Drosha (drosha ribonuclease III) - Rat Genome Database

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Gene: Drosha (drosha ribonuclease III) Rattus norvegicus
Analyze
Symbol: Drosha
Name: drosha ribonuclease III
RGD ID: 1307626
Description: Predicted to enable several functions, including DEAD/H-box RNA helicase binding activity; R-SMAD binding activity; and lipopolysaccharide binding activity. Predicted to be involved in defense response to bacterium; miRNA processing; and positive regulation of gene expression. Predicted to act upstream of or within several processes, including miRNA metabolic process; regulation of miRNA metabolic process; and regulation of regulatory T cell differentiation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of microprocessor complex. Predicted to be active in glutamatergic synapse; nucleus; and postsynaptic density. Orthologous to human DROSHA (drosha ribonuclease III); PARTICIPATES IN microRNA pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: drosha, ribonuclease type III; ethanol induced 2; Etohi2; LOC310159; RGD1307626; ribonuclease 3; ribonuclease III, nuclear; ribonuclease type III, nuclear; Rn3; Rnasen; similar to Ribonuclease III (RNase III) (p241)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8263,591,885 - 63,703,688 (+)NCBIGRCr8
mRatBN7.2261,864,886 - 61,976,688 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl261,864,970 - 61,976,688 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx268,993,506 - 69,106,954 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0267,116,207 - 67,229,662 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0262,117,683 - 62,231,110 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0262,887,267 - 63,000,307 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl262,887,267 - 62,999,572 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0281,692,120 - 81,804,978 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4262,336,007 - 62,447,618 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1262,264,382 - 62,375,798 (+)NCBI
Celera256,722,605 - 56,834,195 (-)NCBICelera
Cytogenetic Map2q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-chloro-7-iodoquinolin-8-ol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
carvedilol  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
DDE  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
doxorubicin  (ISO)
ethanol  (ISO)
finasteride  (EXP)
flutamide  (EXP)
FR900359  (ISO)
gentamycin  (EXP)
ketoconazole  (EXP)
methimazole  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
sodium arsenite  (ISO)
sucrose  (ISO)
sulfadimethoxine  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The widespread regulation of microRNA biogenesis, function and decay. Krol J, etal., Nat Rev Genet. 2010 Sep;11(9):597-610. Epub 2010 Jul 27.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:14508493   PMID:15530651   PMID:15574589   PMID:18548003   PMID:18604195   PMID:18725527   PMID:20180804   PMID:20424607   PMID:22000014   PMID:22053081   PMID:22658674   PMID:22681889  
PMID:22897173   PMID:28819115   PMID:31507089   PMID:36222340  


Genomics

Comparative Map Data
Drosha
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8263,591,885 - 63,703,688 (+)NCBIGRCr8
mRatBN7.2261,864,886 - 61,976,688 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl261,864,970 - 61,976,688 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx268,993,506 - 69,106,954 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0267,116,207 - 67,229,662 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0262,117,683 - 62,231,110 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0262,887,267 - 63,000,307 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl262,887,267 - 62,999,572 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0281,692,120 - 81,804,978 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4262,336,007 - 62,447,618 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1262,264,382 - 62,375,798 (+)NCBI
Celera256,722,605 - 56,834,195 (-)NCBICelera
Cytogenetic Map2q16NCBI
DROSHA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38531,400,494 - 31,532,093 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl531,400,494 - 31,532,196 (-)EnsemblGRCh38hg38GRCh38
GRCh37531,400,601 - 31,532,200 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36531,436,358 - 31,568,039 (-)NCBINCBI36Build 36hg18NCBI36
Celera531,281,095 - 31,412,752 (-)NCBICelera
Cytogenetic Map5p13.3NCBI
HuRef531,368,999 - 31,500,422 (-)NCBIHuRef
