Nsdhl (NAD(P) dependent steroid dehydrogenase-like)

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Gene: Nsdhl (NAD(P) dependent steroid dehydrogenase-like) Rattus norvegicus

Analyze

Symbol:

Nsdhl

Name:

NAD(P) dependent steroid dehydrogenase-like

RGD ID:

1359337

Description:

Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in cholesterol metabolic process. Predicted to act upstream of or within hair follicle development; labyrinthine layer blood vessel development; and smoothened signaling pathway. Predicted to be located in lipid droplet. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in CHILD syndrome and CK syndrome. Orthologous to human NSDHL (NAD(P) dependent steroid dehydrogenase-like); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

MGC105618; sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	X	150,775,034 - 150,807,161 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	150,775,080 - 150,807,142 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	152,967,118 - 152,997,979 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	X	156,499,462 - 156,530,321 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	X	154,042,572 - 154,073,431 (+)	NCBI	Rnor_WKY
Rnor_6.0	X	152,933,118 - 152,964,399 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	152,933,069 - 152,964,390 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	148,661,899 - 148,693,982 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	158,923,025 - 158,954,914 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	158,996,457 - 159,028,346 (+)	NCBI
Celera	1	131,739,125 - 131,770,246 (+)	NCBI		Celera
Cytogenetic Map	X	q37	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adrenoleukodystrophy (ISO)

autistic disorder (ISO)

autosomal recessive congenital ichthyosis (ISO)

Barth syndrome (ISO)

Bloch-Sulzberger syndrome (ISS)

CHILD syndrome (ISO)

CK syndrome (ISO)

connective tissue disease (ISO)

creatine transporter deficiency (ISO)

dyskeratosis congenita (ISO)

Emery-Dreifuss muscular dystrophy (ISO)

epilepsy (ISO)

favism (ISO)

genetic disease (ISO)

head and neck squamous cell carcinoma (ISO)

Hearing Loss (ISO)

intellectual disability (ISO)

paraplegia (ISO)

periventricular nodular heterotopia (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

X-linked chondrodysplasia punctata 1 (ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-amino-2-deoxy-D-glucopyranose (ISO)

22-Hydroxycholesterol (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',5-triiodo-L-thyronine (EXP)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP)

3-methylcholanthrene (ISO)

3H-1,2-dithiole-3-thione (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

7,12-dimethyltetraphene (ISO)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

aldehydo-D-glucosamine (ISO)

all-trans-retinoic acid (ISO)

apigenin (EXP)

Archazolid B (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

beta-D-glucosamine (ISO)

beta-naphthoflavone (ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

buspirone (EXP)

butan-1-ol (ISO)

Butylbenzyl phthalate (EXP)

cannabidiol (ISO)

carbon nanotube (ISO)

clobetasol (ISO)

clofibrate (ISO)

copper(II) sulfate (ISO)

Cuprizon (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

Di-n-hexyl phthalate (EXP)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP)

Dicyclohexyl phthalate (EXP)

difenoconazole (EXP)

diisobutyl phthalate (EXP)

diisononyl phthalate (EXP)

dipentyl phthalate (EXP)

doxorubicin (ISO)

erlotinib hydrochloride (ISO)

ethyl methanesulfonate (ISO)

fenarimol (EXP)

fenofibrate (ISO)

fluoranthene (ISO)

flusilazole (ISO)

formaldehyde (ISO)

fumonisin B1 (ISO)

hydralazine (ISO)

inulin (ISO)

isotretinoin (ISO)

ivermectin (ISO)

ketoconazole (EXP)

lead diacetate (ISO)

leflunomide (ISO)

luteolin (EXP)

LY294002 (ISO)

methyl methanesulfonate (ISO)

miconazole (ISO)

N-methyl-4-phenylpyridinium (EXP)

NADP zwitterion (ISO)

NADP(+) (ISO)

nefazodone (EXP)

nimesulide (EXP)

O-methyleugenol (ISO)

paracetamol (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

potassium dichromate (ISO)

pravastatin (EXP,ISO)

progesterone (ISO)

propiconazole (EXP)

pyrazinecarboxamide (EXP)

rotenone (EXP)

silver atom (ISO)

silver(0) (ISO)

simvastatin (EXP)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

tetracycline (ISO)

trimellitic anhydride (ISO)

