Prkg2 (protein kinase cGMP-dependent 2) - Rat Genome Database

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Gene: Prkg2 (protein kinase cGMP-dependent 2) Rattus norvegicus
Analyze
Symbol: Prkg2
Name: protein kinase cGMP-dependent 2
RGD ID: 3401
Description: Enables cGMP-dependent protein kinase activity and identical protein binding activity. Involved in several processes, including negative regulation of chloride transport; negative regulation of chondrocyte proliferation; and peptidyl-serine autophosphorylation. Located in nuclear membrane. Human ortholog(s) of this gene implicated in acromesomelic dysplasia. Orthologous to human PRKG2 (protein kinase cGMP-dependent 2); PARTICIPATES IN long term depression; INTERACTS WITH 17beta-estradiol 3-benzoate; 3,4-methylenedioxymethamphetamine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CGK 2; cGK2; cGKII; cGMP dependent protein kinase type II; cGMP-dependent protein kinase 2; cGMP-dependent protein kinase II; GDPKII; protein kinase cGMP- dependent type 2; protein kinase, cGMP- dependent, type 2; protein kinase, cGMP- dependent, type II; protein kinase, cGMP-dependent, type II; type II cGMP-dependent protein kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   KMI/Tky  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21410,559,882 - 10,668,479 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1410,559,882 - 10,666,888 (+)Ensembl
Rnor_6.01412,217,121 - 12,313,616 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1412,218,553 - 12,315,229 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01412,159,378 - 12,255,994 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41411,888,101 - 12,005,547 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11411,888,100 - 12,005,547 (+)NCBI
Celera1410,666,687 - 10,755,836 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes. Chikuda H, etal., Genes Dev. 2004 Oct 1;18(19):2418-29. doi: 10.1101/gad.1224204.
2. Guanylyl cyclase and protein kinase G mediate nitric oxide suppression of 5-lipoxygenase metabolism in rat alveolar macrophages. Coffey MJ, etal., Biochim Biophys Acta. 2008 Jun-Jul;1781(6-7):299-305. doi: 10.1016/j.bbalip.2008.04.005. Epub 2008 Apr 24.
3. ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4. F├╝rst J, etal., J Biol Chem. 2005 Sep 2;280(35):31276-82. Epub 2005 May 19.
4. Inhibition of cGMP-dependent protein kinase II by its own splice isoform. Gambaryan S, etal., Biochem Biophys Res Commun 2002 May 24;293(5):1438-44.
5. cGMP-dependent protein kinase type II regulates basal level of aldosterone production by zona glomerulosa cells without increasing expression of the steroidogenic acute regulatory protein gene. Gambaryan S, etal., J Biol Chem 2003 Aug 8;278(32):29640-8. Epub 2003 May 29.
6. Expression of type II cGMP-dependent protein kinase in rat kidney is regulated by dehydration and correlated with renin gene expression. Gambaryan S, etal., J Clin Invest 1996 Aug 1;98(3):662-70.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. STa and cGMP stimulate CFTR translocation to the surface of villus enterocytes in rat jejunum and is regulated by protein kinase G. Golin-Bisello F, etal., Am J Physiol Cell Physiol. 2005 Sep;289(3):C708-16. Epub 2005 May 4.
10. Cloning, expression, and in situ localization of rat intestinal cGMP-dependent protein kinase II. Jarchau T, etal., Proc Natl Acad Sci U S A 1994 Sep 27;91(20):9426-30.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. Expression, purification, and characterization of the cGMP-dependent protein kinases I beta and II using the baculovirus system. Pohler D, etal., FEBS Lett. 1995 Nov 6;374(3):419-25.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. Phenotypic characterization of the Komeda miniature rat Ishikawa, an animal model of dwarfism caused by a mutation in Prkg2. Tsuchida A, etal., Comp Med. 2008 Dec;58(6):560-7.
20. Autophosphorylation of cGMP-dependent protein kinase type II. Vaandrager AB, etal., J Biol Chem 2003 Aug 1;278(31):28651-8. Epub 2003 May 22.
21. Endogenous type II cGMP-dependent protein kinase exists as a dimer in membranes and can Be functionally distinguished from the type I isoforms. Vaandrager AB, etal., J Biol Chem. 1997 May 2;272(18):11816-23.
Additional References at PubMed
PMID:12725729   PMID:14960318   PMID:15312652   PMID:15582712   PMID:15763176   PMID:15958724   PMID:17341596   PMID:17626895   PMID:18656450   PMID:22203739   PMID:23545413   PMID:24966379  
PMID:28057484  


