GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1564611
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pnpla6
Name: patatin-like phospholipase domain containing 6
Acc ID: CHEBI:34795
Term: 3-isobutyl-1-methyl-7H-xanthine
Definition: A 3-isobutyl-1-methylxanthine that has formula C10H14N4O2.
Chemical ID: MESH:D015056
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:16057016480464CTD1-Methyl-3-isobutylxanthine promotes the reaction [Colforsin results in increased expression of and results in increased activity of PNPLA6 protein]

[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PNPLA6 mRNA

Cycloheximide inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of PNPLA6 protein]

PMID:20380879
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.