Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane | increases expression | ISO | NEIL2 (Homo sapiens) | 6480464 | o and p'-DDT results in increased expression of NEIL2 mRNA | CTD | PMID:19371625 | 1,2-dichloroethane | decreases expression | ISO | Neil2 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of NEIL2 mRNA | CTD | PMID:28960355 | 17beta-estradiol | affects expression | ISO | NEIL2 (Homo sapiens) | 6480464 | Estradiol affects the expression of NEIL2 mRNA | CTD | PMID:22574217 | 17beta-estradiol | increases expression | ISO | NEIL2 (Homo sapiens) | 6480464 | Estradiol results in increased expression of NEIL2 mRNA | CTD | PMID:31614463 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Neil2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NEIL2 promoter] | CTD | PMID:19654925 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of NEIL2 mRNA | CTD | PMID:33387578 | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of NEIL2 mRNA | CTD | PMID:31881176 | afimoxifene | multiple interactions | ISO | NEIL2 (Homo sapiens) | 6480464 | afimoxifene inhibits the reaction [Estrogens results in increased expression of NEIL2 mRNA] | CTD | PMID:21233418 | aniline | increases expression | EXP | | 6480464 | aniline results in increased expression of NEIL2 more ... | CTD | PMID:21145906 and PMID:23352893 | arsane | affects methylation | ISO | NEIL2 (Homo sapiens) | 6480464 | Arsenic affects the methylation of NEIL2 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | NEIL2 (Homo sapiens) | 6480464 | Arsenic affects the methylation of NEIL2 gene | CTD | PMID:25304211 | benzo[a]pyrene | multiple interactions | ISO | Neil2 (Mus musculus) | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to NEIL2 promoter] | CTD | PMID:19654925 | benzo[a]pyrene | increases methylation | ISO | NEIL2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of NEIL2 promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | Neil2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of NEIL2 mRNA | CTD | PMID:22228805 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of NEIL2 mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of NEIL2 mRNA | CTD | PMID:30816183 and PMID:32528016 | bromobenzene | increases expression | EXP | | 6480464 | bromobenzene results in increased expression of NEIL2 mRNA | CTD | PMID:32479839 | cadmium atom | multiple interactions | ISO | NEIL2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NEIL2 mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | NEIL2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NEIL2 mRNA | CTD | PMID:35301059 | caffeine | decreases phosphorylation | ISO | NEIL2 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of NEIL2 protein | CTD | PMID:35688186 | carbon nanotube | decreases expression | ISO | Neil2 (Mus musculus) | 6480464 | Nanotubes and Carbon analog results in decreased expression of NEIL2 mRNA | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | NEIL2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to NEIL2 gene] | CTD | PMID:28238834 | cisplatin | multiple interactions | ISO | NEIL2 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of NEIL2 mRNA | CTD | PMID:27392435 | copper atom | multiple interactions | ISO | NEIL2 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of NEIL2 mRNA and Copper binds to and results in decreased activity of NEIL2 protein | CTD | PMID:20622253 and PMID:20971185 | copper(0) | multiple interactions | ISO | NEIL2 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of NEIL2 mRNA and Copper binds to and results in decreased activity of NEIL2 protein | CTD | PMID:20622253 and PMID:20971185 | cyclosporin A | increases expression | ISO | NEIL2 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of NEIL2 mRNA | CTD | PMID:25562108 | dichloroacetic acid | increases expression | ISO | Neil2 (Mus musculus) | 6480464 | Dichloroacetic Acid results in increased expression of NEIL2 mRNA | CTD | PMID:28962523 | diethylstilbestrol | increases expression | ISO | NEIL2 (Homo sapiens) | 6480464 | Diethylstilbestrol results in increased expression of NEIL2 mRNA | CTD | PMID:36621641 | dorsomorphin | multiple interactions | ISO | NEIL2 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | furan | increases expression | EXP | | 6480464 | furan results in increased expression of NEIL2 mRNA | CTD | PMID:25539665 | genistein | increases expression | ISO | NEIL2 (Homo sapiens) | 6480464 | Genistein results in increased expression of NEIL2 mRNA | CTD | PMID:19371625 | iron atom | multiple interactions | ISO | NEIL2 (Homo sapiens) | 6480464 | Iron binds to and results in decreased activity of NEIL2 protein | CTD | PMID:20622253 | iron(0) | multiple interactions | ISO | NEIL2 (Homo sapiens) | 6480464 | Iron binds to and results in decreased activity of NEIL2 protein | CTD | PMID:20622253 | ketoconazole | increases expression | ISO | NEIL2 (Homo sapiens) | 6480464 | Ketoconazole results in increased expression of NEIL2 mRNA | CTD | PMID:36621641 | lead(0) | affects expression | ISO | NEIL2 (Homo sapiens) | 6480464 | Lead affects the expression of NEIL2 mRNA | CTD | PMID:28903495 | mercury dibromide | decreases expression | ISO | NEIL2 (Homo sapiens) | 6480464 | mercuric bromide results in decreased expression of NEIL2 mRNA | CTD | PMID:26272509 | mercury dibromide | multiple interactions | ISO | NEIL2 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NEIL2 mRNA | CTD | PMID:27188386 | methotrexate | decreases expression | ISO | NEIL2 (Homo sapiens) | 6480464 | Methotrexate results in decreased expression of NEIL2 mRNA | CTD | PMID:24449571 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of NEIL2 mRNA | CTD | PMID:33387578 | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of NEIL2 mRNA | CTD | PMID:27993944 | phenylmercury acetate | decreases expression | ISO | NEIL2 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of NEIL2 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | NEIL2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NEIL2 mRNA | CTD | PMID:27188386 | potassium dichromate | increases expression | ISO | Neil2 (Mus musculus) | 6480464 | Potassium Dichromate results in increased expression of NEIL2 mRNA | CTD | PMID:23608068 | resveratrol | increases expression | ISO | NEIL2 (Homo sapiens) | 6480464 | resveratrol results in increased expression of NEIL2 mRNA | CTD | PMID:19371625 | SB 431542 | multiple interactions | ISO | NEIL2 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | increases expression | ISO | NEIL2 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of NEIL2 mRNA | CTD | PMID:25895662 | sunitinib | decreases expression | ISO | NEIL2 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of NEIL2 mRNA | CTD | PMID:31533062 | temozolomide | decreases expression | ISO | NEIL2 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of NEIL2 mRNA | CTD | PMID:31758290 | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of NEIL2 mRNA | CTD | PMID:33387578 | triptonide | increases expression | ISO | Neil2 (Mus musculus) | 6480464 | triptonide results in increased expression of NEIL2 mRNA | CTD | PMID:33045310 | tris(2-butoxyethyl) phosphate | affects expression | ISO | NEIL2 (Homo sapiens) | 6480464 | tris(2-butoxyethyl) phosphate affects the expression of NEIL2 mRNA | CTD | PMID:29024780 | uranium atom | affects expression | ISO | NEIL2 (Homo sapiens) | 6480464 | Uranium affects the expression of NEIL2 mRNA | CTD | PMID:15672453 | zearalenone | increases expression | ISO | NEIL2 (Homo sapiens) | 6480464 | Zearalenone results in increased expression of NEIL2 mRNA | CTD | PMID:19371625 | |