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Gene: Npc2 (NPC intracellular cholesterol transporter 2) Rattus norvegicus
Symbol: Npc2
Name: NPC intracellular cholesterol transporter 2
RGD ID: 628756
Description: Predicted to have cholesterol binding activity; cholesterol transfer activity; and enzyme binding activity. Predicted to be involved in cholesterol homeostasis; cholesterol transport; and response to virus. Predicted to localize to extracellular space and lysosome. Human ortholog(s) of this gene implicated in Niemann-Pick disease and Niemann-Pick disease type C2. Orthologous to human NPC2 (NPC intracellular cholesterol transporter 2); INTERACTS WITH 2,4-dinitrotoluene; acrylamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: epididymal secretory protein 1; epididymal secretory protein E1; Niemann Pick type C2; Niemann-Pick disease, type C2; re1
Homo sapiens (human) : NPC2 (NPC intracellular cholesterol transporter 2)  HGNC  Alliance
Mus musculus (house mouse) : Npc2 (NPC intracellular cholesterol transporter 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Npc2 (NPC intracellular cholesterol transporter 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NPC2 (NPC intracellular cholesterol transporter 2)
Canis lupus familiaris (dog) : NPC2 (NPC intracellular cholesterol transporter 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Npc2 (NPC intracellular cholesterol transporter 2)
Sus scrofa (pig) : NPC2 (NPC intracellular cholesterol transporter 2)
Chlorocebus sabaeus (African green monkey) : NPC2 (NPC intracellular cholesterol transporter 2)
Heterocephalus glaber (naked mole-rat) : Npc2 (NPC intracellular cholesterol transporter 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.06108,467,410 - 108,488,330 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6108,467,410 - 108,488,330 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06117,060,860 - 117,081,780 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46108,793,935 - 108,814,703 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16108,797,391 - 108,818,159 (-)NCBI
Celera6102,222,115 - 102,243,035 (-)NCBICelera
Cytogenetic Map6q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Npc2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 628756
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.