Pnpla6 (patatin like phospholipase domain containing 6) - Rat Genome Database

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Gene: Pnpla6 (patatin like phospholipase domain containing 6) Chinchilla lanigera
Analyze
Symbol: Pnpla6
Name: patatin like phospholipase domain containing 6
RGD ID: 9044868
Description: ENCODES a protein that exhibits lysophospholipase activity (ortholog); INVOLVED IN angiogenesis (ortholog); animal organ morphogenesis (ortholog); ASSOCIATED WITH amenorrhea (ortholog); amyotrophic lateral sclerosis (ortholog); Boucher-Neuhauser syndrome (ortholog); FOUND IN cytosol (ortholog); endoplasmic reticulum (ortholog); membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: neuropathy target esterase; patatin-like phospholipase domain containing 6
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555631,680,818 - 1,703,287 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555631,681,112 - 1,703,287 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Pnpla6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555631,680,818 - 1,703,287 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555631,681,112 - 1,703,287 (-)NCBIChiLan1.0ChiLan1.0
PNPLA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38197,534,164 - 7,561,767 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl197,534,004 - 7,561,764 (+)EnsemblGRCh38hg38GRCh38
GRCh37197,599,050 - 7,626,653 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,505,043 - 7,532,652 (+)NCBINCBI36Build 36hg18NCBI36
Celera197,471,561 - 7,499,172 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef197,270,194 - 7,297,789 (+)NCBIHuRef
CHM1_1197,598,956 - 7,626,567 (+)NCBICHM1_1
T2T-CHM13v2.0197,534,898 - 7,562,499 (+)NCBIT2T-CHM13v2.0
Pnpla6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3983,565,341 - 3,594,267 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl83,565,384 - 3,594,267 (+)EnsemblGRCm39 Ensembl
GRCm3883,515,235 - 3,544,267 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl83,515,384 - 3,544,267 (+)EnsemblGRCm38mm10GRCm38
MGSCv3783,515,384 - 3,544,267 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3683,515,384 - 3,544,267 (+)NCBIMGSCv36mm8
Celera83,741,358 - 3,770,284 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map81.92NCBI
Pnpla6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8126,372,284 - 6,401,632 (+)NCBIGRCr8
mRatBN7.2121,574,387 - 1,603,735 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,560,363 - 1,603,734 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0122,068,749 - 2,098,139 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,069,959 - 2,097,904 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0124,232,111 - 4,260,327 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4122,610,552 - 2,638,753 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera123,430,758 - 3,460,163 (+)NCBICelera
Cytogenetic Map12p12NCBI
PNPLA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22012,205,996 - 12,233,596 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11911,324,029 - 11,351,648 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0196,825,299 - 6,852,900 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1197,683,241 - 7,710,444 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl197,683,789 - 7,710,241 (+)Ensemblpanpan1.1panPan2
PNPLA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,327,547 - 52,349,006 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2052,318,408 - 52,348,963 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2052,115,682 - 52,153,150 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02052,840,755 - 52,878,224 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2052,856,097 - 52,878,224 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12052,060,536 - 52,081,963 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02052,488,224 - 52,525,671 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02052,719,117 - 52,756,573 (+)NCBIUU_Cfam_GSD_1.0
Pnpla6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,202,585 - 213,225,879 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365884,608,963 - 4,632,183 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365884,608,856 - 4,632,198 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PNPLA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl271,577,168 - 71,602,777 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1271,577,165 - 71,602,756 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2272,031,152 - 72,056,544 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PNPLA6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.167,030,802 - 7,056,664 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl67,032,445 - 7,056,661 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666081809,119 - 837,403 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pnpla6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624828643,471 - 664,665 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624828643,552 - 664,665 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000004008   ⟹   ENSCLAP00000003932
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555631,680,818 - 1,703,287 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000004009   ⟹   ENSCLAP00000003933
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555631,680,818 - 1,703,275 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000004010   ⟹   ENSCLAP00000003934
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555631,681,330 - 1,702,125 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000004011   ⟹   ENSCLAP00000003935
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555631,681,330 - 1,701,743 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000004012   ⟹   ENSCLAP00000003936
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555631,683,344 - 1,686,546 (-)Ensembl
RefSeq Acc Id: XM_005413181   ⟹   XP_005413238
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555631,681,112 - 1,701,826 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005413182   ⟹   XP_005413239
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555631,681,112 - 1,701,826 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005413184   ⟹   XP_005413241
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555631,681,112 - 1,703,275 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005413185   ⟹   XP_005413242
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555631,681,112 - 1,703,287 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005413241   ⟸   XM_005413184
- Peptide Label: isoform X3
- UniProtKB: A0A8C2YJT9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005413242   ⟸   XM_005413185
- Peptide Label: isoform X4
- UniProtKB: A0A8C2UPI3 (UniProtKB/TrEMBL),   A0A8C2YJT9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005413239   ⟸   XM_005413182
- Peptide Label: isoform X2
- UniProtKB: A0A8C2YJU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005413238   ⟸   XM_005413181
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YJU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000003935   ⟸   ENSCLAT00000004011
RefSeq Acc Id: ENSCLAP00000003936   ⟸   ENSCLAT00000004012
RefSeq Acc Id: ENSCLAP00000003934   ⟸   ENSCLAT00000004010
RefSeq Acc Id: ENSCLAP00000003932   ⟸   ENSCLAT00000004008
RefSeq Acc Id: ENSCLAP00000003933   ⟸   ENSCLAT00000004009
Protein Domains
Cyclic nucleotide-binding   PNPLA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000002800 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000004008 ENTREZGENE
  ENSCLAT00000004008.1 UniProtKB/TrEMBL
  ENSCLAT00000004009.1 UniProtKB/TrEMBL
  ENSCLAT00000004010.1 UniProtKB/TrEMBL
  ENSCLAT00000004011 ENTREZGENE
  ENSCLAT00000004011.1 UniProtKB/TrEMBL
  ENSCLAT00000004012.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.10 UniProtKB/TrEMBL
  Cytosolic phospholipase A2 catalytic domain UniProtKB/TrEMBL
InterPro Acyl_Trfase/lysoPLipase UniProtKB/TrEMBL
  cNMP-bd-like UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/TrEMBL
  LysoPLipase_patatin_CS UniProtKB/TrEMBL
  PNPLA_dom UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
NCBI Gene Pnpla6 ENTREZGENE
PANTHER NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER UniProtKB/TrEMBL
  PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 6 UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/TrEMBL
  Patatin UniProtKB/TrEMBL
PROSITE CNMP_BINDING_3 UniProtKB/TrEMBL
  PNPLA UniProtKB/TrEMBL
  UPF0028 UniProtKB/TrEMBL
SMART cNMP UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/TrEMBL
  SSF52151 UniProtKB/TrEMBL
UniProt A0A8C2UPI3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2UQZ5_CHILA UniProtKB/TrEMBL
  A0A8C2UR37_CHILA UniProtKB/TrEMBL
  A0A8C2YJT9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YJU6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Pnpla6  patatin like phospholipase domain containing 6    patatin-like phospholipase domain containing 6  Symbol and/or name change 5135510 APPROVED