Triptolide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Yessotoxin (ISO)

zaragozic acid A (EXP,ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

cholesterol biosynthetic process (IEA)

cholesterol metabolic process (IBA,ISO)

hair follicle development (ISO)

labyrinthine layer blood vessel development (ISO)

smoothened signaling pathway (ISO)

Cellular Component

endoplasmic reticulum (IBA,ISO,ISS)

endoplasmic reticulum membrane (IEA)

lipid droplet (ISO,ISS)

Molecular Function

3-beta-hydroxy-delta5-steroid dehydrogenase activity (IEA)

3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity (IEA)

4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity (IEA)

4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity (IEA)

C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity (IEA)

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (IBA)

protein binding (ISO)

sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

alendronate pharmacodynamics pathway (ISO)

cholesterol biosynthetic pathway (ISO)

cholesterol ester storage disease pathway (ISO)

congenital hemidysplasia with ichthyosiform erythroderma and limb defects pathway (ISO)

desmosterolosis pathway (ISO)

hypercholesterolemia pathway (ISO)

ibandronate pharmacodynamics pathway (ISO)

mevalonic aciduria pathway (ISO)

nitrogenous bisphosphonate pharmacodynamics pathway (ISO)

pamidronate pharmacodynamics pathway (ISO)

risedronate pharmacodynamics pathway (ISO)

Smith-Lemli-Opitz Syndrome pathway (ISO)

statin pharmacodynamics pathway (ISO)

steroid biosynthetic pathway (IEA)

Wolman disease pathway (ISO)

X-linked dominant chondrodysplasia punctata 2 pathway (ISO)

zoledronate pharmacodynamics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Placental defects are associated with male lethality in bare patches and striated embryos deficient in the NAD(P)H Steroid Dehydrogenase-like (NSDHL) Enzyme.	Caldas H, etal., Mol Genet Metab 2005 Jan;84(1):48-60.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes.	Herman GE Hum Mol Genet. 2003 Apr 1;12 Spec No 1:R75-88.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
7.	Online Mendelian Inheritance in Man, OMIM (TM).	Online Mendelian Inheritance in Man, OMIM (TM).
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Comprehensive gene review and curation	RGD comprehensive gene curation
14.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15.	Defects of cholesterol biosynthesis.	Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.

Additional References at PubMed

PMID:4435359	PMID:10369263	PMID:14741744	PMID:17028112	PMID:21498505

Genomics

Comparative Map Data

Nsdhl
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	X	150,775,034 - 150,807,161 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	150,775,080 - 150,807,142 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	152,967,118 - 152,997,979 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	X	156,499,462 - 156,530,321 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	X	154,042,572 - 154,073,431 (+)	NCBI	Rnor_WKY
Rnor_6.0	X	152,933,118 - 152,964,399 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	152,933,069 - 152,964,390 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	148,661,899 - 148,693,982 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	158,923,025 - 158,954,914 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	158,996,457 - 159,028,346 (+)	NCBI
Celera	1	131,739,125 - 131,770,246 (+)	NCBI		Celera
Cytogenetic Map	X	q37	NCBI

NSDHL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	152,831,063 - 152,869,729 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	X	152,830,967 - 152,869,729 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	151,999,607 - 152,038,273 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	151,750,167 - 151,788,563 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	151,670,078 - 151,708,475	NCBI
Celera	X	152,333,895 - 152,372,297 (+)	NCBI		Celera
Cytogenetic Map	X	q28	NCBI
HuRef	X	140,816,165 - 140,839,247 (+)	NCBI		HuRef
CHM1_1	X	151,874,102 - 151,912,500 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	151,097,547 - 151,136,220 (+)	NCBI		T2T-CHM13v2.0

Nsdhl
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	71,962,127 - 72,002,134 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	71,962,163 - 72,002,120 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	72,918,521 - 72,958,528 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	72,918,557 - 72,958,514 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	70,163,860 - 70,203,867 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	69,171,241 - 69,211,248 (+)	NCBI		MGSCv36	mm8
Celera	X	63,853,687 - 63,881,911 (+)	NCBI		Celera
Cytogenetic Map	X	A7.3	NCBI
cM Map	X	37.29	NCBI

Nsdhl
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955498	8,135,897 - 8,161,775 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955498	8,135,897 - 8,161,775 (+)	NCBI	ChiLan1.0	ChiLan1.0

NSDHL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	X	152,898,679 - 152,937,146 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	142,405,340 - 142,443,723 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	152,324,553 - 152,362,931 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	152,324,553 - 152,362,931 (+)	Ensembl	panpan1.1		panPan2

