Pnpla6 (patatin-like phospholipase domain containing 6) - Rat Genome Database

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Gene: Pnpla6 (patatin-like phospholipase domain containing 6) Rattus norvegicus
Analyze
Symbol: Pnpla6
Name: patatin-like phospholipase domain containing 6
RGD ID: 1564611
Description: Predicted to enable lysophospholipase activity. Predicted to be involved in lipid catabolic process and phosphatidylcholine metabolic process. Predicted to act upstream of or within angiogenesis and animal organ morphogenesis. Predicted to be located in cytosol and membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Boucher-Neuhauser syndrome; Laurence-Moon syndrome; Oliver-McFarlane syndrome; and hereditary spastic paraplegia 39. Orthologous to human PNPLA6 (patatin like phospholipase domain containing 6); PARTICIPATES IN glycerophospholipid metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC360753; neuropathy target esterase; patatin-like phospholipase domain-containing protein 6; RGD1564611; similar to neuropathy target esterase homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8126,372,284 - 6,401,632 (+)NCBIGRCr8
mRatBN7.2121,574,387 - 1,603,735 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,560,363 - 1,603,734 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0122,068,749 - 2,098,139 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,069,959 - 2,097,904 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0124,232,111 - 4,260,327 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4122,610,552 - 2,638,753 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera123,430,758 - 3,460,163 (+)NCBICelera
Cytogenetic Map12p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-fluorouracil  (ISO)
9-(tetrahydrofuryl)adenine  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzylpenicillin  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bucladesine  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbaryl  (EXP)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
chlorpyrifos  (ISO)
cidofovir anhydrous  (ISO)
clodronic acid  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) chloride  (ISO)
coumarin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP)
DDE  (ISO)
diarsenic trioxide  (ISO)
dichlorvos  (EXP,ISO)
dieldrin  (ISO)
diethylstilbestrol  (EXP)
diisopropyl fluorophosphate  (EXP,ISO)
dioxygen  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glycerylphosphorylcholine  (ISO)
ketoconazole  (EXP)
lysophosphatidylcholine  (ISO)
malaoxon  (ISO)
metformin  (EXP)
methamidophos  (EXP,ISO)
Mipafox  (EXP,ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
nickel atom  (ISO)
paracetamol  (ISO)
paraoxon  (ISO)
phenobarbital  (ISO)
phenol  (ISO)
phenylmethanesulfonyl fluoride  (ISO)
phosphatidylcholine  (ISO)
pirinixic acid  (ISO)
saccharin  (ISO)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
succimer  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichlorfon  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12514188   PMID:14749382   PMID:15044461   PMID:18086666   PMID:19946888   PMID:28206686  


Genomics

Comparative Map Data
Pnpla6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8126,372,284 - 6,401,632 (+)NCBIGRCr8
mRatBN7.2121,574,387 - 1,603,735 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,560,363 - 1,603,734 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0122,068,749 - 2,098,139 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,069,959 - 2,097,904 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0124,232,111 - 4,260,327 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4122,610,552 - 2,638,753 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera123,430,758 - 3,460,163 (+)NCBICelera
Cytogenetic Map12p12NCBI
PNPLA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38197,534,164 - 7,561,767 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl197,534,004 - 7,561,764 (+)EnsemblGRCh38hg38GRCh38
GRCh37197,599,050 - 7,626,653 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,505,043 - 7,532,652 (+)NCBINCBI36Build 36hg18NCBI36
Celera197,471,561 - 7,499,172 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef197,270,194 - 7,297,789 (+)NCBIHuRef
CHM1_1197,598,956 - 7,626,567 (+)NCBICHM1_1
T2T-CHM13v2.0197,534,898 - 7,562,499 (+)NCBIT2T-CHM13v2.0
Pnpla6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3983,565,341 - 3,594,267 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl83,565,384 - 3,594,267 (+)EnsemblGRCm39 Ensembl
