Gene: Nthl1 (nth-like DNA glycosylase 1) Rattus norvegicus
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Symbol: Nthl1
Name: nth-like DNA glycosylase 1
Description: ENCODES a protein that exhibits class I DNA-(apurinic or apyrimidinic site) endonuclease activity (ortholog); DNA N-glycosylase activity (ortholog); DNA-(apurinic or apyrimidinic site) endonuclease activity (ortholog); INVOLVED IN base-excision repair, AP site formation (ortholog); nucleotide-excision repair, DNA incision, 5'-to lesion (ortholog); PARTICIPATES IN base excision repair pathway; ASSOCIATED WITH Acute Hepatitis; familial adenomatous polyposis (ortholog); familial adenomatous polyposis 3 (ortholog); FOUND IN mitochondrion (ortholog); nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; aniline
AGR Description: Predicted to have class I DNA-(apurinic or apyrimidinic site) endonuclease activity, double-stranded DNA binding activity, and oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity; predicted to be involved in base-excision repair, AP site formation and nucleotide-excision repair, DNA incision, 5'-to lesion; predicted to localize to the mitochondrion and nucleus; orthologous to human NTHL1 (nth like DNA glycosylase 1).
Merged Description: Predicted to have class I DNA-(apurinic or apyrimidinic site) endonuclease activity, double-stranded DNA binding activity, and oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity; predicted to be involved in base-excision repair, AP site formation and nucleotide-excision repair, DNA incision, 5'-to lesion; predicted to localize to the mitochondrion and nucleus; orthologous to human NTHL1 (nth like DNA glycosylase 1); PARTICIPATES IN base excision repair pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; aniline.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: endonuclease III-like protein 1; nth (endonuclease III)-like 1 (E.coli); nth endonuclease III-like 1; Nth1; thymine glycol DNA glycosylase/AP lyase
Orthologs:
Homo sapiens (human) : NTHL1 (nth like DNA glycosylase 1)  HGNC  Alliance
Mus musculus (house mouse) : Nthl1 (nth (endonuclease III)-like 1 (E.coli))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nthl1 (nth like DNA glycosylase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NTHL1 (nth like DNA glycosylase 1)
Canis lupus familiaris (dog) : NTHL1 (nth like DNA glycosylase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nthl1 (nth like DNA glycosylase 1)
Sus scrofa (pig) : NTHL1 (nth like DNA glycosylase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01013,996,660 - 14,002,827 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01013,813,645 - 13,819,807 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,883,284 - 13,889,790 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11013,883,284 - 13,889,789 (+)NCBI
Celera1013,335,808 - 13,342,040 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Nthl1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1309289
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.