Tgfb3 (transforming growth factor, beta 3) - Rat Genome Database

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Gene: Tgfb3 (transforming growth factor, beta 3) Rattus norvegicus
Symbol: Tgfb3
Name: transforming growth factor, beta 3
RGD ID: 3851
Description: Predicted to enable several functions, including cytokine activity; transforming growth factor beta binding activity; and transforming growth factor beta receptor binding activity. Involved in several processes, including regulation of signal transduction; response to estrogen; and skeletal system morphogenesis. Located in several cellular components, including T-tubule; neuronal cell body; and secretory granule. Biomarker of diabetic neuropathy. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 5; arrhythmogenic right ventricular cardiomyopathy; and arrhythmogenic right ventricular dysplasia 1. Orthologous to human TGFB3 (transforming growth factor beta 3); PARTICIPATES IN glypican signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; cell cycle pathway, mitotic; INTERACTS WITH (R)-noradrenaline; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC105479; TGF-B3; TGF-beta-3; transforming growth factor beta-3; transforming growth factor beta-3 proprotein
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Uae22
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.26105,704,058 - 105,726,661 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6105,704,236 - 105,726,564 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6105,874,132 - 105,895,952 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06106,173,012 - 106,194,830 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06105,542,654 - 105,564,473 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06109,913,757 - 109,936,217 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6109,913,757 - 109,935,533 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06119,222,052 - 119,244,512 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46110,173,443 - 110,195,215 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16110,176,974 - 110,198,746 (-)NCBI
Celera6103,530,785 - 103,552,563 (-)NCBICelera
RH 3.4 Map6742.1RGD
Cytogenetic Map6q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-noradrenaline  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-methoxyethanol  (EXP)
2-nitrotoluene  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (EXP)
afimoxifene  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alpha-Zearalanol  (ISO)
AM-251  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
Brevetoxin B  (ISO)
bromochloroacetic acid  (EXP)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (EXP)
cantharidin  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
chlorthalidone  (EXP)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diazepam  (ISO)
diazinon  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diuron  (EXP)
endosulfan  (EXP)
erythromycin estolate  (EXP)
ethanol  (EXP)
fenamidone  (ISO)
fenbuconazole  (ISO)
fenpyroximate  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
GW 4064  (ISO)
hexachlorobenzene  (EXP)
hydrogen peroxide  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
levamisole  (ISO)
linuron  (ISO)
lipopolysaccharide  (ISO)
m-xylene  (EXP)
maneb  (ISO)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
microcystin-LR  (EXP)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naproxen  (EXP)
nickel dichloride  (EXP)
nitrofen  (EXP)
Nonylphenol  (ISO)
obeticholic acid  (ISO)
ormeloxifene  (EXP)
ouabain  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
perfluorooctanoic acid  (EXP)
phenylephrine  (EXP)
phenytoin  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
picoxystrobin  (ISO)
prazosin  (EXP)
progesterone  (ISO)
prostaglandin E2  (ISO)
pyrimidifen  (ISO)
quercetin  (EXP)
raloxifene  (ISO)
Rebamipide  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (EXP,ISO)
sulforaphane  (ISO)
sumatriptan  (EXP)
sunitinib  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tranilast  (EXP)
triphenyl phosphate  (EXP)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
cell population proliferation  (ISO)
cell-cell junction organization  (ISO,ISS)
cellular response to growth factor stimulus  (ISO)
detection of hypoxia  (ISO,ISS)
digestive tract development  (IEP)
embryonic neurocranium morphogenesis  (IDA)
epithelial cell proliferation  (ISO)
face morphogenesis  (ISO,ISS)
female pregnancy  (IEP)
filopodium assembly  (ISO)
frontal suture morphogenesis  (IEP)
gene expression  (ISO)
in utero embryonic development  (ISO)
inner ear development  (IEP)
lung alveolus development  (ISO)
lung development  (NAS)
mammary gland development  (ISO)
negative regulation of cell population proliferation  (IDA,ISO,ISS)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of macrophage cytokine production  (ISO,ISS)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (IDA)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
neuron apoptotic process  (ISO)
positive regulation of apoptotic process  (IDA,IMP,ISO)
positive regulation of cell division  (IEA)
positive regulation of cell population proliferation  (ISO,ISS)
positive regulation of collagen biosynthetic process  (ISO,ISS)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of epithelial to mesenchymal transition  (ISO,ISS)
positive regulation of filopodium assembly  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of MAPK cascade  (IDA)
positive regulation of protein secretion  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of tight junction disassembly  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of cell population proliferation  (IBA)
regulation of endothelial cell differentiation  (TAS)
regulation of epithelial cell differentiation  (TAS)
regulation of epithelial cell proliferation  (TAS)
regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
response to estrogen  (IDA)
response to hypoxia  (IEP,ISO,ISS)
response to laminar fluid shear stress  (IEP)
response to progesterone  (ISO,ISS)
roof of mouth development  (ISO)
salivary gland morphogenesis  (ISO,ISS)
secondary palate development  (ISO,ISS)
transforming growth factor beta receptor signaling pathway  (IBA,ISO,ISS)

Cellular Component


References - curated
# Reference Title Reference Citation
1. Nitric oxide attenuates the expression of transforming growth factor-beta(3) mRNA in rat cardiac fibroblasts via destabilization. Abdelaziz N, etal., Hypertension 2001 Aug;38(2):261-6.