GRCm3883,515,235 - 3,544,267 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl83,515,384 - 3,544,267 (+)EnsemblGRCm38mm10GRCm38
MGSCv3783,515,384 - 3,544,267 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3683,515,384 - 3,544,267 (+)NCBIMGSCv36mm8
Celera83,741,358 - 3,770,284 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map81.92NCBI
Pnpla6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555631,680,818 - 1,703,287 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555631,681,112 - 1,703,287 (-)NCBIChiLan1.0ChiLan1.0
PNPLA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22012,205,996 - 12,233,596 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11911,324,029 - 11,351,648 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0196,825,299 - 6,852,900 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1197,683,241 - 7,710,444 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl197,683,789 - 7,710,241 (+)Ensemblpanpan1.1panPan2
PNPLA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,327,547 - 52,349,006 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2052,318,408 - 52,348,963 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2052,115,682 - 52,153,150 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02052,840,755 - 52,878,224 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2052,856,097 - 52,878,224 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12052,060,536 - 52,081,963 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02052,488,224 - 52,525,671 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02052,719,117 - 52,756,573 (+)NCBIUU_Cfam_GSD_1.0
Pnpla6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,202,585 - 213,225,879 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365884,608,963 - 4,632,183 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365884,608,856 - 4,632,198 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PNPLA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl271,577,168 - 71,602,777 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1271,577,165 - 71,602,756 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2272,031,152 - 72,056,544 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PNPLA6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.167,030,802 - 7,056,664 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl67,032,445 - 7,056,661 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666081809,119 - 837,403 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pnpla6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624828643,471 - 664,665 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624828643,552 - 664,665 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pnpla6
55 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:140
Count of miRNA genes:60
Interacting mature miRNAs:70
Transcripts:ENSRNOT00000001298, ENSRNOT00000072952
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12136247923Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)127977298525593Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)1219318387Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001427127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001427128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017604415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000001298   ⟹   ENSRNOP00000001298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl121,560,363 - 1,603,734 (+)Ensembl
Rnor_6.0 Ensembl122,069,959 - 2,097,904 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000072952   ⟹   ENSRNOP00000065231
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl121,574,426 - 1,603,734 (+)Ensembl
Rnor_6.0 Ensembl122,070,365 - 2,097,904 (+)Ensembl
RefSeq Acc Id: NM_001427127   ⟹   NP_001414056
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,372,311 - 6,401,632 (+)NCBI
RefSeq Acc Id: NM_001427128   ⟹   NP_001414057
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,372,311 - 6,401,632 (+)NCBI
RefSeq Acc Id: XM_008769005   ⟹   XP_008767227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,373,834 - 6,401,629 (+)NCBI
mRatBN7.2121,575,747 - 1,603,735 (+)NCBI
Rnor_6.0122,070,165 - 2,098,139 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769007   ⟹   XP_008767229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,373,834 - 6,401,629 (+)NCBI
mRatBN7.2121,575,747 - 1,603,735 (+)NCBI
Rnor_6.0122,070,165 - 2,098,139 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769008   ⟹   XP_008767230
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,373,834 - 6,401,629 (+)NCBI
mRatBN7.2121,575,748 - 1,603,735 (+)NCBI
Rnor_6.0122,070,165 - 2,098,139 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769009   ⟹   XP_008767231
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,372,285 - 6,401,629 (+)NCBI
mRatBN7.2121,574,387 - 1,603,735 (+)NCBI
Rnor_6.0122,068,749 - 2,098,139 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769010   ⟹   XP_008767232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,372,284 - 6,401,629 (+)NCBI
mRatBN7.2121,574,387 - 1,603,735 (+)NCBI
Rnor_6.0122,068,749 - 2,098,139 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769012   ⟹   XP_008767234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,372,285 - 6,401,629 (+)NCBI
mRatBN7.2121,574,387 - 1,603,735 (+)NCBI
Rnor_6.0122,069,073 - 2,098,139 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089893   ⟹   XP_038945821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,373,834 - 6,401,629 (+)NCBI
mRatBN7.2121,575,935 - 1,603,735 (+)NCBI
RefSeq Acc Id: XM_039089895   ⟹   XP_038945823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,373,834 - 6,401,629 (+)NCBI
mRatBN7.2121,575,935 - 1,603,735 (+)NCBI
RefSeq Acc Id: XM_039089897   ⟹   XP_038945825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,372,285 - 6,401,629 (+)NCBI
mRatBN7.2121,574,387 - 1,603,735 (+)NCBI
RefSeq Acc Id: XM_063271425   ⟹   XP_063127495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,373,834 - 6,401,629 (+)NCBI
RefSeq Acc Id: XM_063271426   ⟹   XP_063127496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,373,834 - 6,401,629 (+)NCBI
RefSeq Acc Id: XM_063271427   ⟹   XP_063127497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,373,834 - 6,401,629 (+)NCBI
RefSeq Acc Id: XM_063271428   ⟹   XP_063127498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,373,834 - 6,401,629 (+)NCBI
RefSeq Acc Id: XM_063271429   ⟹   XP_063127499
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,373,834 - 6,401,629 (+)NCBI
RefSeq Acc Id: XM_063271430   ⟹   XP_063127500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,372,285 - 6,401,629 (+)NCBI
RefSeq Acc Id: XM_063271431   ⟹   XP_063127501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,372,285 - 6,401,629 (+)NCBI
RefSeq Acc Id: XM_063271433   ⟹   XP_063127503
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,372,477 - 6,401,629 (+)NCBI
RefSeq Acc Id: XM_063271434   ⟹   XP_063127504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,372,285 - 6,401,629 (+)NCBI
RefSeq Acc Id: XM_063271435   ⟹   XP_063127505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,372,477 - 6,401,629 (+)NCBI
RefSeq Acc Id: XM_063271436   ⟹   XP_063127506
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,372,285 - 6,401,629 (+)NCBI
RefSeq Acc Id: XM_063271437   ⟹   XP_063127507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,372,285 - 6,401,629 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001414056 (Get FASTA)   NCBI Sequence Viewer  
  NP_001414057 (Get FASTA)   NCBI Sequence Viewer  
  XP_008767227 (Get FASTA)   NCBI Sequence Viewer  
  XP_008767229 (Get FASTA)   NCBI Sequence Viewer  
  XP_008767230 (Get FASTA)   NCBI Sequence Viewer  
  XP_008767231 (Get FASTA)   NCBI Sequence Viewer  
  XP_008767232 (Get FASTA)   NCBI Sequence Viewer  
  XP_008767234 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945821 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945823 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945825 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127495 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127496 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127497 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127498 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127499 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127500 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127501 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127503 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127504 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127505 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127506 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127507 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL74933 (Get FASTA)   NCBI Sequence Viewer  
  EDL74934 (Get FASTA)   NCBI Sequence Viewer  
  EDL74935 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001298.6
  ENSRNOP00000065231.2
RefSeq Acc Id: XP_008767231   ⟸   XM_008769009
- Peptide Label: isoform X12
- UniProtKB: D3ZRF6 (UniProtKB/TrEMBL),   A6KQ10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767232   ⟸   XM_008769010
- Peptide Label: isoform X12
- UniProtKB: D3ZRF6 (UniProtKB/TrEMBL),   A6KQ10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767234   ⟸   XM_008769012
- Peptide Label: isoform X13
- UniProtKB: A6KQ09 (UniProtKB/TrEMBL),   A6KQ10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767229   ⟸   XM_008769007
- Peptide Label: isoform X6
- UniProtKB: A6KQ10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767230   ⟸   XM_008769008
- Peptide Label: isoform X8
- UniProtKB: M0R715 (UniProtKB/TrEMBL),   A6KQ10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767227   ⟸   XM_008769005
- Peptide Label: isoform X7
- UniProtKB: A6KQ10 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065231   ⟸   ENSRNOT00000072952
Ensembl Acc Id: ENSRNOP00000001298   ⟸   ENSRNOT00000001298
RefSeq Acc Id: XP_038945825   ⟸   XM_039089897
- Peptide Label: isoform X15
- UniProtKB: A6KQ10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945821   ⟸   XM_039089893
- Peptide Label: isoform X9
- UniProtKB: A6KQ10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945823   ⟸   XM_039089895
- Peptide Label: isoform X11
- UniProtKB: A6KQ10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127501   ⟸   XM_063271431
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063127506   ⟸   XM_063271436
- Peptide Label: isoform X14
RefSeq Acc Id: XP_063127504   ⟸   XM_063271434
- Peptide Label: isoform X13
- UniProtKB: A6KQ09 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127500   ⟸   XM_063271430
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063127507   ⟸   XM_063271437
- Peptide Label: isoform X16
RefSeq Acc Id: NP_001414056   ⟸   NM_001427127
- Peptide Label: isoform 1
RefSeq Acc Id: NP_001414057   ⟸   NM_001427128
- Peptide Label: isoform 2
RefSeq Acc Id: XP_063127503   ⟸   XM_063271433
- Peptide Label: isoform X12
- UniProtKB: D3ZRF6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127505   ⟸   XM_063271435
- Peptide Label: isoform X13
- UniProtKB: A6KQ09 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127495   ⟸   XM_063271425
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063127496   ⟸   XM_063271426
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063127497   ⟸   XM_063271427
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063127498   ⟸   XM_063271428
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063127499   ⟸   XM_063271429
- Peptide Label: isoform X5
Protein Domains
Cyclic nucleotide-binding   PNPLA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R715-F1-model_v2 AlphaFold M0R715 1-1354 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564611 AgrOrtholog
BioCyc Gene G2FUF-20395 BioCyc
Ensembl Genes ENSRNOG00000000977 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001298.8 UniProtKB/TrEMBL
  ENSRNOT00000072952.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.10 UniProtKB/TrEMBL
  Cytosolic phospholipase A2 catalytic domain UniProtKB/TrEMBL
InterPro Acyl_Trfase/lysoPLipase UniProtKB/TrEMBL
  cNMP-bd-like UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/TrEMBL
  LysoPLipase_patatin_CS UniProtKB/TrEMBL
  NTE UniProtKB/TrEMBL
  Patatin/PLipase_A2-rel UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
NCBI Gene 360753 ENTREZGENE
PANTHER NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER UniProtKB/TrEMBL
  PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 6 UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/TrEMBL
  Patatin UniProtKB/TrEMBL
PhenoGen Pnpla6 PhenoGen
PROSITE CNMP_BINDING_3 UniProtKB/TrEMBL
  PNPLA UniProtKB/TrEMBL
  UPF0028 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000977 RatGTEx
SMART cNMP UniProtKB/TrEMBL
Superfamily-SCOP Acyl_Trfase/lysoPlipase UniProtKB/TrEMBL
  cNMP_binding UniProtKB/TrEMBL
UniProt A6KQ09 ENTREZGENE, UniProtKB/TrEMBL
  A6KQ10 ENTREZGENE, UniProtKB/TrEMBL
  D3ZRF6 ENTREZGENE, UniProtKB/TrEMBL
  M0R715 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Pnpla6  patatin-like phospholipase domain containing 6  RGD1564611_predicted  similar to neuropathy target esterase homolog (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564611_predicted  similar to neuropathy target esterase homolog (predicted)  LOC360753  similar to neuropathy target esterase homolog  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC360753  similar to neuropathy target esterase homolog      Symbol and Name status set to provisional 70820 PROVISIONAL