HSP90AB1 (heat shock protein 90 alpha family class B member 1) - Rat Genome Database

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Gene: HSP90AB1 (heat shock protein 90 alpha family class B member 1) Homo sapiens
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Symbol: HSP90AB1
Name: heat shock protein 90 alpha family class B member 1
RGD ID: 1346893
HGNC Page HGNC:5258
Description: Enables several functions, including ATP binding activity; ATP-dependent protein binding activity; and enzyme binding activity. Involved in several processes, including positive regulation of protein localization to cell surface; protein-containing complex assembly; and regulation of protein metabolic process. Acts upstream of with a positive effect on telomere maintenance via telomerase. Located in several cellular components, including COP9 signalosome; cytosol; and extracellular region. Part of HSP90-CDC37 chaperone complex and aryl hydrocarbon receptor complex. Is active in protein folding chaperone complex. Implicated in multiple sclerosis. Biomarker of intrahepatic cholangiocarcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 90-kda heat shock protein beta; 90-kda heat shock protein beta HSP90 beta; D6S182; FLJ26984; heat shock 84 kDa; heat shock 90kD protein 1, beta; heat shock protein 90 kDa; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha family class B member 1; heat shock protein beta; heat shock protein family C member 3; heat shock protein HSP 90-beta; HSP 84; HSP 90; HSP84; HSP90 beta; HSP90-BETA; HSP90B; HSPC2; HSPCB
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: AC013410.1   AC073909.1   AL355615.1   HSP90AB2P   HSP90AB3P   HSP90AB4P   HSP90AB5P   HSP90AB6P   HSP90AB7P   LOC100422441   LOC646197  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38644,246,194 - 44,253,883 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl644,246,166 - 44,253,888 (+)EnsemblGRCh38hg38GRCh38
GRCh37644,213,931 - 44,221,620 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36644,322,827 - 44,329,592 (+)NCBINCBI36Build 36hg18NCBI36
Build 34644,322,826 - 44,329,592NCBI
Celera645,767,994 - 45,774,759 (+)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef643,935,917 - 43,943,640 (+)NCBIHuRef
CHM1_1644,217,626 - 44,225,330 (+)NCBICHM1_1
T2T-CHM13v2.0644,080,360 - 44,088,031 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-adrenaline  (ISO)
(Z)-3-butylidenephthalide  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (ISO)
2-amino-4,6-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dihydrocoumarin  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxynon-2-enal  (ISO)
4-vinylcyclohexene dioxide  (ISO)
6-anilino-5,8-quinolinedione  (ISO)
7,12-dimethyltetraphene  (ISO)
7H-xanthine  (ISO)
9H-xanthine  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP,ISO)
albendazole  (EXP)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
amphibole asbestos  (EXP)
aniline  (ISO)
antimony(0)  (EXP)
antimycin A  (EXP)
arachidonic acid  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (EXP)
astemizole  (ISO)
atrazine  (EXP)
BAPTA  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
Bisphenol B  (EXP)
bisphenol F  (EXP,ISO)
bortezomib  (EXP)
butanal  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP)
caffeine  (EXP)
calcidiol  (ISO)
cannabidiol  (EXP)
carbon nanotube  (ISO)
celastrol  (ISO)
chloropicrin  (EXP)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
Cinobufagin  (EXP)
clofibrate  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
coumarin  (EXP)
coumestrol  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
DDE  (EXP)
DDT  (ISO)
deguelin  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
disodium selenite  (EXP)
disulfiram  (EXP)
dopamine  (EXP)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
enzyme inhibitor  (EXP)
ethanol  (ISO)
Evodiamine  (EXP)
fenofibrate  (ISO)
finasteride  (ISO)
flutamide  (ISO)
folic acid  (ISO)
FR900359  (EXP)
fulvestrant  (EXP)
gamendazole  (ISO)
geldanamycin  (EXP,ISO)
genistein  (ISO)
gentamycin  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hexachlorobenzene  (ISO)
indometacin  (EXP)
isoflavones  (ISO)
ivermectin  (EXP)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
lead nitrate  (ISO)
leflunomide  (ISO)
limonene  (ISO)
lipopolysaccharide  (EXP,ISO)
lovastatin  (ISO)
methyl methanesulfonate  (EXP)
Methylazoxymethanol acetate  (ISO)
methylisothiazolinone  (EXP)
miconazole  (ISO)
morphine  (ISO)
motexafin gadolinium  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (ISO)
nefazodone  (ISO)
nickel dichloride  (EXP)
nimesulide  (ISO)
nitrates  (ISO)
nonanoic acid  (ISO)
Nutlin-3  (EXP)
ochratoxin A  (ISO)
oxidopamine  (ISO)
ozone  (ISO)
p-menthan-3-ol  (EXP)
paracetamol  (EXP,ISO)
paraoxon  (EXP)
PCB138  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
PhIP  (ISO)
phlorizin  (ISO)
pinosylvin  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (EXP)
prostaglandin A1  (ISO)
quercetin  (EXP,ISO)
raloxifene  (EXP)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
selenium atom  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
sulfasalazine  (ISO)
T-2 toxin  (ISO)
tamibarotene  (EXP)
tamoxifen  (ISO)
tanespimycin  (EXP)
tetrachloromethane  (ISO)
thimerosal  (EXP)
thioacetamide  (ISO)
thiostrepton  (EXP)
thiram  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trans-pinosylvin  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
triphenylstannane  (EXP)
troglitazone  (EXP)
tunicamycin  (EXP)
uranium atom  (EXP)
usnic acid  (EXP)
valdecoxib  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vitamin E  (EXP)
vorinostat  (EXP)
warfarin  (ISO)
zearalenone  (ISO)
zinc acetate  (EXP)
zinc pyrithione  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to heat  (IBA,IEA)
cellular response to interleukin-4  (IEA,ISO)
chaperone-mediated protein complex assembly  (IDA)
chaperone-mediated protein folding  (IEA,ISS)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of complement-dependent cytotoxicity  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of proteasomal protein catabolic process  (IEA,ISS)
negative regulation of proteasomal ubiquitin-dependent protein catabolic process  (IDA)
placenta development  (IEA,ISO)
positive regulation of cell differentiation  (IMP)
positive regulation of cell size  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISS)
positive regulation of protein binding  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein localization to cell surface  (IDA)
positive regulation of protein serine/threonine kinase activity  (ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (IDA)
protein folding  (IBA,IEA)
protein stabilization  (IBA)
regulation of cell cycle  (IMP)
regulation of protein localization  (IEA,ISS)
regulation of protein ubiquitination  (IDA)
response to cocaine  (ISO)
response to salt stress  (ISO)
response to unfolded protein  (NAS)
response to xenobiotic stimulus  (ISO)
supramolecular fiber organization  (IMP)
telomerase holoenzyme complex assembly  (IDA)
telomere maintenance via telomerase  (IDA)
virion attachment to host cell  (IMP)

References

References - curated
# Reference Title Reference Citation
1. Antitumor activity of the combination of an HSP90 inhibitor and a PI3K/mTOR dual inhibitor against cholangiocarcinoma. Chen MH, etal., Oncotarget. 2014 May 15;5(9):2372-89. doi: 10.18632/oncotarget.1706.