CHM1_1531,402,053 - 31,533,647 (-)NCBICHM1_1
T2T-CHM13v2.0531,514,128 - 31,645,804 (-)NCBIT2T-CHM13v2.0
Drosha
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391512,824,893 - 12,935,377 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1512,824,901 - 12,935,377 (+)EnsemblGRCm39 Ensembl
GRCm381512,824,804 - 12,935,291 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1512,824,815 - 12,935,291 (+)EnsemblGRCm38mm10GRCm38
MGSCv371512,754,570 - 12,865,046 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361512,778,615 - 12,879,971 (+)NCBIMGSCv36mm8
Celera1512,603,657 - 12,710,691 (+)NCBICelera
Cytogenetic Map15A1NCBI
cM Map155.99NCBI
Drosha
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542617,387,534 - 17,502,294 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542617,387,595 - 17,505,126 (-)NCBIChiLan1.0ChiLan1.0
DROSHA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2478,786,664 - 78,917,884 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1576,940,301 - 77,071,537 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0578,813,923 - 78,945,149 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1584,191,596 - 84,322,590 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl584,194,546 - 84,322,310 (+)Ensemblpanpan1.1panPan2
DROSHA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha475,406,973 - 75,528,472 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0476,334,752 - 76,456,036 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl476,334,773 - 76,456,039 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1476,027,994 - 76,149,740 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0476,157,564 - 76,278,792 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0476,685,947 - 76,807,515 (+)NCBIUU_Cfam_GSD_1.0
Drosha
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213222,153,551 - 222,271,819 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365189,106,142 - 9,219,174 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365189,100,094 - 9,218,405 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DROSHA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1617,565,137 - 17,848,162 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11617,727,695 - 17,847,954 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21618,544,660 - 18,667,126 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DROSHA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1430,665,759 - 30,807,047 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl430,665,131 - 30,795,442 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607120,896,595 - 21,030,930 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Drosha
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475922,949,150 - 23,082,487 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475922,949,225 - 23,082,263 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Drosha
535 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:394
Count of miRNA genes:173
Interacting mature miRNAs:196
Transcripts:ENSRNOT00000018032, ENSRNOT00000048026
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)259846005104846005Rat
6480225Gdil1Gastrointestinal dilation QTL 1enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)25666087974786777Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)259324719102755241Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)259324377103795077Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)259324377103795077Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354592Rf50Renal function QTL 503.5urine output (VT:0003620)timed urine volume (CMO:0000260)25382274774786777Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)25760561276539510Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000048026   ⟹   ENSRNOP00000050633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl261,864,970 - 61,976,688 (+)Ensembl
Rnor_6.0 Ensembl262,887,267 - 62,999,572 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098160   ⟹   ENSRNOP00000076463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl261,865,011 - 61,976,685 (+)Ensembl
RefSeq Acc Id: NM_001107655   ⟹   NP_001101125
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8263,591,978 - 63,703,688 (+)NCBI
mRatBN7.2261,864,970 - 61,976,688 (+)NCBI
Rnor_6.0262,887,267 - 62,999,572 (+)NCBI
Rnor_5.0281,692,120 - 81,804,978 (-)NCBI
RGSC_v3.4262,336,007 - 62,447,618 (+)RGD
Celera256,722,605 - 56,834,195 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006232050   ⟹   XP_006232112
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8263,591,885 - 63,703,685 (+)NCBI
mRatBN7.2261,864,886 - 61,976,685 (+)NCBI
Rnor_6.0262,896,155 - 63,000,307 (+)NCBI
Rnor_5.0281,692,120 - 81,804,978 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039102205   ⟹   XP_038958133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8263,591,906 - 63,703,685 (+)NCBI
mRatBN7.2261,864,898 - 61,976,685 (+)NCBI
RefSeq Acc Id: XM_039102206   ⟹   XP_038958134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8263,591,894 - 63,703,685 (+)NCBI
mRatBN7.2261,864,886 - 61,976,685 (+)NCBI
RefSeq Acc Id: XM_039102207   ⟹   XP_038958135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8263,591,906 - 63,703,685 (+)NCBI
mRatBN7.2261,864,898 - 61,976,685 (+)NCBI
RefSeq Acc Id: XM_063281744   ⟹   XP_063137814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8263,591,906 - 63,703,685 (+)NCBI
RefSeq Acc Id: XM_063281745   ⟹   XP_063137815
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8263,591,885 - 63,659,910 (+)NCBI
RefSeq Acc Id: NP_001101125   ⟸   NM_001107655
- UniProtKB: E9PTR3 (UniProtKB/TrEMBL),   A0A8I5Y0A2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232112   ⟸   XM_006232050
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y0A2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000050633   ⟸   ENSRNOT00000048026
RefSeq Acc Id: XP_038958134   ⟸   XM_039102206
- Peptide Label: isoform X1
- UniProtKB: E9PTR3 (UniProtKB/TrEMBL),   A0A8I5Y0A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958135   ⟸   XM_039102207
- Peptide Label: isoform X1
- UniProtKB: E9PTR3 (UniProtKB/TrEMBL),   A0A8I5Y0A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958133   ⟸   XM_039102205
- Peptide Label: isoform X1
- UniProtKB: E9PTR3 (UniProtKB/TrEMBL),   A0A8I5Y0A2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000076463   ⟸   ENSRNOT00000098160
RefSeq Acc Id: XP_063137815   ⟸   XM_063281745
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063137814   ⟸   XM_063281744
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y0A2 (UniProtKB/TrEMBL)
Protein Domains
DRBM   RNase III

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PTR3-F1-model_v2 AlphaFold E9PTR3 1-1373 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691196
Promoter ID:EPDNEW_R1721
Type:initiation region
Name:Drosha_1
Description:drosha ribonuclease III
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0262,887,275 - 62,887,335EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307626 AgrOrtholog
BioCyc Gene G2FUF-54037 BioCyc
Ensembl Genes ENSRNOG00000013451 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000048026.7 UniProtKB/TrEMBL
  ENSRNOT00000098160.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1520.10 UniProtKB/TrEMBL
  3.30.160.20 UniProtKB/TrEMBL
InterPro dsRNA-bd-like UniProtKB/TrEMBL
  RNase_III UniProtKB/TrEMBL
  RNase_III_bac UniProtKB/TrEMBL
  RNAse_III_DSRM__animal UniProtKB/TrEMBL
  RNase_III_sf UniProtKB/TrEMBL
KEGG Report rno:310159 UniProtKB/TrEMBL
NCBI Gene 310159 ENTREZGENE
PANTHER PTHR11207 UniProtKB/TrEMBL
  RIBONUCLEASE 3 UniProtKB/TrEMBL
Pfam dsrm UniProtKB/TrEMBL
  Ribonucleas_3_3 UniProtKB/TrEMBL
  Ribonuclease_3 UniProtKB/TrEMBL
PhenoGen Drosha PhenoGen
PROSITE DS_RBD UniProtKB/TrEMBL
  RNASE_3_1 UniProtKB/TrEMBL
  RNASE_3_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013451 RatGTEx
SMART DSRM UniProtKB/TrEMBL
  RIBOc UniProtKB/TrEMBL
Superfamily-SCOP dsRNA-binding domain-like UniProtKB/TrEMBL
  RNase_III UniProtKB/TrEMBL
UniProt A0A8I5Y0A2 ENTREZGENE, UniProtKB/TrEMBL
  E9PTR3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Drosha  drosha ribonuclease III  Drosha  drosha, ribonuclease type III  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-01 Drosha  drosha, ribonuclease type III  Rnasen  ribonuclease type III, nuclear  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-20 Rnasen  ribonuclease type III, nuclear  Rnasen  ribonuclease III, nuclear  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Rnasen  ribonuclease III, nuclear  RGD1307626  similar to Ribonuclease III (RNase III) (p241)  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1307626  similar to Ribonuclease III (RNase III) (p241)  RGD1307626_predicted  similar to Ribonuclease III (RNase III) (p241) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1307626_predicted  similar to Ribonuclease III (RNase III) (p241) (predicted)  LOC310159_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC310159_predicted  similar to Ribonuclease III (RNase III) (p241) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL