Enables acyl-CoA delta5-desaturase activity. Involved in several processes, including response to insulin; response to vitamin A; and unsaturated fatty acid metabolic process. Predicted to be located in endoplasmic reticulum membrane and mitochondrion. Biomarker of congestive heart failure; hypertension; and obesity. Orthologous to human FADS1 (fatty acid desaturase 1); PARTICIPATES IN alpha-linolenic acid metabolic pathway; linoleic acid metabolic pathway; unsaturated fatty acid biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; (+)-sesamin; 1-(3-(trifluoromethyl)phenyl)piperazine.
[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FADS1 mRNA and Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to FADS1 gene]
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of FADS1 mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of FADS1 mRNA
[NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FADS1 mRNA
beta-hydroxy simvastatin acid promotes the reaction [Fenofibrate results in increased expression of FADS1 mRNA] and Fenofibrate promotes the reaction [beta-hydroxy simvastatin acid results in increased expression of FADS1 mRNA]
[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FADS1 gene more ...
[bisphenol A co-treated with Fulvestrant] results in increased methylation of FADS1 gene and Fulvestrant inhibits the reaction [[alpha-Linolenic Acid co-treated with Estradiol] results in increased expression of FADS1 mRNA]
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of FADS1 mRNA
[NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FADS1 mRNA
[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FADS1 mRNA and [Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of FADS1 mRNA
[Coumestrol co-treated with Resveratrol] results in increased expression of FADS1 mRNA and [Plant Extracts co-treated with Resveratrol] results in increased expression of FADS1 mRNA
[NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FADS1 mRNA
[[alpha-Linolenic Acid co-treated with Testosterone] results in decreased expression of FADS1 mRNA] which affects the abundance of Fatty Acids more ...
Long-term melatonin administration reduces hyperinsulinemia and improves the altered fatty-acid compositions in type 2 diabetic rats via the restoration of Delta-5 desaturase activity.