2. Antibodies reactive to heat shock protein 90 induce oligodendrocyte precursor cell death in culture. Implications for demyelination in multiple sclerosis. Cid C, etal., FASEB J. 2004 Feb;18(2):409-11. Epub 2003 Dec 19.
3. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
4. Down-regulation of heat shock protein HSP90ab1 in radiation-damaged lung cells other than mast cells. Haase MG, etal., J Histochem Cytochem. 2014 May;62(5):355-68. doi: 10.1369/0022155414529133. Epub 2014 Mar 26.
5. Protective effect of L-Arginine administration on proteins of unloaded m. soleus. Lomonosova YN, etal., Biochemistry (Mosc). 2011 May;76(5):571-80. doi: 10.1134/S0006297911050075.
6. Acute pancreatitis: hypertonic saline increases heat shock proteins 70 and 90 and reduces neutrophil infiltration in lung injury. Moretti AI, etal., Pancreas. 2009 Jul;38(5):507-14.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. A block in the road to fertility: autoantibodies to heat-shock protein 90-beta in human ovarian autoimmunity. Pires ES and Khole VV, Fertil Steril. 2009 Oct;92(4):1395-409. doi: 10.1016/j.fertnstert.2008.08.068. Epub 2008 Nov 19.
10. Chaperoning of glucocorticoid receptors. Pratt WB, etal., Handb Exp Pharmacol. 2006;(172):111-38.
11. Molecular chaperones throughout the life cycle of the androgen receptor. Prescott J and Coetzee GA, Cancer Lett. 2006 Jan 8;231(1):12-9.
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions. Smith DF and Toft DO, Mol Endocrinol. 2008 Oct;22(10):2229-40. Epub 2008 May 1.
14. Gamendazole, an orally active indazole carboxylic acid male contraceptive agent, targets HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A), and stimulates Il1a transcription in rat Sertoli cells. Tash JS, etal., Biol Reprod. 2008 Jun;78(6):1139-52. doi: 10.1095/biolreprod.107.062679. Epub 2008 Jan 23.
15. Interactions of the mineralocorticoid receptor--within and without. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
16. The potential role of heat shock proteins in acute spinal cord injury. Zhou Y, etal., Eur Spine J. 2014 Jul;23(7):1480-90. doi: 10.1007/s00586-014-3214-1. Epub 2014 Feb 6.
Additional References at PubMed
PMID:2469626   PMID:2492519   PMID:2768249   PMID:3301534   PMID:7581991   PMID:7588731   PMID:7821789   PMID:8180474   PMID:9150948   PMID:10197982   PMID:10376793   PMID:10543959  
PMID:10791971   PMID:10811660   PMID:10995457   PMID:11036079   PMID:11099500   PMID:11230166   PMID:11707401   PMID:11785981   PMID:11795466   PMID:12417652   PMID:12471035   PMID:12477932  
PMID:12559950   PMID:14532285   PMID:14574404   PMID:14697242   PMID:14743216   PMID:15001580   PMID:15047060   PMID:15284248   PMID:15302935   PMID:15324660   PMID:15358771   PMID:15489334  
PMID:15492215   PMID:15497503   PMID:15581363   PMID:15592455   PMID:15635413   PMID:15642353   PMID:15657067   PMID:15713458   PMID:15791211   PMID:15822905   PMID:15870294   PMID:15952740  
PMID:16009940   PMID:16049007   PMID:16094384   PMID:16169070   PMID:16207813   PMID:16226712   PMID:16248461   PMID:16263121   PMID:16269234   PMID:16280321   PMID:16293251   PMID:16314389  
PMID:16330544   PMID:16501598   PMID:16531226   PMID:16565220   PMID:16580629   PMID:16582619   PMID:16650407   PMID:16698020   PMID:16809764   PMID:16916647   PMID:16964243   PMID:17010336  
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PMID:20085233   PMID:20111909   PMID:20171186   PMID:20226818   PMID:20353823   PMID:20374249   PMID:20391533   PMID:20451655   PMID:20458337   PMID:20462248   PMID:20467437   PMID:20599762  
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PMID:22810585   PMID:22843495   PMID:22848402   PMID:22849407   PMID:22863883   PMID:22929401   PMID:22939624   PMID:22939629   PMID:22944692   PMID:22952844   PMID:23166591   PMID:23190606  
PMID:23200770   PMID:23246001   PMID:23272104   PMID:23287597   PMID:23349634   PMID:23383273   PMID:23398456   PMID:23402259   PMID:23413029   PMID:23414517   PMID:23428871   PMID:23431407  
PMID:23438482   PMID:23443559   PMID:23455922   PMID:23515950   PMID:23516526   PMID:23533145   PMID:23585225   PMID:23661493   PMID:23703321   PMID:23711381   PMID:23824909   PMID:23825951  
PMID:23874603   PMID:23956138   PMID:24098578   PMID:24147044   PMID:24189400   PMID:24244333   PMID:24292678   PMID:24390425   PMID:24457600   PMID:24466266   PMID:24511009   PMID:24581495  
PMID:24613385   PMID:24618592   PMID:24625528   PMID:24658140   PMID:24711448   PMID:24711643   PMID:24755837   PMID:24794838   PMID:24880080   PMID:24927568   PMID:25036637   PMID:25147182  
PMID:25191796   PMID:25192599   PMID:25202009   PMID:25241761   PMID:25253489   PMID:25277244   PMID:25300907   PMID:25315684   PMID:25324306   PMID:25402006   PMID:25416956   PMID:25437307  
PMID:25468996   PMID:25486457   PMID:25609649   PMID:25670202   PMID:25737280   PMID:25756610   PMID:25798074   PMID:25864199   PMID:25910212   PMID:25921289   PMID:25940091   PMID:25959826  
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PMID:26511315   PMID:26511642   PMID:26517842   PMID:26549023   PMID:26561776   PMID:26593036   PMID:26638075   PMID:26641092   PMID:26643866   PMID:26651243   PMID:26693507   PMID:26725010  
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PMID:27959448   PMID:28027390   PMID:28117675   PMID:28143869   PMID:28215707   PMID:28239659   PMID:28302793   PMID:28319085   PMID:28330616   PMID:28359326   PMID:28369073   PMID:28378594  
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PMID:28977666   PMID:29127155   PMID:29149599   PMID:29180619   PMID:29208956   PMID:29229926   PMID:29298432   PMID:29331416   PMID:29386344   PMID:29435596   PMID:29467282   PMID:29491746  
PMID:29507755   PMID:29509794   PMID:29564676   PMID:29568061   PMID:29615496   PMID:29676528   PMID:29735542   PMID:29768689   PMID:29777862   PMID:29844126   PMID:29845934   PMID:29859926  
PMID:29863498   PMID:29871907   PMID:29872149   PMID:29930177   PMID:29968330   PMID:29991511   PMID:30009671   PMID:30196744   PMID:30209976   PMID:30258100   PMID:30274258   PMID:30305727  
PMID:30349055   PMID:30352685   PMID:30382094   PMID:30442662   PMID:30455355   PMID:30459231   PMID:30463901   PMID:30575818   PMID:30711629   PMID:30737378   PMID:30824926   PMID:30884312  
PMID:30948266   PMID:30997501   PMID:31010829   PMID:31048545   PMID:31073040   PMID:31091453   PMID:31124601   PMID:31180492   PMID:31239290   PMID:31267705   PMID:31300519   PMID:31324722  
PMID:31436131   PMID:31449053   PMID:31462707   PMID:31501420   PMID:31527668   PMID:31536960   PMID:31586073   PMID:31620119   PMID:31636387   PMID:31751430   PMID:31763849   PMID:31801945  
PMID:31839598   PMID:31885746   PMID:31952546   PMID:31980649   PMID:31980815   PMID:31992359   PMID:31995728   PMID:32041737   PMID:32041778   PMID:32051585   PMID:32120844   PMID:32129710  
PMID:32162334   PMID:32206096   PMID:32296183   PMID:32322062   PMID:32347575   PMID:32401531   PMID:32529326   PMID:32552912   PMID:32597834   PMID:32600329   PMID:32687490   PMID:32698014  
PMID:32707033   PMID:32786267   PMID:32807901   PMID:32814053   PMID:32929329   PMID:32962253   PMID:32963011   PMID:32994395   PMID:33022573   PMID:33024031   PMID:33040396   PMID:33080545  
PMID:33145341   PMID:33179566   PMID:33194618   PMID:33239621   PMID:33306668   PMID:33545068   PMID:33567341   PMID:33639524   PMID:33644029   PMID:33711283   PMID:33729478   PMID:33762435  
PMID:33766124   PMID:33916271   PMID:33948363   PMID:33961781   PMID:34017080   PMID:34171383   PMID:34185411   PMID:34196494   PMID:34217296   PMID:34226595   PMID:34244482   PMID:34316707  
PMID:34349018   PMID:34449539   PMID:34534637   PMID:34568836   PMID:34650049   PMID:34709727   PMID:34728620   PMID:34747980   PMID:34795231   PMID:34901782   PMID:34983926   PMID:35008592  
PMID:35013218   PMID:35043518   PMID:35063084   PMID:35124280   PMID:35173535   PMID:35235311   PMID:35241646   PMID:35256949   PMID:35271311   PMID:35298351   PMID:35338135   PMID:35356984  
PMID:35384245   PMID:35446349   PMID:35509820   PMID:35530310   PMID:35545034   PMID:35546148   PMID:35575683   PMID:35676659   PMID:35687106   PMID:35777956   PMID:35819319   PMID:35831314  
PMID:35914814   PMID:35929142   PMID:35944360   PMID:35973989   PMID:35993436   PMID:36030824   PMID:36042349   PMID:36055981   PMID:36114006   PMID:36123327   PMID:36168627   PMID:36180527  
PMID:36180891   PMID:36199071   PMID:36199626   PMID:36215168   PMID:36219563   PMID:36243803   PMID:36244648   PMID:36279628   PMID:36282215   PMID:36300783   PMID:36305789   PMID:36339263  
PMID:36373674   PMID:36424410   PMID:36517590   PMID:36526897   PMID:36560452   PMID:36574265   PMID:36584595   PMID:36652389   PMID:36749630   PMID:36762613   PMID:36779763   PMID:36896912  
PMID:36929488   PMID:36964131   PMID:37001908   PMID:37011862   PMID:37028636   PMID:37045861   PMID:37052853   PMID:37059091   PMID:37071682   PMID:37117180   PMID:37120454   PMID:37132043  
PMID:37167062   PMID:37207277   PMID:37223481   PMID:37249651   PMID:37250795   PMID:37267103   PMID:37314216   PMID:37317656   PMID:37406487   PMID:37415147   PMID:37433992   PMID:37448957  
PMID:37450367   PMID:37487085   PMID:37506885   PMID:37536630   PMID:37616343   PMID:37689310   PMID:37705046   PMID:37729687   PMID:37774976   PMID:37788672   PMID:37820061   PMID:37827155  
PMID:37929963   PMID:38113892   PMID:38172120   PMID:38177924   PMID:38334954   PMID:38416826   PMID:38569033   PMID:38697112   PMID:39231216   PMID:39238192   PMID:39358380   PMID:39366960  
PMID:39422127   PMID:39501047   PMID:39506849  


Genomics

Comparative Map Data
HSP90AB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38644,246,194 - 44,253,883 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl644,246,166 - 44,253,888 (+)EnsemblGRCh38hg38GRCh38
GRCh37644,213,931 - 44,221,620 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36644,322,827 - 44,329,592 (+)NCBINCBI36Build 36hg18NCBI36
Build 34644,322,826 - 44,329,592NCBI
Celera645,767,994 - 45,774,759 (+)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef643,935,917 - 43,943,640 (+)NCBIHuRef
CHM1_1644,217,626 - 44,225,330 (+)NCBICHM1_1
T2T-CHM13v2.0644,080,360 - 44,088,031 (+)NCBIT2T-CHM13v2.0
Hsp90ab1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391745,878,704 - 45,884,187 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1745,878,701 - 45,884,197 (-)EnsemblGRCm39 Ensembl
GRCm381745,567,778 - 45,573,261 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1745,567,775 - 45,573,271 (-)EnsemblGRCm38mm10GRCm38
MGSCv371745,704,727 - 45,710,210 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361745,031,359 - 45,036,842 (-)NCBIMGSCv36mm8
