Haao (3-hydroxyanthranilate 3,4-dioxygenase) - Rat Genome Database

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Gene: Haao (3-hydroxyanthranilate 3,4-dioxygenase) Rattus norvegicus
Analyze
Symbol: Haao
Name: 3-hydroxyanthranilate 3,4-dioxygenase
RGD ID: 71071
Description: Enables 3-hydroxyanthranilate 3,4-dioxygenase activity; iron ion binding activity; and oxygen binding activity. Involved in quinolinate metabolic process. Located in mitochondrial membrane. Used to study Huntington's disease. Orthologous to human HAAO (3-hydroxyanthranilate 3,4-dioxygenase); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3-HAO; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase; HAD
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8616,598,325 - 16,617,590 (+)NCBIGRCr8
mRatBN7.2610,845,235 - 10,864,863 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl610,845,771 - 10,864,877 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx611,140,636 - 11,153,719 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0611,449,968 - 11,463,051 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0610,962,770 - 10,975,905 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.067,045,145 - 7,059,227 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl67,045,152 - 7,058,314 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.066,994,168 - 7,008,145 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.467,197,352 - 7,210,456 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.167,197,351 - 7,210,456 (-)NCBI
Celera610,553,178 - 10,565,875 (+)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (EXP)
acyclovir  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium trinitrate  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
dimethylarsinic acid  (ISO)
enilconazole  (ISO)
epoxiconazole  (ISO)
fenthion  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
GW 4064  (ISO)
hydralazine  (ISO)
lead(0)  (ISO)
methylarsonic acid  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nitrofen  (EXP)
okadaic acid  (ISO)
paracetamol  (ISO)
perfluorododecanoic acid  (EXP)
perfluorononanoic acid  (ISO)
phenobarbital  (EXP)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
Propiverine  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
tauroursodeoxycholic acid  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (IEA,ISO)
mitochondrial membrane  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. 3-Hydroxyanthralinic acid metabolism controls the hepatic SREBP/lipoprotein axis, inhibits inflammasome activation in macrophages, and decreases atherosclerosis in Ldlr-/- mice. Berg M, etal., Cardiovasc Res. 2020 Oct 1;116(12):1948-1957. doi: 10.1093/cvr/cvz258.
2. Effects of oxygen on 3-hydroxyanthranilate oxidase of the kynurenine pathway. Dang Y, etal., Free Radic Biol Med. 1998 Dec;25(9):1033-43.
3. Synthesis of quinolinic acid by 3-hydroxyanthranilic acid oxygenase in rat brain tissue in vitro. Foster AC, etal., J Neurochem. 1986 Jul;47(1):23-30.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Quinolinic acid metabolism in the rat brain. Immunohistochemical identification of 3-hydroxyanthranilic acid oxygenase and quinolinic acid phosphoribosyltransferase in the hippocampal region. Kohler C, etal., J Neurosci. 1988 Mar;8(3):975-87.
8. Immunohistochemical visualization of newly formed quinolinate in the normal and excitotoxically lesioned rat striatum. Lehrmann E, etal., Exp Brain Res 2001 Dec;141(3):389-97.
9. The kynurenine pathway and neurodegenerative disease. Maddison DC and Giorgini F, Semin Cell Dev Biol. 2015 Apr;40:134-41. doi: 10.1016/j.semcdb.2015.03.002. Epub 2015 Mar 12.
10. Gene Data Set MGD Curation, June 12, 2002
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Increase in the level of mRNA for 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice. Nakagawa Y, etal., Biosci Biotechnol Biochem 1995 Nov;59(11):2191-2.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Rat 3-hydroxyanthranilic acid oxygenase: purification from the liver and immunocytochemical localization in the brain. Okuno E, etal., J Neurochem. 1987 Sep;49(3):771-80.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia. Sathyasaikumar KV, etal., Schizophr Bull. 2011 Nov;37(6):1147-56. doi: 10.1093/schbul/sbq112. Epub 2010 Oct 29.
20. Basal ganglia lesions in the rat: effects on quinolinic acid metabolism. Schwarcz R, etal., Brain Res. 1989 Jun 19;490(1):103-9.
Additional References at PubMed
PMID:1611505   PMID:2967497   PMID:7514594   PMID:7805640   PMID:12007609   PMID:12477932   PMID:15489334   PMID:23376485   PMID:28375145   PMID:28792876  


