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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:47519
Term: ketoconazole
Definition: A racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-ketoconazole.
Chemical ID: MESH:D007654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases expressionEXP 6480464CTDKetoconazole results in increased expression of CYP1A1 mRNAPMID:31168027
Cyp1a1multiple interactionsEXP 6480464CTD[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of CYP1A1 mRNA; Ketoconazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]PMID:18493746 PMID:31168027
Cyp1a1decreases activityISOCyp1a1 (Mus musculus)6480464CTDKetoconazole results in decreased activity of CYP1A1 proteinPMID:18420780
Cyp1a1decreases activityISOCYP1A1 (Homo sapiens)6480464CTDKetoconazole results in decreased activity of CYP1A1 proteinPMID:14709627 PMID:17283379 PMID:34181028
Cyp1a1increases activityISOCYP1A1 (Homo sapiens)6480464CTDKetoconazole results in increased activity of CYP1A1 proteinPMID:19070657
Cyp1a1increases expressionISOCyp1a1 (Mus musculus)6480464CTDKetoconazole results in increased expression of CYP1A1 mRNAPMID:17283379 PMID:26886340
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDKetoconazole results in increased expression of CYP1A1 mRNA; Ketoconazole results in increased expression of CYP1A1 proteinPMID:17283379 PMID:25000292 PMID:26886340
Cyp1a1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTDKetoconazole binds to and results in decreased activity of and results in increased expression of CYP1A1 protein; Ketoconazole results in increased expression of and results in increased activity of CYP1A1 proteinPMID:17283379 PMID:26886340
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD[Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 protein; Dactinomycin inhibits the reaction [Ketoconazole results in increased expression of CYP1A1 mRNA]; Ketoconazole binds to and results in decreased activity of and results in increased expression of CYP1A1 protein; Ketoconazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Ketoconazole results in increased expression of and results in increased activity of CYP1A1 proteinPMID:17283379 PMID:18493746 PMID:19070657 PMID:21753779 PMID:26886340
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