2. Tgf-beta1, Tgf-beta2, Tgf-beta3 and Msx2 expression is elevated during frontonasal suture morphogenesis and during active postnatal facial growth. Adab K, etal., Orthod Craniofac Res. 2002 Nov;5(4):227-37.
3. Transforming growth factor-beta induces cellular injury in experimental diabetic neuropathy. Anjaneyulu M, etal., Exp Neurol. 2008 Jun;211(2):469-79. Epub 2008 Mar 2.
4. TGF-beta3 inhibits pentagastrin-stimulated gastric acid secretion in rats. Beckert S, etal., Med Sci Monit. 2005 Mar;11(3):BR80-3.
5. Growth associated proteins in tumor cells and stroma related to disease progression of colon cancer accounting for tumor tissue PGE2 content. Cahlin C, etal., Int J Oncol. 2008 Apr;32(4):909-18.
6. Involvement of protein kinase C-dependent mitogen-activated protein kinase p44/42 signaling pathway for cross-talk between estradiol and transforming growth factor-beta3 in increasing basic fibroblast growth factor in folliculostellate cells. Chaturvedi K and Sarkar DK, Endocrinology. 2004 Feb;145(2):706-15. Epub 2003 Nov 6.
7. Ontogenic expression of TGFbeta 1, 2, and 3 and its receptors in the rat gastric mucosa. de Andrade Sa ER, etal., Dev Dyn. 2003 Jul;227(3):450-7.
8. Localization of transforming growth factors, TGFbeta1 and TGFbeta3, in hypothalamic magnocellular neurones and the neurohypophysis. Fevre-Montange M, etal., J Neuroendocrinol. 2004 Jul;16(7):571-6.
9. Microarray analysis of mechanical shear effects on flexor tendon cells. Fong KD, etal., Plast Reconstr Surg. 2005 Oct;116(5):1393-404; discussion 1405-6.
10. Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival. Friess H, etal., Gastroenterology. 1993 Dec;105(6):1846-56. doi: 10.1016/0016-5085(93)91084-u.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Effects of endogenous carbon monoxide on collagen synthesis in pulmonary artery in rats under hypoxia. Gong LM, etal., Life Sci. 2004 Jan 23;74(10):1225-41.
14. Zhonghua xin xue guan bing za zhi Hu BC, etal., Zhonghua Xin Xue Guan Bing Za Zhi. 2005 Feb;33(2):127-31.
15. Transforming growth factor-beta 1, 2, 3 and receptor type I and II in diabetic foot ulcers. Jude EB, etal., Diabet Med. 2002 Jun;19(6):440-7.
16. Expression of TGFbeta family in the developing internal ear of rat embryos. Kim HJ, etal., J Korean Med Sci. 2006 Feb;21(1):136-42.
17. Effects of TGF-betas and a specific antagonist on apoptosis of immature rat male germ cells in vitro. Konrad L, etal., Apoptosis. 2006 May;11(5):739-48.
18. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
19. Both high intratumoral microvessel density determined using CD105 antibody and elevated plasma levels of CD105 in colorectal cancer patients correlate with poor prognosis. Li C, etal., Br J Cancer. 2003 May 6;88(9):1424-31.