Celera1749,000,428 - 49,005,921 (-)NCBICelera
Cytogenetic Map17B3NCBI
cM Map1722.59NCBI
Hsp90ab1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8922,930,249 - 22,935,929 (+)NCBIGRCr8
mRatBN7.2915,432,986 - 15,438,358 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl915,433,691 - 15,438,488 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx924,019,488 - 24,024,885 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0929,082,165 - 29,087,562 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0927,382,927 - 27,388,324 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0917,817,791 - 17,823,163 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl917,817,721 - 17,823,243 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0916,706,512 - 16,711,884 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4911,033,496 - 11,038,868 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1911,030,786 - 11,036,319 (+)NCBI
Celera913,176,225 - 13,181,597 (+)NCBICelera
Cytogenetic Map9q12NCBI
Hsp90ab1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554379,873,908 - 9,878,459 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554379,872,649 - 9,878,459 (+)NCBIChiLan1.0ChiLan1.0
HSP90AB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2558,750,514 - 58,757,909 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1654,620,583 - 54,627,983 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0643,842,796 - 43,849,637 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1645,126,060 - 45,132,972 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl645,125,773 - 45,133,872 (+)Ensemblpanpan1.1panPan2
HSP90AB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11212,658,415 - 12,664,945 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1212,660,008 - 12,664,940 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1212,682,075 - 12,689,685 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01213,139,324 - 13,147,144 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1213,140,459 - 13,147,650 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11212,665,005 - 12,672,579 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01212,752,685 - 12,760,264 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01212,846,448 - 12,854,258 (+)NCBIUU_Cfam_GSD_1.0
Hsp90ab1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494648,123,181 - 48,129,743 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647615,830,459 - 15,835,535 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647615,830,459 - 15,836,994 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSP90AB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl739,244,458 - 39,250,481 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1739,237,299 - 39,250,479 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2745,106,779 - 45,119,936 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HSP90AB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11727,914,261 - 27,921,666 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1727,911,013 - 27,921,251 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604444,300,580 - 44,307,963 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hsp90ab1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475415,609,920 - 15,614,263 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475415,609,932 - 15,615,580 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HSP90AB1
32 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p21.1(chr6:42368558-44590544)x1 copy number loss See cases [RCV000051011] Chr6:42368558..44590544 [GRCh38]
Chr6:42336296..44558281 [GRCh37]
Chr6:42444274..44666259 [NCBI36]
Chr6:6p21.1
pathogenic
GRCh38/hg38 6p21.2-21.1(chr6:37777369-45653843)x1 copy number loss See cases [RCV000052181] Chr6:37777369..45653843 [GRCh38]
Chr6:37745145..45621580 [GRCh37]
Chr6:37853123..45729558 [NCBI36]
Chr6:6p21.2-21.1
pathogenic
GRCh38/hg38 6p21.1-12.3(chr6:41638061-46512949)x1 copy number loss See cases [RCV000052182] Chr6:41638061..46512949 [GRCh38]
Chr6:41605799..46480686 [GRCh37]
Chr6:41713777..46588645 [NCBI36]
Chr6:6p21.1-12.3
pathogenic
GRCh38/hg38 6p21.1(chr6:43656888-44382430)x3 copy number gain See cases [RCV000140726] Chr6:43656888..44382430 [GRCh38]
Chr6:43624625..44350167 [GRCh37]
Chr6:43732603..44458145 [NCBI36]
Chr6:6p21.1
likely benign|uncertain significance
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3
pathogenic
GRCh37/hg19 6p21.1-12.3(chr6:43636308-50947320)x1 copy number loss See cases [RCV000446897] Chr6:43636308..50947320 [GRCh37]
Chr6:6p21.1-12.3
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
NM_007355.4(HSP90AB1):c.502C>T (p.Arg168Cys) single nucleotide variant not specified [RCV004329718] Chr6:44249822 [GRCh38]
Chr6:44217559 [GRCh37]
Chr6:6p21.1
uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
NM_007355.4(HSP90AB1):c.1653G>A (p.Lys551=) single nucleotide variant not provided [RCV000968090] Chr6:44252189 [GRCh38]
Chr6:44219926 [GRCh37]
Chr6:6p21.1
benign
NM_007355.4(HSP90AB1):c.846A>G (p.Leu282=) single nucleotide variant not provided [RCV000883475] Chr6:44250488 [GRCh38]
Chr6:44218225 [GRCh37]
Chr6:6p21.1
benign|likely benign
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1
pathogenic
NM_007355.4(HSP90AB1):c.117C>T (p.Phe39=) single nucleotide variant not provided [RCV000958579] Chr6:44248746 [GRCh38]
