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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor
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Accession:CHEBI:76838 term browser browse the term
Definition:An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of any such enzyme incorporating one atom of oxygen and using reduced flavin or flavoprotein as donor (EC 1.14.14.*).
Synonyms:related_synonym: EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitors;   EC 1.14.14.* (oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor;   EC 1.14.14.* (oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitors;   EC 1.14.14.* inhibitor;   EC 1.14.14.* inhibitors



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1-aminobenzotriazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 multiple interactions ISO 1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of ACAT1 protein] CTD PMID:32435916 NCBI chr 8:62,876,003...62,905,080
Ensembl chr 8:53,979,813...54,008,855
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO 1-aminobenzotriazole inhibits the reaction [Chlorpyrifos metabolite results in decreased activity of ACHE protein] CTD PMID:30625376 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acot2 acyl-CoA thioesterase 2 multiple interactions ISO 1-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of ACOT2 protein] CTD PMID:32435916 NCBI chr 6:109,341,426...109,352,818
Ensembl chr 6:103,611,544...103,619,245
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 multiple interactions ISO 1-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of ALDH1B1 protein] CTD PMID:32435916 NCBI chr 5:64,859,000...64,864,008
Ensembl chr 5:60,063,225...60,068,378
JBrowse link
G Car3 carbonic anhydrase 3 multiple interactions ISO 1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of CAR3 protein] CTD PMID:32435916 NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Cd86 CD86 molecule multiple interactions ISO 1-aminobenzotriazole inhibits the reaction [Benzo(a)pyrene results in increased expression of CD86 protein] CTD PMID:21742781 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Ces3a carboxylesterase 3a multiple interactions ISO 1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of CES3B protein] CTD PMID:32435916 NCBI chr19:49,902,312...49,910,484 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO
EXP
1-aminobenzotriazole inhibits the reaction [Skatole results in increased expression of CYP1A1 mRNA]
1-aminobenzotriazole results in increased expression of CYP1A1 protein
1-aminobenzotriazole inhibits the reaction [Oxygen results in increased activity of CYP1A1 protein]; [1-aminobenzotriazole co-treated with Oxygen] results in increased activity of CYP1A1 protein
CTD PMID:10640292 PMID:20187624 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases activity
multiple interactions
EXP
ISO
1-aminobenzotriazole results in increased expression of CYP1A2 protein
1-aminobenzotriazole results in decreased activity of CYP1A2 protein
[1-aminobenzotriazole co-treated with Oxygen] results in increased activity of CYP1A2 protein; [Oxygen co-treated with 1-aminobenzotriazole] results in increased expression of CYP1A2 protein
CTD PMID:10640292 PMID:15618748 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
decreases activity
ISO 1-aminobenzotriazole inhibits the reaction [CYP2D6 protein results in increased hydroxylation of bufuralol]
1-aminobenzotriazole results in decreased activity of CYP2D6 protein
CTD PMID:11375247 PMID:15618748 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity
multiple interactions
ISO 1-aminobenzotriazole results in decreased activity of CYP2E1 protein
1-aminobenzotriazole inhibits the reaction [CYP2E1 protein affects the metabolism of Urethane]; 1-aminobenzotriazole inhibits the reaction [CYP2E1 protein results in increased oxidation of 1,3-butadiene]
1-aminobenzotriazole inhibits the reaction [[[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 1-methylpyrene] which results in increased mutagenesis of HPRT1 gene]
CTD PMID:10828257 PMID:12704224 PMID:15618748 PMID:25243916 PMID:27421776 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 multiple interactions ISO 1-aminobenzotriazole inhibits the reaction [Skatole results in increased expression of CYP2F1 mRNA] CTD PMID:20187624 NCBI chr 1:91,543,768...91,557,553
Ensembl chr 1:82,416,130...82,429,896
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO 1-aminobenzotriazole results in decreased activity of CYP3A4 protein CTD PMID:11375247 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO 1-aminobenzotriazole inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA] CTD PMID:24555085 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Ech1 enoyl-CoA hydratase 1 multiple interactions ISO 1-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of ECH1 protein] CTD PMID:32435916 NCBI chr 1:93,241,076...93,248,314
Ensembl chr 1:84,112,751...84,120,795
JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase multiple interactions ISO 1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of FTCD protein] CTD PMID:32435916 NCBI chr20:12,054,710...12,068,219
Ensembl chr20:12,055,208...12,068,735
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO 1-aminobenzotriazole inhibits the reaction [propylene dichloride results in increased expression of FTH1 protein] CTD PMID:32435916 NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions ISO 1-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of FTL1 protein] CTD PMID:32435916 NCBI chr 1:105,072,858...105,074,705
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO 1-aminobenzotriazole inhibits the reaction [Acetaminophen results in increased activity of GPT protein]; 1-aminobenzotriazole inhibits the reaction [Acetaminophen results in increased expression of GPT protein]; 1-aminobenzotriazole promotes the reaction [Amiodarone promotes the reaction [Dexamethasone results in increased expression of GPT protein]]; [1-aminobenzotriazole co-treated with ochratoxin A] results in increased activity of GPT protein; [Emodin co-treated with 1-aminobenzotriazole] results in increased expression of GPT protein CTD PMID:25900201 PMID:34492313 PMID:36227364 PMID:38825056 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions ISO 1-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of GSTM1 protein] CTD PMID:32435916 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO 1-aminobenzotriazole inhibits the reaction [captax results in increased expression of H2AX protein]; 1-aminobenzotriazole inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein]; 1-aminobenzotriazole inhibits the reaction [Trichloroethylene results in increased phosphorylation of H2AX protein] CTD PMID:28300663 PMID:29722447 PMID:35279910 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO [1-aminobenzotriazole co-treated with ochratoxin A] results in increased expression of HAVCR1 protein CTD PMID:36227364 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO 1-aminobenzotriazole inhibits the reaction [[Acetaminophen co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; 1-aminobenzotriazole inhibits the reaction [[Butylated Hydroxyanisole co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; 1-aminobenzotriazole inhibits the reaction [[Diclofenac co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; 1-aminobenzotriazole inhibits the reaction [[Ticlopidine co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA] CTD PMID:18227147 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 multiple interactions ISO 1-aminobenzotriazole inhibits the reaction [[[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 1-methylpyrene] which results in increased mutagenesis of HPRT1 gene] CTD PMID:25243916 NCBI chr  X:137,655,744...137,687,718
Ensembl chr  X:132,736,096...132,768,154
JBrowse link
G Inmt indolethylamine N-methyltransferase multiple interactions ISO 1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of INMT protein] CTD PMID:32435916 NCBI chr 4:85,648,459...85,652,755
Ensembl chr 4:84,318,197...84,322,493
JBrowse link
G Krt8 keratin 8 multiple interactions ISO 1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of KRT8 protein] CTD PMID:32435916 NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:133,124,203...133,131,728
JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO [1-aminobenzotriazole co-treated with ochratoxin A] results in increased expression of LCN2 protein CTD PMID:36227364 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Rgn regucalcin multiple interactions ISO 1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of RGN protein] CTD PMID:32435916 NCBI chr  X:4,172,537...4,190,112
Ensembl chr  X:1,619,032...1,634,450
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO 1-aminobenzotriazole inhibits the reaction [[[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 1-methylpyrene] which results in increased mutagenesis of HPRT1 gene] CTD PMID:25243916 NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Ubp1 upstream binding protein 1 multiple interactions ISO 1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of UBP1 protein] CTD PMID:32435916 NCBI chr 8:122,748,005...122,793,824
Ensembl chr 8:113,869,979...113,915,625
JBrowse link
1-phenylimidazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP 1-phenylimidazole inhibits the reaction [[[[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde] which co-treated with Glutathione] results in increased glutathionylation of malealdehyde]; 1-phenylimidazole inhibits the reaction [CYP2E1 protein results in increased reduction of Tirapazamine] CTD PMID:7710944 PMID:21842885 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
3,3'-diindolylmethane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions
ISO 3,3'-diindolylmethane results in increased expression of ABCB1 mRNA
[3,3'-diindolylmethane results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; Ketoconazole inhibits the reaction [3,3'-diindolylmethane results in increased expression of ABCB1 mRNA]
CTD PMID:25542144 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Actg1 actin, gamma 1 multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [Estradiol results in decreased expression of ACTG1 mRNA] CTD PMID:11179685 NCBI chr10:106,118,106...106,120,951
Ensembl chr10:105,619,737...105,624,232
Ensembl chr 3:105,619,737...105,624,232
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Lipopolysaccharides results in increased expression of ADGRE1 mRNA] CTD PMID:24162184 NCBI chr 9:2,329,398...2,484,959
Ensembl chr 9:2,242,474...2,398,000
JBrowse link
G Ahr aryl hydrocarbon receptor affects response to substance
affects localization
multiple interactions
ISO
EXP
AHR protein affects the susceptibility to 3,3'-diindolylmethane
3,3'-diindolylmethane affects the localization of AHR protein
3,3'-diindolylmethane binds to and results in decreased activity of AHR protein; 3,3'-diindolylmethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
3,3'-diindolylmethane binds to and results in increased activity of AHR protein; 3,3'-diindolylmethane inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]
3,3'-diindolylmethane binds to and results in increased activity of AHR protein; 3,3'-diindolylmethane inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PTGS2 promoter]]; 3,3'-diindolylmethane promotes the reaction [AHR protein binds to CYP1A1 promoter]; AHR mutant form inhibits the reaction [3,3'-diindolylmethane promotes the reaction [sulforaphane results in increased expression of HMOX1 mRNA]]; AHR mutant form inhibits the reaction [3,3'-diindolylmethane promotes the reaction [sulforaphane results in increased expression of NQO1 mRNA]]
CTD PMID:8384853 PMID:9771935 PMID:11294972 PMID:16972788 PMID:19056653 More... NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Lipopolysaccharides results in increased expression of AIF1 protein] CTD PMID:24162184 NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Ar androgen receptor decreases activity ISO 3,3'-diindolylmethane results in decreased activity of AR protein CTD PMID:30247711 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [ARNT protein binds to CYP1A1 promoter] CTD PMID:16972788 NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO 3,3'-diindolylmethane results in increased expression of ATF3 CTD PMID:15670751 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of ATP5F1A mRNA] CTD PMID:11179685 NCBI chr18:73,567,537...73,575,473
Ensembl chr18:71,292,374...71,300,794
JBrowse link
G Bad BCL2-associated agonist of cell death decreases phosphorylation ISO 3,3'-diindolylmethane results in decreased phosphorylation of BAD protein CTD PMID:22290291 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO 3,3'-diindolylmethane results in increased expression of BAX protein CTD PMID:22290291 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO [3,3'-diindolylmethane results in increased phosphorylation of and results in increased activity of TP53 protein] which results in increased expression of BBC3 CTD PMID:22290291 NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO 3,3'-diindolylmethane promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]
3,3'-diindolylmethane analog results in decreased expression of BCL2 mRNA
3,3'-diindolylmethane analog results in decreased expression of BCL2 protein; 3,3'-diindolylmethane results in decreased expression of BCL2 protein
CTD PMID:16051428 PMID:16580691 PMID:22290291 PMID:26593444 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO 3,3'-diindolylmethane results in increased expression of BCL2L1 mRNA; 3,3'-diindolylmethane results in increased expression of BCL2L1 protein CTD PMID:18025290 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479
JBrowse link
G Bcl2l10 Bcl2-like 10 increases expression ISO 3,3'-diindolylmethane results in increased expression of BCL2L10 mRNA CTD PMID:22514694 NCBI chr 8:84,987,833...84,993,878
Ensembl chr 8:76,107,326...76,113,367
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO 3,3'-diindolylmethane results in decreased expression of BIRC5 protein CTD PMID:22290291 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Brd2 bromodomain containing 2 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of BRD2 mRNA] CTD PMID:11179685 NCBI chr20:4,728,282...4,737,286
Ensembl chr20:4,728,151...4,735,388
JBrowse link
G Calm2 calmodulin 2 multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [Estradiol results in decreased expression of CALM2 mRNA] CTD PMID:11179685 NCBI chr 6:12,845,170...12,857,830
Ensembl chr 6:7,091,567...7,104,287
Ensembl chr15:7,091,567...7,104,287
JBrowse link
G Casp3 caspase 3 increases activity ISO 3,3'-diindolylmethane results in increased activity of CASP3 protein CTD PMID:21820497 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccn1 cellular communication network factor 1 affects methylation ISO 3,3'-diindolylmethane affects the methylation of CCN1 promoter CTD PMID:24466240 NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO 3,3'-diindolylmethane results in decreased expression of CCNB1 CTD PMID:22290291 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO 3,3'-diindolylmethane analog results in decreased expression of CCND1 protein; 3,3'-diindolylmethane results in decreased expression of CCND1 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [3,3'-diindolylmethane analog results in decreased expression of CCND1 protein]
CTD PMID:16051428 PMID:22290291 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO 3,3'-diindolylmethane results in decreased expression of CCND3 protein CTD PMID:22514694 NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccr4 C-C motif chemokine receptor 4 affects methylation ISO 3,3'-diindolylmethane affects the methylation of CCR4 promoter CTD PMID:24466240 NCBI chr 8:123,054,505...123,060,244
Ensembl chr 8:114,176,974...114,178,056
JBrowse link
G Cd40lg CD40 ligand increases expression ISO 3,3'-diindolylmethane results in increased expression of CD40LG mRNA CTD PMID:22514694 NCBI chr  X:140,164,341...140,176,057
Ensembl chr  X:135,126,969...135,138,306
JBrowse link
G Cd69 Cd69 molecule multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of CD69 protein] CTD PMID:24200994 NCBI chr 4:164,411,485...164,419,403
Ensembl chr 4:162,725,446...162,733,542
JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO 3,3'-diindolylmethane results in decreased expression of CDC25C CTD PMID:22290291 NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [bisphenol A results in decreased expression of CDH1 protein]; 3,3'-diindolylmethane inhibits the reaction [Estradiol results in decreased expression of CDH1 protein]; 3,3'-diindolylmethane inhibits the reaction [Triclosan results in decreased expression of CDH1 protein] CTD PMID:28844962 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh11 cadherin 11 decreases expression ISO 3,3'-diindolylmethane results in decreased expression of CDH11 protein CTD PMID:18025290 NCBI chr19:2,152,961...2,312,140
Ensembl chr19:2,148,458...2,304,272
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of CDH2 protein]; 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of CDH2 protein]; 3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of CDH2 protein] CTD PMID:28844962 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
decreases activity
ISO 3,3'-diindolylmethane promotes the reaction [CDK2 protein binds to CDKN1A protein]
3,3'-diindolylmethane results in decreased activity of CDK2 protein
CTD PMID:15611077 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO 3,3'-diindolylmethane results in decreased expression of CDK4 protein CTD PMID:22514694 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO 3,3'-diindolylmethane results in decreased expression of CDK6 protein CTD PMID:22290291 PMID:22514694 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO 3,3'-diindolylmethane promotes the reaction [CDK2 protein binds to CDKN1A protein]
3,3'-diindolylmethane results in increased expression of CDKN1A mRNA; 3,3'-diindolylmethane results in increased expression of CDKN1A protein
CTD PMID:12203118 PMID:15611077 PMID:18025290 PMID:22290291 PMID:22495798 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO 3,3'-diindolylmethane results in increased expression of CDKN1B protein CTD PMID:22290291 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D increases expression ISO 3,3'-diindolylmethane results in increased expression of CDKN2D protein CTD PMID:22290291 NCBI chr 8:28,108,036...28,110,809
Ensembl chr 8:19,831,866...19,834,674
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex decreases phosphorylation ISO 3,3'-diindolylmethane results in decreased phosphorylation of CHUK protein CTD PMID:22290291 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Cks1b CDC28 protein kinase regulatory subunit 1B multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [Estradiol results in decreased expression of CKS1B mRNA] CTD PMID:11179685 NCBI chr 2:177,130,751...177,135,333
Ensembl chr 2:174,833,050...174,837,636
JBrowse link
G Ctsb cathepsin B multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of CTSB protein]; 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of CTSB protein]; 3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of CTSB protein] CTD PMID:28844962 NCBI chr15:41,565,607...41,586,479
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Ctsd cathepsin D multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of CTSD protein]; 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of CTSD protein]; 3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of CTSD protein] CTD PMID:28844962 NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 affects methylation
multiple interactions
ISO 3,3'-diindolylmethane affects the methylation of CXCR4 promoter
3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of CXCR4 protein]; 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of CXCR4 protein]; 3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of CXCR4 protein]
CTD PMID:24466240 PMID:28844962 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO 3,3'-diindolylmethane analog affects the localization of and results in increased expression of CYCS protein CTD PMID:16051428 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression ISO 3,3'-diindolylmethane analog results in increased expression of CYP19A1 mRNA; 3,3'-diindolylmethane results in increased expression of CYP19A1 mRNA CTD PMID:11294972 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases activity
increases expression
decreases activity
ISO
EXP
3,3'-diindolylmethane promotes the reaction [AHR protein binds to CYP1A1 promoter]; 3,3'-diindolylmethane promotes the reaction [ARNT protein binds to CYP1A1 promoter]; 3,3'-diindolylmethane promotes the reaction [ESR1 protein binds to CYP1A1 promoter]; [3,3'-diindolylmethane results in increased expression of CYP1A1 mRNA] which results in increased abundance of aflatoxin B1-DNA adduct
3,3'-diindolylmethane analog results in increased activity of CYP1A1 protein; 3,3'-diindolylmethane results in increased activity of CYP1A1 protein
3,3'-diindolylmethane results in increased expression of CYP1A1 protein
3,3'-diindolylmethane analog results in increased expression of CYP1A1 mRNA; 3,3'-diindolylmethane results in increased expression of CYP1A1 mRNA; 3,3'-diindolylmethane results in increased expression of CYP1A1 protein
3,3'-diindolylmethane results in decreased activity of CYP1A1 protein
CTD PMID:8384853 PMID:9771935 PMID:11179685 PMID:11294972 PMID:11597580 More... NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
decreases activity
increases oxidation
ISO
EXP
[3,3'-diindolylmethane results in increased expression of CYP1A2 mRNA] which results in increased abundance of aflatoxin B1-DNA adduct; Quercetin inhibits the reaction [CYP1A2 protein results in increased oxidation of 3,3'-diindolylmethane]; resveratrol inhibits the reaction [CYP1A2 protein results in increased oxidation of 3,3'-diindolylmethane]
3,3'-diindolylmethane results in increased expression of CYP1A2 protein
3,3'-diindolylmethane results in increased expression of CYP1A2 mRNA; 3,3'-diindolylmethane results in increased expression of CYP1A2 protein
3,3'-diindolylmethane results in decreased activity of CYP1A2 protein
CTD PMID:8384853 PMID:15672752 PMID:16544949 PMID:19770484 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO 3,3'-diindolylmethane analog results in increased expression of CYP1B1 mRNA; 3,3'-diindolylmethane results in increased expression of CYP1B1 mRNA CTD PMID:11294972 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP 3,3'-diindolylmethane results in increased expression of CYP2B1 protein CTD PMID:8384853 NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP 3,3'-diindolylmethane results in increased expression of CYP2B2 protein CTD PMID:8384853 NCBI chr 1:90,722,243...90,736,272
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
decreases activity
multiple interactions
ISO 3,3'-diindolylmethane results in increased expression of CYP3A4 mRNA
3,3'-diindolylmethane results in decreased activity of CYP3A4 protein
[3,3'-diindolylmethane results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Ketoconazole inhibits the reaction [3,3'-diindolylmethane results in increased expression of CYP3A4 mRNA]
CTD PMID:19770484 PMID:25542144 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO 3,3'-diindolylmethane results in increased expression of DDIT3 protein CTD PMID:22290291 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression ISO 3,3'-diindolylmethane results in decreased expression of DNMT1 mRNA CTD PMID:24466240 NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta decreases expression ISO 3,3'-diindolylmethane results in decreased expression of DNMT3B mRNA CTD PMID:24466240 NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:142,130,592...142,169,124
JBrowse link
G Eef1g eukaryotic translation elongation factor 1 gamma multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [Estradiol results in increased expression of EEF1G mRNA] CTD PMID:11179685 NCBI chr 1:215,289,815...215,300,421
Ensembl chr 1:205,860,698...205,872,382
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [Paclitaxel results in decreased phosphorylation of and results in decreased activity of ERBB2 protein]; 3,3'-diindolylmethane results in decreased phosphorylation of and results in decreased activity of ERBB2 protein CTD PMID:16580691 NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression
ISO 3,3'-diindolylmethane binds to and results in increased activity of ESR1 protein; 3,3'-diindolylmethane promotes the reaction [ESR1 protein binds to CYP1A1 promoter]; 3,3'-diindolylmethane promotes the reaction [ESR1 protein binds to TFF1 promoter]; ESR1 mutant form promotes the reaction [3,3'-diindolylmethane promotes the reaction [sulforaphane results in increased expression of HMOX1 mRNA]]
3,3'-diindolylmethane results in decreased expression of ESR1
CTD PMID:16972788 PMID:19223575 PMID:23583297 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases expression
ISO 3,3'-diindolylmethane promotes the reaction [ESR2 protein binds to KRT19 promoter]; 3,3'-diindolylmethane promotes the reaction [ESR2 protein binds to TMEM121B promoter]; ESR2 affects the reaction [3,3'-diindolylmethane promotes the reaction [NCOA2 protein binds to KRT19 promoter]]; ESR2 affects the reaction [3,3'-diindolylmethane results in increased expression of KRT19 mRNA]; ESR2 affects the reaction [3,3'-diindolylmethane results in increased expression of TMEM121B mRNA]; Raloxifene Hydrochloride inhibits the reaction [3,3'-diindolylmethane results in increased expression of ESR2 mRNA]; Tamoxifen inhibits the reaction [3,3'-diindolylmethane results in increased expression of ESR2 mRNA] CTD PMID:20160136 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fau FAU ubiquitin like and ribosomal protein S30 fusion multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [Estradiol results in decreased expression of FAU mRNA] CTD PMID:11179685 NCBI chr 1:212,779,429...212,781,028
Ensembl chr 1:203,350,189...203,351,742
Ensembl chr 1:203,350,189...203,351,742
Ensembl chr 6:203,350,189...203,351,742
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO 3,3'-diindolylmethane results in increased expression of GDF15 mRNA CTD PMID:15670751 NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Gnas GNAS complex locus multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in decreased expression of GNAS mRNA] CTD PMID:11179685 NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 increases expression ISO 3,3'-diindolylmethane results in increased expression of GREB1 mRNA CTD PMID:23583297 NCBI chr 6:45,169,289...45,321,973
Ensembl chr 6:39,440,504...39,581,633
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation ISO 3,3'-diindolylmethane results in decreased phosphorylation of GSK3B protein CTD PMID:22290291 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression
multiple interactions
ISO 3,3'-diindolylmethane results in decreased expression of GSTM1 mRNA
[3,3'-diindolylmethane results in decreased expression of GSTM1 mRNA] which results in increased abundance of aflatoxin B1-DNA adduct