Genomics

Comparative Map Data
Haao
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8616,598,325 - 16,617,590 (+)NCBIGRCr8
mRatBN7.2610,845,235 - 10,864,863 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl610,845,771 - 10,864,877 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx611,140,636 - 11,153,719 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0611,449,968 - 11,463,051 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0610,962,770 - 10,975,905 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.067,045,145 - 7,059,227 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl67,045,152 - 7,058,314 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.066,994,168 - 7,008,145 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.467,197,352 - 7,210,456 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.167,197,351 - 7,210,456 (-)NCBI
Celera610,553,178 - 10,565,875 (+)NCBICelera
Cytogenetic Map6q12NCBI
HAAO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38242,767,089 - 42,792,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl242,767,089 - 42,792,593 (-)EnsemblGRCh38hg38GRCh38
GRCh37242,994,229 - 43,019,723 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36242,847,734 - 42,873,219 (-)NCBINCBI36Build 36hg18NCBI36
Build 34242,905,880 - 42,931,366NCBI
Celera242,833,485 - 42,858,995 (-)NCBICelera
Cytogenetic Map2p21NCBI
HuRef242,728,505 - 42,754,300 (-)NCBIHuRef
CHM1_1242,923,585 - 42,949,123 (-)NCBICHM1_1
T2T-CHM13v2.0242,772,378 - 42,797,833 (-)NCBIT2T-CHM13v2.0
Haao
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391784,138,777 - 84,157,589 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1784,138,585 - 84,155,392 (-)EnsemblGRCm39 Ensembl
GRCm381783,831,348 - 83,848,981 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1783,831,156 - 83,847,963 (-)EnsemblGRCm38mm10GRCm38
MGSCv371784,230,694 - 84,246,130 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361783,739,421 - 83,756,289 (-)NCBIMGSCv36mm8
Celera1788,186,650 - 88,204,249 (-)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1754.85NCBI
Haao
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544110,110,380 - 10,129,015 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544110,114,863 - 10,128,948 (-)NCBIChiLan1.0ChiLan1.0
HAAO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21283,605,885 - 83,652,485 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A83,606,853 - 83,657,841 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A42,857,216 - 42,882,738 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A43,704,468 - 43,729,886 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A43,704,468 - 43,729,887 (-)Ensemblpanpan1.1panPan2
HAAO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11045,368,157 - 45,379,521 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1045,368,178 - 45,379,160 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1045,234,849 - 45,243,211 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01046,244,310 - 46,257,893 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11045,953,712 - 45,967,274 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01046,242,070 - 46,255,650 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01046,426,251 - 46,439,827 (-)NCBIUU_Cfam_GSD_1.0
Haao
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629237,521,284 - 37,557,728 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365088,971,477 - 8,986,404 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365088,971,516 - 8,987,235 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAAO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl397,580,851 - 97,595,021 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1397,580,756 - 97,595,033 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HAAO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11464,460,553 - 64,485,731 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1464,460,703 - 64,485,378 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604547,421,217 - 47,446,709 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Haao
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473824,407,551 - 24,421,561 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473824,409,531 - 24,421,384 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Haao
82 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:162
Count of miRNA genes:117
Interacting mature miRNAs:128
Transcripts:ENSRNOT00000045996
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6507449719988050Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6984331220338915Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6984331220338915Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 41 41 41 25
Low 2 1 13 19 2 2 36 6 23 11 2
Below cutoff 1 26 3 5 5 38 4 17 5