20. Differential protein expression and subcellular distribution of TGFbeta1, beta2 and beta3 in cardiomyocytes during pressure overload-induced hypertrophy. Li JM and Brooks G, J Mol Cell Cardiol. 1997 Aug;29(8):2213-24.
21. Requirement of Smad3 and CREB-1 in mediating transforming growth factor-beta (TGF beta) induction of TGF beta 3 secretion. Liu G, etal., J Biol Chem. 2006 Oct 6;281(40):29479-90. Epub 2006 Aug 4.
22. Transforming growth factor beta3 regulates the dynamics of Sertoli cell tight junctions via the p38 mitogen-activated protein kinase pathway. Lui WY, etal., Biol Reprod. 2003 May;68(5):1597-612. Epub 2002 Nov 27.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
26. Transforming growth factor-beta 2 and TGF-beta 3 regulate fetal rat cranial suture morphogenesis by regulating rates of cell proliferation and apoptosis. Opperman LA, etal., Dev Dyn. 2000 Oct;219(2):237-47.
27. Transforming growth factor-beta3 (Tgf-beta3) down-regulates Tgf-beta3 receptor type I (Tbetar-I) during rescue of cranial sutures from osseous obliteration. Opperman LA, etal., Orthod Craniofac Res 2002 Feb;5(1):5-16.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
30. Transforming growth factor-beta stimulates vascular endothelial growth factor production by folliculostellate pituitary cells. Renner U, etal., Endocrinology 2002 Oct;143(10):3759-65.
31. GOA pipeline RGD automated data pipeline
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Temporal and spatial expression of Pax9 and Sonic hedgehog during development of normal mouse palates and cleft palates in TGF-beta3 null embryos. Sasaki Y, etal., Arch Oral Biol. 2007 Mar;52(3):260-7. Epub 2006 Nov 13.
35. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Shi Y and Massague J, Cell. 2003 Jun 13;113(6):685-700.
36. TGF-beta expression during rat pregnancy and activity on decidual cell survival. Shooner C, etal., Reprod Biol Endocrinol. 2005 May 31;3:20.
37. Genetic association studies of cleft lip and/or palate with hypodontia outside the cleft region. Slayton RL, etal., Cleft Palate Craniofac J. 2003 May;40(3):274-9.
38. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
39. Regulation of TGF-beta ligand and receptor expression in neonatal rat lungs exposed to chronic hypoxia. Vicencio AG, etal., J Appl Physiol 2002 Sep;93(3):1123-30.
40. MSX1 and TGFB3 contribute to clefting in South America. Vieira AR, etal., J Dent Res. 2003 Apr;82(4):289-92.
41. Differential cytokine activity and morphology during wound healing in the neonatal and adult rat skin. Wagner W and Wehrmann M, J Cell Mol Med. 2007 Nov-Dec;11(6):1342-51.
42. Cloning and expression of glucocorticoid-induced genes in fetal rat lung fibroblasts. Transforming growth factor-beta 3. Wang J, etal., J Biol Chem 1995 Feb 10;270(6):2722-8.
43. Inhibitory effects of tranilast on expression of transforming growth factor-beta isoforms and receptors in injured arteries. Ward MR, etal., Atherosclerosis. 1998 Apr;137(2):267-75. doi: 10.1016/s0021-9150(97)00275-x.
44. Quantitative monitoring of the mRNA expression pattern of the TGF-beta-isoforms (beta 1, beta 2, beta 3) during transdifferentiation of hepatic stellate cells using a newly developed real-time SYBR Green PCR. Wickert L, etal., Biochem Biophys Res Commun 2002 Jul 12;295(2):330-5.
45. Cell-type-specific activation of PAK2 by transforming growth factor beta independent of Smad2 and Smad3. Wilkes MC, etal., Mol Cell Biol. 2003 Dec;23(23):8878-89.
46. Effects of aging on growth factors gene and protein expression in the dorsal and ventral lobes of rat prostate. Zhao H, etal., Biochem Biophys Res Commun 2002 Mar 29;292(2):482-91.
47. Transforming growth factor-beta(s) and their receptors in aging rat prostate. Zhao H, etal., Biochem Biophys Res Commun. 2002 Jun 7;294(2):464-9.
Additional References at PubMed
PMID:1333888   PMID:1821856   PMID:7493021   PMID:7493022   PMID:7848824   PMID:8167376   PMID:8509457   PMID:10433915   PMID:10521784   PMID:11157754   PMID:11158066   PMID:12198241  
PMID:12477932   PMID:12480179   PMID:12639893   PMID:12789468   PMID:12815624   PMID:14691138   PMID:14697364   PMID:14729481   PMID:15122060   PMID:15375625   PMID:15882576   PMID:15961560  
PMID:16245336   PMID:16617054   PMID:16806156   PMID:17159989   PMID:17401695   PMID:18039789   PMID:18049952   PMID:18080134   PMID:18156205   PMID:18243111   PMID:18471258   PMID:18498113  
PMID:18505915   PMID:18718461   PMID:18790002   PMID:19073914   PMID:19103189   PMID:19161227   PMID:19651533   PMID:19656380   PMID:20534521   PMID:20653032   PMID:20682309   PMID:20875417  
PMID:21308733   PMID:21423151   PMID:21865583   PMID:21984612   PMID:22528365   PMID:23750457   PMID:24092879   PMID:24142722   PMID:24306208   PMID:26113040   PMID:26315405   PMID:26356269  
PMID:26637070   PMID:27108397   PMID:28912269   PMID:30537736   PMID:31176490   PMID:34592976   PMID:34696976   PMID:35028925  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.26105,704,058 - 105,726,661 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6105,704,236 - 105,726,564 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6105,874,132 - 105,895,952 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06106,173,012 - 106,194,830 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06105,542,654 - 105,564,473 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06109,913,757 - 109,936,217 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6109,913,757 - 109,935,533 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06119,222,052 - 119,244,512 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46110,173,443 - 110,195,215 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16110,176,974 - 110,198,746 (-)NCBI
Celera6103,530,785 - 103,552,563 (-)NCBICelera
RH 3.4 Map6742.1RGD
Cytogenetic Map6q31NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381475,958,097 - 75,983,011 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1475,958,097 - 75,983,011 (-)EnsemblGRCh38hg38GRCh38
GRCh371476,424,440 - 76,449,354 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361475,494,195 - 75,517,242 (-)NCBINCBI36Build 36hg18NCBI36
Build 341475,494,194 - 75,517,242NCBI
Celera1456,462,579 - 56,486,236 (-)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1456,593,103 - 56,616,766 (-)NCBIHuRef
CHM1_11476,362,235 - 76,385,896 (-)NCBICHM1_1
T2T-CHM13v2.01470,167,287 - 70,192,202 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391286,103,517 - 86,125,815 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1286,103,519 - 86,125,815 (-)EnsemblGRCm39 Ensembl
GRCm381286,056,743 - 86,079,041 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1286,056,745 - 86,079,041 (-)EnsemblGRCm38mm10GRCm38
MGSCv371287,397,693 - 87,419,991 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361286,945,847 - 86,967,637 (-)NCBIMGSCv36mm8
Celera1287,516,891 - 87,539,154 (-)NCBICelera
Cytogenetic Map12D2NCBI
cM Map1240.09NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495543829,415 - 55,180 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543833,129 - 55,180 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11476,263,873 - 76,289,264 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01456,516,697 - 56,542,097 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11475,359,505 - 75,382,412 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1475,359,505 - 75,382,412 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1848,920,874 - 48,946,037 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl848,923,423 - 48,945,816 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha848,603,511 - 48,629,028 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0849,145,129 - 49,170,643 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl849,147,212 - 49,170,366 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1848,817,670 - 48,843,148 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0848,839,598 - 48,865,116 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0849,235,714 - 49,261,227 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440864027,060,257 - 27,083,429 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364884,986,748 - 5,008,496 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364884,986,712 - 5,008,728 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl799,133,879 - 99,162,232 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1799,133,873 - 99,162,239 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27105,178,639 - 105,208,968 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12453,203,593 - 53,227,483 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2453,203,301 - 53,227,325 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605341,419,765 - 41,443,760 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462473425,716,972 - 25,739,199 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473425,717,011 - 25,739,942 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Tgfb3