CTD PMID:19770484 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G H3f3a H3.3 histone A multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [Estradiol results in increased expression of H3-3A mRNA] CTD PMID:11179685 NCBI chr13:95,065,085...95,076,695
Ensembl chr13:92,533,298...92,544,908
JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of HDAC1 mRNA] CTD PMID:24200994 NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:141,853,989...141,881,111
JBrowse link
G Hdac10 histone deacetylase 10 multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [enterotoxin B, staphylococcal results in decreased expression of HDAC10 mRNA] CTD PMID:24200994 NCBI chr 7:122,078,768...122,084,457
Ensembl chr 7:120,199,129...120,204,228
JBrowse link
G Hdac2 histone deacetylase 2 decreases expression
multiple interactions
ISO 3,3'-diindolylmethane results in decreased expression of HDAC2 protein
3,3'-diindolylmethane inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of HDAC2 mRNA]
CTD PMID:22800507 PMID:24200994 NCBI chr20:42,101,815...42,126,486
Ensembl chr20:40,548,250...40,571,609
JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [enterotoxin B, staphylococcal results in decreased expression of HDAC5 mRNA] CTD PMID:24200994 NCBI chr10:87,653,139...87,688,078
Ensembl chr10:87,152,978...87,188,235
JBrowse link
G Hdac8 histone deacetylase 8 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of HDAC8 mRNA] CTD PMID:24200994 NCBI chr  X:71,425,240...71,632,865
Ensembl chr  X:67,385,289...67,592,923
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [sulforaphane results in increased expression of HMOX1 mRNA]; AHR mutant form inhibits the reaction [3,3'-diindolylmethane promotes the reaction [sulforaphane results in increased expression of HMOX1 mRNA]]; ESR1 mutant form promotes the reaction [3,3'-diindolylmethane promotes the reaction [sulforaphane results in increased expression of HMOX1 mRNA]] CTD PMID:23583297 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hrk harakiri, BCL2 interacting protein increases expression ISO 3,3'-diindolylmethane results in increased expression of HRK mRNA CTD PMID:22514694 NCBI chr12:44,048,402...44,070,561 JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression
multiple interactions
ISO 3,3'-diindolylmethane analog results in decreased expression of HSPA5 protein
3,3'-diindolylmethane analog promotes the reaction [HSPA5 protein affects the expression of and affects the activity of MMP9 protein]
CTD PMID:25794856 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of HSPB1 mRNA] CTD PMID:11179685 NCBI chr12:26,430,640...26,432,301
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Ifng interferon gamma multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [enterotoxin B, staphylococcal results in increased secretion of IFNG protein] CTD PMID:24200994 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il2 interleukin 2 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [enterotoxin B, staphylococcal results in increased secretion of IL2 protein] CTD PMID:24200994 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO 3,3'-diindolylmethane results in increased expression of IL6 mRNA
3,3'-diindolylmethane inhibits the reaction [enterotoxin B, staphylococcal results in increased secretion of IL6 protein]
CTD PMID:18025290 PMID:24200994 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kdr kinase insert domain receptor decreases expression ISO 3,3'-diindolylmethane analog results in decreased expression of KDR protein CTD PMID:25794856 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Klf10 KLF transcription factor 10 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in decreased expression of KLF10 mRNA] CTD PMID:11179685 NCBI chr 7:71,352,612...71,358,680
Ensembl chr 7:69,465,619...69,473,994
JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 decreases expression ISO 3,3'-diindolylmethane results in decreased expression of KLK3 mRNA CTD PMID:22495798 NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:94,402,993...94,407,052
JBrowse link
G Krt18 keratin 18 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of KRT18 mRNA] CTD PMID:11179685 NCBI chr 7:135,036,168...135,039,844
Ensembl chr 7:133,157,475...133,161,166
Ensembl chr10:133,157,475...133,161,166
JBrowse link
G Krt19 keratin 19 multiple interactions
increases expression
ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of KRT19 mRNA]; 3,3'-diindolylmethane promotes the reaction [ESR2 protein binds to KRT19 promoter]; 3,3'-diindolylmethane promotes the reaction [NCOA2 protein binds to KRT19 promoter]; ESR2 affects the reaction [3,3'-diindolylmethane promotes the reaction [NCOA2 protein binds to KRT19 promoter]]; ESR2 affects the reaction [3,3'-diindolylmethane results in increased expression of KRT19 mRNA]; NCOA2 mutant form inhibits the reaction [3,3'-diindolylmethane results in increased expression of KRT19 mRNA] CTD PMID:11179685 PMID:20160136 NCBI chr10:85,576,235...85,580,952
Ensembl chr10:85,066,802...85,171,799
JBrowse link
G Magea9 MAGE family member A9 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of MAGEA9 mRNA] CTD PMID:11179685 NCBI chr  X:147,655,721...147,661,093
Ensembl chr  X:142,619,395...142,624,653
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [3,3'-diindolylmethane results in decreased phosphorylation of MAPK1 protein]; 3,3'-diindolylmethane promotes the reaction [Paclitaxel results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]; 3,3'-diindolylmethane results in decreased phosphorylation of and results in decreased activity of MAPK1 protein CTD PMID:16580691 PMID:22290291 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO 3,3'-diindolylmethane results in decreased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [3,3'-diindolylmethane results in decreased phosphorylation of MAPK3 protein]; 3,3'-diindolylmethane promotes the reaction [Paclitaxel results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]; 3,3'-diindolylmethane results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
CTD PMID:16580691 PMID:22290291 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression ISO 3,3'-diindolylmethane analog results in decreased expression of MDM2 mRNA CTD PMID:26593444 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of MMP2 protein]; 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of MMP2 protein]; 3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of MMP2 protein] CTD PMID:28844962 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO 3,3'-diindolylmethane analog promotes the reaction [HSPA5 protein affects the expression of and affects the activity of MMP9 protein]; 3,3'-diindolylmethane analog results in decreased expression of and results in decreased activity of MMP9 protein; 3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of MMP9 protein]; 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of MMP9 protein]; 3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of MMP9 protein] CTD PMID:25794856 PMID:28844962 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in decreased expression of COX2 mRNA] CTD PMID:11179685 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Myb MYB proto-oncogene, transcription factor decreases expression ISO 3,3'-diindolylmethane analog results in decreased expression of MYB mRNA CTD PMID:26593444 NCBI chr 1:17,759,309...17,793,306
Ensembl chr 1:15,939,761...15,973,057
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO 3,3'-diindolylmethane results in decreased expression of MYC protein
3,3'-diindolylmethane analog results in decreased expression of MYC mRNA
CTD PMID:22290291 PMID:26593444 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Myl6 myosin light chain 6 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of MYL6 mRNA] CTD PMID:11179685 NCBI chr 7:1,495,301...1,498,512
Ensembl chr 7:910,774...933,791
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [NCOA2 protein binds to KRT19 promoter]; ESR2 affects the reaction [3,3'-diindolylmethane promotes the reaction [NCOA2 protein binds to KRT19 promoter]]; NCOA2 mutant form inhibits the reaction [3,3'-diindolylmethane results in increased expression of KRT19 mRNA]; NCOA2 mutant form inhibits the reaction [3,3'-diindolylmethane results in increased expression of TMEM121B mRNA] CTD PMID:20160136 NCBI chr 5:10,618,712...10,852,776
Ensembl chr 5:5,835,706...6,067,451
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions
ISO 3,3'-diindolylmethane results in increased expression of NFE2L2 mRNA; 3,3'-diindolylmethane results in increased expression of NFE2L2 protein
sulforaphane promotes the reaction [3,3'-diindolylmethane results in increased expression of NFE2L2 mRNA]; sulforaphane promotes the reaction [3,3'-diindolylmethane results in increased expression of NFE2L2 protein]
CTD PMID:23583297 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:24162184 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO 3,3'-diindolylmethane promotes the reaction [sulforaphane results in increased expression of NQO1 mRNA]; AHR mutant form inhibits the reaction [3,3'-diindolylmethane promotes the reaction [sulforaphane results in increased expression of NQO1 mRNA]]
3,3'-diindolylmethane results in increased expression of NQO1 mRNA
CTD PMID:15672752 PMID:22495798 PMID:23583297 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO 3,3'-diindolylmethane results in increased activity of NR1I2 protein
[3,3'-diindolylmethane results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; [3,3'-diindolylmethane results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:25542144 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Numa1 nuclear mitotic apparatus protein 1 multiple interactions EXP 3,3'-diindolylmethane inhibits the reaction [[Butylhydroxybutylnitrosamine co-treated with Cacodylic Acid] results in increased expression of NUMA1 protein] CTD PMID:26251508 NCBI chr 1:165,709,893...165,784,848
Ensembl chr 1:156,326,259...156,372,855
JBrowse link
G Nup133 nucleoporin 133 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in decreased expression of NUP133 mRNA] CTD PMID:11179685 NCBI chr19:68,789,065...68,838,692
Ensembl chr19:51,891,629...51,941,239
JBrowse link
G Papola poly (A) polymerase alpha multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of PAPOLA mRNA] CTD PMID:11179685 NCBI chr 6:130,446,236...130,499,371
Ensembl chr 6:124,682,105...124,734,468
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [3,3'-diindolylmethane co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of PARP1 protein CTD PMID:16580691 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Plau plasminogen activator, urokinase increases expression ISO 3,3'-diindolylmethane results in increased expression of PLAU mRNA CTD PMID:18025290 NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions ISO [3,3'-diindolylmethane results in increased phosphorylation of and results in increased activity of TP53 protein] which results in increased expression of PMAIP1 CTD PMID:22290291 NCBI chr18:62,255,970...62,262,384
Ensembl chr18:59,986,017...59,992,429
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions EXP 3,3'-diindolylmethane inhibits the reaction [[Butylhydroxybutylnitrosamine co-treated with Cacodylic Acid] results in decreased expression of PTEN protein] CTD PMID:26251508 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
ISO
EXP
3,3'-diindolylmethane inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PTGS2 promoter]]; 3,3'-diindolylmethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]; 3,3'-diindolylmethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 protein]
3,3'-diindolylmethane inhibits the reaction [[Butylhydroxybutylnitrosamine co-treated with Cacodylic Acid] results in increased expression of PTGS2 protein]
3,3'-diindolylmethane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
3,3'-diindolylmethane results in decreased expression of PTGS2 mRNA; 3,3'-diindolylmethane results in decreased expression of PTGS2 protein
CTD PMID:19056653 PMID:22290291 PMID:24162184 PMID:26251508 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression
multiple interactions
ISO
EXP
3,3'-diindolylmethane results in decreased expression of RELA protein
3,3'-diindolylmethane inhibits the reaction [[Butylhydroxybutylnitrosamine co-treated with Cacodylic Acid] results in increased phosphorylation of RELA protein]
CTD PMID:22290291 PMID:26251508 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ribc1 RIB43A domain with coiled-coils 1 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of RIBC1 mRNA] CTD PMID:11179685 NCBI chr  X:24,571,126...24,583,170
Ensembl chr  X:21,091,717...21,103,200
JBrowse link
G Rpl10 ribosomal protein L10 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of RPL10 mRNA]; 3,3'-diindolylmethane promotes the reaction [Estradiol results in increased expression of RPL10 mRNA] CTD PMID:11179685 NCBI chr  X:157,205,850...157,208,057
Ensembl chr  X:152,054,452...152,056,761
JBrowse link
G Rpl13a ribosomal protein L13A multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [Estradiol results in increased expression of RPL13A mRNA] CTD PMID:11179685 NCBI chr 1:104,746,223...104,748,975
Ensembl chr 1:95,609,370...95,620,463
JBrowse link
G Rpl31 ribosomal protein L31 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of RPL31 mRNA] CTD PMID:11179685 NCBI chr 9:49,143,044...49,147,155
Ensembl chr 9:41,647,426...41,662,129
Ensembl chr 8:41,647,426...41,662,129
JBrowse link
G Rpl41 ribosomal protein L41 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in decreased expression of RPL41 mRNA] CTD PMID:11179685 NCBI chr 7:1,562,417...1,563,497 JBrowse link
G Rpl7 ribosomal protein L7 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of RPL7 mRNA] CTD PMID:11179685 NCBI chr 5:8,000,446...8,003,454 JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in decreased expression of RPLP0 mRNA] CTD PMID:11179685 NCBI chr12:46,715,121...46,718,390
Ensembl chr12:41,054,179...41,057,632
JBrowse link
G Rps15a ribosomal protein S15a multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in decreased expression of RPS15A mRNA] CTD PMID:11179685 NCBI chr 1:181,854,396...181,861,330
Ensembl chr 1:172,419,761...172,426,995
JBrowse link
G Rps17 ribosomal protein S17 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in decreased expression of RPS17 mRNA] CTD PMID:11179685 NCBI chr 1:144,705,150...144,707,736
Ensembl chr 1:135,295,919...135,298,535
Ensembl chr 8:135,295,919...135,298,535
JBrowse link
G Rps3 ribosomal protein S3 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of RPS3 mRNA] CTD PMID:11179685 NCBI chr 1:163,190,476...163,195,885
Ensembl chr 1:153,777,472...153,783,680
JBrowse link
G Rps4x ribosomal protein S4, X-linked multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [Estradiol results in increased expression of RPS4X mRNA] CTD PMID:11179685 NCBI chr  X:71,338,478...71,342,921
Ensembl chr  X:67,298,525...67,303,019
Ensembl chr 4:67,298,525...67,303,019
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [Estradiol results in increased expression of RPS6 mRNA] CTD PMID:11179685 NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of SNAI1 protein]; 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of SNAI1 protein]; 3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of SNAI1 protein] CTD PMID:28844962 NCBI chr 3:176,667,476...176,671,965
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of SNAI2 protein]; 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of SNAI2 protein]; 3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of SNAI2 protein] CTD PMID:28844962 NCBI chr11:99,686,934...99,690,349
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [ESR1 protein binds to TFF1 promoter] CTD PMID:16972788 NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 affects methylation ISO 3,3'-diindolylmethane affects the methylation of TGFBR1 promoter CTD PMID:24466240 NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO 3,3'-diindolylmethane analog results in increased expression of TIMP1 protein CTD PMID:25794856 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tmem121b transmembrane protein 121B multiple interactions
increases expression
ISO 3,3'-diindolylmethane promotes the reaction [ESR2 protein binds to TMEM121B promoter]; ESR2 affects the reaction [3,3'-diindolylmethane results in increased expression of TMEM121B mRNA]; NCOA2 mutant form inhibits the reaction [3,3'-diindolylmethane results in increased expression of TMEM121B mRNA] CTD PMID:20160136 NCBI chr 4:155,367,397...155,372,310
Ensembl chr 4:153,698,194...153,699,912
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
ISO
EXP
3,3'-diindolylmethane results in decreased expression of TNF mRNA
3,3'-diindolylmethane inhibits the reaction [[Butylhydroxybutylnitrosamine co-treated with Cacodylic Acid] results in increased expression of TNF protein]
3,3'-diindolylmethane inhibits the reaction [enterotoxin B, staphylococcal results in increased secretion of TNF protein]
CTD PMID:22514694 PMID:24200994 PMID:26251508 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO 3,3'-diindolylmethane results in increased expression of TNFRSF1A mRNA CTD PMID:22514694 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tnfrsf25 TNF receptor superfamily member 25 decreases expression ISO 3,3'-diindolylmethane results in decreased expression of TNFRSF25 mRNA CTD PMID:22514694 NCBI chr 5:167,904,377...167,909,052
Ensembl chr 5:162,622,075...162,626,341
JBrowse link
G Tnfsf8 TNF superfamily member 8 increases expression ISO 3,3'-diindolylmethane results in increased expression of TNFSF8 mRNA CTD PMID:22514694 NCBI chr 5:82,266,436...82,292,858
Ensembl chr 5:77,251,373...77,277,421
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO 3,3'-diindolylmethane results in increased expression of and results in increased phosphorylation of and results in increased activity of TP53 protein; [3,3'-diindolylmethane results in increased phosphorylation of and results in increased activity of TP53 protein] which results in increased expression of BBC3; [3,3'-diindolylmethane results in increased phosphorylation of and results in increased activity of TP53 protein] which results in increased expression of PMAIP1; wortmannin inhibits the reaction [3,3'-diindolylmethane results in increased phosphorylation of TP53 protein] CTD PMID:22290291 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Traf4 Tnf receptor associated factor 4 decreases expression ISO 3,3'-diindolylmethane results in decreased expression of TRAF4 mRNA CTD PMID:22514694 NCBI chr10:63,552,251...63,558,356
Ensembl chr10:63,054,181...63,060,284
JBrowse link
G Tyms thymidylate synthetase multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of TYMS mRNA] CTD PMID:11179685 NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
G Ubb ubiquitin B multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [Estradiol results in increased expression of UBB mRNA] CTD PMID:11179685 NCBI chr10:47,746,923...47,748,628
Ensembl chr10:47,245,637...47,249,333
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO 3,3'-diindolylmethane results in decreased expression of XIAP protein CTD PMID:22290291 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Xrcc6 X-ray repair cross complementing 6 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of XRCC6 mRNA] CTD PMID:11179685 NCBI chr 7:115,423,026...115,443,884
Ensembl chr 7:113,543,057...113,563,762
JBrowse link
5'-hydroxyomeprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP 5-hydroxymethylomeprazole results in increased expression of CYP1A1 protein CTD PMID:10103034 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
alpha-naphthoflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 multiple interactions EXP [alpha-naphthoflavone co-treated with Methylcholanthrene] results in decreased acetylation of ADAMTS1 promoter; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased acetylation of ADAMTS1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased expression of ADAMTS1 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of ADAMTS1 promoter] CTD PMID:29094188 NCBI chr11:38,418,565...38,427,384
Ensembl chr11:24,931,761...24,941,103
JBrowse link
G Ahr aryl hydrocarbon receptor affects binding
decreases activity
multiple interactions
ISO
EXP
[alpha-naphthoflavone binds to AHR protein] which binds to ESR1 protein; [alpha-naphthoflavone binds to AHR protein] which binds to ESRRA protein; [alpha-naphthoflavone binds to AHR protein] which binds to NR2F1 protein; alpha-naphthoflavone binds to AHR protein
alpha-naphthoflavone results in decreased activity of AHR protein
[alpha-naphthoflavone results in decreased activity of AHR protein] which results in decreased expression of CYP1A1 mRNA; AHR gene mutant form inhibits the reaction [alpha-naphthoflavone results in increased expression of IGFBP4 protein]; AHR protein promotes the reaction [alpha-naphthoflavone results in decreased expression of CDH13 mRNA]; alpha-naphthoflavone binds to and results in decreased activity of AHR protein; alpha-naphthoflavone binds to and results in increased activity of AHR protein; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [hydroquinone results in increased expression of AHR protein]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to BAX promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to CASP9 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to CDK2 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to DNAJB6 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to HES1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to ICAM1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to IGF2 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to JAG1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to SP1 promoter]]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of and results in increased activity of AHR protein]; alpha-naphthoflavone promotes the reaction [beta-Naphthoflavone results in decreased expression of AHR mRNA]
[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of IL10 protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] results in decreased susceptibility to [SB 203580 results in increased expression of CYP1A1]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Benzo(a)pyrene; alpha-naphthoflavone binds to and results in decreased activity of AHR protein; alpha-naphthoflavone binds to and results in increased activity of AHR protein; alpha-naphthoflavone inhibits the reaction [AHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of and results in increased activity of AHR protein]
[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Skatole results in increased expression of CYP1A1 mRNA]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Skatole results in increased expression of CYP2F1 mRNA]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FLG mRNA]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Hexachlorobenzene; [alpha-naphthoflavone results in decreased activity of AHR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in increased abundance of Reactive Oxygen Species]; alpha-naphthoflavone analog inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; alpha-naphthoflavone analog results in increased activity of [AHR protein binds to ARNT protein]; alpha-naphthoflavone binds to and results in decreased activity of AHR protein; alpha-naphthoflavone inhibits the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]; alpha-naphthoflavone inhibits the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [[Benzo(a)pyrene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [[benzo(k)fluoranthene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [[chrysene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [[Oxygen deficiency co-treated with Tetrachlorodibenzodioxin] results in decreased stability of AHR protein]; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased activity of BRCA1 protein]; alpha-naphthoflavone inhibits the reaction [AHR promotes the reaction [Tetrachlorodibenzodioxin results in decreased uptake of Glucose]]; alpha-naphthoflavone inhibits the reaction [AHR protein binds to and results in increased metabolism of Benzo(a)pyrene]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased activity of AHR protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of AHR protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of AHR protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of and results in increased activity of AHR protein]; alpha-naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]
CTD PMID:1329656 PMID:7669069 PMID:8390116 PMID:8738555 PMID:9006915 More... NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases methylation
EXP alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased acetylation of AKT1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of AKT1 mRNA]
alpha-naphthoflavone results in increased methylation of AKT1 promoter
CTD PMID:29094188 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Ar androgen receptor multiple interactions
increases expression
ISO alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of AR protein]; alpha-naphthoflavone inhibits the reaction [Particulate Matter analog inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]]; alpha-naphthoflavone inhibits the reaction [Vehicle Emissions analog inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]]; bicalutamide inhibits the reaction [alpha-naphthoflavone inhibits the reaction [Particulate Matter analog inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]]]; bicalutamide inhibits the reaction [alpha-naphthoflavone inhibits the reaction [Vehicle Emissions analog inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]]]
alpha-naphthoflavone results in increased expression of AR protein
CTD PMID:12970580 PMID:15041469 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO alpha-naphthoflavone analog results in increased activity of [AHR protein binds to ARNT protein]; alpha-naphthoflavone inhibits the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]; alpha-naphthoflavone inhibits the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]
ARNT protein affects the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]
CTD PMID:11768231 PMID:21127131 PMID:30508555 NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP
alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene metabolite results in increased expression of BAX mRNA]
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to BAX promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of BAX mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of BAX promoter]
CTD PMID:20562217 PMID:29094188 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bmp15 bone morphogenetic protein 15 multiple interactions EXP [Methylcholanthrene co-treated with alpha-naphthoflavone] results in increased expression of BMP15 mRNA CTD PMID:29094188 NCBI chr  X:18,840,943...18,846,006
Ensembl chr  X:16,169,123...16,174,187
JBrowse link
G Bpgm bisphosphoglycerate mutase multiple interactions
increases expression
ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of BPGM mRNA]
alpha-naphthoflavone results in increased expression of BPGM mRNA
CTD PMID:23152189 NCBI chr 4:64,106,809...64,135,749