Chr6:44216483 [GRCh37]
Chr6:6p21.1
benign
NM_007355.4(HSP90AB1):c.2019C>G (p.Pro673=) single nucleotide variant not provided [RCV000958856] Chr6:44253332 [GRCh38]
Chr6:44221069 [GRCh37]
Chr6:6p21.1
benign
NM_007355.4(HSP90AB1):c.1517G>A (p.Arg506Gln) single nucleotide variant not specified [RCV004319933] Chr6:44252053 [GRCh38]
Chr6:44219790 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.1839C>T (p.Asp613=) single nucleotide variant not provided [RCV000894641] Chr6:44253152 [GRCh38]
Chr6:44220889 [GRCh37]
Chr6:6p21.1
benign
NM_007355.4(HSP90AB1):c.1655A>T (p.Lys552Met) single nucleotide variant not specified [RCV004325251] Chr6:44252191 [GRCh38]
Chr6:44219928 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.1984G>A (p.Ala662Thr) single nucleotide variant not specified [RCV004315229] Chr6:44253297 [GRCh38]
Chr6:44221034 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.964T>G (p.Ser322Ala) single nucleotide variant not specified [RCV004311934] Chr6:44251054 [GRCh38]
Chr6:44218791 [GRCh37]
Chr6:6p21.1
uncertain significance
GRCh37/hg19 6p21.1-12.3(chr6:43636308-50947320) copy number loss not specified [RCV002053568] Chr6:43636308..50947320 [GRCh37]
Chr6:6p21.1-12.3
pathogenic
GRCh37/hg19 6p21.1-q12(chr6:43636308-64947206)x3 copy number gain not provided [RCV002221457] Chr6:43636308..64947206 [GRCh37]
Chr6:6p21.1-q12
likely pathogenic
NM_007355.4(HSP90AB1):c.244C>T (p.Arg82Cys) single nucleotide variant not specified [RCV004195015] Chr6:44249473 [GRCh38]
Chr6:44217210 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.1390G>A (p.Asp464Asn) single nucleotide variant not specified [RCV004232096] Chr6:44251812 [GRCh38]
Chr6:44219549 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.1345C>T (p.Arg449Cys) single nucleotide variant not specified [RCV004212810] Chr6:44251767 [GRCh38]
Chr6:44219504 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.2008C>G (p.Leu670Val) single nucleotide variant not specified [RCV004167281] Chr6:44253321 [GRCh38]
Chr6:44221058 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.295A>G (p.Ile99Val) single nucleotide variant not specified [RCV004084479] Chr6:44249524 [GRCh38]
Chr6:44217261 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.688G>A (p.Ala230Thr) single nucleotide variant not specified [RCV004358004] Chr6:44250330 [GRCh38]
Chr6:44218067 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.226A>C (p.Ile76Leu) single nucleotide variant not specified [RCV004351135] Chr6:44249455 [GRCh38]
Chr6:44217192 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.1372C>T (p.His458Tyr) single nucleotide variant not specified [RCV004335339] Chr6:44251794 [GRCh38]
Chr6:44219531 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.1962G>A (p.Leu654=) single nucleotide variant not provided [RCV003436559] Chr6:44253275 [GRCh38]
Chr6:44221012 [GRCh37]
Chr6:6p21.1
likely benign
GRCh37/hg19 6p21.1(chr6:44185578-44552951)x3 copy number gain not specified [RCV003986637] Chr6:44185578..44552951 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.1336A>G (p.Thr446Ala) single nucleotide variant not specified [RCV004404594] Chr6:44251758 [GRCh38]
Chr6:44219495 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.1451A>G (p.Tyr484Cys) single nucleotide variant not specified [RCV004404596] Chr6:44251873 [GRCh38]
Chr6:44219610 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.1453T>C (p.Tyr485His) single nucleotide variant not specified [RCV004404597] Chr6:44251875 [GRCh38]
Chr6:44219612 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.1541C>T (p.Thr514Ile) single nucleotide variant not specified [RCV004404598] Chr6:44252077 [GRCh38]
Chr6:44219814 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.1647G>C (p.Glu549Asp) single nucleotide variant not specified [RCV004404599] Chr6:44252183 [GRCh38]
Chr6:44219920 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.1915C>T (p.Arg639Trp) single nucleotide variant not specified [RCV004404600] Chr6:44253228 [GRCh38]
Chr6:44220965 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.662G>A (p.Arg221Gln) single nucleotide variant not specified [RCV004404601] Chr6:44250304 [GRCh38]
Chr6:44218041 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.737A>G (p.Glu246Gly) single nucleotide variant not specified [RCV004404602] Chr6:44250379 [GRCh38]
Chr6:44218116 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.784G>T (p.Gly262Cys) single nucleotide variant not specified [RCV004404603] Chr6:44250426 [GRCh38]
Chr6:44218163 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.1050G>C (p.Lys350Asn) single nucleotide variant not specified [RCV004635205] Chr6:44251140 [GRCh38]
Chr6:44218877 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.503G>A (p.Arg168His) single nucleotide variant not specified [RCV004635206] Chr6:44249823 [GRCh38]
Chr6:44217560 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.1882A>G (p.Ile628Val) single nucleotide variant not specified [RCV004635204] Chr6:44253195 [GRCh38]
Chr6:44220932 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.824A>G (p.Lys275Arg) single nucleotide variant not specified [RCV004929080] Chr6:44250466 [GRCh38]
Chr6:44218203 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.1403C>T (p.Ser468Phe) single nucleotide variant not specified [RCV004929081] Chr6:44251825 [GRCh38]
