GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1564611
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pnpla6
Name: patatin-like phospholipase domain containing 6
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISORGD:15580756480464CTDChlorpyrifos results in decreased activity of PNPLA6 protein

PMID:27117976
increases expressionISORGD:15580756480464CTDChlorpyrifos results in increased expression of PNPLA6 mRNA

PMID:23220036, PMID:25137620
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.