GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1564611
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pnpla6
Name: patatin-like phospholipase domain containing 6
Acc ID: CHEBI:82142
Term: Mipafox
Definition: A phosphoramide that has formula C6H16FN2OP.
Chemical ID: MESH:C005238
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDmipafox results in decreased activity of PNPLA6 protein

PMID:3714122, PMID:7713347
affects response to substanceISORGD:16057016480464CTDPNPLA6 protein mutant form affects the susceptibility to mipafox

PMID:20382209
decreases activityISORGD:15580756480464CTDmipafox results in decreased activity of PNPLA6 protein

PMID:24395470, PMID:27117976, PMID:8486913, PMID:9268605
decreases activityISORGD:16057016480464CTDmipafox results in decreased activity of PNPLA6 protein

PMID:16766477, PMID:20382209, PMID:24395470, PMID:24413757, PMID:9268605
multiple interactionsISORGD:15580756480464CTD[Paraoxon co-treated with mipafox] results in decreased activity of PNPLA6 protein

PMID:19620706
multiple interactionsISORGD:16057016480464CTDmipafox inhibits the reaction [PNPLA6 protein results in increased hydrolysis of phenyl valerate]

PMID:20603202
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.