Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:neticonazole
go back to main search page
Accession:CHEBI:135281 term browser browse the term
Definition:An enamine that is ethene which is substituted at positions 1, 1, and 2 by o-pentoxyphenyl, 1H-imidazol-1-yl, and methylthio groups, respectively (the E isomer). An inhibitor of P450-dependent C-14alpha-demethylation of lanosterol (preventing conversion to ergosterol and inhibiting cell wall synthesis in fungi), it is used in Japan (generally as the corresponding hydrochloride salt) as an antifungal drug for the treatment of superficial skin infections.
Synonyms:exact_synonym: 1-{(E)-2-(methylthio)-1-[2-(pentyloxy)phenyl]vinyl}-1H-imidazole
 related_synonym: Atolant;   Formula=C17H22N2OS;   InChI=1S/C17H22N2OS/c1-3-4-7-12-20-17-9-6-5-8-15(17)16(13-21-2)19-11-10-18-14-19/h5-6,8-11,13-14H,3-4,7,12H2,1-2H3/b16-13+;   InChIKey=VWOIKFDZQQLJBJ-DTQAZKPQSA-N;   SMILES=C(=C\\SC)(\\C1=C(OCCCCC)C=CC=C1)/N2C=CN=C2;   neticonazol;   neticonazolum
 xref: CAS:130726-68-0;   Drug_Central:1902
 xref_mesh: MESH:C084784
 xref: PMID:11156023;   PMID:16651719;   PMID:8254891;   PMID:8734665;   PMID:9062749;   Patent:CA2458026;   Patent:EP1568366;   Patent:EP227011;   Patent:US4740601;   Reaxys:5381743;   Wikipedia:Neticonazole
 cyclic_relationship: is_conjugate_base_of CHEBI:141384


show annotations for term's descendants           Sort by:
 
neticonazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO neticonazole affects the localization of and results in increased activity of NR1I3 protein CTD PMID:30247703 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            antifungal drug 5138
              neticonazole 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  heteroarene 16447
                                    monocyclic heteroarene 13303
                                      azole 12471
                                        diazole 8126
                                          imidazoles 7655
                                            imidazole antifungal agent 1258
                                              imidazole antifungal drug 793
                                                neticonazole 1
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.