NSDHL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	120,720,118 - 120,754,573 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	120,720,183 - 120,754,143 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	106,088,695 - 106,122,830 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	122,944,801 - 122,978,966 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	122,944,858 - 122,978,974 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	119,661,018 - 119,695,117 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	122,151,713 - 122,185,683 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	122,026,748 - 122,060,840 (+)	NCBI		UU_Cfam_GSD_1.0

Nsdhl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	117,982,486 - 118,009,864 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936714	246,551 - 273,912 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936714	246,574 - 273,930 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NSDHL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	123,906,199 - 123,929,117 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	123,906,130 - 123,921,935 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	141,376,781 - 141,391,919 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NSDHL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	127,342,788 - 127,389,117 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	127,342,850 - 127,390,536 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666065	65,176,040 - 65,215,613 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nsdhl
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624883	4,039,898 - 4,066,123 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624883	4,039,876 - 4,062,309 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Nsdhl
23 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	439
Count of miRNA genes:	217
Interacting mature miRNAs:	250
Transcripts:	ENSRNOT00000022985
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10059603	Bw174	Body weight QTL 174	3.4	0.025	body mass (VT:0001259)	body weight (CMO:0000012)	X	113937816	152453651	Rat
634346	Insul4	Insulin level QTL 4	0		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	X	126975089	152453651	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	20	55	41	19	41			74	33	32	11
Low		23	2				8	11		2	9		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001009399	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099682	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099683	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC087626	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474110	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000490	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000091154 ⟹ ENSRNOP00000069662

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	150,775,080 - 150,807,142 (+)	Ensembl
Rnor_6.0 Ensembl	X	152,933,069 - 152,964,390 (+)	Ensembl

RefSeq Acc Id:

NM_001009399 ⟹ NP_001009399

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	X	150,775,092 - 150,805,947 (+)	NCBI
Rnor_6.0	X	152,933,126 - 152,963,190 (+)	NCBI
Rnor_5.0	1	148,661,899 - 148,693,982 (+)	NCBI
RGSC_v3.4	X	158,923,025 - 158,954,914 (+)	RGD
Celera	1	131,739,125 - 131,770,246 (+)	NCBI

Sequence:

show sequence

CTGGTATTCAGCTGGAGTTCGCTGGTTGCCGGTTGCTTGCAAGCTGAGGTCTATCGTTTGAGTG
TCTAAACCCGGAAGAAGAGTTGATTACAAACGAGACCATACTTTGAGCCATAATGGAACAGGCT
GTTCGTAGTGAATCAAAGAAAGGCCAGGTCACAGGGACAGATTTGATAAATGAAGTTTCCAAAG
CTAAGAAGTGCACAGTGATTGGAGGCTCTGGGTTCCTGGGGCAGCACATGGTAGAGCAGTTGCT
ATCGCGAGGCTATGCTGTCAATGTATTTGATGTCCGCCAAGGCTTTGATAACCCTCGGGTGCAG
TTCTTCATAGGTGACCTGTGCAACCAACAGGACCTGTACCCAGCTCTCAAAGGTGTAAGCACAG
TTTTCCACTGTGCGTCACCCCCGTCAAACAGTAACAACAAGGAGCTCTTTTATAGAGTGAATTC
CACTGGCACCAAGACTGTCATTGAAACCTGCAAAGAGGCTGGAGTTCAGAAACTCATTTTAACC
AGCTCTGCCAGTGTTGTCTTTGAGGGTGTCGATATAAAAAATGGAACTGAAGACCTCCCTTATG
CCATGAAGCCCATTGACTACTATACAGAGACCAAGATCTTGCAGGAAAGAGCAGTACTGGATGC
CAACGACCCTAAGAAGAATTTTTTAACTGCAGCCATTCGTCCTCATGGCATATTTGGCCCAAGA
GATCCCCAGTTGGTCCCAGTCTTAATTGATGCAGCTAGAAAAGGCAAAATGAAGTTCATGATTG
GAAATGGGAAGAACCTGGTGGACTTCACCTTCGTGGAGAATGTAGTTCATGGACACATCTTAGC
AGCTGAGCACCTCTCTCGAGATGCAGGTCTGGGTGGGAAGGCATTTCACATCACCAACGATGAG
CCAATCCCTTTCTGGACGTTCCTGTCCCGCATTCTGACAGGCCTCAATTATGAGGCCCCCAAGT
ACCACATCCCCTACAGGGTGGCCTACTATCTTGCTTTCCTGCTATCTCTACTGGTAATGGTGCT
CAGCCCTCTCATCCAAATCCAGACAACTTTTACACCATTTCGGGTGGCACTGGCTGGAACATTC
CACTATTACAGTTGTGAGAAAGCCAAAAAGCTCATTGGGTACCGGCCACTGGTCACCATGGATG
ATGCTGTGGAAAGGACTGTGCAGAGTTTCCACCACCTGCGGAAGGACAAGTGAAGCTCCCCAGT
GCCCTCACCAGTAACTTTCTCCTCTCTGTTCTAAAGAACCAATATCCCTAAGTGAGTTTCTTCT
GAGCTGCATGCCCCTTGCTGGTTAGATGACAGCATACTTGACTCCCTCTATGATATTGGAGGTG
ACAACAACAGGAGACATTTCTCCCAGAATAGCATTGGACTTCTCAGGCAGACTCACAGTCTACT
GTTTTGGTCTTTCTCTCTCCTCCCCCTACTTCTGTCTCCTGGGTTCATTATCAGAAAGATAATA
CTAAAGTGAAAGCTTTGTTTAAGGTCTTAAAAATTGAAGAAAATCAGAAATTGTAAAGACAGTA
AGACTTCAGACATACATTTTATAAGATCACAGTACAATAGTTAGAAGTACTGATGAGTGTATTC
CCAATCCCTGGTCCCTAAGGCTAAATCCACTGCTTGTTCCTTGCTCCCTCGTATACTCTCAAGG
TCTCTTTCAAAGATGGTTGCAGTGTTTGTCTCCATTGTTTTTCCATAAAGTATTTCCATTTAAA
AAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_017602022 ⟹ XP_017457511

