Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:neticonazole
go back to main search page
Accession:CHEBI:135281 term browser browse the term
Definition:An enamine that is ethene which is substituted at positions 1, 1, and 2 by o-pentoxyphenyl, 1H-imidazol-1-yl, and methylthio groups, respectively (the E isomer). An inhibitor of P450-dependent C-14alpha-demethylation of lanosterol (preventing conversion to ergosterol and inhibiting cell wall synthesis in fungi), it is used in Japan (generally as the corresponding hydrochloride salt) as an antifungal drug for the treatment of superficial skin infections.
Synonyms:exact_synonym: 1-{(E)-2-(methylthio)-1-[2-(pentyloxy)phenyl]vinyl}-1H-imidazole
 related_synonym: Atolant;   Formula=C17H22N2OS;   InChI=1S/C17H22N2OS/c1-3-4-7-12-20-17-9-6-5-8-15(17)16(13-21-2)19-11-10-18-14-19/h5-6,8-11,13-14H,3-4,7,12H2,1-2H3/b16-13+;   InChIKey=VWOIKFDZQQLJBJ-DTQAZKPQSA-N;   SMILES=C(=C\\SC)(\\C1=C(OCCCCC)C=CC=C1)/N2C=CN=C2;   neticonazol;   neticonazolum
 xref: CAS:130726-68-0 "ChemIDplus";   CAS:130726-68-0 "DrugCentral";   Drug_Central:1902 "DrugCentral"
 xref_mesh: MESH:C084784
 xref: PMID:11156023 "Europe PMC";   PMID:16651719 "Europe PMC";   PMID:8254891 "Europe PMC";   PMID:8734665 "Europe PMC";   PMID:9062749 "Europe PMC";   Patent:CA2458026;   Patent:EP1568366;   Patent:EP227011;   Patent:US4740601;   Reaxys:5381743 "Reaxys";   Wikipedia:Neticonazole
 cyclic_relationship: is_conjugate_base_of CHEBI:141384


show annotations for term's descendants       view all columns           Sort by:
 
neticonazole term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 JBrowse link 13 89,585,072 89,591,278 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        pharmaceutical 19097
          drug 19097
            antifungal drug 5100
              neticonazole 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic molecule 19343
                              organic cyclic compound 19093
                                organic heterocyclic compound 18157
                                  heteroarene 15146
                                    monocyclic heteroarene 11614
                                      azole 10473
                                        diazole 8040
                                          imidazoles 7591
                                            imidazole antifungal agent 1230
                                              imidazole antifungal drug 763
                                                neticonazole 1
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.