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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gamendazole
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Accession:CHEBI:90703 term browser browse the term
Definition:A member of the class of indazoles that is 3-(indazol-3-yl}prop-2-enoic acid carrying additional 2,4-dichlorobenzyl and trifluoromethyl substituents at positions 1 and 6 respectively. An orally active antispermatogenic compound with antifertility effects that is a potential male contraceptive drug.
Synonyms:exact_synonym: (2E)-3-{1-[(2,4-dichlorophenyl)methyl]-6-(trifluoromethyl)-1H-indazol-3-yl}prop-2-enoic acid
 related_synonym: Formula=C18H11Cl2F3N2O2;   InChI=1S/C18H11Cl2F3N2O2/c19-12-3-1-10(14(20)8-12)9-25-16-7-11(18(21,22)23)2-4-13(16)15(24-25)5-6-17(26)27/h1-8H,9H2,(H,26,27)/b6-5+;   InChIKey=KYYQMVUKYQCSQY-AATRIKPKSA-N;   SMILES=N=1N(C2=C(C1\\C=C\\C(O)=O)C=CC(=C2)C(F)(F)F)CC3=CC=C(C=C3Cl)Cl;   trans-3-(1-benzyl-6-(trifluoromethyl)-1H-indazol-3-yl)acrylic acid
 xref: PMID:18218611;   PMID:18218612;   PMID:21129982;   PMID:22995542;   PMID:26308587;   PMID:26413399;   Reaxys:12542895;   Wikipedia:Gamendazole



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gamendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 affects binding EXP Gamendazole binds to Eef1a1 protein RGD PMID:18218611 RGD:10401123 NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839
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G Hsp90ab1 heat shock protein 90 alpha family class B member 1 affects binding EXP gamendazole binds to Hsp90ab1 protein RGD PMID:18218611 RGD:10401123 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19810
    role 19759
      application 19468
        antispermatogenic agent 1114
          gamendazole 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19809
      composite particle 19809
        hadron 19809
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19706
                    p-block element atom 19706
                      carbon group element atom 19628
                        carbon atom 19618
                          organic molecular entity 19618
                            organic molecule 19558
                              organic cyclic compound 19349
                                carbocyclic compound 18309
                                  benzenoid aromatic compound 17453
                                    benzenes 17235
                                      chlorobenzenes 13610
                                        dichlorobenzene 10612
                                          lonidamine 21
                                            gamendazole 2
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