GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1564611
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pnpla6
Name: patatin-like phospholipase domain containing 6
Acc ID: CHEBI:110423
Term: clodronic acid
Definition: An organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases.
Chemical ID: MESH:D004002
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:16057016480464CTDClodronic Acid results in decreased expression of PNPLA6 mRNA

PMID:25596134
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.