Ensembl chr 4:63,140,018...63,168,581
JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions ISO alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased activity of BRCA1 protein]; alpha-naphthoflavone inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA] CTD PMID:16489025 PMID:18259752 NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Calr calreticulin multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CALR mRNA] CTD PMID:29094188 NCBI chr19:40,213,367...40,218,262
Ensembl chr19:23,308,351...23,313,414
JBrowse link
G Casp12 caspase 12 increases cleavage ISO alpha-naphthoflavone results in increased cleavage of CASP12 protein CTD PMID:30508555 NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage
decreases activity
ISO
EXP
alpha-naphthoflavone results in increased activity of CASP3 protein
alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased cleavage of CASP3 protein]
alpha-naphthoflavone results in increased cleavage of CASP3 protein
alpha-naphthoflavone results in decreased activity of CASP3 protein
CTD PMID:15710172 PMID:18334599 PMID:30508555 PMID:35908932 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO alpha-naphthoflavone results in increased activity of CASP8 protein CTD PMID:18334599 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO
EXP
alpha-naphthoflavone results in increased activity of CASP9 protein
[alpha-naphthoflavone co-treated with Methylcholanthrene] results in decreased acetylation of CASP9 promoter; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to CASP9 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CASP9 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of CASP9 promoter]
CTD PMID:18334599 PMID:29094188 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cat catalase multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein] CTD PMID:20600218 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl1 C-C motif chemokine ligand 1 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CCL1] CTD PMID:16679317 NCBI chr10:67,625,962...67,628,740
Ensembl chr10:67,128,331...67,131,159
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
increases expression
multiple interactions
ISO alpha-naphthoflavone results in decreased expression of CCL2 mRNA
alpha-naphthoflavone results in increased expression of CCL2 mRNA
alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCL2 mRNA]
CTD PMID:22262711 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Plant Extracts results in decreased expression of CCNB1 mRNA] CTD PMID:25051199 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of CCND1 mRNA]; alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of CCND1 protein] CTD PMID:31364906 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cd9 CD9 molecule multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased expression of CD9 mRNA] CTD PMID:29094188 NCBI chr 4:159,942,553...159,975,463
Ensembl chr 4:158,256,328...158,289,222
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Plant Extracts results in decreased expression of CDC25C mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of CDC25C protein] CTD PMID:22266097 PMID:25051199 NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in decreased expression of CDH1 mRNA]; alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in decreased expression of CDH1 protein] CTD PMID:31364906 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh13 cadherin 13 multiple interactions EXP AHR protein promotes the reaction [alpha-naphthoflavone results in decreased expression of CDH13 mRNA]; alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CDH13 mRNA]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of CDH13 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDH13 mRNA] CTD PMID:12559965 NCBI chr19:63,258,251...64,296,122
Ensembl chr19:46,349,430...47,387,459
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of CDK1 protein] CTD PMID:22266097 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
decreases methylation
EXP alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to CDK2 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased methylation of CDK2 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of CDK2 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CDK2 mRNA]
alpha-naphthoflavone results in decreased methylation of CDK2 promoter
CTD PMID:29094188 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene promotes the reaction [eupatorin-5-methyl ether results in increased expression of CDKN1A protein]]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CDKN1A mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDKN1A protein] CTD PMID:21887816 PMID:22266097 PMID:23994263 PMID:24361490 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDKN1B protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CDKN1B protein] CTD PMID:15157999 PMID:22266097 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta multiple interactions ISO alpha-naphthoflavone promotes the reaction [Particulate Matter results in increased expression of CEBPD mRNA] CTD PMID:21652769 NCBI chr11:98,268,856...98,269,994
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Particulate Matter results in increased expression of CSF2 mRNA] CTD PMID:20801209 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Ctsd cathepsin D multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]] CTD PMID:11165043 NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Cygb cytoglobin multiple interactions ISO alpha-naphthoflavone inhibits the reaction [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYGB mRNA] CTD PMID:25781201 NCBI chr10:102,376,506...102,386,272
Ensembl chr10:101,877,676...101,887,442
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 multiple interactions
increases expression
ISO alpha-naphthoflavone promotes the reaction [CYP11B1 protein results in increased chemical synthesis of Hydrocortisone]
alpha-naphthoflavone results in increased expression of CYP11B1 mRNA
CTD PMID:22172629 NCBI chr 7:108,719,349...108,726,024
Ensembl chr 7:106,838,590...106,845,004
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO alpha-naphthoflavone results in decreased expression of CYP17A1 mRNA CTD PMID:24875446 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO [alpha-naphthoflavone results in decreased activity of CYP19A1 protein] which results in decreased susceptibility to o,p'-DDT; alpha-naphthoflavone binds to and results in decreased activity of CYP19A1 protein; alpha-naphthoflavone inhibits the reaction [Aflatoxin B1 results in increased expression of CYP19A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP19A1 protein]
alpha-naphthoflavone results in increased expression of CYP19A1 protein
CTD PMID:9435150 PMID:20678559 PMID:20823264 PMID:21296134 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
affects binding
increases expression
multiple interactions
decreases activity
ISO
EXP
alpha-naphthoflavone results in increased activity of CYP1A1 protein
CYP1A1 protein binds to alpha-naphthoflavone
alpha-naphthoflavone results in increased expression of CYP1A1 mRNA
alpha-naphthoflavone analog results in increased expression of CYP1A1 mRNA; alpha-naphthoflavone results in increased expression of CYP1A1 mRNA; alpha-naphthoflavone results in increased expression of CYP1A1 protein
[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Skatole results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [[3,4,5,3',4'-pentachlorobiphenyl co-treated with Benzo(a)pyrene] results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]; alpha-naphthoflavone inhibits the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [[Benzo(a)pyrene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [[benzo(k)fluoranthene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [[chrysene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] which results in increased metabolism of Benzo(a)pyrene]; alpha-naphthoflavone inhibits the reaction [afimoxifene results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Calcitriol promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]]; alpha-naphthoflavone inhibits the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Cycloheximide results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Resveratrol results in increased expression of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [STO 609 results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [Vehicle Emissions results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]
alpha-naphthoflavone results in decreased activity of CYP1A1 protein
[alpha-naphthoflavone results in decreased activity of AHR protein] which results in decreased expression of CYP1A1 mRNA; [alpha-naphthoflavone results in decreased activity of CYP1A1 protein] inhibits the reaction [Vinyl Compounds analog results in decreased susceptibility to sodium arsenite]; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of CYP1A1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of CYP1A1 promoter]; alpha-naphthoflavone inhibits the reaction [norisoboldine results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; alpha-naphthoflavone promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
[[alpha-naphthoflavone results in decreased activity of CYP1A2 protein] co-treated with [alpha-naphthoflavone results in decreased activity of CYP1A1 protein]] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] results in decreased susceptibility to [SB 203580 results in increased expression of CYP1A1]; alpha-naphthoflavone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; SRC protein affects the reaction [alpha-naphthoflavone results in increased expression of CYP1A1 mRNA]; SU 6656 inhibits the reaction [alpha-naphthoflavone results in increased expression of CYP1A1 mRNA]
alpha-naphthoflavone analog results in increased activity of CYP1A1 protein
CTD PMID:1329656 PMID:6477826 PMID:7669069 PMID:8390116 PMID:8637871 More... NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
affects binding
increases expression
increases metabolic processing
affects metabolic processing
decreases activity
ISO
EXP
[alpha-naphthoflavone results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; alpha-naphthoflavone binds to and results in decreased activity of CYP1A2 protein; alpha-naphthoflavone inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]; alpha-naphthoflavone inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]; alpha-naphthoflavone inhibits the reaction [CYP1A2 protein results in increased metabolism of Triazines]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
CYP1A2 protein binds to alpha-naphthoflavone
alpha-naphthoflavone results in increased expression of CYP1A2 protein
[2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with alpha-naphthoflavone] results in increased expression of CYP1A2 protein; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
[[alpha-naphthoflavone results in decreased activity of CYP1A2 protein] co-treated with [alpha-naphthoflavone results in decreased activity of CYP1A1 protein]] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]; [alpha-naphthoflavone results in decreased activity of CYP1A2 protein] which results in decreased reduction of and results in decreased oxidation of 9-anthraldehyde
CYP1A2 protein results in increased metabolism of alpha-naphthoflavone
alpha-naphthoflavone results in increased expression of CYP1A2 mRNA; alpha-naphthoflavone results in increased expression of CYP1A2 protein
CYP1A2 protein affects the metabolism of alpha-naphthoflavone
CTD PMID:2180560 PMID:9305587 PMID:15306208 PMID:15766918 PMID:15860655 More... NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
affects binding
increases metabolic processing
increases expression
decreases expression
decreases activity
ISO
EXP
alpha-naphthoflavone binds to and results in decreased activity of CYP1B1 protein; alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1B1 mRNA]; alpha-naphthoflavone inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1B1 mRNA]; alpha-naphthoflavone inhibits the reaction [[CYP1B1 protein co-treated with NADP] results in increased metabolism of 2,4,3',5'-tetramethoxystilbene]; alpha-naphthoflavone inhibits the reaction [[CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene] which results in increased expression of TP53 protein modified form]; alpha-naphthoflavone inhibits the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]
CYP1B1 protein binds to alpha-naphthoflavone
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1B1 mRNA]
CYP1B1 protein results in increased metabolism of alpha-naphthoflavone
alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1B1 protein]; alpha-naphthoflavone inhibits the reaction [AHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]]
alpha-naphthoflavone results in increased expression of CYP1B1 mRNA
alpha-naphthoflavone results in decreased expression of CYP1B1 mRNA
alpha-naphthoflavone results in decreased activity of CYP1B1 protein
CTD PMID:11577022 PMID:15075337 PMID:15280921 PMID:16120791 PMID:19182260 More... NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [Calcitriol promotes the reaction [VDR protein binds to CYP24A1 promoter]]]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]]; alpha-naphthoflavone inhibits the reaction [Cycloheximide promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]] CTD PMID:19244278 NCBI chr 3:179,694,647...179,709,083
Ensembl chr 3:159,275,947...159,290,383
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP2C11 mRNA] CTD PMID:18467041 NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 multiple interactions ISO [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Skatole results in increased expression of CYP2F1 mRNA] CTD PMID:20187624 NCBI chr 1:91,543,768...91,557,553
Ensembl chr 1:82,416,130...82,429,896
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO alpha-naphthoflavone results in decreased activity of CYP2J2 protein CTD PMID:12851038 NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
multiple interactions
affects binding
increases activity
ISO alpha-naphthoflavone results in decreased activity of CYP3A4 protein
[[alpha-naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [alpha-naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; alpha-naphthoflavone binds to and results in decreased activity of CYP3A4 protein; alpha-naphthoflavone inhibits the reaction [CYP3A4 protein results in increased hydrolysis of Testosterone]; alpha-naphthoflavone inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; alpha-naphthoflavone inhibits the reaction [CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)]
alpha-naphthoflavone binds to CYP3A4 protein
CTD PMID:1740010 PMID:2271712 PMID:15005856 PMID:17198380 PMID:19299527 More... NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Dazl deleted in azoospermia-like multiple interactions ISO alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene metabolite results in decreased expression of DAZL mRNA] CTD PMID:20562217 NCBI chr 9:18,193,363...18,210,100
Ensembl chr 9:10,695,592...10,712,323
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO alpha-naphthoflavone results in increased expression of DDIT3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; ARNT protein affects the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; pyrazolanthrone inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; SB 203580 inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; SRC protein affects the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; SU 6656 inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]
CTD PMID:30508555 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of DDR2 mRNA] CTD PMID:29094188 NCBI chr13:84,726,412...84,851,032
Ensembl chr13:82,195,463...82,317,363
JBrowse link
G Ddx4 DEAD-box helicase 4 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene metabolite results in decreased expression of DDX4 mRNA] CTD PMID:20562217 NCBI chr 2:45,961,174...46,016,097
Ensembl chr 2:44,227,946...44,282,723
JBrowse link
G Ddx5 DEAD-box helicase 5 multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of DDX5 mRNA] CTD PMID:29094188 NCBI chr10:92,224,393...92,231,928
Ensembl chr10:91,723,508...91,732,283
JBrowse link
G Dll1 delta like canonical Notch ligand 1 multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of DLL1 mRNA] CTD PMID:29094188 NCBI chr 1:64,985,161...64,993,274
Ensembl chr 1:56,312,066...56,320,179
JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 decreases methylation
multiple interactions
EXP alpha-naphthoflavone results in decreased methylation of DNAJB6 promoter
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to DNAJB6 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of DNAJB6 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of DNAJB6 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of DNAJB6 promoter]
CTD PMID:29094188 NCBI chr 4:6,010,081...6,232,052
Ensembl chr 4:5,452,683...5,556,659
JBrowse link
G Dusp5 dual specificity phosphatase 5 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased expression of DUSP5 mRNA]; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased expression of DUSP5 protein] CTD PMID:19578757 NCBI chr 1:262,543,774...262,557,201
Ensembl chr 1:252,538,449...252,551,818
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of EGFR protein] CTD PMID:17934341 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased expression of EGLN1 mRNA]; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased expression of EGLN1 protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of EGLN1 mRNA] CTD PMID:18072750 NCBI chr19:69,765,276...69,804,681
Ensembl chr19:52,869,486...52,907,777
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO alpha-naphthoflavone results in increased phosphorylation of EIF2S1 protein CTD PMID:30508555 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Eno1 enolase 1 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ENO1 mRNA] CTD PMID:23152189 NCBI chr 5:166,002,867...166,014,252
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Oxygen deficiency inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of ENPP2 mRNA]]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of ENPP2 mRNA] CTD PMID:19028555 NCBI chr 7:88,092,140...88,214,758
Ensembl chr 7:86,202,350...86,324,827
JBrowse link
G Ervfrd-1 endogenous retrovirus group FRD member 1, envelope multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of ERVFRD-1 mRNA] CTD PMID:24361490 NCBI chr12:27,787,680...27,794,732
Ensembl chr12:22,151,211...22,158,264
JBrowse link
G Esr1 estrogen receptor 1 affects binding
multiple interactions
ISO
EXP
[alpha-naphthoflavone binds to AHR protein] which binds to ESR1 protein
alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [Estradiol binds to ESR1 protein]]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of ESR1 protein]; alpha-naphthoflavone inhibits the reaction [Particulate Matter analog inhibits the reaction [Estradiol binds to ESR1 protein]]; alpha-naphthoflavone inhibits the reaction [Vehicle Emissions analog inhibits the reaction [Estradiol binds to ESR1 protein]]
[alpha-naphthoflavone co-treated with beta-Naphthoflavone] results in decreased expression of ESR1 mRNA; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased expression of ESR1 mRNA]
CTD PMID:10620335 PMID:15253042 PMID:22975028 PMID:29094188 PMID:35181438 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions EXP [alpha-naphthoflavone co-treated with beta-Naphthoflavone] results in decreased expression of ESR2 mRNA CTD PMID:22975028 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Esrra estrogen related receptor, alpha affects binding ISO [alpha-naphthoflavone binds to AHR protein] which binds to ESRRA protein CTD PMID:10620335 NCBI chr 1:213,533,309...213,543,432
Ensembl chr 1:204,104,101...204,114,268
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FAS mRNA] CTD PMID:16940415 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FASL mRNA] CTD PMID:16940415 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]] CTD PMID:20876236 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Flg filaggrin multiple interactions ISO [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FLG mRNA] CTD PMID:21835898 NCBI chr 2:181,583,801...181,596,464 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of FOS mRNA]] CTD PMID:10478842 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Foxn3 forkhead box N3 multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of FOXN3 mRNA] CTD PMID:29094188 NCBI chr 6:124,191,695...124,572,070
Ensembl chr 6:118,466,025...118,842,401
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO
EXP
alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of FOXO3 protein]
[Methylcholanthrene co-treated with alpha-naphthoflavone] results in increased expression of FOXO3 mRNA
CTD PMID:22266097 PMID:29094188 NCBI chr20:47,251,968...47,348,254
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Foxp3 forkhead box P3 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [tetrandrine results in increased expression of FOXP3 mRNA] CTD PMID:26640276 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Fshr follicle stimulating hormone receptor multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of FSHR protein] CTD PMID:20823264 NCBI chr 6:10,952,329...11,160,288
Ensembl chr 6:5,198,825...5,406,785
JBrowse link
G Gdf9 growth differentiation factor 9 increases expression
multiple interactions
EXP alpha-naphthoflavone results in increased expression of GDF9 mRNA
[Methylcholanthrene co-treated with alpha-naphthoflavone] results in increased expression of GDF9 mRNA
CTD PMID:29094188 NCBI chr10:38,090,021...38,100,801
Ensembl chr10:37,595,679...37,599,672
JBrowse link
G Gpi glucose-6-phosphate isomerase multiple interactions
increases expression
ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GPI mRNA]
alpha-naphthoflavone results in increased expression of GPI mRNA
CTD PMID:23152189 NCBI chr 1:95,965,389...95,996,932
Ensembl chr 1:86,828,216...86,856,086
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GSR mRNA] CTD PMID:23152189 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression ISO alpha-naphthoflavone results in decreased expression of GSTP1 mRNA CTD PMID:18762178 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hes1 hes family bHLH transcription factor 1 multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to HES1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of HES1 mRNA] CTD PMID:29094188 NCBI chr11:84,210,632...84,213,045
Ensembl chr11:70,705,764...70,708,192
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Chlorpyrifos results in increased expression of HIF1A protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased expression of HIF1A protein] CTD PMID:38844257 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hk1 hexokinase 1 multiple interactions
increases expression
ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of HK1 mRNA]
alpha-naphthoflavone results in increased expression of HK1 mRNA
CTD PMID:23152189 NCBI chr20:30,773,222...30,874,814
Ensembl chr20:30,230,486...30,332,131
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR protein] CTD PMID:19931295 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of HSPA8 mRNA] CTD PMID:29094188 NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP alpha-naphthoflavone inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased expression of ICAM1 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to ICAM1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of ICAM1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of ICAM1 mRNA] CTD PMID:26519956 PMID:29094188 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Igf2 insulin-like growth factor 2 decreases acetylation
multiple interactions
EXP alpha-naphthoflavone results in decreased acetylation of IGF2 promoter
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to IGF2 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of IGF2 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of IGF2 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of IGF2 promoter]
CTD PMID:29094188 NCBI chr 1:207,243,873...207,261,263
Ensembl chr 1:197,814,410...197,823,018
JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 multiple interactions
increases expression
EXP AHR gene mutant form inhibits the reaction [alpha-naphthoflavone results in increased expression of IGFBP4 protein] CTD PMID:23639626 NCBI chr10:84,491,471...84,503,487
Ensembl chr10:83,989,591...84,007,225
JBrowse link
G Il10 interleukin 10 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [[Benzo(a)pyrene co-treated with Lipopolysaccharides] affects the expression of IL10 mRNA]; alpha-naphthoflavone inhibits the reaction [[Benzo(a)pyrene co-treated with Lipopolysaccharides] affects the expression of IL10 protein]
[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of IL10 protein]; alpha-naphthoflavone inhibits the reaction [tetrandrine results in increased expression of IL10 mRNA]
CTD PMID:11737050 PMID:17681673 PMID:26640276 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
decreases expression
ISO alpha-naphthoflavone analog inhibits the reaction [IL1B protein results in increased expression of SAA1 mRNA]; alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL1B mRNA]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1B mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of IL1B mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1B mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1B protein]
alpha-naphthoflavone inhibits the reaction [Particulate Matter results in increased expression of IL1B mRNA]
alpha-naphthoflavone results in increased expression of IL1B mRNA
alpha-naphthoflavone results in decreased expression of IL1B mRNA
CTD PMID:14993811 PMID:15019843 PMID:18617548 PMID:21127131 PMID:22262711 More... NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions
increases expression
ISO alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL1RN mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1RN mRNA]
alpha-naphthoflavone results in increased expression of IL1RN mRNA
CTD PMID:22262711 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO
EXP
alpha-naphthoflavone inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; alpha-naphthoflavone inhibits the reaction [Vehicle Emissions results in increased expression of IL6 mRNA]
alpha-naphthoflavone inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased expression of IL6 mRNA]
alpha-naphthoflavone results in increased expression of IL6 mRNA
CTD PMID:21162728 PMID:26519956 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgb8 integrin subunit beta 8 multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased expression of ITGB8 mRNA] CTD PMID:29094188 NCBI chr 6:146,267,982...146,351,245
Ensembl chr 6:140,127,203...140,208,476
JBrowse link
G Jag1 jagged canonical Notch ligand 1 decreases methylation
multiple interactions
EXP alpha-naphthoflavone results in decreased methylation of JAG1 promoter
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to JAG1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of JAG1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of JAG1 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of JAG1 promoter]
