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001004082   ⟸   NM_001004082
- UniProtKB: P34058 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026920   ⟸   ENSRNOT00000026920
RefSeq Acc Id: ENSRNOP00000074112   ⟸   ENSRNOT00000086986
Protein Domains
HATPase_c

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696546
Promoter ID:EPDNEW_R7065
Type:multiple initiation site
Name:Hsp90ab1_1
Description:heat shock protein 90 alpha family class B member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0917,817,739 - 17,817,799EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
9 16709303 16709304 G T snv SBH/Ygl (KNAW), SBH/Ygl (MCW)
9 16710685 16710686 C T snv Crl:SD (UDEL), LE/Stm (KyushuU), LE/OrlBarth (UDEL)
9 16710690 16710691 G A snv LE/OrlBarth (UDEL), Crl:SD (UDEL), COP/CrCrl (MCW & UW)
9 16710727 16710728 C A snv LE/OrlBarth (UDEL), Crl:SD (UDEL)
9 16711269 16711270 G A snv IS-Tlk/Kyo (KyushuU)
9 16711313 16711314 C T snv HWY/Slc (KyushuU)
9 16711316 16711317 G A snv ZFDM (KyushuU)
9 16711360 16711361 G C snv SBN/Ygl (MCW), FHH/EurMcwi (MCW), COP/CrCrl (MCW & UW), SBH/Ygl (MCW), SS/JrHsdMcwi (MCW), GH/OmrMcwi (MCW), ACI/EurMcwi (MCW)
9 16711367 16711368 C T snv LE/OrlBarth (UDEL), Crl:SD (UDEL)
9 16711381 16711382 T G snv SBH/Ygl (MCW)
9 16711391 16711392 C G snv Crl:SD (UDEL), LE/OrlBarth (UDEL)
9 16711394 16711395 C T snv LE/OrlBarth (UDEL), SS/JrHsdMcwi (MCW), SBN/Ygl (MCW), FHH/EurMcwi (MCW), SBH/Ygl (MCW), GH/OmrMcwi (MCW), COP/CrCrl (MCW & UW), ACI/EurMcwi (MCW), SDLEF7/Barth (UDEL), Crl:SD (UDEL)
9 16711395 16711396 G T snv SBN/Ygl (MCW), SBH/Ygl (MCW)
9 16711416 16711417 A C snv SBH/Ygl (MCW)
9 16711431 16711432 T C snv LE/OrlBarth (UDEL), SDLEF7/Barth (UDEL), Crl:SD (UDEL)
9 16711478 16711479 G A snv Crl:SD (UDEL), SDLEF7/Barth (UDEL), LE/OrlBarth (UDEL)
9 16711502 16711503 A G snv SDLEF7/Barth (UDEL), Crl:SD (UDEL)
9 16711523 16711524 C T snv SDLEF7/Barth (UDEL)
9 16711717 16711718 C T snv HTX/Kyo (KyushuU), F344/NSlc (KyushuU), F344/Stm (KyushuU), F344/Jcl (KyushuU), F344/DuCrlCrlj (KyushuU)


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
9 17819100 17819101 A G snv ACI/N (MCW)
9 17819101 17819102 C T snv ACI/N (MCW)
9 17820337 17820338 T G snv F344/NRrrc (MCW)
9 17820582 17820583 G T snv SBH/Ygl (MCW)
9 17821316 17821317 A G snv ACI/N (MCW), WN/N (MCW), BN/SsN (MCW), F344/NRrrc (MCW)
9 17821329 17821330 G T snv CDS
9 17821330 17821331 C A snv CDS
9 17821916 17821917 T C snv CDR, CDS
9 17821964 17821965 C T snv COP/CrCrl (MCW & UW), ACI/EurMcwi (MCW), SBH/Ygl (MCW), CDS, GH/OmrMcwi (MCW), CDR, SS/JrHsdMcwi (MCW), SR/JrHsd (MCW)
9 17821969 17821970 G A snv GH/OmrMcwi (MCW), CDR, FHH/EurMcwi (MCW), CDS, SBH/Ygl (MCW), COP/CrCrl (MCW & UW), SS/JrHsdMcwi (MCW), SR/JrHsd (MCW), ACI/EurMcwi (MCW)
9 17822006 17822007 C A snv CDR, ACI/N (MCW), CDS
9 17822609 17822610 G A snv CDS, SBH/Ygl (MCW), CDR
9 17822639 17822640 G C snv COP/CrCrl (MCW & UW), ACI/EurMcwi (MCW), SBH/Ygl (MCW)
9 17822646 17822647 C T snv ACI/EurMcwi (MCW), COP/CrCrl (MCW & UW), GH/OmrMcwi (MCW), SBH/Ygl (MCW), FHL/EurMcwi (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW)
9 17822660 17822661 T G snv SBH/Ygl (MCW), CDS, CDR
9 17822670 17822671 C G snv FHH/EurMcwi (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), CDS, GH/OmrMcwi (MCW), FHL/EurMcwi (MCW), SBH/Ygl (MCW), CDR
9 17822673 17822674 C T snv FHL/EurMcwi (MCW), ACI/EurMcwi (MCW), SR/JrHsd (MCW), SBH/Ygl (MCW), GH/OmrMcwi (MCW), COP/CrCrl (MCW & UW), CDR, CDS, FHH/EurMcwi (MCW), SS/JrHsdMcwi (MCW)
9 17822674 17822675 G T snv SBH/Ygl (MCW), CDS, CDR
9 17822695 17822696 A C snv SBH/Ygl (MCW), CDS, CDR
9 17822710 17822711 T C snv SBH/Ygl (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), CDR, CDS, ACI/EurMcwi (MCW), GH/OmrMcwi (MCW)
9 17822713 17822714 A C snv ACI/EurMcwi (MCW)
9 17822757 17822758 G A snv SR/JrHsd (MCW), FHL/EurMcwi (MCW), SBH/Ygl (MCW), FHH/EurMcwi (MCW), ACI/EurMcwi (MCW), GH/OmrMcwi (MCW)
9 17822772 17822773 G A snv SR/JrHsd (MCW), ACI/EurMcwi (MCW)