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	X	150,775,034 - 150,807,161 (+)	NCBI
Rnor_6.0	X	152,933,118 - 152,964,399 (+)	NCBI

Sequence:

show sequence

AAGGGTGGCTGGTATTCAGCTGGAGTTCGCTGGTTGCCGGTTGCTTGCAAGCTGAGGTCTATCG
TTTGAGTGTCTAAACCCGGCTAAGAAGTGCACAGTGATTGGAGGCTCTGGGTTCCTGGGGCAGC
ACATGGTAGAGCAGTTGCTATCGCGAGGCTATGCTGTCAATGTATTTGATGTCCGCCAAGGCTT
TGATAACCCTCGGGTGCAGTTCTTCATAGGTGACCTGTGCAACCAACAGGACCTGTACCCAGCT
CTCAAAGGTGTAAGCACAGTTTTCCACTGTGCGTCACCCCCGTCAAACAGTAACAACAAGGAGC
TCTTTTATAGAGTGAATTCCACTGGCACCAAGACTGTCATTGAAACCTGCAAAGAGGCTGGAGT
TCAGAAACTCATTTTAACCAGCTCTGCCAGTGTTGTCTTTGAGGGTGTCGATATAAAAAATGGA
ACTGAAGACCTCCCTTATGCCATGAAGCCCATTGACTACTATACAGAGACCAAGATCTTGCAGG
AAAGAGCAGTACTGGATGCCAACGACCCTAAGAAGAATTTTTTAACTGCAGCCATTCGTCCTCA
TGGCATATTTGGCCCAAGAGATCCCCAGTTGGTCCCAGTCTTAATTGATGCAGCTAGAAAAGGC
AAAATGAAGTTCATGATTGGAAATGGGAAGAACCTGGTGGACTTCACCTTCGTGGAGAATGTAG
TTCATGGACACATCTTAGCAGCTGAGCACCTCTCTCGAGATGCAGGTCTGGGTGGGAAGGCATT
TCACATCACCAACGATGAGCCAATCCCTTTCTGGACGTTCCTGTCCCGCATTCTGACAGGCCTC
AATTATGAGGCCCCCAAGTACCACATCCCCTACAGGGTGGCCTACTATCTTGCTTTCCTGCTAT
CTCTACTGGTAATGGTGCTCAGCCCTCTCATCCAAATCCAGACAACTTTTACACCATTTCGGGT
GGCACTGGCTGGAACATTCCACTATTACAGTTGTGAGAAAGCCAAAAAGCTCATTGGGTACCGG
CCACTGGTCACCATGGATGATGCTGTGGAAAGGACTGTGCAGAGTTTCCACCACCTGCGGAAGG
ACAAGTGAAGCTCCCCAGTGCCCTCACCAGTAACTTTCTCCTCTCTGTTCTAAAGAACCAATAT
CCCTAAGTGAGTTTCTTCTGAGCTGCATGCCCCTTGCTGGTTAGATGACAGCATACTTGACTCC
CTCTATGATATTGGAGGTGACAACAACAGGAGACATTTCTCCCAGAATAGCATTGGACTTCTCA
GGCAGACTCACAGTCTACTGTTTTGGTCTTTCTCTCTCCTCCCCCTACTTCTGTCTCCTGGGTT
CATTATCAGAAAGATAATACTAAAGTGAAAGCTTTGTTTAAGGTCTTAAAAATTGAAGAAAATC