CTD PMID:29094188 NCBI chr 3:144,859,453...144,894,883
Ensembl chr 3:124,406,794...124,442,209
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO
EXP
alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of JUN protein]
alpha-naphthoflavone results in increased expression of JUN mRNA
CTD PMID:15019843 PMID:15897893 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 protein]]; alpha-naphthoflavone inhibits the reaction [benzo(k)fluoranthene inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]]; alpha-naphthoflavone inhibits the reaction [benzo(k)fluoranthene inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 protein]]; alpha-naphthoflavone inhibits the reaction [chrysene inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]]; alpha-naphthoflavone inhibits the reaction [chrysene inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 protein]] CTD PMID:12799773 NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:94,402,993...94,407,052
JBrowse link
G Krt14 keratin 14 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Plant Extracts results in decreased expression of KRT14 mRNA] CTD PMID:25051199 NCBI chr10:85,638,182...85,642,450
Ensembl chr10:85,066,802...85,171,799
JBrowse link
G Ldha lactate dehydrogenase A multiple interactions
increases expression
ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LDHA mRNA]
alpha-naphthoflavone results in increased expression of LDHA mRNA
CTD PMID:23152189 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:97,366,021...97,433,472
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of LHCGR protein] CTD PMID:20823264 NCBI chr 6:11,415,361...11,480,834
Ensembl chr 6:5,661,871...5,724,521
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK1 protein]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK1 protein]
alpha-naphthoflavone results in increased phosphorylation of MAPK1 protein
SU 6656 inhibits the reaction [alpha-naphthoflavone results in increased phosphorylation of MAPK1 protein]
CTD PMID:19578757 PMID:20876236 PMID:21205633 PMID:26358519 PMID:30508555 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK3 protein]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK3 protein]
SU 6656 inhibits the reaction [alpha-naphthoflavone results in increased phosphorylation of MAPK3 protein]
CTD PMID:19578757 PMID:20876236 PMID:21205633 PMID:26358519 PMID:30508555 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Oxygen deficiency results in increased expression of MDM2 mRNA]]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MDM2 mRNA] CTD PMID:19578757 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions EXP
ISO
alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP1 mRNA]
alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP1 mRNA]; alpha-naphthoflavone inhibits the reaction [Tretinoin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP1 mRNA]]
CTD PMID:15075337 PMID:19022365 NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP
ISO
alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP2 mRNA]
alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of MMP2 mRNA]; alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of MMP2 protein]
CTD PMID:19022365 PMID:31364906 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP3 mRNA] CTD PMID:19022365 NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP
ISO
alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP9 mRNA]
alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of MMP9 mRNA]; alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of MMP9 protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased secretion of and results in increased activity of MMP9 protein]
CTD PMID:19022365 PMID:23462309 PMID:31364906 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mt1 metallothionein 1 increases expression ISO alpha-naphthoflavone results in increased expression of MT1 mRNA CTD PMID:14998373 NCBI chr19:10,831,959...10,832,975
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr  X:10,826,032...10,827,049
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of MTOR protein] CTD PMID:22266097 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP
ISO
alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of MYC protein]
alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of MYC mRNA]; alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of MYC protein]
CTD PMID:22100782 PMID:31364906 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Myog myogenin multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of MYOG protein] CTD PMID:24431215 NCBI chr13:48,297,476...48,300,065
Ensembl chr13:45,745,436...45,748,039
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of NCF1 mRNA] CTD PMID:19559082 NCBI chr12:28,121,816...28,131,080
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of NDUFS1 mRNA] CTD PMID:23152189 NCBI chr 9:72,040,286...72,073,605
Ensembl chr 9:64,546,225...64,579,893
JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of NDUFS3 mRNA] CTD PMID:23152189 NCBI chr 3:97,332,477...97,339,654
Ensembl chr 3:76,876,646...76,883,824
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of NFATC1 protein] CTD PMID:19028555 NCBI chr18:76,321,386...76,430,997
Ensembl chr18:74,046,904...74,156,028
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
EXP
ISO
alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein]
alpha-naphthoflavone results in increased expression of NOS2 protein
CTD PMID:26086121 PMID:33722737 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Notch2 notch receptor 2 decreases acetylation
increases methylation
multiple interactions
EXP alpha-naphthoflavone results in decreased acetylation of NOTCH2 promoter
alpha-naphthoflavone results in increased methylation of NOTCH2 promoter
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased acetylation of NOTCH2 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of NOTCH2 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of NOTCH2 promoter]
CTD PMID:29094188 NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:185,610,589...185,744,088
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression
EXP alpha-naphthoflavone results in increased activity of NQO1 protein
alpha-naphthoflavone results in increased expression of NQO1 mRNA
CTD PMID:16906435 PMID:17069994 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity EXP alpha-naphthoflavone results in increased activity of NR1I3 protein CTD PMID:27732639 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nr2f1 nuclear receptor subfamily 2, group F, member 1 affects binding ISO [alpha-naphthoflavone binds to AHR protein] which binds to NR2F1 protein CTD PMID:10620335 NCBI chr 2:9,776,179...9,785,924
Ensembl chr 2:8,040,377...8,050,123
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO alpha-naphthoflavone results in increased cleavage of PARP1 protein CTD PMID:30508555 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pfkm phosphofructokinase, muscle multiple interactions
increases expression
ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PFKM mRNA]
alpha-naphthoflavone results in increased expression of PFKM mRNA
CTD PMID:23152189 NCBI chr 7:131,100,684...131,138,250
Ensembl chr 7:129,221,653...129,259,192
JBrowse link
G Pgk1 phosphoglycerate kinase 1 multiple interactions
increases expression
ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PGK1 mRNA]
alpha-naphthoflavone results in increased expression of PGK1 mRNA
CTD PMID:23152189 NCBI chr  X:75,336,988...75,352,962
Ensembl chr  X:71,271,440...71,287,418
JBrowse link
G Pgm1 phosphoglucomutase 1 increases expression
multiple interactions
ISO alpha-naphthoflavone results in increased expression of PGM1 mRNA
alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PGM1 mRNA]
CTD PMID:23152189 NCBI chr 5:119,710,734...119,770,159
Ensembl chr 5:114,595,293...114,654,728
JBrowse link
G Pgr progesterone receptor increases expression ISO alpha-naphthoflavone results in increased expression of PGR protein CTD PMID:22266097 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PKM mRNA] CTD PMID:23152189 NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:60,057,402...60,079,599
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO alpha-naphthoflavone inhibits the reaction [beta-Naphthoflavone results in increased expression of PPARA protein] CTD PMID:21849270 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Prdm1 PR/SET domain 1 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene metabolite results in decreased expression of PRDM1 mRNA] CTD PMID:20562217 NCBI chr20:49,542,465...49,564,088
Ensembl chr20:47,959,858...47,981,488
JBrowse link
G Prkcb protein kinase C, beta multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of PRKCB protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of PRKCB protein] CTD PMID:16797713 PMID:17222441 NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
G Prl prolactin multiple interactions EXP alpha-naphthoflavone promotes the reaction [beta-Naphthoflavone results in decreased expression of PRL mRNA] CTD PMID:22975028 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
increases expression
ISO alpha-naphthoflavone results in decreased expression of PTGS2 mRNA
alpha-naphthoflavone inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]
alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PTGS2 mRNA]; alpha-naphthoflavone inhibits the reaction [Chlorpyrifos results in increased expression of PTGS2 protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased expression of PTGS2 protein]; alpha-naphthoflavone inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]; alpha-naphthoflavone inhibits the reaction [Vehicle Emissions results in increased expression of PTGS2 mRNA]; alpha-naphthoflavone promotes the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]
alpha-naphthoflavone results in increased expression of PTGS2 mRNA
CTD PMID:21162728 PMID:21652769 PMID:22262711 PMID:26358519 PMID:27393915 More... NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased phosphorylation of PTK2 protein] CTD PMID:16359657 NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Rack1 receptor for activated C kinase 1 multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of RACK1 protein] CTD PMID:16797713 PMID:17222441 NCBI chr10:33,668,560...33,676,031
Ensembl chr10:33,169,169...33,174,975
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of RB1 protein] CTD PMID:15157999 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
ISO alpha-naphthoflavone inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased phosphorylation of RELA protein]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of RELA protein]
alpha-naphthoflavone results in decreased expression of RELA protein
CTD PMID:24431215 PMID:33722737 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Serpinb2 serpin family B member 2 multiple interactions
decreases expression
increases expression
ISO alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SERPINB2 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]; alpha-naphthoflavone inhibits the reaction [Tretinoin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]]
alpha-naphthoflavone results in decreased expression of SERPINB2 mRNA
alpha-naphthoflavone results in increased expression of SERPINB2 mRNA
CTD PMID:15075337 PMID:22262711 NCBI chr13:24,051,933...24,065,032
Ensembl chr13:23,541,400...23,550,408
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
increases expression
ISO alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC2A1 mRNA]
alpha-naphthoflavone results in increased expression of SLC2A1 mRNA
CTD PMID:23152189 NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions EXP alpha-naphthoflavone inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in decreased expression of SLC5A5 protein] CTD PMID:26519956 NCBI chr16:18,580,705...18,590,692
Ensembl chr16:18,546,709...18,556,697
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of SMAD3 protein] CTD PMID:27519288 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions EXP alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to SP1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of SP1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of SP1 mRNA] CTD PMID:29094188 NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions
increases phosphorylation
ISO SRC protein affects the reaction [alpha-naphthoflavone results in increased expression of CYP1A1 mRNA]; SRC protein affects the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]
alpha-naphthoflavone results in increased phosphorylation of SRC protein
CTD PMID:30508555 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Stat5b signal transducer and activator of transcription 5B multiple interactions ISO [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein] CTD PMID:21205633 NCBI chr10:86,205,148...86,276,178
Ensembl chr10:85,705,670...85,775,668
JBrowse link
G Tcf7 transcription factor 7 increases expression ISO alpha-naphthoflavone results in increased expression of TCF7 mRNA CTD PMID:18762178 NCBI chr10:36,924,363...36,954,279
Ensembl chr10:36,423,445...36,453,535
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP
ISO
alpha-naphthoflavone promotes the reaction [beta-Naphthoflavone results in decreased expression of TGFB1 mRNA]
alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased expression of TGFB1 mRNA]
CTD PMID:22975028 PMID:27519288 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase decreases expression
multiple interactions
ISO alpha-naphthoflavone results in decreased expression of TIPARP mRNA
alpha-naphthoflavone promotes the reaction [Particulate Matter results in increased expression of TIPARP mRNA]
CTD PMID:18762178 PMID:21652769 NCBI chr 2:152,063,769...152,090,414
Ensembl chr 2:149,753,682...149,780,327
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO alpha-naphthoflavone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of TNF mRNA]
alpha-naphthoflavone inhibits the reaction [Particulate Matter results in increased expression of TNF mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TNF mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of TNF protein]
CTD PMID:17934341 PMID:20801209 PMID:23099484 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions ISO alpha-naphthoflavone inhibits the reaction [hydroquinone results in increased expression of TNFRSF1A protein] CTD PMID:34200499 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B multiple interactions ISO alpha-naphthoflavone inhibits the reaction [hydroquinone results in increased expression of TNFRSF1B protein] CTD PMID:34200499 NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:157,070,642...157,104,206
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO alpha-naphthoflavone inhibits the reaction [norisoboldine inhibits the reaction [TNFSF11 protein results in increased expression of VEGFA mRNA]] CTD PMID:26221077 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
EXP
ISO
alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [leptomycin B results in increased expression of TP53 protein]]
alpha-naphthoflavone inhibits the reaction [[CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene] which results in increased expression of TP53 protein modified form]
alpha-naphthoflavone results in increased expression of TP53 protein
alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased phosphorylation of TRP53 protein]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene affects the localization of TRP53 protein]
CTD PMID:9006915 PMID:15459018 PMID:29274324 PMID:32553695 PMID:35908932 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression
multiple interactions
ISO alpha-naphthoflavone results in increased expression of TPI1 mRNA
alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TPI1 mRNA]
CTD PMID:23152189 NCBI chr 4:159,301,558...159,305,088
Ensembl chr 4:157,615,386...157,619,541
JBrowse link
G Vdr vitamin D receptor multiple interactions ISO alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [Calcitriol promotes the reaction [VDR protein binds to CYP24A1 promoter]]] CTD PMID:19244278 NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:128,987,981...129,037,677
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO
EXP
alpha-naphthoflavone affects the reaction [Hexachlorobenzene results in increased expression of VEGFA protein]; alpha-naphthoflavone inhibits the reaction [Chlorpyrifos results in increased expression of VEGFA protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased expression of VEGFA protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased secretion of VEGFA protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA protein]; alpha-naphthoflavone promotes the reaction [Chlorpyrifos results in increased expression of VEGFA protein]
alpha-naphthoflavone inhibits the reaction [norisoboldine results in decreased expression of VEGFA mRNA]
alpha-naphthoflavone inhibits the reaction [norisoboldine inhibits the reaction [TNFSF11 protein results in increased expression of VEGFA mRNA]]
CTD PMID:19182260 PMID:26221077 PMID:26358519 PMID:32526215 PMID:38844257 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vim vimentin multiple interactions ISO alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of VIM mRNA]; alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of VIM protein] CTD PMID:31364906 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Wapl WAPL cohesin release factor multiple interactions ISO alpha-naphthoflavone promotes the reaction [3-methylcholanthrylene results in increased expression of WAPL mRNA] CTD PMID:15797623 NCBI chr16:10,011,741...10,081,472
Ensembl chr16:10,004,941...10,073,510
JBrowse link
amentoflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO amentoflavone inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein] CTD PMID:34599948 NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of AIF1 protein] CTD PMID:28185818 NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAX protein] CTD PMID:28185818 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]
CTD PMID:28185818 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form] CTD PMID:28185818 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO amentoflavone inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CD36 mRNA]; amentoflavone inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CD36 protein]; CD36 protein inhibits the reaction [amentoflavone inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PPARG protein]] CTD PMID:34599948 NCBI chr 4:18,209,088...18,302,142
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CDKN1A protein] CTD PMID:28185818 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO amentoflavone results in decreased activity of CYP1B1 protein CTD PMID:16271822 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Dct dopachrome tautomerase decreases expression ISO amentoflavone analog results in decreased expression of DCT mRNA; amentoflavone analog results in decreased expression of DCT protein CTD PMID:17473463 NCBI chr15:101,469,159...101,508,029
Ensembl chr15:95,062,003...95,100,836
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GFAP protein] CTD PMID:28185818 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein] CTD PMID:28185818 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK1 protein]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK1 protein] CTD PMID:28185818 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK3 protein]]; amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK3 protein] CTD PMID:28185818 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
ISO amentoflavone results in decreased expression of NOS2 protein
amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NOS2 protein]
CTD PMID:12144868 PMID:28185818 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO amentoflavone inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PPARG protein]; CD36 protein inhibits the reaction [amentoflavone inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PPARG protein]] CTD PMID:34599948 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptgds prostaglandin D2 synthase affects binding ISO amentoflavone binds to PTGDS protein CTD PMID:26456343 NCBI chr 3:28,680,044...28,682,978
Ensembl chr 3:8,281,899...8,284,833
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
ISO amentoflavone results in decreased expression of PTGS2 mRNA; amentoflavone results in decreased expression of PTGS2 protein
[amentoflavone results in decreased expression of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone
CTD PMID:12144868 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO amentoflavone results in decreased expression of SREBF1 mRNA CTD PMID:34599948 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]; amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] CTD PMID:28185818 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tyr tyrosinase decreases activity ISO amentoflavone analog results in decreased activity of TYR protein CTD PMID:17473463 NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:141,115,036...141,210,207
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases activity ISO amentoflavone results in decreased activity of UGT1A1 protein CTD PMID:29470958 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 decreases activity ISO amentoflavone results in decreased activity of UGT1A3 protein CTD PMID:29470958 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 decreases activity ISO amentoflavone results in decreased activity of UGT1A4 protein CTD PMID:29470958 NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases activity
multiple interactions
ISO amentoflavone results in decreased activity of UGT1A6 protein
amentoflavone inhibits the reaction [UGT1A6 protein results in increased glucuronidation of 4-cresol]
CTD PMID:29470958 PMID:32421801 NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 decreases activity ISO amentoflavone results in decreased activity of UGT1A9 protein CTD PMID:29470958 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 decreases activity ISO amentoflavone results in decreased activity of UGT2B17 protein CTD PMID:29470958 NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,024,006...21,035,986
JBrowse link
aminoglutethimide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp1 acid phosphatase 1 decreases expression ISO Aminoglutethimide results in decreased expression of ACP1 protein CTD PMID:26102013 NCBI chr 6:53,233,937...53,249,576
Ensembl chr 6:47,506,380...47,522,021
JBrowse link
G Anp32b acidic nuclear phosphoprotein 32 family member B decreases expression ISO Aminoglutethimide results in decreased expression of ANP32B protein CTD PMID:26102013 NCBI chr 5:65,538,872...65,561,305
Ensembl chr 5:60,743,443...60,765,717
JBrowse link
G Basp1 brain abundant, membrane attached signal protein 1 decreases expression ISO Aminoglutethimide results in decreased expression of BASP1 protein CTD PMID:26102013 NCBI chr 2:77,546,628...77,594,297
Ensembl chr 2:75,816,122...75,864,043
JBrowse link
G Bcap31 B-cell receptor-associated protein 31 decreases expression ISO Aminoglutethimide results in decreased expression of BCAP31 protein CTD PMID:26102013 NCBI chr  X:156,548,911...156,581,002
Ensembl chr  X:151,397,576...151,428,506
JBrowse link
G Cct4 chaperonin containing TCP1 subunit 4 increases expression ISO Aminoglutethimide results in increased expression of CCT4 protein CTD PMID:26102013 NCBI chr14:101,193,057...101,205,935
Ensembl chr14:96,991,859...97,005,267
JBrowse link
G Cct6a chaperonin containing TCP1 subunit 6A decreases expression ISO Aminoglutethimide results in decreased expression of CCT6A protein CTD PMID:26102013 NCBI chr12:32,508,842...32,519,072
Ensembl chr12:26,872,574...26,883,337
JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 decreases expression ISO Aminoglutethimide results in decreased expression of CCT7 protein CTD PMID:26102013 NCBI chr 4:119,546,730...119,563,973
Ensembl chr 4:117,989,232...118,006,580
JBrowse link
G Comt catechol-O-methyltransferase increases expression ISO Aminoglutethimide results in increased expression of COMT protein CTD PMID:26102013 NCBI chr11:96,072,371...96,091,956
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Cuta cutA divalent cation tolerance homolog decreases expression ISO Aminoglutethimide results in decreased expression of CUTA protein CTD PMID:26102013 NCBI chr20:5,024,816...5,026,446
Ensembl chr20:5,022,956...5,024,552
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO Aminoglutethimide inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA] CTD PMID:16935330 NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO Aminoglutethimide results in decreased expression of CYP17A1 mRNA CTD PMID:16935330 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
increases activity
decreases activity
ISO Aminoglutethimide inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; Aminoglutethimide inhibits the reaction [CYP19A1 protein affects the chemical synthesis of 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine]; Aminoglutethimide inhibits the reaction [CYP19A1 protein affects the metabolism of Methadone]
Aminoglutethimide results in increased activity of CYP19A1 protein
Aminoglutethimide results in decreased activity of CYP19A1 protein
CTD PMID:15242824 PMID:15968818 PMID:16935330 PMID:17910019 PMID:20087668 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression
multiple interactions
ISO Aminoglutethimide results in decreased expression of FSHB protein
Aminoglutethimide inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased abundance of Acetaldehyde]
CTD PMID:9208491 PMID:22285649 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Gatd3a glutamine amidotransferase class 1 domain containing 3A increases expression ISO Aminoglutethimide results in increased expression of GATD3 protein CTD PMID:26102013 NCBI chr20:10,514,459...10,522,556
Ensembl chr20:10,514,744...10,522,885
JBrowse link
G Gns glucosamine (N-acetyl)-6-sulfatase decreases expression ISO Aminoglutethimide results in decreased expression of GNS protein CTD PMID:26102013 NCBI chr 7:58,774,625...58,808,650
Ensembl chr 7:56,889,232...56,923,151
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Aminoglutethimide results in increased expression of GPX1 protein CTD PMID:26102013 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gsn gelsolin decreases expression ISO Aminoglutethimide results in decreased expression of GSN protein CTD PMID:26102013 NCBI chr 3:38,982,605...39,035,849
Ensembl chr 3:18,585,172...18,638,402
JBrowse link
G H1f2 H1.2 linker histone, cluster member increases expression ISO Aminoglutethimide results in increased expression of H1-2 protein CTD PMID:26102013 NCBI chr17:41,818,962...41,820,453
Ensembl chr17:41,388,477...41,392,635
JBrowse link
G H2ac12 H2A clustered histone 12 increases expression ISO Aminoglutethimide results in increased expression of H2AC12 protein CTD PMID:26102013 NCBI chr17:47,182,193...47,182,658
Ensembl chr17:42,486,415...42,486,941
JBrowse link
G H2az1 H2A.Z variant histone 1 increases expression ISO Aminoglutethimide results in increased expression of H2AZ1 protein CTD PMID:26102013 NCBI chr 2:229,026,464...229,031,411
