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Gene: Tgfb3 (transforming growth factor, beta 3) Rattus norvegicus
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Symbol: Tgfb3
Name: transforming growth factor, beta 3
Description: Exhibits protein heterodimerization activity. Involved in several processes, including aging; regulation of signal transduction; and skeletal system morphogenesis. Localizes to several cellular components, including the T-tubule; extracellular space; and neuronal cell body. Biomarker of diabetic neuropathy. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 5; arrhythmogenic right ventricular cardiomyopathy; and arrhythmogenic right ventricular dysplasia 1. Orthologous to human TGFB3 (transforming growth factor beta 3); PARTICIPATES IN glypican signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; cell cycle pathway, mitotic; INTERACTS WITH (R)-noradrenaline; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MGC105479; TGF-B3; TGF-beta-3; transforming growth factor beta-3; transforming growth factor beta-3 proprotein
Orthologs:
Homo sapiens (human) : TGFB3 (transforming growth factor beta 3)  HGNC  Alliance
Mus musculus (house mouse) : Tgfb3 (transforming growth factor, beta 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tgfb3 (transforming growth factor beta 3)
Pan paniscus (bonobo/pygmy chimpanzee) : TGFB3 (transforming growth factor beta 3)
Canis lupus familiaris (dog) : TGFB3 (transforming growth factor beta 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tgfb3 (transforming growth factor beta 3)
Sus scrofa (pig) : TGFB3 (transforming growth factor beta 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.06109,913,757 - 109,936,217 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06119,222,052 - 119,244,512 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46110,173,443 - 110,195,215 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16110,176,974 - 110,198,746 (-)NCBI
Celera6103,530,785 - 103,552,563 (-)NCBICelera
Cytogenetic Map6q31NCBI
RH 3.4 Map6742.1RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Tgfb3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3851
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.