HAAO (3-hydroxyanthranilate 3,4-dioxygenase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: HAAO (3-hydroxyanthranilate 3,4-dioxygenase) Canis lupus familiaris
Analyze
Symbol: HAAO
Name: 3-hydroxyanthranilate 3,4-dioxygenase
RGD ID: 12164479
Description: ENCODES a protein that exhibits 3-hydroxyanthranilate 3,4-dioxygenase activity (ortholog); iron ion binding (ortholog); oxygen binding (ortholog); INVOLVED IN neuron cellular homeostasis (ortholog); quinolinate metabolic process (ortholog); response to cadmium ion (ortholog); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; ASSOCIATED WITH atherosclerosis (ortholog); genetic disease (ortholog); Huntington's disease (ortholog); FOUND IN cytosol (ortholog); mitochondrial membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11045,368,157 - 45,379,521 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1045,368,178 - 45,379,160 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1045,234,849 - 45,243,211 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01046,244,310 - 46,257,893 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11045,953,712 - 45,967,274 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01046,242,070 - 46,255,650 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01046,426,251 - 46,439,827 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HAAO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11045,368,157 - 45,379,521 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1045,368,178 - 45,379,160 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1045,234,849 - 45,243,211 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01046,244,310 - 46,257,893 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11045,953,712 - 45,967,274 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01046,242,070 - 46,255,650 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01046,426,251 - 46,439,827 (-)NCBIUU_Cfam_GSD_1.0
HAAO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38242,767,089 - 42,792,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl242,767,089 - 42,792,593 (-)EnsemblGRCh38hg38GRCh38
GRCh37242,994,229 - 43,019,723 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36242,847,734 - 42,873,219 (-)NCBINCBI36Build 36hg18NCBI36
Build 34242,905,880 - 42,931,366NCBI
Celera242,833,485 - 42,858,995 (-)NCBICelera
Cytogenetic Map2p21NCBI
HuRef242,728,505 - 42,754,300 (-)NCBIHuRef
CHM1_1242,923,585 - 42,949,123 (-)NCBICHM1_1
T2T-CHM13v2.0242,772,378 - 42,797,833 (-)NCBIT2T-CHM13v2.0
Haao
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391784,138,777 - 84,157,589 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1784,138,585 - 84,155,392 (-)EnsemblGRCm39 Ensembl
GRCm381783,831,348 - 83,848,981 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1783,831,156 - 83,847,963 (-)EnsemblGRCm38mm10GRCm38
MGSCv371784,230,694 - 84,246,130 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361783,739,421 - 83,756,289 (-)NCBIMGSCv36mm8
Celera1788,186,650 - 88,204,249 (-)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1754.85NCBI
Haao
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8616,598,325 - 16,617,590 (+)NCBIGRCr8
mRatBN7.2610,845,235 - 10,864,863 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl610,845,771 - 10,864,877 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx611,140,636 - 11,153,719 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0611,449,968 - 11,463,051 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0610,962,770 - 10,975,905 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.067,045,145 - 7,059,227 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl67,045,152 - 7,058,314 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.066,994,168 - 7,008,145 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.467,197,352 - 7,210,456 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.167,197,351 - 7,210,456 (-)NCBI
Celera610,553,178 - 10,565,875 (+)NCBICelera
Cytogenetic Map6q12NCBI
Haao
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544110,110,380 - 10,129,015 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544110,114,863 - 10,128,948 (-)NCBIChiLan1.0ChiLan1.0
HAAO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21283,605,885 - 83,652,485 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A83,606,853 - 83,657,841 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A42,857,216 - 42,882,738 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A43,704,468 - 43,729,886 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A43,704,468 - 43,729,887 (-)Ensemblpanpan1.1panPan2
Haao
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629237,521,284 - 37,557,728 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365088,971,477 - 8,986,404 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365088,971,516 - 8,987,235 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAAO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl397,580,851 - 97,595,021 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1397,580,756 - 97,595,033 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HAAO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11464,460,553 - 64,485,731 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1464,460,703 - 64,485,378 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604547,421,217 - 47,446,709 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Haao
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473824,407,551 - 24,421,561 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473824,409,531 - 24,421,384 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HAAO
163 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 7 6 6 6 1 5 1
Low 4 1 15 6 11 3 5 5
Below cutoff 4 6 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000003833   ⟹   ENSCAFP00000003546
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1045,368,178 - 45,379,160 (-)Ensembl
RefSeq Acc Id: XM_038489153   ⟹   XP_038345081
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11045,953,712 - 45,967,274 (-)NCBI
RefSeq Acc Id: XM_038551153   ⟹   XP_038407081
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01046,426,251 - 46,439,827 (-)NCBI
RefSeq Acc Id: XM_038615056   ⟹   XP_038470984
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01046,242,070 - 46,255,650 (-)NCBI
RefSeq Acc Id: XM_038636243   ⟹   XP_038492171
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1045,234,849 - 45,243,211 (-)NCBI
RefSeq Acc Id: XM_038680441   ⟹   XP_038536369
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01046,244,310 - 46,257,893 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000003546   ⟸   ENSCAFT00000003833
RefSeq Acc Id: XP_038345081   ⟸   XM_038489153
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038470984   ⟸   XM_038615056
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038536369   ⟸   XM_038680441
- Peptide Label: isoform X1
- UniProtKB: A0A8I3Q5V3 (UniProtKB/TrEMBL),   A0A8C0TB80 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038492171   ⟸   XM_038636243
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038407081   ⟸   XM_038551153
- Peptide Label: isoform X1
- UniProtKB: A0A8C0R7S4 (UniProtKB/TrEMBL),   A0A8C0TB80 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002435 Ensembl
  ENSCAFG00030014870 UniProtKB/TrEMBL
  ENSCAFG00040019947 UniProtKB/TrEMBL
  ENSCAFG00845025017 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030027404.1 UniProtKB/TrEMBL
  ENSCAFT00030027484.1 UniProtKB/TrEMBL
  ENSCAFT00040036894.1 UniProtKB/TrEMBL
  ENSCAFT00845044164 ENTREZGENE
  ENSCAFT00845044164.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.10 UniProtKB/TrEMBL
InterPro 3hydroanth_dOase UniProtKB/TrEMBL
  3hydroanth_dOase_met UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
  RmlC_Cupin_sf UniProtKB/TrEMBL
NCBI Gene HAAO ENTREZGENE
PANTHER 3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE UniProtKB/TrEMBL
  PTHR15497 UniProtKB/TrEMBL
Pfam 3-HAO UniProtKB/TrEMBL
PIRSF 3hydroanth_dOase_animal UniProtKB/TrEMBL
Superfamily-SCOP SSF51182 UniProtKB/TrEMBL
UniProt A0A8C0NA82_CANLF UniProtKB/TrEMBL
  A0A8C0R7S4 ENTREZGENE
  A0A8C0TB80 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q5V3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:41580 ENTREZGENE