Genomics

Comparative Map Data
Prkg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21410,559,882 - 10,668,479 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1410,559,882 - 10,666,888 (+)Ensembl
Rnor_6.01412,217,121 - 12,313,616 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1412,218,553 - 12,315,229 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01412,159,378 - 12,255,994 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41411,888,101 - 12,005,547 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11411,888,100 - 12,005,547 (+)NCBI
Celera1410,666,687 - 10,755,836 (+)NCBICelera
Cytogenetic Map14p22NCBI
PRKG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38481,087,370 - 81,217,836 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl481,087,370 - 81,215,222 (-)EnsemblGRCh38hg38GRCh38
GRCh37482,008,524 - 82,136,376 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36482,228,861 - 82,345,239 (-)NCBINCBI36hg18NCBI36
Build 34482,367,015 - 82,483,394NCBI
Celera479,302,549 - 79,418,932 (-)NCBI
Cytogenetic Map4q21.21NCBI
HuRef477,753,401 - 77,870,008 (-)NCBIHuRef
CHM1_1481,986,323 - 82,102,706 (-)NCBICHM1_1
T2T-CHM13v2.0484,417,063 - 84,544,924 (-)NCBI
Prkg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39599,077,632 - 99,185,042 (-)NCBIGRCm39mm39
GRCm39 Ensembl599,077,632 - 99,185,210 (-)Ensembl
GRCm38598,929,773 - 99,037,375 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl598,929,773 - 99,037,351 (-)EnsemblGRCm38mm10GRCm38
MGSCv37599,358,792 - 99,466,098 (-)NCBIGRCm37mm9NCBIm37
MGSCv36599,171,570 - 99,277,381 (-)NCBImm8
Celera596,252,278 - 96,360,518 (-)NCBICelera
Cytogenetic Map5E3NCBI
cM Map548.35NCBI
Prkg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554335,286,153 - 5,491,924 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554335,286,594 - 5,387,571 (-)NCBIChiLan1.0ChiLan1.0
PRKG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1448,836,953 - 48,960,383 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl448,836,953 - 48,960,383 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0442,987,217 - 43,114,993 (+)NCBIMhudiblu_PPA_v0panPan3
PRKG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1325,266,435 - 5,365,396 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl325,266,442 - 5,365,396 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3236,517,409 - 36,617,588 (+)NCBI
ROS_Cfam_1.0325,294,681 - 5,395,076 (-)NCBI
ROS_Cfam_1.0 Ensembl325,294,693 - 5,395,085 (-)Ensembl
UMICH_Zoey_3.1325,324,348 - 5,424,902 (-)NCBI
UNSW_CanFamBas_1.0325,231,256 - 5,331,589 (-)NCBI
UU_Cfam_GSD_1.03234,635,113 - 34,735,693 (+)NCBI
Prkg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244052856,966,547 - 7,070,004 (+)NCBI
SpeTri2.0NW_004936749900,208 - 991,891 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8136,755,469 - 136,852,906 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18136,754,698 - 136,854,589 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28146,048,858 - 146,148,011 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1729,511,796 - 29,629,943 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl729,511,380 - 29,618,330 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660378,011,684 - 8,129,346 (-)NCBIVero_WHO_p1.0
Prkg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247579,798,808 - 9,906,517 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247579,799,777 - 9,904,825 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
D14Got16  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21410,654,327 - 10,654,483 (+)MAPPERmRatBN7.2
Rnor_6.01412,301,002 - 12,301,157NCBIRnor6.0
Rnor_5.01412,243,454 - 12,243,609UniSTSRnor5.0
RGSC_v3.41411,992,408 - 11,992,564RGDRGSC3.4
RGSC_v3.41411,992,409 - 11,992,564UniSTSRGSC3.4
RGSC_v3.11411,992,408 - 11,992,564RGD
Celera1410,743,200 - 10,743,355UniSTS
RH 2.0 Map14178.6RGD
Cytogenetic Map14p22UniSTS
BE120376  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21410,571,897 - 10,572,086 (+)MAPPERmRatBN7.2
Rnor_6.01412,218,561 - 12,218,749NCBIRnor6.0
Rnor_5.01412,160,818 - 12,161,006UniSTSRnor5.0
RGSC_v3.41411,889,541 - 11,889,729UniSTSRGSC3.4
Celera1410,668,115 - 10,668,303UniSTS
Cytogenetic Map14p22UniSTS
RH137660  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21410,666,550 - 10,666,727 (+)MAPPERmRatBN7.2
Rnor_6.01412,313,279 - 12,313,455NCBIRnor6.0
Rnor_5.01412,255,657 - 12,255,833UniSTSRnor5.0
RGSC_v3.41412,005,210 - 12,005,386UniSTSRGSC3.4
Celera1410,755,499 - 10,755,675UniSTS
Cytogenetic Map14p22UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14121760611030812Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14121760616960180Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat


Related Rat Strains
The following Strains have been annotated to Prkg2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:44
Interacting mature miRNAs:54
Transcripts:ENSRNOT00000003237
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 7 3 1
Low 1 10 5 4 4 5 5 71 35 29 5 5
Below cutoff 31 15 7 17 7 3 6 8 5 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003237   ⟹   ENSRNOP00000003237
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1410,559,882 - 10,666,888 (+)Ensembl
Rnor_6.0 Ensembl1412,218,553 - 12,315,229 (+)Ensembl
RefSeq Acc Id: NM_013012   ⟹   NP_037144
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21410,559,882 - 10,666,918 (+)NCBI
Rnor_6.01412,217,121 - 12,313,616 (+)NCBI
Rnor_5.01412,159,378 - 12,255,994 (+)NCBI
RGSC_v3.41411,888,101 - 12,005,547 (+)RGD
Celera1410,666,687 - 10,755,836 (+)RGD
Sequence:
RefSeq Acc Id: XM_039091638   ⟹   XP_038947566
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21410,560,003 - 10,668,479 (+)NCBI
Protein Sequences
Protein RefSeqs NP_037144 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947566 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA85284 (Get FASTA)   NCBI Sequence Viewer  
  EDL99610 (Get FASTA)   NCBI Sequence Viewer  
  EDL99611 (Get FASTA)   NCBI Sequence Viewer  
  Q64595 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_037144   ⟸   NM_013012
- UniProtKB: Q64595 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003237   ⟸   ENSRNOT00000003237
RefSeq Acc Id: XP_038947566   ⟸   XM_039091638
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64595-F1-model_v2 AlphaFold Q64595 1-762 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
14 12243721 12243722 G A snv BN/SsN (MCW)
14 12243748 12243749 A G snv WKY/NHsd (RGD)


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
14 12185978 12185979 G A snv BN/SsN (KNAW)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
14 11914702 11914703 G A snv BN/SsN (KNAW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3401 AgrOrtholog
BioCyc Gene G2FUF-16367 BioCyc
Ensembl Genes ENSRNOG00000002361 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000003237 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003237 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.10 UniProtKB/Swiss-Prot
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  cGMP_dep_kinase UniProtKB/Swiss-Prot
  cNMP-bd-like UniProtKB/Swiss-Prot
  cNMP-bd_CS UniProtKB/Swiss-Prot
  cNMP-bd_dom UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  RmlC-like_jellyroll UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  STKc_cGK UniProtKB/Swiss-Prot
KEGG Report rno:25523 UniProtKB/Swiss-Prot
NCBI Gene 25523 ENTREZGENE
Pfam cNMP_binding UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
PhenoGen Prkg2 PhenoGen
PIRSF cGMP-dep_kinase UniProtKB/Swiss-Prot
PRINTS CGMPKINASE UniProtKB/Swiss-Prot
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  CNMP_BINDING_1 UniProtKB/Swiss-Prot
  CNMP_BINDING_2 UniProtKB/Swiss-Prot
  CNMP_BINDING_3 UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART cNMP UniProtKB/Swiss-Prot
  S_TK_X UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
TIGR TC234258
UniProt KGP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-04-27 Prkg2  protein kinase cGMP-dependent 2  Prkg2  protein kinase, cGMP-dependent, type II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Prkg2  protein kinase, cGMP-dependent, type II    protein kinase, cGMP- dependent, type II  Name updated 1299863 APPROVED
2002-06-10 Prkg2  protein kinase, cGMP- dependent, type 2      Symbol and Name status set to approved 70586 APPROVED
2001-10-24 Prkg2  protein kinase, cAMP- dependent, type II      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED
2001-10-24 Prkg2  protein kinase, cGMP- dependent, type II      Name updated 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in intestinal mucosa and in kidney juxtaglomerular cells, ascending thin limb of Henles loop, and brush border of proximal tubules 61502
gene_process involved in the osmotic changes regulating granule swelling and exocytosis in intestinal brush border 61502
gene_process may have a role in regulating renin release 61502