Chr6:44219562 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.1665G>C (p.Glu555Asp) single nucleotide variant not specified [RCV004929082] Chr6:44252201 [GRCh38]
Chr6:44219938 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.235C>T (p.Pro79Ser) single nucleotide variant not specified [RCV004929083] Chr6:44249464 [GRCh38]
Chr6:44217201 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.2022G>T (p.Gln674His) single nucleotide variant not specified [RCV004929084] Chr6:44253335 [GRCh38]
Chr6:44221072 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.1564G>T (p.Val522Leu) single nucleotide variant not specified [RCV004929085] Chr6:44252100 [GRCh38]
Chr6:44219837 [GRCh37]
Chr6:6p21.1
uncertain significance
NM_007355.4(HSP90AB1):c.2144A>G (p.Glu715Gly) single nucleotide variant not specified [RCV004929086] Chr6:44253567 [GRCh38]
Chr6:44221304 [GRCh37]
Chr6:6p21.1
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:893
Count of miRNA genes:237
Interacting mature miRNAs:241
Transcripts:ENST00000353801, ENST00000371554, ENST00000371646
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597087959GWAS1184033_Hmean corpuscular volume QTL GWAS1184033 (human)3e-24mean corpuscular volumemean corpuscular volume (CMO:0000038)64424963744249638Human
597112230GWAS1208304_Herythrocyte count QTL GWAS1208304 (human)4e-12erythrocyte countred blood cell count (CMO:0000025)64424963744249638Human
1358839MULTSCL5_HMultiple sclerosis susceptibility QTL 5 (human)Multiple sclerosis susceptibility61958431145584311Human
597106580GWAS1202654_Hreticulocyte count QTL GWAS1202654 (human)2e-10reticulocyte counttotal reticulocyte count (CMO:0003020)64424963744249638Human
597351308GWAS1447382_Hbody height QTL GWAS1447382 (human)4e-16body height (VT:0001253)body height (CMO:0000106)64425233944252340Human
1358857MULTSCL19_HMultiple sclerosis susceptibility QTL 19 (human)Multiple sclerosis susceptibility61958431145584311Human
597089257GWAS1185331_Hmean reticulocyte volume QTL GWAS1185331 (human)9e-32reticulocyte morphology trait (VT:0002424)mean corpuscular volume (CMO:0000038)64424963744249638Human

Markers in Region
A006I17  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37644,221,893 - 44,222,087UniSTSGRCh37
Build 36644,329,871 - 44,330,065RGDNCBI36
Celera645,775,038 - 45,775,232RGD
Cytogenetic Map6p12UniSTS
Cytogenetic Map6p12.1-p11.2UniSTS
HuRef643,943,908 - 43,944,102UniSTS
GeneMap99-GB4 RH Map6170.36UniSTS
GDB:451694  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37644,221,445 - 44,221,541UniSTSGRCh37
GRCh37488,815,265 - 88,815,361UniSTSGRCh37
Build 36489,034,289 - 89,034,385RGDNCBI36
Celera645,774,590 - 45,774,686UniSTS
Celera486,104,960 - 86,105,056RGD
Cytogenetic Map6p12UniSTS
Cytogenetic Map4q22.1UniSTS
Cytogenetic Map6p12.1-p11.2UniSTS
HuRef643,943,460 - 43,943,556UniSTS
HuRef484,560,547 - 84,560,643UniSTS
RH65822  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37644,221,925 - 44,222,104UniSTSGRCh37
Build 36644,329,903 - 44,330,082RGDNCBI36
Celera645,775,070 - 45,775,249RGD
Cytogenetic Map6p12UniSTS
Cytogenetic Map6p12.1-p11.2UniSTS
HuRef643,943,940 - 43,944,119UniSTS
GeneMap99-GB4 RH Map6153.46UniSTS
NCBI RH Map6667.9UniSTS
MARC_6805-6806:992007483:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37644,216,400 - 44,217,146UniSTSGRCh37
GRCh37488,813,028 - 88,813,174UniSTSGRCh37
Build 36489,032,052 - 89,032,198RGDNCBI36
Celera486,102,723 - 86,102,869RGD
Celera645,769,545 - 45,770,291UniSTS
HuRef643,938,414 - 43,939,160UniSTS
HuRef484,558,301 - 84,558,447UniSTS
WI-8585  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4p15.33UniSTS
Cytogenetic Map6p12UniSTS
Cytogenetic Map15q22.1UniSTS
Whitehead-YAC Contig Map4 UniSTS
RH67971  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6p12UniSTS
HuRef643,942,835 - 43,943,019UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2432 2788 2246 4956 1725 2350 4 622 1948 464 2269 7285 6458 52 3719 850 1738 1616 174 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_028283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001371238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF275719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH007358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK025370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK130494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL136543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL139392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY359878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC014485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC068474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE539681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG482327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI252490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ028821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX420114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX649079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD653541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX761569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D17804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D28342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC340766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC341882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC350708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC365600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ314872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M16660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000353801   ⟹   ENSP00000325875