AGAAATTGTAAAGACAGTAAGACTTCAGACATACATTTTATAAGATCACAGTACAATAGTTAGA
AGTACTGATGAGTGTATTCCCAATCCCTGGTCCCTAAGGCTAAATCCACTGCTTGTTCCTTGCT
CCCTCGTATACTCTCAAGGTCTCTTTCAAAGATGGTTGCAGTGTTTGTCTCCATTGTTTTTCCA
TAAAGTATTTCCATTTATCCACAGAATCTGGTGGTCTTTATTGCTCAGTGGTAATGCAATGCAA
TGGCACAGTGTGTGCTGTGTTAGCTGGTCAGCTCCTAATTCATAGGAGATGTTGGACTGCTTGG
CAATAATCCAAAGAGAGTGGCCTCCTTCATTGCTATGATGTTTGAGTAGAAACTCCTCCATGAG
ATGGTGCAAAACAGGCTACAGACACCTTTGCAGCTCACTTCACAGAACATTATCAGGCCACCTT
CTAAAGAGTACAGGCCACTAACAATCCAGCTATTTCTGTTCTCTGAACTCAGTCAAATGTATTC
TTGAAAAATTCTAAGCTCTTCTTCATCACTCTTCAAAAGTAAGAAGATGATTGGAAGAAAATAC
AACAAGGAGATAAAAGTCATACAGTTTGTGCTGCTGGCTTATTAGCTCTGCATGGGGAGGGGCC
ATGGTAAGTTGCCAAGGCATTCAGATATAAATGTAATTAAGATGCCATGTTTGCTTGCAGTAAT
GAAGTTATAATCAGAAACTGCTAAAGTATGATAAAAACAGTGATTGTTTATGCACTTATGGAAG
ACAAAGTGAAGTGATGTGGTTTCTTCAGAACAGGTGATGCACTGAGGTCGGACCTTGAAGGATG
GAGAGATGGTCACTGAGTGCATTTCTGACTAAAGATGTCAGTCTCATAGTCAGCAGCATGTGCT
TCTTGGCTGTATACAACTTCAGTTCAGTAGAGGACACAAGTGGGAAAGCCAGCTTGGGAAGCAG
TAGGACATTGGTCAGGCTAAAGAGGGAGGCAGGGAATAACCTTTACTCTGTAGATAAAGACAAC
CTGCGATGTTTCATACAATTAAAGATGTTCTCAATGGAGCGGAAAGATCAAGAAAATCCTCCTG
AGTACTCTACATGGGAGACCAGAGAGTAACAGCATAACAATGAGTTAGAAATAGAAGTACACAG
AAAGAAGATGCACCTCAGATGGTAACAAAGCTTGAGAGTTGCTCAGAACTGCTGGCTAAGAAGG
CAATAGGGCAAGCTAACAAACCCTGAGACCCAAATGCCTTAAAACTCCCTCAAAAATGTTAACA
GCACTTGGACCAAAAATGACCCTTGTCAATCTCAGGTGTCCAATGTGTTCTTCTTCCTTCTCCT
TTGTAAGCCTTCTTGTCACTGTAACAAAATACCTGAAATAAACAATTTGAGAAAAGGAAATGTT
CTTTAAAGAA

hide sequence

RefSeq Acc Id:

XM_039099682 ⟹ XP_038955610

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	X	150,775,044 - 150,807,161 (+)	NCBI

RefSeq Acc Id:

XM_039099683 ⟹ XP_038955611

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	X	150,775,049 - 150,807,161 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001009399	(Get FASTA)	NCBI Sequence Viewer
	XP_017457511	(Get FASTA)	NCBI Sequence Viewer
	XP_038955610	(Get FASTA)	NCBI Sequence Viewer
	XP_038955611	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH87626	(Get FASTA)	NCBI Sequence Viewer
	EDL82839	(Get FASTA)	NCBI Sequence Viewer
	Q5PPL3	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001009399 ⟸ NM_001009399

- UniProtKB:

Q5PPL3 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MEQAVRSESKKGQVTGTDLINEVSKAKKCTVIGGSGFLGQHMVEQLLSRGYAVNVFDVRQGFDN
PRVQFFIGDLCNQQDLYPALKGVSTVFHCASPPSNSNNKELFYRVNSTGTKTVIETCKEAGVQK
LILTSSASVVFEGVDIKNGTEDLPYAMKPIDYYTETKILQERAVLDANDPKKNFLTAAIRPHGI
FGPRDPQLVPVLIDAARKGKMKFMIGNGKNLVDFTFVENVVHGHILAAEHLSRDAGLGGKAFHI
TNDEPIPFWTFLSRILTGLNYEAPKYHIPYRVAYYLAFLLSLLVMVLSPLIQIQTTFTPFRVAL
AGTFHYYSCEKAKKLIGYRPLVTMDDAVERTVQSFHHLRKDK

hide sequence

RefSeq Acc Id:

XP_017457511 ⟸ XM_017602022

- Peptide Label:

isoform X2

- Sequence:

show sequence

MVEQLLSRGYAVNVFDVRQGFDNPRVQFFIGDLCNQQDLYPALKGVSTVFHCASPPSNSNNKEL
FYRVNSTGTKTVIETCKEAGVQKLILTSSASVVFEGVDIKNGTEDLPYAMKPIDYYTETKILQE
RAVLDANDPKKNFLTAAIRPHGIFGPRDPQLVPVLIDAARKGKMKFMIGNGKNLVDFTFVENVV
HGHILAAEHLSRDAGLGGKAFHITNDEPIPFWTFLSRILTGLNYEAPKYHIPYRVAYYLAFLLS
LLVMVLSPLIQIQTTFTPFRVALAGTFHYYSCEKAKKLIGYRPLVTMDDAVERTVQSFHHLRKD
K

hide sequence

RefSeq Acc Id:

ENSRNOP00000069662 ⟸ ENSRNOT00000091154

RefSeq Acc Id:	XP_038955610 ⟸ XM_039099682
- Peptide Label:	isoform X1
- UniProtKB:	Q5PPL3 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038955611 ⟸ XM_039099683
- Peptide Label:	isoform X3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5PPL3-F1-model_v2	AlphaFold	Q5PPL3	1-362	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13702030

Promoter ID:

EPDNEW_R12553

Type:

multiple initiation site

Name:

Nsdhl_1

Description:

NAD dependent steroid dehydrogenase-like

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	152,933,146 - 152,933,206	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359337	AgrOrtholog
BioCyc Gene	G2FUF-692	BioCyc
Ensembl Genes	ENSRNOG00000057814	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000069662	ENTREZGENE
	ENSRNOP00000069662.1	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000091154	ENTREZGENE
	ENSRNOT00000091154.2	UniProtKB/Swiss-Prot
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7317527	IMAGE-MGC_LOAD
InterPro	3Beta_OHSteriod_DH/Estase	UniProtKB/Swiss-Prot
	NAD(P)-bd_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:309262	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105618	IMAGE-MGC_LOAD
NCBI Gene	309262	ENTREZGENE
PANTHER	BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA	UniProtKB/Swiss-Prot
	EPIMERASE DOMAIN-CONTAINING PROTEIN	UniProtKB/Swiss-Prot
Pfam	3Beta_HSD	UniProtKB/Swiss-Prot
PhenoGen	Nsdhl	PhenoGen
Superfamily-SCOP	SSF51735	UniProtKB/Swiss-Prot
UniProt	NSDHL_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Nsdhl	NAD(P) dependent steroid dehydrogenase-like			Symbol and Name status set to approved	1299863	APPROVED
2005-07-29	Nsdhl	NAD(P) dependent steroid dehydrogenase-like			Symbol and Name status set to provisional	70820	PROVISIONAL

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InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

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Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)