9 17822781 17822782 A G snv SBH/Ygl (MCW), SR/JrHsd (MCW), FHH/EurMcwi (MCW), GH/OmrMcwi (MCW), ACI/EurMcwi (MCW)
9 17822794 17822795 G A snv ACI/EurMcwi (MCW), SBH/Ygl (MCW), SR/JrHsd (MCW)
9 17822800 17822801 A C snv ACI/EurMcwi (MCW)
9 17822802 17822803 C T snv FHL/EurMcwi (MCW), SBH/Ygl (MCW), GH/OmrMcwi (MCW)
9 17822803 17822804 G A snv ACI/EurMcwi (MCW)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
9 11034805 11034806 A G snv ACI/N (KNAW)
9 11034806 11034807 C T snv ACI/N (KNAW)
9 11035995 11035996 A G snv LCR/1Mco (UMich), HCR/2Mco (UMich)
9 11036042 11036043 T G snv BN/NHsdMcwi (KNAW), LCR/1Mco (UMich), F344/NRrrc (KNAW)
9 11036287 11036288 G T snv SBH/Ygl (ICL)
9 11037021 11037022 A G snv HCR/2Mco (UMich), ACI/N (KNAW), WN/N (KNAW), LE/Stm (KNAW), F344/NRrrc (KNAW), BN/SsN (KNAW), LCR/2Mco (UMich)
9 11037047 11037048 A C snv LCR/1Mco (UMich), HCR/2Mco (UMich), SS/JrHsdMcwi (MCW), HCR/1Mco (UMich), LCR/2Mco (UMich), SR/JrHsd (MCW)
9 11037054 11037055 C T snv HCR/1Mco (UMich), LCR/2Mco (UMich), HCR/2Mco (UMich), LCR/1Mco (UMich)
9 11037058 11037059 A T snv HCR/1Mco (UMich), HCR/2Mco (UMich), LCR/1Mco (UMich), LCR/2Mco (UMich)
9 11037082 11037083 A G snv SS/JrHsdMcwi (MCW), HCR/1Mco (UMich), LCR/1Mco (UMich)
9 11037711 11037712 C A snv ACI/N (KNAW), HCR/2Mco (UMich)
9 11037728 11037729 T C snv HCR/1Mco (UMich), LCR/1Mco (UMich)
9 11038365 11038366 T G snv GH/OmrMcwi (MCW), COP/CrCrl (MCW & UW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303075 AgrOrtholog
Ensembl Genes ENSRNOG00000019834 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000026920 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000074112 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026920 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000086986 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.790 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7131767 IMAGE-MGC_LOAD
InterPro HATPase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HATPase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heat_shock_protein_90_CS UniProtKB/Swiss-Prot
  HSP90_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp90_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp90_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:301252 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94263 IMAGE-MGC_LOAD
NCBI Gene 301252 ENTREZGENE
PANTHER PTHR11528 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HATPase_c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hsp90ab1 PhenoGen
PIRSF Hsp90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS HEATSHOCK90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HSP90 UniProtKB/Swiss-Prot
SMART HATPase_c UniProtKB/Swiss-Prot
Superfamily-SCOP SSF110942 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54211 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55874 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K793_RAT UniProtKB/TrEMBL
  HS90B_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q1PSW2 UniProtKB/Swiss-Prot
  Q66H55 UniProtKB/Swiss-Prot
  Q68GV5 UniProtKB/Swiss-Prot
  Q9QWC6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Hsp90ab1  heat shock protein 90 alpha family class B member 1  Hsp90ab1  heat shock protein 90kDa alpha family class B member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-25 Hsp90ab1  heat shock protein 90kDa alpha family class B member 1  Hsp90ab1  heat shock protein 90 alpha (cytosolic), class B member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-04-27 Hsp90ab1  heat shock protein 90 alpha (cytosolic), class B member 1  Hsp90ab1  heat shock protein 90kDa alpha (cytosolic), class B member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 Hsp90ab1  heat shock protein 90kDa alpha (cytosolic), class B member 1  Hspcb  heat shock 90kDa protein 1, beta  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2006-03-30 Hspcb  heat shock 90kDa protein 1, beta      Symbol and Name status set to approved 1299863 APPROVED
2005-02-14 Hspcb  heat shock 90kDa protein 1, beta      Symbol and Name status set to provisional 70820 PROVISIONAL