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl644,247,087 - 44,253,883 (+)Ensembl
Ensembl Acc Id: ENST00000371554   ⟹   ENSP00000360609
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl644,247,866 - 44,253,883 (+)Ensembl
Ensembl Acc Id: ENST00000371646   ⟹   ENSP00000360709
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl644,247,101 - 44,253,883 (+)Ensembl
Ensembl Acc Id: ENST00000620073   ⟹   ENSP00000481908
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl644,246,166 - 44,253,888 (+)Ensembl
RefSeq Acc Id: NM_001271969   ⟹   NP_001258898
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38644,247,101 - 44,253,883 (+)NCBI
HuRef643,935,917 - 43,943,640 (+)NCBI
CHM1_1644,218,418 - 44,225,330 (+)NCBI
T2T-CHM13v2.0644,081,267 - 44,088,031 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271970   ⟹   NP_001258899
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38644,246,194 - 44,253,883 (+)NCBI
HuRef643,935,917 - 43,943,640 (+)NCBI
CHM1_1644,217,626 - 44,225,330 (+)NCBI
T2T-CHM13v2.0644,080,360 - 44,088,031 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271971   ⟹   NP_001258900
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38644,247,101 - 44,253,883 (+)NCBI
GRCh37644,213,903 - 44,221,625 (+)NCBI
HuRef643,935,917 - 43,943,640 (+)NCBI
CHM1_1644,218,418 - 44,225,330 (+)NCBI
T2T-CHM13v2.0644,081,267 - 44,088,031 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271972   ⟹   NP_001258901
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38644,247,101 - 44,253,883 (+)NCBI
GRCh37644,213,903 - 44,221,625 (+)NCBI
HuRef643,935,917 - 43,943,640 (+)NCBI
CHM1_1644,218,418 - 44,225,330 (+)NCBI
T2T-CHM13v2.0644,081,267 - 44,088,031 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001371238   ⟹   NP_001358167
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38644,247,943 - 44,253,883 (+)NCBI
T2T-CHM13v2.0644,082,109 - 44,088,031 (+)NCBI
Sequence:
RefSeq Acc Id: NM_007355   ⟹   NP_031381
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38644,247,101 - 44,253,883 (+)NCBI
GRCh37644,213,903 - 44,221,625 (+)NCBI
Build 36644,322,827 - 44,329,592 (+)NCBI Archive
HuRef643,935,917 - 43,943,640 (+)NCBI
CHM1_1644,218,418 - 44,225,330 (+)NCBI
T2T-CHM13v2.0644,081,267 - 44,088,031 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258898 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258899 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258900 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258901 (Get FASTA)   NCBI Sequence Viewer  
  NP_001358167 (Get FASTA)   NCBI Sequence Viewer  
  NP_031381 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA36025 (Get FASTA)   NCBI Sequence Viewer  
  AAA36026 (Get FASTA)   NCBI Sequence Viewer  
  AAD14062 (Get FASTA)   NCBI Sequence Viewer  
  AAF82792 (Get FASTA)   NCBI Sequence Viewer  
  AAH04928 (Get FASTA)   NCBI Sequence Viewer  
  AAH07327 (Get FASTA)   NCBI Sequence Viewer  
  AAH09206 (Get FASTA)   NCBI Sequence Viewer  
  AAH12807 (Get FASTA)   NCBI Sequence Viewer  
  AAH14485 (Get FASTA)   NCBI Sequence Viewer  
  AAH16753 (Get FASTA)   NCBI Sequence Viewer  
  AAH68474 (Get FASTA)   NCBI Sequence Viewer  
  AAQ63401 (Get FASTA)   NCBI Sequence Viewer  
  ABC40731 (Get FASTA)   NCBI Sequence Viewer  
  BAA05708 (Get FASTA)   NCBI Sequence Viewer  
  BAA22050 (Get FASTA)   NCBI Sequence Viewer  
  BAB15121 (Get FASTA)   NCBI Sequence Viewer  
  BAF83423 (Get FASTA)   NCBI Sequence Viewer  
  BAG35187 (Get FASTA)   NCBI Sequence Viewer  
  BAG57821 (Get FASTA)   NCBI Sequence Viewer  
  BAG59814 (Get FASTA)   NCBI Sequence Viewer  
  CAB66478 (Get FASTA)   NCBI Sequence Viewer  
  EAX04257 (Get FASTA)   NCBI Sequence Viewer  
  EAX04258 (Get FASTA)   NCBI Sequence Viewer  
  EAX04259 (Get FASTA)   NCBI Sequence Viewer  
  EAX04260 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000325875
  ENSP00000325875.3
  ENSP00000360609
  ENSP00000360609.1
  ENSP00000360709
  ENSP00000360709.5
  ENSP00000481908
  ENSP00000481908.1
GenBank Protein P08238 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_031381   ⟸   NM_007355
- Peptide Label: isoform a
- UniProtKB: Q9NQW0 (UniProtKB/Swiss-Prot),   Q5T9W7 (UniProtKB/Swiss-Prot),   B2R5P0 (UniProtKB/Swiss-Prot),   Q9NTK6 (UniProtKB/Swiss-Prot),   P08238 (UniProtKB/Swiss-Prot),   B4DGL0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258899   ⟸   NM_001271970
- Peptide Label: isoform a
- UniProtKB: Q9NQW0 (UniProtKB/Swiss-Prot),   Q5T9W7 (UniProtKB/Swiss-Prot),   B2R5P0 (UniProtKB/Swiss-Prot),   Q9NTK6 (UniProtKB/Swiss-Prot),   P08238 (UniProtKB/Swiss-Prot),   B4DGL0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258898   ⟸   NM_001271969
- Peptide Label: isoform a
- UniProtKB: Q9NQW0 (UniProtKB/Swiss-Prot),   Q5T9W7 (UniProtKB/Swiss-Prot),   B2R5P0 (UniProtKB/Swiss-Prot),   Q9NTK6 (UniProtKB/Swiss-Prot),   P08238 (UniProtKB/Swiss-Prot),   B4DGL0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258901   ⟸   NM_001271972
- Peptide Label: isoform c
- UniProtKB: B4DGL0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258900   ⟸   NM_001271971