97 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:475
Count of miRNA genes:243
Interacting mature miRNAs:292
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,704,264 - 105,704,588 (+)MAPPERmRatBN7.2
Rnor_6.06109,913,824 - 109,914,147NCBIRnor6.0
Rnor_5.06119,222,119 - 119,222,442UniSTSRnor5.0
RGSC_v3.46110,173,506 - 110,173,829UniSTSRGSC3.4
Celera6103,530,852 - 103,531,175UniSTS
Cytogenetic Map6q31UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,704,286 - 105,704,442 (+)MAPPERmRatBN7.2
Rnor_6.06109,913,846 - 109,914,001NCBIRnor6.0
Rnor_5.06119,222,141 - 119,222,296UniSTSRnor5.0
RGSC_v3.46110,173,528 - 110,173,683UniSTSRGSC3.4
Celera6103,530,874 - 103,531,029UniSTS
RH 3.4 Map6742.1UniSTS
Cytogenetic Map6q31UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 43 8 2 2 2 6 9 20 34 11 6
Low 3 49 39 17 39 2 2 74 15 7 2
Below cutoff


RefSeq Acc Id: ENSRNOT00000013516   ⟹   ENSRNOP00000013516
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6105,704,236 - 105,726,564 (-)Ensembl
Rnor_6.0 Ensembl6109,913,757 - 109,935,533 (-)Ensembl
RefSeq Acc Id: NM_013174   ⟹   NP_037306
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.26105,704,198 - 105,725,975 (-)NCBI
Rnor_6.06109,913,757 - 109,935,533 (-)NCBI
Rnor_5.06119,222,052 - 119,244,512 (-)NCBI
RGSC_v3.46110,173,443 - 110,195,215 (-)RGD
Celera6103,530,785 - 103,552,563 (-)NCBI
RefSeq Acc Id: XM_006240366   ⟹   XP_006240428
Rat AssemblyChrPosition (strand)Source
mRatBN7.26105,704,058 - 105,726,661 (-)NCBI
Rnor_6.06109,913,757 - 109,936,217 (-)NCBI
Rnor_5.06119,222,052 - 119,244,512 (-)NCBI
RefSeq Acc Id: XM_039111816   ⟹   XP_038967744
Rat AssemblyChrPosition (strand)Source
mRatBN7.26105,704,058 - 105,726,661 (-)NCBI
RefSeq Acc Id: NP_037306   ⟸   NM_013174
- Peptide Label: preproprotein
- UniProtKB: Q56A31 (UniProtKB/Swiss-Prot),   Q07258 (UniProtKB/Swiss-Prot),   A6JE51 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240428   ⟸   XM_006240366
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000013516   ⟸   ENSRNOT00000013516
RefSeq Acc Id: XP_038967744   ⟸   XM_039111816
- Peptide Label: isoform X1
- UniProtKB: Q07258 (UniProtKB/Swiss-Prot),   Q56A31 (UniProtKB/Swiss-Prot),   A6JE51 (UniProtKB/TrEMBL)
Protein Domains
TGF-beta family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q07258-F1-model_v2 AlphaFold Q07258 1-412 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3851 AgrOrtholog
BioCyc Gene G2FUF-36762 BioCyc
Ensembl Genes ENSRNOG00000009867 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013516 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cystine-knot cytokines UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFB3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25717 UniProtKB/Swiss-Prot
PANTHER PTHR11848 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tgfb3 PhenoGen
PIRSF TGF-beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFBETA3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009867 RatGTEx
SMART TGFB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Cystine-knot cytokines UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC217795
  TGFB3_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q56A31 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Tgfb3  transforming growth factor, beta 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression lacking in young prostates but present in both the stroma and epithelium of aging prostates 70812
gene_expression expression peaks in fetal lung fibroblasts during early canalicular stage 70296
gene_expression expression peaks in fetal lung fibroblasts during early canalicular stage 70329
gene_function inhibits pentagastrin-induced gastric acid secretion when administered either before or after pentagastrin treatment 1579861
gene_process may function in cell growth and remodeling of extracellular matrix; may be involved in development of interstitial fibrosis 70329
gene_process stimulates growth of fetal lung epithelial cells at low concentrations and inhibits differentiation at higher concentrations 70296
gene_process stimulates growth of fetal lung epithelial cells at low concentrations and inhibits differentiation at higher concentrations 70329
gene_process may play a role in fetal lung maturation 70296
gene_regulation down-regulates its own expression 70296
gene_regulation down-regulates its own expression 70329
gene_regulation transcrpition induced by triiodothyronine (T3) 70670
gene_regulation induced by glucocorticoids 70296
gene_regulation induced by glucocorticoids 70329