Ensembl chr 2:226,355,708...226,358,485
JBrowse link
G H2bc12 H2B clustered histone 12 increases expression ISO Aminoglutethimide results in increased expression of H2BC12 protein CTD PMID:26102013 NCBI chr17:47,181,477...47,181,940 JBrowse link
G H3c13 H3 clustered histone 13 increases expression ISO Aminoglutethimide results in increased expression of H3C13 protein CTD PMID:26102013 NCBI chr17:41,959,540...41,960,009
Ensembl chr 2:183,795,504...183,809,469
Ensembl chr17:183,795,504...183,809,469
Ensembl chr 2:183,795,504...183,809,469
Ensembl chr17:183,795,504...183,809,469
Ensembl chr17:183,795,504...183,809,469
Ensembl chr 2:183,795,504...183,809,469
JBrowse link
G Hmgb2 high mobility group box 2 decreases expression ISO Aminoglutethimide results in decreased expression of HMGB2 protein CTD PMID:26102013 NCBI chr16:37,721,374...37,723,950
Ensembl chr16:32,710,658...32,713,140
Ensembl chr 1:32,710,658...32,713,140
JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 decreases expression ISO Aminoglutethimide results in decreased expression of HNRNPH1 protein CTD PMID:26102013 NCBI chr10:35,187,412...35,203,909
Ensembl chr10:34,693,555...34,702,846
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 multiple interactions ISO [Colforsin co-treated with Aminoglutethimide] results in decreased expression of HSD17B1 mRNA CTD PMID:16935330 NCBI chr10:86,510,011...86,512,211
Ensembl chr10:86,009,728...86,011,927
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 decreases expression ISO Aminoglutethimide results in decreased expression of HSD17B10 protein CTD PMID:26102013 NCBI chr  X:24,568,551...24,571,012
Ensembl chr  X:21,089,122...21,109,488
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 multiple interactions
decreases expression
ISO Aminoglutethimide inhibits the reaction [Colforsin results in increased expression of HSD17B4 mRNA]
Aminoglutethimide results in decreased expression of HSD17B4 mRNA
CTD PMID:16935330 NCBI chr18:45,515,427...45,604,467
Ensembl chr18:43,328,824...43,417,952
JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 decreases expression EXP Aminoglutethimide results in decreased expression of HSD17B7 mRNA CTD PMID:9231770 NCBI chr13:84,702,875...84,722,810
Ensembl chr13:82,173,179...82,190,017
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO Aminoglutethimide results in increased expression of HSPA1A protein CTD PMID:26102013 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227
JBrowse link
G Hyou1 hypoxia up-regulated 1 increases expression ISO Aminoglutethimide results in increased expression of HYOU1 protein CTD PMID:26102013 NCBI chr 8:53,602,882...53,614,998
Ensembl chr 8:44,706,263...44,718,186
JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 decreases expression ISO Aminoglutethimide results in decreased expression of IMPDH2 protein CTD PMID:26102013 NCBI chr 8:118,135,204...118,139,892
Ensembl chr 8:109,256,728...109,261,359
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression
multiple interactions
ISO Aminoglutethimide results in decreased expression of LHB protein
Aminoglutethimide inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased abundance of Acetaldehyde]
CTD PMID:9208491 PMID:22285649 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lmna lamin A/C decreases expression ISO Aminoglutethimide results in decreased expression of LMNA protein CTD PMID:26102013 NCBI chr 2:176,237,564...176,265,301
Ensembl chr 2:173,939,751...173,960,423
JBrowse link
G Lmnb2 lamin B2 decreases expression ISO Aminoglutethimide results in decreased expression of LMNB2 protein CTD PMID:26102013 NCBI chr 7:9,443,308...9,459,468
Ensembl chr 7:8,789,314...8,808,665
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 decreases expression ISO Aminoglutethimide results in decreased expression of MCM3 protein CTD PMID:26102013 NCBI chr 9:30,715,602...30,733,746
Ensembl chr 9:23,219,169...23,237,314
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Aminoglutethimide] which results in increased expression of MPO protein modified form; [Aminoglutethimide co-treated with Hydrogen Peroxide] results in increased oxidation of MPO protein; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Aminoglutethimide CTD PMID:20199096 PMID:26102013 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Myo18a myosin XVIIIa decreases expression ISO Aminoglutethimide results in decreased expression of MYO18A protein CTD PMID:26102013 NCBI chr10:63,152,303...63,253,543
Ensembl chr10:62,654,281...62,755,468
JBrowse link
G Npm3 nucleophosmin/nucleoplasmin, 3 decreases expression ISO Aminoglutethimide results in decreased expression of NPM3 protein CTD PMID:26102013 NCBI chr 1:254,544,664...254,546,649
Ensembl chr 1:244,595,644...244,597,591
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Aminoglutethimide results in increased activity of NR1I2 protein CTD PMID:21068194 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nup210 nucleoporin 210 decreases expression ISO Aminoglutethimide results in decreased expression of NUP210 protein CTD PMID:26102013 NCBI chr 4:125,068,736...125,167,238
Ensembl chr 4:123,511,559...123,609,874
JBrowse link
G Pgr progesterone receptor multiple interactions
decreases expression
ISO [Aminoglutethimide co-treated with 17 alpha-Hydroxyprogesterone Caproate] results in decreased expression of PGR protein
Aminoglutethimide results in decreased expression of PGR protein
CTD PMID:8565696 PMID:9208491 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pitpnb phosphatidylinositol transfer protein, beta increases expression ISO Aminoglutethimide results in increased expression of PITPNB protein CTD PMID:26102013 NCBI chr12:50,909,140...50,958,193
Ensembl chr12:45,249,333...45,298,314
JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha decreases expression ISO Aminoglutethimide results in decreased expression of PPP1CA protein CTD PMID:26102013 NCBI chr 1:210,914,576...210,918,193
Ensembl chr 1:201,485,085...201,497,327
JBrowse link
G Prdx3 peroxiredoxin 3 increases expression ISO Aminoglutethimide results in increased expression of PRDX3 protein CTD PMID:26102013 NCBI chr 1:269,987,691...270,000,111
Ensembl chr 1:260,001,637...260,014,111
JBrowse link
G Psmb4 proteasome 20S subunit beta 4 decreases expression ISO Aminoglutethimide results in decreased expression of PSMB4 protein CTD PMID:26102013 NCBI chr 2:185,131,787...185,134,561
Ensembl chr 2:182,442,756...182,445,746
JBrowse link
G Rtraf RNA transcription, translation and transport factor decreases expression ISO Aminoglutethimide results in decreased expression of RTRAF protein CTD PMID:26102013 NCBI chr15:4,482,699...4,507,115
Ensembl chr15:4,442,573...4,457,972
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression EXP Aminoglutethimide results in decreased expression of SPP1 mRNA CTD PMID:23558518 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Ssb small RNA binding exonuclease protection factor La decreases expression ISO Aminoglutethimide results in decreased expression of SSB protein CTD PMID:26102013 NCBI chr 3:75,024,385...75,034,016
Ensembl chr 3:54,616,619...54,626,203
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression
increases expression
ISO Aminoglutethimide results in decreased expression of STAR mRNA
Aminoglutethimide results in increased expression of STAR mRNA
CTD PMID:10960482 PMID:16935330 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 decreases expression ISO Aminoglutethimide results in decreased expression of TPT1 protein CTD PMID:26102013 NCBI chr15:57,562,217...57,568,968
Ensembl chr15:51,146,154...51,159,625
JBrowse link
G Ubc ubiquitin C increases expression ISO Aminoglutethimide results in increased expression of UBC protein CTD PMID:26102013 NCBI chr12:36,899,673...36,905,275
Ensembl chr12:31,239,152...31,243,925
JBrowse link
G Ube2k ubiquitin-conjugating enzyme E2K decreases expression ISO Aminoglutethimide results in decreased expression of UBE2K protein CTD PMID:26102013 NCBI chr14:43,011,681...43,077,825
Ensembl chr14:42,658,016...42,718,630
JBrowse link
G Wdr1 WD repeat domain 1 increases expression ISO Aminoglutethimide results in increased expression of WDR1 protein CTD PMID:26102013 NCBI chr14:76,470,238...76,504,086
Ensembl chr14:72,257,956...72,291,766
JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta increases expression ISO Aminoglutethimide results in increased expression of YWHAQ protein CTD PMID:26102013 NCBI chr 6:46,664,358...46,694,875
Ensembl chr 6:40,935,949...40,966,273
JBrowse link
anastrozole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cycs cytochrome c, somatic multiple interactions ISO [Oleic Acid co-treated with anastrozole] affects the localization of CYCS protein; [Olive Oil co-treated with anastrozole] affects the localization of CYCS protein CTD PMID:24161488 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Anastrozole results in decreased activity of CYP19A1 protein CTD PMID:15837728 PMID:16001952 PMID:16023338 PMID:16023854 PMID:16034487 More... NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression EXP anastrozole results in increased expression of FSHB protein CTD PMID:10657858 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression ISO anastrozole results in decreased expression of GJA1 protein CTD PMID:29180066 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP anastrozole results in increased expression of LHB protein CTD PMID:10657858 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions
decreases expression
ISO [Tamoxifen co-treated with anastrozole] results in decreased expression of MKI67 protein
anastrozole results in decreased expression of MKI67 protein
CTD PMID:15767642 PMID:16002280 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Pgr progesterone receptor decreases expression ISO anastrozole results in decreased expression of PGR protein CTD PMID:16002280 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Por cytochrome p450 oxidoreductase decreases activity ISO Anastrozole results in decreased activity of POR protein CTD PMID:35206146 NCBI chr12:26,587,674...26,655,612
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO anastrozole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
beauvericin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aatf apoptosis antagonizing transcription factor decreases expression ISO beauvericin results in decreased expression of AATF mRNA CTD PMID:29203277 NCBI chr10:69,796,502...69,889,671
Ensembl chr10:69,299,037...69,392,201
JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of ABCA1 mRNA CTD PMID:31100301 NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of ABCG1 mRNA CTD PMID:31100301 NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,126,687...9,182,948
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of ACAT2 protein CTD PMID:32407736 NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:47,695,788...47,752,821
JBrowse link
G Acin1 apoptotic chromatin condensation inducer 1 decreases expression ISO beauvericin results in decreased expression of ACIN1 mRNA CTD PMID:29203277 NCBI chr15:32,072,121...32,117,004
Ensembl chr15:28,102,112...28,147,001
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of ACSL4 protein CTD PMID:32407736 NCBI chr  X:110,739,633...110,803,416
Ensembl chr  X:105,942,799...106,006,427
JBrowse link
G Actb actin, beta decreases expression ISO beauvericin results in decreased expression of ACTB mRNA CTD PMID:29203277 NCBI chr12:16,776,664...16,779,634
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Aen apoptosis enhancing nuclease decreases expression ISO beauvericin results in decreased expression of AEN mRNA CTD PMID:29203277 NCBI chr 1:142,224,499...142,233,902
Ensembl chr 1:132,815,142...132,824,523
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 decreases expression ISO beauvericin results in decreased expression of AIFM1 mRNA CTD PMID:29203277 NCBI chr  X:132,528,107...132,567,237
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Ak4 adenylate kinase 4 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of AK4 mRNA CTD PMID:31100301 NCBI chr 5:121,154,565...121,214,403
Ensembl chr 5:116,039,616...116,098,618
JBrowse link
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of ALDH5A1 protein CTD PMID:32407736 NCBI chr17:40,560,373...40,586,711
Ensembl chr17:40,130,883...40,158,677
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A decreases expression ISO beauvericin results in decreased expression of ALDOA mRNA CTD PMID:29203277 NCBI chr 1:190,832,820...190,838,021
Ensembl chr 1:181,402,275...181,406,182
JBrowse link
G Anapc13 anaphase promoting complex subunit 13 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of ANAPC13 protein CTD PMID:32407736 NCBI chr 8:112,084,405...112,092,821
Ensembl chr 8:103,205,520...103,213,936
JBrowse link
G Aprt adenine phosphoribosyl transferase decreases expression ISO beauvericin results in decreased expression of APRT mRNA CTD PMID:29203277 NCBI chr19:67,534,737...67,537,027
Ensembl chr19:50,626,202...50,628,431
JBrowse link
G Ar androgen receptor multiple interactions ISO beauvericin inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA] CTD PMID:30716354 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha decreases expression ISO beauvericin results in decreased expression of ARHGDIA mRNA CTD PMID:29203277 NCBI chr10:106,352,858...106,356,347
Ensembl chr10:105,854,533...105,858,023
JBrowse link
G Arpp21 cAMP regulated phosphoprotein 21 increases expression ISO beauvericin results in increased expression of ARPP21 mRNA CTD PMID:29203277 NCBI chr 8:120,912,964...121,077,586
Ensembl chr 8:112,034,642...112,194,297
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of ATP1A1 protein CTD PMID:32407736 NCBI chr 2:191,709,311...191,737,414
Ensembl chr 2:189,020,722...189,048,837
JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of ATP1A3 protein CTD PMID:32407736 NCBI chr 1:89,700,645...89,729,782
Ensembl chr 1:80,572,796...80,601,918
JBrowse link
G Atp5pb ATP synthase peripheral stalk-membrane subunit b multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of ATP5PB protein CTD PMID:32407736 NCBI chr 2:196,112,459...196,123,737
Ensembl chr 2:193,424,047...193,435,418
JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of ATP5PF protein CTD PMID:32407736 NCBI chr11:37,368,045...37,375,721
Ensembl chr11:23,881,592...23,889,119
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
multiple interactions
ISO beauvericin results in decreased expression of BAX mRNA
[zearalenol co-treated with beauvericin] results in increased expression of BAX mRNA
CTD PMID:29203277 PMID:32956828 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
ISO beauvericin results in increased expression of BCL2 mRNA
[zearalenol co-treated with beauvericin] results in increased expression of BCL2 mRNA
CTD PMID:29203277 PMID:32956828 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 increases expression ISO beauvericin results in increased expression of BIRC2 mRNA CTD PMID:29203277 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO beauvericin results in increased expression of BIRC3 mRNA CTD PMID:29203277 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Btf3l4 basic transcription factor 3-like 4 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of BTF3L4 protein CTD PMID:32407736 NCBI chr 5:128,796,594...128,816,219
Ensembl chr 5:123,567,907...123,586,866
JBrowse link
G C1qtnf3 C1q and TNF related 3 decreases expression ISO beauvericin results in decreased expression of C1QTNF3 mRNA CTD PMID:29203277 NCBI chr 2:61,644,225...61,666,640
Ensembl chr 2:59,917,188...59,939,433
JBrowse link
G C1qtnf6 C1q and TNF related 6 increases expression ISO beauvericin results in increased expression of C1QTNF6 mRNA CTD PMID:29203277 NCBI chr 7:111,958,348...111,964,948
Ensembl chr 7:110,077,878...110,084,412
JBrowse link
G Caap1 caspase activity and apoptosis inhibitor 1 decreases expression ISO beauvericin results in decreased expression of CAAP1 mRNA CTD PMID:29203277 NCBI chr 5:114,428,991...114,530,047
Ensembl chr 5:109,361,912...109,414,314
JBrowse link
G Card11 caspase recruitment domain family, member 11 decreases expression ISO beauvericin results in decreased expression of CARD11 mRNA CTD PMID:29203277 NCBI chr12:18,735,088...18,872,045
Ensembl chr12:13,621,087...13,758,112
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
EXP
ISO
beauvericin results in increased activity of CASP3 protein
[zearalenol co-treated with beauvericin] results in increased expression of CASP3 mRNA
CTD PMID:25178661 PMID:32956828 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity EXP beauvericin results in increased activity of CASP7 protein CTD PMID:25178661 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 increases expression ISO beauvericin results in increased expression of CASP8 mRNA CTD PMID:29203277 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases expression ISO beauvericin results in increased expression of CASP9 mRNA CTD PMID:29203277 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Ccar2 cell cycle and apoptosis regulator 2 decreases expression ISO beauvericin results in decreased expression of CCAR2 mRNA CTD PMID:29203277 NCBI chr15:51,622,519...51,637,911
Ensembl chr15:45,212,803...45,227,636
JBrowse link
G Ccdc124 coiled-coil domain containing 124 decreases expression ISO beauvericin results in decreased expression of CCDC124 mRNA CTD PMID:29203277 NCBI chr16:18,600,737...18,606,556
Ensembl chr16:18,566,745...18,572,564
JBrowse link
G Ccdc180 coiled-coil domain containing 180 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of CCDC180 protein CTD PMID:32407736 NCBI chr 5:64,950,522...65,019,127
Ensembl chr 5:60,154,910...60,223,522
JBrowse link
G Ccdc86 coiled-coil domain containing 86 decreases expression ISO beauvericin results in decreased expression of CCDC86 mRNA CTD PMID:29203277 NCBI chr 1:217,015,059...217,021,439
Ensembl chr 1:207,590,168...207,596,544
JBrowse link
G Ccng2 cyclin G2 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of CCNG2 mRNA CTD PMID:31100301 NCBI chr14:15,088,694...15,097,190
Ensembl chr14:14,804,322...14,812,830
JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of CCT5 protein CTD PMID:32407736 NCBI chr 2:84,302,621...84,313,773
Ensembl chr 2:82,590,630...82,602,930
JBrowse link
G Cd47 Cd47 molecule multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of CD47 protein CTD PMID:32407736 NCBI chr11:64,374,816...64,438,763
Ensembl chr11:50,906,177...50,969,425
JBrowse link
G Cd81 Cd81 molecule multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of CD81 protein CTD PMID:32407736 NCBI chr 1:207,665,274...207,681,094
Ensembl chr 1:198,241,484...198,251,660
JBrowse link
G Cdk2ap2 cyclin-dependent kinase 2 associated protein 2 decreases expression ISO beauvericin results in decreased expression of CDK2AP2 mRNA CTD PMID:29203277 NCBI chr 1:210,819,155...210,822,604
Ensembl chr 1:201,391,466...201,393,137
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of CEBPB mRNA CTD PMID:31100301 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator increases expression ISO beauvericin results in increased expression of CFLAR mRNA CTD PMID:29203277 NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Chchd2 coiled-coil-helix-coiled-coil-helix domain containing 2 decreases expression ISO beauvericin results in decreased expression of CHCHD2 mRNA CTD PMID:29203277 NCBI chr12:32,464,847...32,470,871
Ensembl chr12:26,828,736...26,834,755
JBrowse link
G Ciapin1 cytokine induced apoptosis inhibitor 1 decreases expression ISO beauvericin results in decreased expression of CIAPIN1 mRNA CTD PMID:29203277 NCBI chr19:10,185,955...10,199,120
Ensembl chr19:10,180,100...10,195,503
JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of CNP protein CTD PMID:32407736 NCBI chr10:86,011,504...86,018,063
Ensembl chr10:85,511,160...85,517,720
JBrowse link
G Coa6 cytochrome c oxidase assembly factor 6 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of COA6 protein CTD PMID:32407736 NCBI chr19:71,293,066...71,295,668
Ensembl chr19:54,395,742...54,399,407
JBrowse link
G Coro1c coronin 1C multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of CORO1C protein CTD PMID:32407736 NCBI chr12:48,373,573...48,445,718
Ensembl chr12:42,712,991...42,785,179
JBrowse link
G Cotl1 coactosin-like F-actin binding protein 1 decreases expression ISO beauvericin results in decreased expression of COTL1 mRNA CTD PMID:29203277 NCBI chr19:64,780,309...64,814,629
Ensembl chr19:47,871,694...47,911,689
JBrowse link
G Cplane2 ciliogenesis and planar polarity effector complex subunit 2 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of CPLANE2 protein CTD PMID:32407736 NCBI chr 5:158,798,503...158,799,451
Ensembl chr 5:153,515,376...153,522,508
JBrowse link
G Cpne1 copine 1 decreases expression ISO beauvericin results in decreased expression of CPNE1 mRNA CTD PMID:29203277 NCBI chr 3:165,047,615...165,089,994
Ensembl chr 3:144,588,995...144,598,636
JBrowse link
G Crim1 cysteine rich transmembrane BMP regulator 1 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of CRIM1 mRNA CTD PMID:31100301 NCBI chr 6:22,447,983...22,622,459
Ensembl chr 6:16,697,829...16,870,259
JBrowse link
G Csdc2 cold shock domain containing C2 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of CSDC2 protein CTD PMID:32407736 NCBI chr 7:115,332,134...115,346,599
Ensembl chr 7:113,451,998...113,466,463
JBrowse link
G Csk C-terminal Src kinase decreases expression ISO beauvericin results in decreased expression of CSK mRNA CTD PMID:29203277 NCBI chr 8:66,925,650...66,944,861
Ensembl chr 8:58,029,749...58,048,292
JBrowse link
G Ctps1 CTP synthase 1 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of CTPS1 protein CTD PMID:32407736 NCBI chr 5:139,372,349...139,440,441
Ensembl chr 5:134,125,025...134,154,180
JBrowse link
G Ctsd cathepsin D multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of CTSD protein CTD PMID:32407736 NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Cyp4f39 cytochrome P450, family 4, subfamily f, polypeptide 39 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of CYP4F22 protein CTD PMID:32407736 NCBI chr 7:12,082,821...12,156,076
Ensembl chr 7:11,433,371...11,536,181
JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of DCXR protein CTD PMID:32407736 NCBI chr10:106,504,730...106,506,619 JBrowse link
G Ddias DNA damage-induced apoptosis suppressor decreases expression ISO beauvericin results in decreased expression of DDIAS mRNA CTD PMID:29203277 NCBI chr 1:156,318,559...156,342,869
Ensembl chr 1:146,906,154...146,930,462
JBrowse link
G Ddx47 DEAD-box helicase 47 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of DDX47 protein CTD PMID:32407736 NCBI chr 4:169,577,013...169,589,473
Ensembl chr 4:167,845,640...167,859,115
JBrowse link
G Dhrs7 dehydrogenase/reductase 7 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of DHRS7 protein CTD PMID:32407736 NCBI chr 6:97,068,149...97,083,744
Ensembl chr 6:91,251,323...91,347,892
JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 increases expression ISO beauvericin results in increased expression of EDEM1 mRNA CTD PMID:29203277 NCBI chr 4:143,350,989...143,385,693
Ensembl chr 4:141,797,701...141,829,717
JBrowse link
G Eif5a eukaryotic translation initiation factor 5A decreases expression ISO beauvericin results in decreased expression of EIF5A mRNA CTD PMID:29203277 NCBI chr10:55,138,821...55,143,272
Ensembl chr10:54,640,024...54,644,656
JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 increases expression ISO beauvericin results in increased expression of FAIM2 mRNA CTD PMID:29203277 NCBI chr 7:132,512,095...132,539,192
Ensembl chr 7:130,633,348...130,659,168
JBrowse link
G Fmc1 formation of mitochondrial complex V assembly factor 1 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of FMC1 protein CTD PMID:32407736 NCBI chr 4:68,241,009...68,249,045
Ensembl chr 4:67,274,104...67,282,140
JBrowse link
G Gaa alpha glucosidase multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of GAA protein CTD PMID:32407736 NCBI chr10:105,028,106...105,045,365
Ensembl chr10:104,529,747...104,546,836
JBrowse link
G Gna14 G protein subunit alpha 14 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of GNA14 protein CTD PMID:32407736 NCBI chr 1:223,141,802...223,324,210
Ensembl chr 1:213,716,020...213,897,423
JBrowse link
G Gnai3 G protein subunit alpha i3 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of GNAI3 protein CTD PMID:32407736 NCBI chr 2:198,430,920...198,468,874
Ensembl chr 2:195,742,642...195,780,742
JBrowse link
G Gnb1 G protein subunit beta 1 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of GNB1 protein CTD PMID:32407736 NCBI chr 5:171,357,778...171,424,489
Ensembl chr 5:166,075,629...166,142,124
JBrowse link
G Golga1 golgin A1 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of GOLGA1 protein CTD PMID:32407736 NCBI chr 3:43,175,400...43,222,319
Ensembl chr 3:22,767,761...22,812,585
JBrowse link
G Gpnmb glycoprotein nmb multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of GPNMB protein CTD PMID:32407736 NCBI chr 4:79,341,128...79,362,366
Ensembl chr 4:78,010,197...78,049,367
JBrowse link
G Gpr18 G protein-coupled receptor 18 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of GPR18 mRNA CTD PMID:31100301 NCBI chr15:105,404,062...105,407,812
Ensembl chr15:98,997,259...99,001,470
JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of HEXB protein CTD PMID:32407736 NCBI chr 2:30,218,608...30,238,771
Ensembl chr 2:28,484,012...28,504,223
JBrowse link
G Hist2h2be histone cluster 2 H2B family member E multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of HIST2H2BE protein CTD PMID:32407736 NCBI chr 2:186,469,452...186,471,899 JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of HMGCS1 mRNA CTD PMID:31100301 NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hnrnpm heterogeneous nuclear ribonucleoprotein M multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of HNRNPM protein CTD PMID:32407736 NCBI chr 7:15,140,877...15,178,871
Ensembl chr 7:14,438,688...14,476,762
JBrowse link
G Hnrnpu heterogeneous nuclear ribonucleoprotein U multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of HNRNPU protein CTD PMID:32407736 NCBI chr13:92,609,791...92,618,580
Ensembl chr13:90,074,181...90,086,588
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of HSPA5 mRNA CTD PMID:31100301 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Immt inner membrane mitochondrial protein multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of IMMT protein CTD PMID:32407736 NCBI chr 4:105,438,657...105,477,370
Ensembl chr 4:103,880,459...103,919,109
JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO beauvericin results in increased expression of INSIG1 mRNA CTD PMID:29203277 NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:7,315,495...7,323,952
JBrowse link
G Islr2 immunoglobulin superfamily containing leucine-rich repeat 2 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of ISLR2 protein CTD PMID:32407736 NCBI chr 8:67,504,042...67,512,125
Ensembl chr 8:58,608,709...58,614,650
JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of ITGB1 protein CTD PMID:32407736 NCBI chr19:73,602,277...73,650,271
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Klf12 KLF transcription factor 12 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of KLF12 protein CTD PMID:32407736 NCBI chr15:83,037,548...83,469,998
Ensembl chr15:76,637,654...77,062,056
JBrowse link
G Kpnb1 karyopherin subunit beta 1 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of KPNB1 protein CTD PMID:32407736 NCBI chr10:82,642,082...82,670,856
Ensembl chr10:82,145,420...82,174,605
JBrowse link
G Krt16 keratin 16 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of KRT16 protein CTD PMID:32407736 NCBI chr10:85,669,276...85,672,211
Ensembl chr10:85,066,802...85,171,799
JBrowse link
G Krt27 keratin 27 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of KRT27 protein CTD PMID:32407736 NCBI chr10:84,794,848...84,800,131
Ensembl chr10:84,298,508...84,303,967
JBrowse link
G Krt5 keratin 5 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of KRT5 protein CTD PMID:32407736 NCBI chr 7:134,724,840...134,730,569
Ensembl chr 7:132,846,136...132,851,850
JBrowse link
G Krt76 keratin 76 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of KRT76 protein CTD PMID:32407736 NCBI chr 7:134,895,677...134,904,162
Ensembl chr 7:133,016,992...133,025,496
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of LAMP2 protein CTD PMID:32407736 NCBI chr  X:122,038,734...122,087,745
Ensembl chr  X:117,057,606...117,260,522
JBrowse link
G Lat linker for activation of T cells decreases expression ISO beauvericin results in decreased expression of LAT mRNA CTD PMID:29203277 NCBI chr 1:190,367,111...190,372,515
Ensembl chr 1:180,936,534...180,941,578
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation EXP beauvericin results in decreased phosphorylation of MAPK1 protein CTD PMID:25178661 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation EXP beauvericin results in decreased phosphorylation of MAPK3 protein CTD PMID:25178661 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Matn4 matrilin 4 decreases expression ISO beauvericin results in decreased expression of MATN4 mRNA CTD PMID:29203277 NCBI chr 3:173,539,966...173,554,984
Ensembl chr 3:153,120,632...153,135,865
JBrowse link
G Mavs mitochondrial antiviral signaling protein increases expression ISO beauvericin results in increased expression of MAVS mRNA CTD PMID:29203277 NCBI chr 3:138,904,673...138,919,129
Ensembl chr 3:118,451,743...118,466,094
JBrowse link
G Med6 mediator complex subunit 6 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of MED6 protein CTD PMID:32407736 NCBI chr 6:107,001,664...107,015,130
Ensembl chr 6:101,270,410...101,283,876
JBrowse link
G Moap1 modulator of apoptosis 1 increases expression ISO beauvericin results in increased expression of MOAP1 mRNA CTD PMID:29203277 NCBI chr 6:127,647,389...127,649,324
Ensembl chr 6:121,882,366...121,898,643
Ensembl chr17:121,882,366...121,898,643
JBrowse link
G Mrpl12 mitochondrial ribosomal protein L12 decreases expression
multiple interactions
ISO beauvericin results in decreased expression of MRPL12 mRNA
[beauvericin co-treated with enniatins] results in decreased expression of MRPL12 mRNA
CTD PMID:29203277 PMID:31100301 NCBI chr10:106,256,746...106,261,249
Ensembl chr10:105,758,410...105,762,913
JBrowse link
G Mrpl4 mitochondrial ribosomal protein L4 decreases expression ISO beauvericin results in decreased expression of MRPL4 mRNA CTD PMID:29203277 NCBI chr 8:27,815,771...27,821,786
Ensembl chr 8:19,539,593...19,545,608
JBrowse link
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 decreases expression
multiple interactions
ISO beauvericin results in decreased expression of ATP6 mRNA
[beauvericin co-treated with enniatins co-treated with ochratoxin A] results in increased expression of ATP6 mRNA; [beauvericin co-treated with enniatins] results in decreased expression of ATP6 mRNA; [beauvericin co-treated with enniatins] results in increased expression of ATP6 mRNA; [Plant Extracts co-treated with beauvericin co-treated with enniatins] results in decreased expression of ATP6 mRNA; [Plant Extracts co-treated with beauvericin] results in decreased expression of ATP6 mRNA; [Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone co-treated with beauvericin] results in decreased expression of ATP6 mRNA
CTD PMID:29203277 PMID:31100301 PMID:34015425 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599
JBrowse link
G Mt-atp8 mitochondrially encoded ATP synthase membrane subunit 8 decreases expression
multiple interactions
ISO beauvericin results in decreased expression of ATP8 mRNA
[beauvericin co-treated with enniatins co-treated with ochratoxin A] results in decreased expression of ATP8 mRNA; [beauvericin co-treated with enniatins] affects the expression of ATP8 mRNA; [beauvericin co-treated with enniatins] results in decreased expression of ATP8 mRNA; [Plant Extracts co-treated with beauvericin co-treated with enniatins] results in decreased expression of ATP8 mRNA; [Plant Extracts co-treated with beauvericin] results in decreased expression of ATP8 mRNA; [Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone co-treated with beauvericin] results in decreased expression of ATP8 mRNA
CTD PMID:29203277 PMID:31100301 PMID:34015425 NCBI chr MT:7,758...7,961
Ensembl chr MT:7,758...7,961
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I multiple interactions
decreases expression
ISO [beauvericin co-treated with enniatins co-treated with ochratoxin A] results in decreased expression of COX1 mRNA; [beauvericin co-treated with enniatins] affects the expression of COX1 mRNA; [beauvericin co-treated with enniatins] results in decreased expression of COX1 mRNA; [Plant Extracts co-treated with beauvericin co-treated with enniatins] results in decreased expression of COX1 mRNA; [Plant Extracts co-treated with beauvericin] results in decreased expression of COX1 mRNA; [Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone co-treated with beauvericin] results in decreased expression of COX1 mRNA
beauvericin results in decreased expression of COX1 mRNA
CTD PMID:31100301 PMID:34015425 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III decreases expression
multiple interactions
ISO beauvericin results in decreased expression of COX3 mRNA
[beauvericin co-treated with enniatins co-treated with ochratoxin A] results in decreased expression of COX3 mRNA; [beauvericin co-treated with enniatins] results in decreased expression of COX3 mRNA; [Plant Extracts co-treated with beauvericin co-treated with enniatins] results in decreased expression of COX3 mRNA; [Plant Extracts co-treated with beauvericin] results in decreased expression of COX3 mRNA; [Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone co-treated with beauvericin] results in decreased expression of COX3 mRNA
CTD PMID:29203277 PMID:31100301 PMID:34015425 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
JBrowse link
G Mt-cyb mitochondrially encoded cytochrome b decreases expression ISO beauvericin results in decreased expression of CYTB mRNA CTD PMID:29203277 NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
JBrowse link
G Mt-nd2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 decreases expression
increases expression
multiple interactions
ISO beauvericin results in decreased expression of ND2 mRNA
beauvericin results in increased expression of ND2 mRNA
[beauvericin co-treated with enniatins co-treated with ochratoxin A] results in increased expression of ND2 mRNA; [beauvericin co-treated with enniatins] results in decreased expression of ND2 mRNA; [beauvericin co-treated with enniatins] results in increased expression of ND2 mRNA; [Plant Extracts co-treated with beauvericin co-treated with enniatins] results in increased expression of ND2 mRNA; [Plant Extracts co-treated with beauvericin] results in increased expression of ND2 mRNA; [Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone co-treated with beauvericin] results in increased expression of ND2 mRNA
CTD PMID:29203277 PMID:31100301 PMID:34015425 NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942
JBrowse link
G Mt-nd3 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 decreases expression
increases expression
multiple interactions
ISO beauvericin results in decreased expression of ND3 mRNA
beauvericin results in increased expression of ND3 mRNA
[beauvericin co-treated with enniatins co-treated with ochratoxin A] results in increased expression of ND3 mRNA; [beauvericin co-treated with enniatins] results in decreased expression of ND3 mRNA; [beauvericin co-treated with enniatins] results in increased expression of ND3 mRNA; [Plant Extracts co-treated with beauvericin co-treated with enniatins] results in increased expression of ND3 mRNA; [Plant Extracts co-treated with beauvericin] results in increased expression of ND3 mRNA; [Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone co-treated with beauvericin] results in increased expression of ND3 mRNA
CTD PMID:29203277 PMID:31100301 PMID:34015425 NCBI chr MT:9,451...9,798
Ensembl chr MT:9,451...9,798
JBrowse link
G Mt-nd4 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 decreases expression
multiple interactions
ISO beauvericin results in decreased expression of ND4 mRNA
[beauvericin co-treated with enniatins co-treated with ochratoxin A] results in decreased expression of ND4 mRNA; [beauvericin co-treated with enniatins] results in decreased expression of ND4 mRNA; [beauvericin co-treated with enniatins] results in increased expression of ND4 mRNA; [Plant Extracts co-treated with beauvericin co-treated with enniatins] results in increased expression of ND4 mRNA; [Plant Extracts co-treated with beauvericin] results in increased expression of ND4 mRNA; [Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone co-treated with beauvericin] results in decreased expression of ND4 mRNA
CTD PMID:29203277 PMID:31100301 PMID:34015425 NCBI chr MT:10,160...11,537
Ensembl chr MT:10,160...11,537
JBrowse link
G Mt-nd4l mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L decreases expression
increases expression
multiple interactions
ISO beauvericin results in decreased expression of ND4L mRNA
beauvericin results in increased expression of ND4L mRNA
[beauvericin co-treated with enniatins co-treated with ochratoxin A] results in increased expression of ND4L mRNA; [beauvericin co-treated with enniatins] results in decreased expression of ND4L mRNA; [Plant Extracts co-treated with beauvericin co-treated with enniatins] results in increased expression of ND4L mRNA; [Plant Extracts co-treated with beauvericin] results in increased expression of ND4L mRNA
CTD PMID:29203277 PMID:31100301 PMID:34015425 NCBI chr MT:9,870...10,166
Ensembl chr MT:9,870...10,166
JBrowse link
G Mt-nd5 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 decreases expression
increases expression
multiple interactions
ISO beauvericin results in decreased expression of ND5 mRNA
beauvericin results in increased expression of ND5 mRNA
[beauvericin co-treated with enniatins co-treated with ochratoxin A] results in increased expression of ND5 mRNA; [beauvericin co-treated with enniatins] results in decreased expression of ND5 mRNA; [Plant Extracts co-treated with beauvericin co-treated with enniatins] results in increased expression of ND5 mRNA; [Plant Extracts co-treated with beauvericin] results in increased expression of ND5 mRNA
CTD PMID:29203277 PMID:31100301 PMID:34015425 NCBI chr MT:11,736...13,565
Ensembl chr MT:11,736...13,565
JBrowse link
G Mt-nd6 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 decreases expression
multiple interactions
ISO beauvericin results in decreased expression of ND6 mRNA
[beauvericin co-treated with enniatins co-treated with ochratoxin A] results in decreased expression of ND6 mRNA; [beauvericin co-treated with enniatins] results in decreased expression of ND6 mRNA; [Plant Extracts co-treated with beauvericin co-treated with enniatins] results in increased expression of ND6 mRNA; [Plant Extracts co-treated with beauvericin] results in increased expression of ND6 mRNA
CTD PMID:34015425 NCBI chr MT:13,543...14,061
Ensembl chr MT:13,543...14,061
JBrowse link
G Mtrf1l mitochondrial translation release factor 1 like multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of MTRF1L protein CTD PMID:32407736 NCBI chr 1:44,614,162...44,626,367
Ensembl chr 1:42,210,583...42,220,836
JBrowse link
G Myo18a myosin XVIIIa increases expression ISO beauvericin results in increased expression of MYO18A mRNA CTD PMID:29203277 NCBI chr10:63,152,303...63,253,543
Ensembl chr10:62,654,281...62,755,468
JBrowse link
G Nars1 asparaginyl-tRNA synthetase 1 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of NARS1 protein CTD PMID:32407736 NCBI chr18:60,259,506...60,275,782
Ensembl chr18:57,989,308...58,005,622
JBrowse link
G Nars2 asparaginyl-tRNA synthetase 2, mitochondrial multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of NARS2 protein CTD PMID:32407736 NCBI chr 1:160,711,680...160,823,311
Ensembl chr 1:151,300,467...151,413,521
JBrowse link
G Ndrg1 N-myc downstream regulated 1 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of NDRG1 protein CTD PMID:32407736 NCBI chr 7:100,573,526...100,614,902
Ensembl chr 7:98,684,487...98,725,880
JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A increases expression ISO beauvericin results in increased expression of NLRP1 mRNA CTD PMID:29203277 NCBI chr10:56,277,134...56,332,229
Ensembl chr10:55,778,560...55,825,180
JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 increases expression ISO beauvericin results in increased expression of NOD1 mRNA CTD PMID:29203277 NCBI chr 4:85,391,142...85,442,281
Ensembl chr 4:84,060,880...84,111,404
JBrowse link
G Nol3 nucleolar protein 3 increases expression ISO beauvericin results in increased expression of NOL3 mRNA CTD PMID:29203277 NCBI chr19:50,066,493...50,068,175
Ensembl chr19:33,154,062...33,158,250
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of NQO1 mRNA CTD PMID:31100301 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nudt1 nudix hydrolase 1 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of NUDT1 protein CTD PMID:32407736 NCBI chr12:19,416,411...19,423,448
Ensembl chr12:14,302,694...14,305,826
JBrowse link
G Oga O-GlcNAcase increases expression ISO beauvericin results in increased expression of OGA mRNA CTD PMID:29203277 NCBI chr 1:254,547,311...254,589,596
Ensembl chr 1:244,598,292...244,634,359
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase increases expression ISO beauvericin results in increased expression of OGT mRNA CTD PMID:29203277 NCBI chr  X:70,811,317...70,856,123
Ensembl chr  X:66,771,349...66,816,146
JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 multiple interactions
increases expression
ISO [beauvericin co-treated with enniatins co-treated with ochratoxin A] results in decreased expression of OSGIN1 mRNA; [beauvericin co-treated with enniatins] results in decreased expression of OSGIN1 mRNA; [Plant Extracts co-treated with beauvericin] results in increased expression of OSGIN1 mRNA
beauvericin results in increased expression of OSGIN1 mRNA
CTD PMID:31100301 PMID:34015425 NCBI chr19:64,380,336...64,409,165
Ensembl chr19:47,492,171...47,500,516
JBrowse link
G Ostc oligosaccharyltransferase complex non-catalytic subunit multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of OSTC protein CTD PMID:32407736 NCBI chr 2:221,924,727...221,940,253
Ensembl chr 2:219,236,952...219,266,107
JBrowse link
G Parvg parvin, gamma multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of PARVG protein CTD PMID:32407736 NCBI chr 7:117,336,160...117,366,341
Ensembl chr 7:115,456,209...115,475,104
JBrowse link
G Pawr pro-apoptotic WT1 regulator decreases expression ISO beauvericin results in decreased expression of PAWR mRNA CTD PMID:29203277 NCBI chr 7:45,531,480...45,611,492
Ensembl chr 7:43,645,084...43,725,028
JBrowse link
G Pdcd11 programmed cell death 11 decreases expression ISO beauvericin results in decreased expression of PDCD11 mRNA CTD PMID:29203277 NCBI chr 1:255,922,198...255,963,336
Ensembl chr 1:245,980,880...246,021,999
JBrowse link
G Pdcd2 programmed cell death 2 decreases expression ISO beauvericin results in decreased expression of PDCD2 mRNA CTD PMID:29203277 NCBI chr 1:65,158,034...65,163,524
Ensembl chr 1:56,463,931...56,490,437
JBrowse link
G Pdcd2l programmed cell death 2-like increases expression ISO beauvericin results in increased expression of PDCD2L mRNA CTD PMID:29203277 NCBI chr 1:86,810,292...86,822,554
Ensembl chr 1:86,810,292...86,822,554
JBrowse link
G Pdcd4 programmed cell death 4 decreases expression ISO beauvericin results in decreased expression of PDCD4 mRNA CTD PMID:29203277 NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:252,921,392...252,944,275
JBrowse link
G Pdcd5 programmed cell death 5 increases expression ISO beauvericin results in increased expression of PDCD5 mRNA CTD PMID:29203277 NCBI chr 1:97,442,755...97,448,084
Ensembl chr 1:88,305,869...88,311,200
JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein increases expression ISO beauvericin results in increased expression of PDCD6IP mRNA CTD PMID:29203277 NCBI chr 8:122,469,223...122,524,993
Ensembl chr 8:113,590,998...113,646,773
JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 decreases expression ISO beauvericin results in decreased expression of PDIA4 mRNA CTD PMID:29203277 NCBI chr 4:78,134,144...78,153,191
Ensembl chr 4:76,803,198...76,822,107
JBrowse link
G Pfn1 profilin 1 decreases expression
multiple interactions
ISO beauvericin results in decreased expression of PFN1 mRNA
[beauvericin co-treated with enniatins] results in increased expression of PFN1 protein
CTD PMID:29203277 PMID:32407736 NCBI chr10:55,863,882...55,866,587
Ensembl chr10:55,365,262...55,527,631
JBrowse link
G Pgam1 phosphoglycerate mutase 1 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of PGAM1 protein CTD PMID:32407736 NCBI chr 1:250,673,152...250,680,762
Ensembl chr 1:240,723,920...240,738,452
JBrowse link
G Pgk1 phosphoglycerate kinase 1 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of PGK1 protein CTD PMID:32407736 NCBI chr  X:75,336,988...75,352,962
Ensembl chr  X:71,271,440...71,287,418
JBrowse link
G Phgdh phosphoglycerate dehydrogenase multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of PHGDH protein CTD PMID:32407736 NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:185,906,966...185,935,944
JBrowse link
G Phka2 phosphorylase kinase regulatory subunit alpha 2 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of PHKA2 protein CTD PMID:32407736 NCBI chr  X:37,979,629...38,102,656
Ensembl chr  X:34,171,323...34,293,466
JBrowse link
G Pidd1 p53-induced death domain protein 1 decreases expression ISO beauvericin results in decreased expression of PIDD1 mRNA CTD PMID:29203277 NCBI chr 1:205,966,392...205,972,359
Ensembl chr 1:196,536,834...196,542,699
JBrowse link
G Plk1 polo-like kinase 1 decreases expression ISO beauvericin results in decreased expression of PLK1 mRNA CTD PMID:29203277 NCBI chr 1:186,147,658...186,157,637
Ensembl chr 1:176,716,420...176,726,400
JBrowse link
G Pls3 plastin 3 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of PLS3 protein CTD PMID:32407736 NCBI chr  X:116,401,247...116,495,898
Ensembl chr  X:111,589,254...111,683,891
JBrowse link
G Ppa1 inorganic pyrophosphatase 1 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of PPA1 protein CTD PMID:32407736 NCBI chr20:30,132,088...30,160,492
Ensembl chr20:29,590,707...29,619,215
JBrowse link
G Ppan peter pan homolog decreases expression ISO beauvericin results in decreased expression of PPAN mRNA CTD PMID:29203277 NCBI chr 8:27,700,147...27,704,127
Ensembl chr 8:19,423,961...19,427,938
JBrowse link
G Ppib peptidylprolyl isomerase B decreases expression ISO beauvericin results in decreased expression of PPIB mRNA CTD PMID:29203277 NCBI chr 8:75,498,966...75,504,823
Ensembl chr 8:66,603,861...66,630,428
JBrowse link
G Ppp1r14b protein phosphatase 1, regulatory (inhibitor) subunit 14B decreases expression ISO beauvericin results in decreased expression of PPP1R14B mRNA CTD PMID:29203277 NCBI chr 1:213,594,416...213,596,527
Ensembl chr 1:204,163,299...204,167,319
Ensembl chr12:204,163,299...204,167,319
JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of PPT1 protein CTD PMID:32407736 NCBI chr 5:140,406,318...140,427,201
Ensembl chr 5:135,121,163...135,142,048
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of PRKCA protein CTD PMID:32407736 NCBI chr10:93,388,991...93,787,617
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Psma5 proteasome 20S subunit alpha 5 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of PSMA5 protein CTD PMID:32407736 NCBI chr 2:198,584,502...198,607,867
Ensembl chr 2:195,896,365...195,919,731
JBrowse link
G Psme4 proteasome activator subunit 4 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of PSME4 protein CTD PMID:32407736 NCBI chr14:108,706,643...108,810,330
Ensembl chr14:104,505,716...104,609,408
JBrowse link
G Ptges3 prostaglandin E synthase 3 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of PTGES3 protein CTD PMID:32407736 NCBI chr 7:1,075,230...1,092,363
Ensembl chr 7:490,656...508,084
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of PTPRC protein CTD PMID:32407736 NCBI chr13:52,147,717...52,259,810
Ensembl chr13:49,596,193...49,708,692
JBrowse link
G Rab11fip5 RAB11 family interacting protein 5 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of RAB11FIP5 protein CTD PMID:32407736 NCBI chr 4:119,428,766...119,466,277
Ensembl chr 4:117,871,308...117,908,741
JBrowse link
G Rab5a RAB5A, member RAS oncogene family multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of RAB5A protein CTD PMID:32407736 NCBI chr 9:6,720,057...6,749,456
Ensembl chr 9:6,484,469...6,512,873
JBrowse link
G Rac3 Rac family small GTPase 3 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of RAC3 protein CTD PMID:32407736 NCBI chr10:106,501,133...106,503,569
Ensembl chr10:105,993,087...106,005,260
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of RAP1A protein CTD PMID:32407736 NCBI chr 2:195,896,967...195,974,851
Ensembl chr 2:193,208,635...193,286,501
JBrowse link
G Relt RELT, TNF receptor decreases expression ISO beauvericin results in decreased expression of RELT mRNA CTD PMID:29203277 NCBI chr 1:164,619,059...164,636,707
Ensembl chr 1:155,206,976...155,214,196
JBrowse link
G Rp2 RP2 activator of ARL3 GTPase multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of RP2 protein CTD PMID:32407736 NCBI chr  X:4,426,071...4,470,200
Ensembl chr  X:1,873,306...1,916,688
JBrowse link
G Rpl37a ribosomal protein L37A multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of RPL37A protein CTD PMID:32407736 NCBI chr 9:81,748,091...81,750,174 JBrowse link
G Rpl5 ribosomal protein L5 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of RPL5 protein CTD PMID:32407736 NCBI chr14:1,988,792...1,995,236
Ensembl chr14:1,843,770...1,850,290
JBrowse link
G Rpl8 ribosomal protein L8 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of RPL8 protein CTD PMID:32407736 NCBI chr 7:110,506,815...110,509,106
Ensembl chr 7:108,622,324...108,628,482
Ensembl chr 3:108,622,324...108,628,482
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of RXRA protein CTD PMID:32407736 NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Scml2 Scm polycomb group protein like 2 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of SCML2 protein CTD PMID:32407736 NCBI chr  X:37,331,893...37,486,465
Ensembl chr  X:33,524,530...33,652,742
JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of SDF2L1 protein CTD PMID:32407736 NCBI chr11:97,376,878...97,379,120
Ensembl chr11:83,872,659...83,874,902
JBrowse link
G Sdr42e2 short chain dehydrogenase/reductase family 42E, member 2 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of SDR42E2 protein CTD PMID:32407736 NCBI chr 1:184,788,773...184,814,064
Ensembl chr 1:175,362,150...175,382,050
JBrowse link
G Sec13 SEC13 homolog, nuclear pore and COPII coat complex component decreases expression ISO beauvericin results in decreased expression of SEC13 mRNA CTD PMID:29203277 NCBI chr 4:148,433,344...148,446,735
Ensembl chr 4:146,875,524...146,891,173
JBrowse link
G Siva1 SIVA1, apoptosis-inducing factor decreases expression ISO beauvericin results in decreased expression of SIVA1 mRNA CTD PMID:29203277 NCBI chr 6:137,526,416...137,530,790
Ensembl chr 6:131,705,323...131,709,690
JBrowse link
G Slc1a5 solute carrier family 1 member 5 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of SLC1A5 protein CTD PMID:32407736 NCBI chr 1:86,584,949...86,599,052
Ensembl chr 1:77,456,694...77,470,952
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of SLC2A1 protein CTD PMID:32407736 NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of SLC3A2 protein CTD PMID:32407736 NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:205,604,468...205,618,931
JBrowse link
G Snrpd2 small nuclear ribonucleoprotein D2 polypeptide multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of SNRPD2 protein CTD PMID:32407736 NCBI chr 1:87,926,030...87,929,259
Ensembl chr 1:78,798,377...78,803,351
Ensembl chr20:78,798,377...78,803,351
JBrowse link
G Snrpd3 small nuclear ribonucleoprotein D3 polypeptide multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of SNRPD3 protein CTD PMID:32407736 NCBI chr20:13,129,555...13,145,100
Ensembl chr20:13,130,119...13,145,978
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases activity EXP beauvericin results in decreased activity of SRC protein CTD PMID:25178661 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Srm spermidine synthase decreases expression ISO beauvericin results in decreased expression of SRM mRNA CTD PMID:29203277 NCBI chr 5:164,309,002...164,312,203
Ensembl chr 5:159,025,873...159,029,405
JBrowse link
G Srsf7 serine and arginine rich splicing factor 7 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of SRSF7 protein CTD PMID:32407736 NCBI chr 6:20,564,035...20,571,205
Ensembl chr 6:14,811,808...14,818,965
JBrowse link
G Srxn1 sulfiredoxin 1 multiple interactions
decreases expression
ISO [beauvericin co-treated with enniatins co-treated with ochratoxin A] results in decreased expression of SRXN1 mRNA; [beauvericin co-treated with enniatins] results in decreased expression of SRXN1 mRNA; [Plant Extracts co-treated with beauvericin co-treated with enniatins] results in decreased expression of SRXN1 mRNA; [Plant Extracts co-treated with beauvericin] results in decreased expression of SRXN1 mRNA
beauvericin results in decreased expression of SRXN1 mRNA
CTD PMID:31100301 PMID:34015425 NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Ssbp1 single stranded DNA binding protein 1 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of SSBP1 protein CTD PMID:32407736 NCBI chr 4:70,232,740...70,242,824
Ensembl chr 4:69,266,102...69,276,135
JBrowse link
G Tbc1d2b TBC1 domain family, member 2B multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of TBC1D2B protein CTD PMID:32407736 NCBI chr 8:99,626,019...99,694,669
Ensembl chr 8:90,746,233...90,814,832
JBrowse link
G Tcn2 transcobalamin 2 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of TCN2 protein CTD PMID:32407736 NCBI chr14:83,036,935...83,052,187