- Peptide Label: isoform b
- UniProtKB: B4DGL0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001358167   ⟸   NM_001371238
- Peptide Label: isoform a
- UniProtKB: Q9NQW0 (UniProtKB/Swiss-Prot),   Q5T9W7 (UniProtKB/Swiss-Prot),   P08238 (UniProtKB/Swiss-Prot),   B2R5P0 (UniProtKB/Swiss-Prot),   Q9NTK6 (UniProtKB/Swiss-Prot),   B4DGL0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSP00000481908   ⟸   ENST00000620073
Ensembl Acc Id: ENSP00000360609   ⟸   ENST00000371554
Ensembl Acc Id: ENSP00000360709   ⟸   ENST00000371646
Ensembl Acc Id: ENSP00000325875   ⟸   ENST00000353801
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08238-F1-model_v2 AlphaFold P08238 1-724 view protein structure

Promoters
RGD ID:7208199
Promoter ID:EPDNEW_H9846
Type:initiation region
Name:HSP90AB1_1
Description:heat shock protein 90 alpha family class B member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38644,247,101 - 44,247,161EPDNEW
RGD ID:6804362
Promoter ID:HG_KWN:53700
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000353801,   ENST00000371556,   ENST00000371562,   ENST00000371565,   OTTHUMT00000040728,   OTTHUMT00000040731
Position:
Human AssemblyChrPosition (strand)Source
Build 36644,322,066 - 44,322,857 (+)MPROMDB
RGD ID:6804008
Promoter ID:HG_KWN:53701
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   CD4+TCell_2Hour,   Jurkat,   K562,   Lymphoblastoid
Transcripts:ENST00000371554
Position:
Human AssemblyChrPosition (strand)Source
Build 36644,322,786 - 44,323,697 (+)MPROMDB
RGD ID:6851142
Promoter ID:EP73368
Type:single initiation site
Name:HS_HSPCB
Description:Heat shock 90kDa protein 1, beta.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 36644,322,816 - 44,322,876EPD
RGD ID:6814841
Promoter ID:HG_XEF:6848
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:NM_001004082,   NM_001019786,   NM_001030484,   NM_001045073,   NM_001070035,   NM_001070038,   NM_001079637,   NM_001081938,   NM_001093155,   NM_001123532,   NM_001124231,   NM_001124591,   NM_001141944,   NM_001146473,   NM_001173702,   NM_001177004,   NM_001177009,   NM_001182692,   NM_001184054,   NM_008302,   NM_074225,   NM_079175,   NM_124642,   NM_124983,   NM_124985,   NM_131310,   NM_131328,   NM_206959,   NM_210756,   NR_033595
Position:
Human AssemblyChrPosition (strand)Source
Build 36644,324,106 - 44,324,606 (+)MPROMDB
RGD ID:6804359
Promoter ID:HG_KWN:53702
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid
Transcripts:UC003OXC.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36644,324,786 - 44,325,807 (+)MPROMDB
RGD ID:6804358
Promoter ID:HG_KWN:53703
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000040726,   OTTHUMT00000040727,   OTTHUMT00000040732
Position:
Human AssemblyChrPosition (strand)Source
Build 36644,326,371 - 44,327,542 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5258 AgrOrtholog
COSMIC HSP90AB1 COSMIC
Ensembl Genes ENSG00000096384 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000353801 ENTREZGENE
  ENST00000353801.7 UniProtKB/Swiss-Prot
  ENST00000371554 ENTREZGENE
  ENST00000371554.2 UniProtKB/Swiss-Prot
  ENST00000371646 ENTREZGENE
  ENST00000371646.10 UniProtKB/Swiss-Prot
  ENST00000620073 ENTREZGENE
  ENST00000620073.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.790 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.230.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.11260 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000096384 GTEx
HGNC ID HGNC:5258 ENTREZGENE
Human Proteome Map HSP90AB1 Human Proteome Map
InterPro HATPase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HATPase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heat_shock_protein_90_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP90_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp90_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp90_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3326 UniProtKB/Swiss-Prot
NCBI Gene 3326 ENTREZGENE
OMIM 140572 OMIM
PANTHER PTHR11528 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HATPase_c_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29524 PharmGKB
PIRSF Hsp90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS HEATSHOCK90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HSP90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HATPase_c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF110942 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54211 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55874 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2R5P0 ENTREZGENE
  B4DGL0 ENTREZGENE, UniProtKB/TrEMBL
  HS90B_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q5T9W7 ENTREZGENE
  Q6PK50_HUMAN UniProtKB/TrEMBL
  Q9NQW0 ENTREZGENE
  Q9NTK6 ENTREZGENE
UniProt Secondary B2R5P0 UniProtKB/Swiss-Prot
  Q5T9W7 UniProtKB/Swiss-Prot
  Q9NQW0 UniProtKB/Swiss-Prot
  Q9NTK6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-28 HSP90AB1  heat shock protein 90 alpha family class B member 1  HSP90AB1  heat shock protein 90kDa alpha family class B member 1  Symbol and/or name change 5135510 APPROVED
2015-11-24 HSP90AB1  heat shock protein 90kDa alpha family class B member 1  HSP90AB1  heat shock protein 90kDa alpha (cytosolic), class B member 1  Symbol and/or name change 5135510 APPROVED