Sequence


RefSeq Acc Id: ENSRNOT00000045996   ⟹   ENSRNOP00000043835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl610,845,771 - 10,858,893 (+)Ensembl
Rnor_6.0 Ensembl67,045,152 - 7,058,314 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095216   ⟹   ENSRNOP00000095895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl610,845,771 - 10,858,893 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096657   ⟹   ENSRNOP00000085878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl610,845,771 - 10,864,877 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118756   ⟹   ENSRNOP00000080815
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl610,845,771 - 10,858,894 (+)Ensembl
RefSeq Acc Id: NM_020076   ⟹   NP_064461
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8616,598,325 - 16,611,430 (+)NCBI
mRatBN7.2610,845,785 - 10,858,889 (+)NCBI
Rnor_6.067,045,152 - 7,058,314 (-)NCBI
Rnor_5.066,994,168 - 7,008,145 (-)NCBI
RGSC_v3.467,197,352 - 7,210,456 (-)RGD
Celera610,553,178 - 10,565,875 (+)RGD
Sequence:
RefSeq Acc Id: XM_039112794   ⟹   XP_038968722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8616,598,360 - 16,617,590 (+)NCBI
mRatBN7.2610,845,235 - 10,864,863 (+)NCBI
RefSeq Acc Id: XM_063262373   ⟹   XP_063118443
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8616,598,360 - 16,611,435 (+)NCBI
RefSeq Acc Id: XM_063262374   ⟹   XP_063118444
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8616,598,360 - 16,617,590 (+)NCBI
RefSeq Acc Id: NP_064461   ⟸   NM_020076
- UniProtKB: Q5RKK0 (UniProtKB/Swiss-Prot),   P70474 (UniProtKB/Swiss-Prot),   Q64556 (UniProtKB/Swiss-Prot),   P46953 (UniProtKB/Swiss-Prot),   A0A0G2JSV5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000043835   ⟸   ENSRNOT00000045996
RefSeq Acc Id: XP_038968722   ⟸   XM_039112794
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GEE8 (UniProtKB/TrEMBL),   A0A8I5ZR59 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000080815   ⟸   ENSRNOT00000118756
RefSeq Acc Id: ENSRNOP00000085878   ⟸   ENSRNOT00000096657
RefSeq Acc Id: ENSRNOP00000095895   ⟸   ENSRNOT00000095216
RefSeq Acc Id: XP_063118444   ⟸   XM_063262374
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063118443   ⟸   XM_063262373
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P46953-F1-model_v2 AlphaFold P46953 1-286 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694371
Promoter ID:EPDNEW_R4896
Type:initiation region
Name:Haao_1
Description:3-hydroxyanthranilate 3,4-dioxygenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.067,058,297 - 7,058,357EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71071 AgrOrtholog
BioCyc Gene G2FUF-38619 BioCyc
BioCyc Pathway PWY-5651 [L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde] BioCyc
BioCyc Pathway Image PWY-5651 BioCyc
Ensembl Genes ENSRNOG00000031263 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045996 ENTREZGENE
  ENSRNOT00000045996.3 UniProtKB/TrEMBL
  ENSRNOT00000095216.1 UniProtKB/TrEMBL
  ENSRNOT00000096657.1 UniProtKB/TrEMBL
  ENSRNOT00000118756.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7108551 IMAGE-MGC_LOAD
InterPro 3hydroanth_dOase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3hydroanth_dOase_met UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC_Cupin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:56823 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93472 IMAGE-MGC_LOAD
NCBI Gene 56823 ENTREZGENE
PANTHER 3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15497 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 3-HAO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Haao PhenoGen
PIRSF 3hydroanth_dOase_animal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031263 RatGTEx
Superfamily-SCOP SSF51182 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt 3HAO_RAT UniProtKB/Swiss-Prot
  A0A0G2JSV5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZR59 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASE6_RAT UniProtKB/TrEMBL
  A0A8I6GEE8 ENTREZGENE, UniProtKB/TrEMBL
  A6H9K8_RAT UniProtKB/TrEMBL
  A6H9L0_RAT UniProtKB/TrEMBL
  A6H9L1_RAT UniProtKB/TrEMBL
  A6H9L3_RAT UniProtKB/TrEMBL
  P46953 ENTREZGENE
  P70474 ENTREZGENE
  Q5RKK0 ENTREZGENE
  Q64556 ENTREZGENE
UniProt Secondary P70474 UniProtKB/Swiss-Prot
  Q5RKK0 UniProtKB/Swiss-Prot
  Q64556 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Haao  3-hydroxyanthranilate 3,4-dioxygenase      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference