GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1564611
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pnpla6
Name: patatin-like phospholipase domain containing 6
Acc ID: CHEBI:17941
Term: diisopropyl fluorophosphate
Definition: A dialkyl phosphate that has formula C6H14FO3P.
Chemical ID: MESH:D007531
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDIsoflurophate results in decreased activity of PNPLA6 protein

PMID:7713347
affects response to substanceISORGD:16057016480464CTDPNPLA6 protein mutant form affects the susceptibility to Isoflurophate

PMID:20382209
decreases activityISORGD:15580756480464CTDIsoflurophate results in decreased activity of PNPLA6 protein

PMID:24395470, PMID:9268605
decreases activityISORGD:16057016480464CTDIsoflurophate results in decreased activity of PNPLA6 protein

PMID:20382209, PMID:24395470, PMID:9268605
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.