Ensembl chr14:78,813,343...78,828,489
JBrowse link
G Tcp11l1 t-complex 11 like 1 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of TCP11L1 protein CTD PMID:32407736 NCBI chr 3:111,478,787...111,547,553
Ensembl chr 3:90,998,270...91,092,006
JBrowse link
G Tcp11l2 t-complex 11 like 2 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of TCP11L2 protein CTD PMID:32407736 NCBI chr 7:21,037,955...21,072,857
Ensembl chr 7:19,150,252...19,185,095
JBrowse link
G Thyn1 thymocyte nuclear protein 1 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of THYN1 protein CTD PMID:32407736 NCBI chr 8:33,665,614...33,674,593
Ensembl chr 8:25,406,500...25,415,445
JBrowse link
G Timm9 translocase of inner mitochondrial membrane 9 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of TIMM9 protein CTD PMID:32407736 NCBI chr 6:95,346,065...95,358,895
Ensembl chr 6:89,610,094...89,622,924
JBrowse link
G Tk1 thymidine kinase 1 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of TK1 protein CTD PMID:32407736 NCBI chr10:103,533,449...103,544,818
Ensembl chr10:103,031,521...103,046,920
JBrowse link
G Tmem263 transmembrane protein 263 multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of TMEM263 protein CTD PMID:32407736 NCBI chr 7:20,497,852...20,516,011
Ensembl chr 7:18,610,149...18,628,534
JBrowse link
G Tnfsf10 TNF superfamily member 10 decreases expression ISO beauvericin results in decreased expression of TNFSF10 mRNA CTD PMID:29203277 NCBI chr 2:112,136,550...112,155,903
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tomm22 translocase of outer mitochondrial membrane 22 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of TOMM22 protein CTD PMID:32407736 NCBI chr 7:113,103,863...113,109,056
Ensembl chr 7:111,216,571...111,246,799
JBrowse link
G Tomm7 translocase of outer mitochondrial membrane 7 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of TOMM7 protein CTD PMID:32407736 NCBI chr 4:12,197,503...12,204,344
Ensembl chr 4:11,305,110...11,311,962
JBrowse link
G Tuba1b tubulin, alpha 1B multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of TUBA1B protein CTD PMID:32407736 NCBI chr 7:131,969,606...131,972,587
Ensembl chr 7:130,081,032...130,196,186
JBrowse link
G Tubb3 tubulin, beta 3 class III multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of TUBB3 protein CTD PMID:32407736 NCBI chr19:68,365,687...68,374,741
Ensembl chr19:51,457,184...51,466,243
JBrowse link
G Tubb4a tubulin, beta 4A class IVa multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of TUBB4A protein CTD PMID:32407736 NCBI chr 9:2,004,836...2,012,281
Ensembl chr 9:1,917,845...1,925,291
JBrowse link
G Tubb4b tubulin, beta 4B class IVb multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of TUBB4B protein CTD PMID:32407736 NCBI chr 3:28,435,999...28,438,455
Ensembl chr 3:8,037,799...8,040,296
JBrowse link
G Tubb5 tubulin, beta 5 class I multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of TUBB protein CTD PMID:32407736 NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,912,778...2,916,940
JBrowse link
G Txnip thioredoxin interacting protein increases expression
multiple interactions
decreases expression
ISO beauvericin results in increased expression of TXNIP mRNA
[beauvericin co-treated with enniatins co-treated with ochratoxin A] results in increased expression of TXNIP mRNA; [Plant Extracts co-treated with beauvericin co-treated with enniatins] results in increased expression of TXNIP mRNA; [Plant Extracts co-treated with beauvericin] results in increased expression of TXNIP mRNA
beauvericin results in decreased expression of TXNIP mRNA
CTD PMID:29203277 PMID:34015425 NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:184,092,991...184,096,886
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions
decreases expression
ISO [beauvericin co-treated with enniatins co-treated with ochratoxin A] results in increased expression of UCP2 mRNA; [beauvericin co-treated with enniatins] results in decreased expression of UCP2 mRNA; [Plant Extracts co-treated with beauvericin co-treated with enniatins] results in increased expression of UCP2 mRNA; [Plant Extracts co-treated with beauvericin] results in increased expression of UCP2 mRNA; [Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone co-treated with beauvericin] results in decreased expression of UCP2 mRNA
beauvericin results in decreased expression of UCP2 mRNA
CTD PMID:31100301 PMID:34015425 NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:154,839,209...154,845,611
JBrowse link
G Ucp3 uncoupling protein 3 multiple interactions ISO [beauvericin co-treated with enniatins] results in decreased expression of UCP3 mRNA CTD PMID:31100301 NCBI chr 1:164,227,910...164,240,893
Ensembl chr 1:154,815,777...154,828,762
JBrowse link
G Ybx1 Y box binding protein 1 decreases expression ISO beauvericin results in decreased expression of YBX1 mRNA CTD PMID:29203277 NCBI chr 5:138,167,444...138,188,155
Ensembl chr 5:132,882,145...132,898,862
JBrowse link
G Ybx3 Y box binding protein 3 decreases expression ISO beauvericin results in decreased expression of YBX3 mRNA CTD PMID:29203277 NCBI chr 4:166,861,180...166,884,532
Ensembl chr 4:165,129,758...165,153,161
JBrowse link
G Ykt6 YKT6 v-SNARE homolog multiple interactions ISO [beauvericin co-treated with enniatins] results in increased expression of YKT6 protein CTD PMID:32407736 NCBI chr14:85,041,393...85,057,347
Ensembl chr14:80,832,187...80,843,385
JBrowse link
carbon monoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases activity EXP Carbon Monoxide results in increased activity of ABCC2 protein CTD PMID:13678533 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
increases expression
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein
[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased expression of PECAM1 protein; Carbon Monoxide results in increased expression of ADIPOQ protein
CTD PMID:19356108 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Adm adrenomedullin increases expression EXP Carbon Monoxide results in increased expression of ADM mRNA; Carbon Monoxide results in increased expression of ADM protein CTD PMID:10666155 NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of AGR2 mRNA CTD PMID:29621558 NCBI chr 6:58,435,908...58,456,678
Ensembl chr 6:52,708,602...52,729,371
JBrowse link
G Agt angiotensinogen decreases response to substance ISO AGT protein results in decreased susceptibility to Carbon Monoxide CTD PMID:18174886 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
AKT1 protein affects the reaction [Carbon Monoxide results in increased localization of NRF1 protein]; Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]; Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of AKT1 protein]
Carbon Monoxide inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein; Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein]
CTD PMID:17179207 PMID:18037988 PMID:18215737 PMID:18845810 PMID:19356108 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alad aminolevulinate dehydratase increases activity
multiple interactions
EXP Carbon Monoxide results in increased activity of ALAD protein
Carbon Monoxide inhibits the reaction [[Phenobarbital co-treated with bromobenzene] results in decreased activity of ALAD protein]
CTD PMID:1032310 PMID:6740708 NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G Areg amphiregulin multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of AREG mRNA CTD PMID:29621558 NCBI chr14:17,256,384...17,265,641
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G Bach1 BTB domain and CNC homolog 1 decreases phosphorylation ISO Carbon Monoxide results in decreased phosphorylation of BACH1 protein CTD PMID:18845810 NCBI chr11:40,425,721...40,461,118
Ensembl chr11:26,939,480...26,972,447
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of BAD protein] CTD PMID:18037988 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]] CTD PMID:11880364 NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
decreases expression
EXP Carbon Monoxide results in decreased expression of and results in decreased secretion of BDNF protein
Carbon Monoxide results in decreased expression of BDNF mRNA
CTD PMID:27113706 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]] CTD PMID:11880364 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
EXP
ISO
[Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; Carbon Monoxide inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein; Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]; sulforaphane inhibits the reaction [Carbon Monoxide results in increased expression of CASP3 mRNA]; tin protoporphyrin IX inhibits the reaction [Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]]
Carbon Monoxide results in increased expression of CASP3 protein
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP3 mRNA
Carbon Monoxide results in increased activity of CASP3 protein
CTD PMID:17173083 PMID:19356108 PMID:19520142 PMID:25562542 PMID:31268311 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity EXP Carbon Monoxide results in increased activity of CASP7 protein CTD PMID:25562542 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
EXP
ISO
Carbon Monoxide results in increased activity of CASP8 protein
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP8 mRNA
CTD PMID:25562542 PMID:31268311 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
increases expression
EXP
ISO
Carbon Monoxide results in increased activity of CASP9 protein
sulforaphane inhibits the reaction [Carbon Monoxide results in increased expression of CASP9 mRNA]; sulforaphane inhibits the reaction [Carbon Monoxide results in increased expression of CASP9 protein]
Carbon Monoxide results in increased expression of CASP9 mRNA; Carbon Monoxide results in increased expression of CASP9 protein
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP9 mRNA
CTD PMID:25562542 PMID:31268311 PMID:37860845 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cat catalase multiple interactions
decreases expression
ISO
EXP
CAT protein inhibits the reaction [Carbon Monoxide results in increased localization of NFE2L2 protein]; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of AKT1 protein]
Carbon Monoxide results in decreased expression of CAT protein
CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]]; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein]; NFE2L2 protein inhibits the reaction [Carbon Monoxide results in decreased expression of CAT protein]
CTD PMID:17179207 PMID:18845810 PMID:34032369 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl1 C-C motif chemokine ligand 1 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of CCL1 mRNA CTD PMID:29621558 NCBI chr10:67,625,962...67,628,740
Ensembl chr10:67,128,331...67,131,159
JBrowse link
G Cd86 CD86 molecule decreases expression EXP Carbon Monoxide results in decreased expression of CD86 protein CTD PMID:12201358 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Clca1 chloride channel accessory 1 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of CLCA1 mRNA CTD PMID:29621558 NCBI chr 2:236,599,022...236,624,714
Ensembl chr 2:233,938,677...233,964,369
JBrowse link
G Col11a1 collagen type XI alpha 1 chain multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of COL11A1 mRNA CTD PMID:29621558 NCBI chr 2:204,509,136...204,702,264
Ensembl chr 2:201,820,715...202,013,853
JBrowse link
G Crp C-reactive protein increases expression ISO Carbon Monoxide results in increased expression of CRP protein CTD PMID:18629312 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of CXCL11 mRNA CTD PMID:29621558 NCBI chr14:15,973,728...15,976,503
Ensembl chr14:15,689,424...15,692,271
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP Carbon Monoxide inhibits the reaction [CYP1A1 protein results in increased reduction of sodium chromate(VI)] CTD PMID:1903091 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO Carbon Monoxide promotes the reaction [1-ethynylpyrene results in increased expression of CYP1B1 mRNA] CTD PMID:10581206 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP Carbon Monoxide inhibits the reaction [CYP2B1 protein results in increased reduction of sodium chromate(VI)] CTD PMID:1903091 NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity
multiple interactions
ISO
EXP
Carbon Monoxide results in decreased activity of CYP2E1 protein
Carbon Monoxide inhibits the reaction [CYP2E1 protein results in increased reduction of sodium chromate(VI)]
CTD PMID:1903091 PMID:15036350 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Dnm1l dynamin 1-like multiple interactions
increases expression
EXP sulforaphane inhibits the reaction [Carbon Monoxide results in increased expression of DNM1L protein] CTD PMID:37860845 NCBI chr11:98,084,049...98,135,663
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Duox2 dual oxidase 2 increases expression
decreases expression
EXP Carbon Monoxide results in increased expression of DUOX2 mRNA
Carbon Monoxide results in decreased expression of DUOX2 protein
CTD PMID:29223502 NCBI chr 3:129,680,543...129,698,886
Ensembl chr 3:109,226,924...109,245,902
JBrowse link
G Edn1 endothelin 1 increases expression
multiple interactions
EXP
ISO
Carbon Monoxide results in increased expression of EDN1 mRNA; Carbon Monoxide results in increased expression of EDN1 protein
Carbon Monoxide deficiency promotes the reaction [HMOX2 mutant form results in increased expression of EDN1 protein]
CTD PMID:11781074 PMID:12969895 PMID:20197249 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 mRNA]; Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]; UCP2 protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]] CTD PMID:22046279 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eno2 enolase 2 increases secretion ISO Carbon Monoxide results in increased secretion of ENO2 protein CTD PMID:34533065 NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:157,572,088...157,580,980
JBrowse link
G Epo erythropoietin increases expression EXP Carbon Monoxide results in increased expression of EPO mRNA; Carbon Monoxide results in increased expression of EPO protein CTD PMID:9263988 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha increases expression EXP Carbon Monoxide results in increased expression of ERO1A mRNA CTD PMID:12752442 NCBI chr15:20,974,771...21,010,170
Ensembl chr15:18,492,945...18,530,478
JBrowse link
G Ezr ezrin multiple interactions ISO [[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Carbon Monoxide] which results in decreased expression of EZR protein CTD PMID:37141245 NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:46,967,658...47,011,505
JBrowse link
G Fgb fibrinogen beta chain multiple interactions ISO FGB gene SNP affects the reaction [Carbon Monoxide results in increased expression of IL6 protein] CTD PMID:19750100 NCBI chr 2:170,693,966...170,700,875
Ensembl chr 2:168,394,916...168,405,979
JBrowse link
G Foxp3 forkhead box P3 multiple interactions ISO [Air Pollutants results in increased abundance of Carbon Monoxide] which affects the methylation of FOXP3 gene; [Air Pollutants results in increased abundance of Carbon Monoxide] which results in increased methylation of FOXP3 promoter CTD PMID:29317916 PMID:33603036 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Gabpa GA binding protein transcription factor subunit alpha increases expression
multiple interactions
ISO
EXP
Carbon Monoxide results in increased expression of GABPA mRNA
Carbon Monoxide results in increased expression of GABPA protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of GABPA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of GABPA protein]; Carbon Monoxide promotes the reaction [GABPA protein binds to TFAM promoter]
CTD PMID:17179207 NCBI chr11:37,375,040...37,404,060
Ensembl chr11:23,888,815...23,917,605
JBrowse link
G Gata4 GATA binding protein 4 multiple interactions ISO Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased activity of GATA4 protein] CTD PMID:18037988 NCBI chr15:41,635,572...41,707,252
Ensembl chr15:37,459,601...37,505,636
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
EXP Carbon Monoxide results in increased expression of GCLC mRNA
[NFE2L2 protein co-treated with Carbon Monoxide] results in increased expression of GCLC mRNA
CTD PMID:34032369 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gpr182 G protein-coupled receptor 182 increases expression EXP Carbon Monoxide results in increased expression of GPR182 mRNA CTD PMID:10666155 NCBI chr 7:65,471,254...65,474,110
Ensembl chr 7:63,578,750...63,589,210
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of GPX4 protein] CTD PMID:18037988 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation
ISO Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of GSK3B protein]
Carbon Monoxide results in increased phosphorylation of GSK3B protein
CTD PMID:18037988 PMID:18845810 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases chemical synthesis
increases expression
increases activity
ISO
EXP
Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]; Carbon Monoxide inhibits the reaction [IFNG protein results in decreased expression of HMOX1 protein]; HMOX1 protein affects the reaction [Carbon Monoxide results in increased secretion of IL10 protein]; HMOX1 protein promotes the reaction [Carbon Monoxide results in increased expression of IL22 mRNA]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of HMOX1 mRNA]
HMOX1 protein results in increased chemical synthesis of Carbon Monoxide
[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein; [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]
Carbon Monoxide results in increased expression of HMOX1 protein
Edaravone promotes the reaction [Carbon Monoxide results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; Hemin promotes the reaction [Carbon Monoxide results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]
CTD PMID:11880364 PMID:16365149 PMID:18037988 PMID:18845810 PMID:19520142 More... NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hmox2 heme oxygenase 2 multiple interactions
affects chemical synthesis
affects abundance
EXP Carbon Monoxide deficiency promotes the reaction [HMOX2 mutant form results in increased expression of EDN1 protein]
HMOX2 protein affects the chemical synthesis of Carbon Monoxide
HMOX2 protein affects the abundance of Carbon Monoxide
CTD PMID:11342580 PMID:12969895 NCBI chr10:11,303,512...11,337,640
Ensembl chr10:10,797,055...10,831,148
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP
ISO
[Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
CTD PMID:19356108 PMID:19608869 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of IFNG protein; Carbon Monoxide inhibits the reaction [IFNG protein promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]]; Carbon Monoxide inhibits the reaction [IFNG protein results in decreased expression of HMOX1 protein]
[Air Pollutants results in increased abundance of Carbon Monoxide] which affects the methylation of IFNG gene; [Air Pollutants results in increased abundance of Carbon Monoxide] which results in increased methylation of IFNG gene
CTD PMID:16365149 PMID:29621558 PMID:33603036 PMID:35287715 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
ISO
EXP
Carbon Monoxide promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]; HMOX1 protein affects the reaction [Carbon Monoxide results in increased secretion of IL10 protein]
[Air Pollutants results in increased abundance of Carbon Monoxide] which affects the methylation of IL10 gene; [Air Pollutants results in increased abundance of Carbon Monoxide] which results in increased methylation of IL10 gene
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL10 protein]; iodopravadoline inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL10 protein]]
Carbon Monoxide results in increased expression of IL10 mRNA
CTD PMID:21444764 PMID:31732924 PMID:33603036 PMID:35287715 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Carbon Monoxide inhibits the reaction [IFNG protein promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]] CTD PMID:16365149 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il13 interleukin 13 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of IL13 mRNA CTD PMID:29621558 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il17a interleukin 17A multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of IL17A protein CTD PMID:29621558 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il18 interleukin 18 decreases response to substance
multiple interactions
ISO Carbon Monoxide results in decreased susceptibility to IL18 protein
Carbon Monoxide inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]; Carbon Monoxide inhibits the reaction [IL18 protein results in increased expression of PTEN protein]
CTD PMID:18215737 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions
increases expression
ISO
EXP
Carbon Monoxide results in decreased expression of IL1B protein
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Carbon Monoxide results in increased expression of IL1B protein]; iodopravadoline inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Carbon Monoxide results in increased expression of IL1B protein]]
CTD PMID:21444764 PMID:31732924 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression
multiple interactions
EXP Carbon Monoxide results in increased expression of IL1RL1 protein
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL1RL1 protein]; iodopravadoline inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL1RL1 protein]]
CTD PMID:31732924 NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:42,697,192...42,727,256
JBrowse link
G Il33 interleukin 33 multiple interactions
increases expression
EXP (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL33 protein]; AM 251 inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL33 protein]] CTD PMID:31732924 NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:227,721,435...227,736,373
JBrowse link
G Il4 interleukin 4 decreases expression
multiple interactions
ISO
EXP
Carbon Monoxide results in decreased expression of IL4 protein
[Air Pollutants results in increased abundance of Carbon Monoxide] which affects the methylation of IL4 gene; [Air Pollutants results in increased abundance of Carbon Monoxide] which results in increased methylation of IL4 gene
[Carbon Monoxide co-treated with (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone] results in increased expression of IL4 protein; iodopravadoline inhibits the reaction [[Carbon Monoxide co-treated with (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone] results in increased expression of IL4 protein]
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of IL4 protein
CTD PMID:21444764 PMID:29621558 PMID:31732924 PMID:33603036 PMID:35287715 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased secretion of IL6 protein; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of IL6 protein]; FGB gene SNP affects the reaction [Carbon Monoxide results in increased expression of IL6 protein]; IL6 gene SNP affects the reaction [Carbon Monoxide results in increased expression of IL6 protein] CTD PMID:18629312 PMID:19608869 PMID:19750100 PMID:31268311 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irf8 interferon regulatory factor 8 decreases activity ISO Carbon Monoxide results in decreased activity of IRF8 protein CTD PMID:16365149 NCBI chr19:65,699,284...65,721,066
Ensembl chr19:48,790,588...48,811,829
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO Carbon Monoxide inhibits the reaction [NFE2L2 protein binds to KEAP1 protein] CTD PMID:18845810 NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]] CTD PMID:11880364 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mbp myelin basic protein affects response to substance ISO MBP polymorphism affects the susceptibility to Carbon Monoxide CTD PMID:36481359 NCBI chr18:78,130,652...78,241,174
Ensembl chr18:75,855,878...75,966,404
JBrowse link
G Mfn2 mitofusin 2 multiple interactions
decreases expression
EXP sulforaphane affects the reaction [Carbon Monoxide results in decreased expression of MFN2 protein]; sulforaphane inhibits the reaction [Carbon Monoxide results in decreased expression of MFN2 mRNA]
Carbon Monoxide results in decreased expression of MFN2 mRNA; Carbon Monoxide results in decreased expression of MFN2 protein
CTD PMID:37860845 NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mir1224 microRNA 1224 multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR1224 mRNA CTD PMID:31268311 NCBI chr11:93,811,291...93,811,375
Ensembl chr11:80,306,902...80,306,986
JBrowse link
G Mir186 microRNA 186 multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR186 mRNA CTD PMID:31268311 NCBI chr 2:249,241,650...249,241,735
Ensembl chr 2:246,582,806...246,582,891
JBrowse link
G Mir21 microRNA 21 multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR21 mRNA CTD PMID:31268311 NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mir342 microRNA 342 multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR342 mRNA CTD PMID:31268311 NCBI chr 6:133,329,655...133,329,753
Ensembl chr 6:127,565,269...127,565,367
JBrowse link
G Mir374b microRNA 374b multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR374B mRNA CTD PMID:31268311 NCBI chr  X:72,657,495...72,657,562
Ensembl chr  X:68,591,732...68,591,799
JBrowse link
G Mir615 microRNA 615 multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR615 mRNA CTD PMID:31268311 NCBI chr 7:136,030,353...136,030,444
Ensembl chr 7:134,151,887...134,151,978
JBrowse link
G Mir93 microRNA 93 multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR93 mRNA CTD PMID:31268311 NCBI chr12:22,156,844...22,156,930
Ensembl chr12:17,043,135...17,043,221
JBrowse link
G Mirlet7i microRNA let-7i multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIRLET7I mRNA CTD PMID:31268311 NCBI chr 7:60,527,877...60,527,961
Ensembl chr 7:58,642,480...58,642,571
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO Carbon Monoxide results in increased expression of MMP9 mRNA CTD PMID:20197249 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions EXP [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone co-treated with Carbon Monoxide] results in increased expression of MRC1 protein; iodopravadoline inhibits the reaction [[(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone co-treated with Carbon Monoxide] results in increased expression of MRC1 protein] CTD PMID:31732924 NCBI chr17:82,157,725...82,239,411
Ensembl chr17:77,249,187...77,330,857
JBrowse link
G Ndrg1 N-myc downstream regulated 1 multiple interactions ISO Carbon Monoxide inhibits the reaction [Oxygen deficiency results in increased expression of NDRG1 mRNA]; Carbon Monoxide inhibits the reaction [Oxygen deficiency results in increased expression of NDRG1 protein] CTD PMID:11006124 NCBI chr 7:100,573,526...100,614,902
Ensembl chr 7:98,684,487...98,725,880
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
increases localization
decreases phosphorylation
ISO
EXP
Carbon Monoxide inhibits the reaction [NFE2L2 protein binds to KEAP1 protein]; Carbon Monoxide promotes the reaction [NFE2L2 protein binds to NRF1 promoter]; CAT protein inhibits the reaction [Carbon Monoxide results in increased localization of NFE2L2 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of SOD2 mRNA]
Carbon Monoxide results in increased expression of NFE2L2 mRNA; Carbon Monoxide results in increased expression of NFE2L2 protein
[NFE2L2 protein co-treated with Carbon Monoxide] results in increased expression of GCLC mRNA; Edaravone promotes the reaction [Carbon Monoxide results in increased expression of NFE2L2 protein]; NFE2L2 protein inhibits the reaction [Carbon Monoxide results in decreased expression of CAT protein]; NFE2L2 protein promotes the reaction [Carbon Monoxide results in increased expression of NFE2L2 mRNA]
Carbon Monoxide results in decreased phosphorylation of NFE2L2 protein
CTD PMID:18845810 PMID:25348283 PMID:34032369 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]] CTD PMID:11880364 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ngf nerve growth factor affects expression
multiple interactions
EXP Carbon Monoxide affects the expression of NGF mRNA
Carbon Monoxide results in decreased expression of and affects the secretion of NGF protein
CTD PMID:27113706 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
ISO
EXP
Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; PPARG protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
Carbon Monoxide results in decreased expression of NOS2 protein
CTD PMID:12201358 PMID:22046279 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein CTD PMID:19356108 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nppa natriuretic peptide A increases expression EXP Carbon Monoxide results in increased expression of NPPA mRNA CTD PMID:11781074 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions
increases expression
increases localization
ISO
EXP
AKT1 protein affects the reaction [Carbon Monoxide results in increased localization of NRF1 protein]; Carbon Monoxide promotes the reaction [NFE2L2 protein binds to NRF1 promoter]
Carbon Monoxide results in increased expression of NRF1 protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein]; Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]; Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]; CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]]
Carbon Monoxide results in increased expression of NRF1 mRNA
CTD PMID:17179207 PMID:18845810 NCBI chr 4:59,632,366...59,738,166
Ensembl chr 4:58,664,957...58,825,328
JBrowse link
G Ntf3 neurotrophin 3 decreases expression
multiple interactions
EXP Carbon Monoxide results in decreased expression of NTF3 mRNA
Carbon Monoxide results in decreased expression of and results in decreased secretion of NTF3 protein
CTD PMID:27113706 NCBI chr 4:160,601,161...160,670,623
Ensembl chr 4:158,914,957...158,984,596
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 increases expression EXP [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased expression of PECAM1 protein CTD PMID:19356108 NCBI chr10:92,090,263...92,152,002
Ensembl chr10:91,590,521...91,652,116
JBrowse link
G Pla2g7 phospholipase A2 group VII affects expression ISO Carbon Monoxide affects the expression of PLA2G7 CTD PMID:21356620 NCBI chr 9:24,859,491...24,901,747
Ensembl chr 9:17,362,225...17,404,476
JBrowse link
G Polg DNA polymerase gamma, catalytic subunit increases expression ISO Carbon Monoxide results in increased expression of POLG mRNA; Carbon Monoxide results in increased expression of POLG protein CTD PMID:17179207 NCBI chr 1:142,792,119...142,808,933
Ensembl chr 1:133,382,766...133,398,567
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO [Carbon Monoxide results in increased abundance of Reactive Oxygen Species] which results in increased sumoylation of PPARG protein; Acetylcysteine inhibits the reaction [[Carbon Monoxide results in increased abundance of Reactive Oxygen Species] which results in increased sumoylation of PPARG protein]; PPARG protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]] CTD PMID:22046279 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression
multiple interactions
ISO
EXP
Carbon Monoxide results in increased expression of PPARGC1A mRNA
Carbon Monoxide results in increased expression of PPARGC1A protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of PPARGC1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of PPARGC1A protein]; Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]
CTD PMID:17179207 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prg2 proteoglycan 2, pro eosinophil major basic protein multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of PRG2 mRNA CTD PMID:29621558 NCBI chr 3:90,469,192...90,472,759
Ensembl chr 3:70,062,535...70,066,101
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions
decreases expression
EXP sulforaphane inhibits the reaction [Carbon Monoxide results in decreased expression of PRKAA2 mRNA] CTD PMID:37860845 NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:119,813,226...119,879,543
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Carbon Monoxide inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions ISO [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]] CTD PMID:11880364 NCBI chr14:101,891,238...101,922,324
Ensembl chr14:97,695,161...97,720,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]] CTD PMID:11880364 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Selp selectin P increases expression ISO Carbon Monoxide results in increased expression of SELP protein modified form CTD PMID:18629312 NCBI chr13:79,009,379...79,044,994
Ensembl chr13:76,476,295...76,511,845
JBrowse link
G Sftpd surfactant protein D multiple interactions ISO [[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Carbon Monoxide] which results in increased expression of SFTPD protein CTD PMID:37141245 NCBI chr16:17,080,575...17,093,047
Ensembl chr16:17,046,483...17,059,927
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO Carbon Monoxide results in decreased expression of SOD1 protein CTD PMID:18629312 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO
EXP
Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of SOD2 mRNA]
Carbon Monoxide results in increased expression of SOD2 protein
CTD PMID:17179207 PMID:18037988 PMID:18845810 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sostdc1 sclerostin domain containing 1 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of SOSTDC1 mRNA CTD PMID:29621558 NCBI chr 6:58,778,623...58,782,797
Ensembl chr 6:53,051,354...53,055,579
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression
multiple interactions
ISO
EXP
Carbon Monoxide results in increased expression of TFAM mRNA; Carbon Monoxide results in increased expression of TFAM protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]; Carbon Monoxide promotes the reaction [GABPA protein binds to TFAM promoter]; Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]; CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]]
CTD PMID:17179207 NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,356,197...17,368,292
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
decreases expression
decreases response to substance
EXP
ISO
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Carbon Monoxide results in increased expression of TNF protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Carbon Monoxide inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; iodopravadoline inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Carbon Monoxide results in increased expression of TNF protein]]
Carbon monoxide decreases expression of Tnf mRNA in reperfused liver nonparenchymal cells
Carbon Monoxide results in decreased susceptibility to TNF protein
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased secretion of TNF protein; [HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein; [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of IL6 protein]; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]
Carbon Monoxide results in decreased expression of TNF protein
CTD
RGD
PMID:11880364 PMID:17173083 PMID:19356108 PMID:19608869 PMID:21444764 More... RGD:15023490 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases expression ISO Carbon Monoxide results in increased expression of TNFRSF1B protein modified form CTD PMID:18629312 NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:157,070,642...157,104,206
JBrowse link
G Tnfsf4 TNF superfamily member 4 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of TNFSF4 mRNA CTD PMID:29621558 NCBI chr13:76,256,654...76,280,133
Ensembl chr13:73,723,329...73,746,788
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions ISO UCP2 protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]]; UCP2 protein promotes the reaction [Carbon Monoxide results in increased abundance of Reactive Oxygen Species] CTD PMID:22046279 NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:154,839,209...154,845,611
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein decreases phosphorylation ISO Carbon Monoxide results in decreased phosphorylation of VASP protein CTD PMID:26582457 NCBI chr 1:88,038,026...88,053,783
Ensembl chr 1:78,910,011...78,925,061
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO
EXP
Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
[Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
CTD PMID:19356108 PMID:19608869 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Xdh xanthine dehydrogenase increases activity
increases metabolic processing
EXP Carbon Monoxide results in increased activity of XDH protein
Carbon Monoxide results in increased metabolism of XDH protein
CTD PMID:1447108 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
cimetidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 affects transport
multiple interactions
ISO ABCG2 protein affects the transport of Cimetidine
Cimetidine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]
CTD PMID:15365089 PMID:15722455 PMID:26907376 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide multiple interactions ISO Cimetidine inhibits the reaction [ADH1C protein results in increased oxidation of Ethanol] CTD PMID:23220590 NCBI chr 2:229,470,703...229,482,291
Ensembl chr 2:226,797,303...226,808,892
JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide multiple interactions ISO Cimetidine inhibits the reaction [ADH4 protein results in increased oxidation of Ethanol] CTD PMID:23220590 NCBI chr 2:229,622,092...229,640,120
Ensembl chr 2:226,947,466...226,987,591
JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide multiple interactions ISO Cimetidine inhibits the reaction [ADH5 protein results in increased oxidation of S-hydroxymethylglutathione] CTD PMID:23220590 NCBI chr 2:229,648,557...229,660,964
Ensembl chr 2:226,947,466...226,987,591
JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide multiple interactions ISO Cimetidine inhibits the reaction [ADH7 protein results in increased oxidation of Ethanol] CTD PMID:23220590 NCBI chr 2:229,422,125...229,436,584
Ensembl chr 2:226,741,788...226,763,182
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Cimetidine promotes the reaction [Metformin results in decreased expression of ADIPOQ mRNA] CTD PMID:20956498 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Ahr aryl hydrocarbon receptor affects expression
multiple interactions
ISO Cimetidine affects the expression of AHR protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of AHR protein
CTD PMID:22733800 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions ISO Cimetidine inhibits the reaction [ALDH1A1 protein results in increased oxidation of Acetaldehyde] CTD PMID:23220590 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 multiple interactions ISO Cimetidine inhibits the reaction [ALDH3A1 protein results in increased oxidation of benzaldehyde] CTD PMID:23220590 NCBI chr10:46,392,464...46,402,151
Ensembl chr10:45,892,924...45,902,681
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases activity ISO Cimetidine results in increased activity of APAF1 protein CTD PMID:17273750 NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Ar androgen receptor multiple interactions
decreases expression
ISO
EXP
Cimetidine inhibits the reaction [Dihydrotestosterone binds to AR protein]
Cimetidine results in decreased expression of AR protein
CTD PMID:6835285 PMID:26021711 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO Cimetidine results in increased expression of BAX protein
Cimetidine inhibits the reaction [Ethanol results in increased expression of BAX protein]
CTD PMID:20127008 PMID:27983966 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO Cimetidine results in decreased expression of BCL2 protein
Cimetidine inhibits the reaction [Ethanol results in decreased expression of BCL2 protein]
CTD PMID:20127008 PMID:27983966 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp1 caspase 1 increases activity
multiple interactions
ISO Cimetidine results in increased activity of CASP1 protein
CASP1 protein affects the reaction [Cimetidine results in increased expression of IL18 protein]
CTD PMID:16723495 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp12 caspase 12 multiple interactions ISO Cimetidine inhibits the reaction [Ethanol results in increased expression of CASP12 protein] CTD PMID:27983966 NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases expression
ISO
EXP
Cimetidine results in increased activity of CASP3 protein
Cimetidine inhibits the reaction [Ethanol results in increased expression of CASP3 protein]
Cimetidine results in increased expression of CASP3 protein
CTD PMID:17273750 PMID:20127008 PMID:26021711 PMID:27983966 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity ISO Cimetidine results in increased activity of CASP7 protein CTD PMID:17273750 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 increases activity ISO Cimetidine results in increased activity of CASP8 protein CTD PMID:17273750 PMID:20127008 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO Cimetidine results in increased activity of CASP9 protein CTD PMID:17273750 PMID:20127008 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Cimetidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein] CTD PMID:12107048 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cd14 CD14 molecule decreases expression ISO Cimetidine results in decreased expression of CD14 protein CTD PMID:11556524 NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cst3 cystatin C multiple interactions ISO Cimetidine inhibits the reaction [Cisplatin results in increased expression of CST3] CTD PMID:22525860 NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:136,336,920...136,340,822
JBrowse link
G Ctsd cathepsin D decreases activity EXP Cimetidine results in decreased activity of CTSD protein CTD PMID:12903910 NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Ctsl cathepsin L decreases activity EXP Cimetidine results in decreased activity of CTSL protein CTD PMID:12903910 NCBI chr17:770,104...776,266
Ensembl chr17:764,309...770,548
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases expression
decreases activity
ISO Cimetidine inhibits the reaction [Cocaine results in increased expression of CYP1A1 protein]
Cimetidine results in decreased expression of CYP1A1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP1A1 protein
Cimetidine results in decreased activity of CYP1A1 protein
CTD PMID:11856816 PMID:22733800 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO Cimetidine inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]; NADP promotes the reaction [Cimetidine inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]]; styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP1A2 protein] CTD PMID:7946932 PMID:19909766 PMID:31863871 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases expression
multiple interactions
decreases activity
ISO Cimetidine results in decreased expression of CYP2B6 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP2B6 protein
Cimetidine results in decreased activity of CYP2B6 protein
CTD PMID:22733800 NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP Cimetidine inhibits the reaction [CYP2C11 protein results in increased glutathionylation of lamotrigine] CTD PMID:19961160 NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity
multiple interactions
ISO
EXP
Cimetidine results in decreased activity of CYP2D6 protein
Cimetidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]
styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP2D6 protein]
CTD PMID:17651725 PMID:19909766 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression
multiple interactions
ISO Cimetidine results in decreased expression of CYP2E1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP2E1 protein
CTD PMID:22733800 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 multiple interactions ISO Cimetidine inhibits the reaction [Cocaine results in increased expression of CYP2J2 protein] CTD PMID:11856816 NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases expression
decreases activity
ISO [Monocrotophos co-treated with Cimetidine] results in increased expression of CYP3A4 protein; Cimetidine inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Nifedipine]; styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP3A4 protein]
Cimetidine results in decreased expression of CYP3A4 protein
CTD PMID:2271712 PMID:16041596 PMID:18846481 PMID:19909766 PMID:22733800 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Cimetidine inhibits the reaction [Ethanol results in increased expression of DDIT3 protein] CTD PMID:27983966 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Cimetidine inhibits the reaction [EGFR protein results in increased phosphorylation of EGFR protein]
[Cimetidine results in decreased abundance of Cyclic AMP] inhibits the reaction [EGFR protein results in increased phosphorylation of EGFR protein]
CTD PMID:17295779 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Fshb follicle stimulating hormone subunit beta affects expression ISO Cimetidine affects the expression of FSHB protein CTD PMID:435711 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Gast gastrin affects expression ISO Cimetidine affects the expression of GAST protein CTD PMID:12503773 NCBI chr10:85,765,216...85,767,881
Ensembl chr10:85,264,832...85,267,496
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects expression
multiple interactions
ISO Cimetidine affects the expression of GSTP1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of GSTP1 protein
CTD PMID:22733800 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP [piperine co-treated with Cimetidine co-treated with Pyruvates] inhibits the reaction [Puromycin Aminonucleoside results in increased expression of HMOX1 protein] CTD PMID:12806184 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions ISO Cimetidine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine] CTD PMID:14569158 NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions
decreases activity
increases expression
ISO
EXP
[Cimetidine binds to and results in decreased activity of HRH2 protein] results in decreased susceptibility to [Histamine co-treated with [Oxygen deficiency co-treated with Oxygen]]; [Cimetidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin; [Cimetidine binds to and results in decreased activity of HRH2 protein] which results in decreased abundance of Cyclic AMP; Burimamide inhibits the reaction [[Cyclic AMP binds to and results in decreased activity of HRH2 protein] which results in decreased abundance of Cimetidine]; Cimetidine binds to and results in decreased activity of HRH2 protein; Cimetidine binds to and results in increased activity of HRH2 protein; Cimetidine inhibits the reaction [HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]]
Cimetidine results in decreased activity of HRH2 protein
[Cimetidine binds to and results in decreased activity of HRH2 protein] which results in decreased susceptibility to clobenpropit; Cimetidine binds to and results in decreased activity of HRH2 protein; Cimetidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine]
Cimetidine binds to and results in increased activity of HRH2 protein; Cimetidine inhibits the reaction [HRH2 results in decreased susceptibility to Morphine]; HRH2 protein affects the reaction [Cimetidine results in increased expression of IL18 protein]
Cimetidine results in increased expression of HRH2 protein
CTD PMID:1912125 PMID:2461127 PMID:6522242 PMID:9681472 PMID:12235264 More... NCBI chr17:10,371,083...10,412,979
Ensembl chr17:10,368,298...10,407,631
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Cimetidine inhibits the reaction [Ethanol results in increased expression of HSPA5 protein] CTD PMID:27983966 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO Cimetidine results in decreased expression of ICAM1 protein CTD PMID:17189874 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma multiple interactions
increases expression
ISO Cimetidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]]
Cimetidine results in increased expression of IFNG mRNA; Cimetidine results in increased expression of IFNG protein
CTD PMID:10569698 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il16 interleukin 16 multiple interactions ISO Cimetidine inhibits the reaction [HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]] CTD PMID:12235264 NCBI chr 1:147,026,852...147,127,177
Ensembl chr 1:137,617,944...137,718,130
JBrowse link
G Il18 interleukin 18 multiple interactions
increases expression
ISO CASP1 protein affects the reaction [Cimetidine results in increased expression of IL18 protein]; Famotidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Cimetidine results in increased expression of IL18 protein]; Ranitidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein]
HRH2 protein affects the reaction [Cimetidine results in increased expression of IL18 protein]
CTD PMID:16723495 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Cimetidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Cimetidine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein] CTD PMID:12065299 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Itga4 integrin subunit alpha 4 decreases expression ISO Cimetidine results in decreased expression of ITGA4 protein CTD PMID:11556524 NCBI chr 3:84,569,487...84,646,276
Ensembl chr 3:64,163,085...64,233,715
JBrowse link
G Itgax integrin subunit alpha X decreases expression ISO Cimetidine results in decreased expression of ITGAX protein CTD PMID:11556524 NCBI chr 1:192,140,089...192,171,151
Ensembl chr 1:182,719,609...182,740,698
JBrowse link
G Lrp1 LDL receptor related protein 1 decreases expression ISO Cimetidine results in decreased expression of LRP1 protein CTD PMID:11556524 NCBI chr 7:65,265,639...65,346,196
Ensembl chr 7:63,380,356...63,460,910
JBrowse link
G Ncam1 neural cell adhesion molecule 1 decreases expression ISO Cimetidine results in decreased expression of NCAM mRNA; Cimetidine results in decreased expression of NCAM protein CTD PMID:17273750 NCBI chr 8:58,762,088...59,062,131
Ensembl chr 8:49,865,633...50,166,014
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Cimetidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Cimetidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:12065299 PMID:12107048 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 decreases expression
multiple interactions
ISO Cimetidine results in decreased expression of NR1I2 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of NR1I2 protein
CTD PMID:22733800 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases expression
multiple interactions
ISO Cimetidine results in decreased expression of NR1I3 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of NR1I3 protein
CTD PMID:22733800 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Ntf3 neurotrophin 3 multiple interactions EXP Cimetidine inhibits the reaction [Histamine results in increased expression of NTF3 protein] CTD PMID:21276809 NCBI chr 4:160,601,161...160,670,623
Ensembl chr 4:158,914,957...158,984,596
JBrowse link
G Pde4b phosphodiesterase 4B multiple interactions ISO Cimetidine inhibits the reaction [Histamine results in increased expression of PDE4B mRNA] CTD PMID:11131300 NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:116,799,971...117,367,696
JBrowse link
G Prl prolactin affects expression ISO Cimetidine affects the expression of PRL protein CTD PMID:435711 PMID:9037573 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Prok1 prokineticin 1 decreases expression EXP Cimetidine results in decreased expression of PROK1 protein CTD PMID:26021711 NCBI chr 2:197,538,747...197,547,550
Ensembl chr 2:194,853,991...194,859,250
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Cimetidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Cimetidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein]
Cimetidine inhibits the reaction [Ethanol results in increased expression of RELA protein]
CTD PMID:12065299 PMID:12107048 PMID:24300194 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Selp selectin P decreases expression ISO Cimetidine results in decreased expression of SELP protein CTD PMID:17189874 NCBI chr13:79,009,379...79,044,994
Ensembl chr13:76,476,295...76,511,845
JBrowse link
G Slc22a1 solute carrier family 22 member 1 increases uptake
multiple interactions
EXP
ISO
SLC22A1 protein results in increased uptake of Cimetidine
Cimetidine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]
CTD PMID:16006492 PMID:19357179 NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions
increases transport
decreases response to substance
increases uptake
ISO
EXP
1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A2 protein results in increased uptake of Cimetidine]; Cimetidine inhibits the reaction [SLC22A2 protein affects the transport of Tetraethylammonium]; Cimetidine inhibits the reaction [SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Cimetidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Cimetidine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; p-Aminohippuric Acid inhibits the reaction [SLC22A2 protein results in increased uptake of Cimetidine]
SLC22A2 protein results in increased transport of Cimetidine
SLC22A2 gene polymorphism results in decreased susceptibility to Cimetidine
CTD PMID:15496291 PMID:16006492 PMID:18230276 PMID:19357179 PMID:21599003 More... NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions
increases transport
ISO Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin]
Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]
SLC22A3 protein results in increased transport of Cimetidine
CTD PMID:10966924 PMID:18253050 PMID:19357179 PMID:21697722 NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:48,235,476...48,324,612
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions
increases uptake
ISO 1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A6 protein results in increased uptake of Cimetidine]; Cimetidine inhibits the reaction [SLC22A6 protein affects the transport of p-Aminohippuric Acid]; p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of Cimetidine] CTD PMID:15496291 PMID:16006492 PMID:16098483 NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a7 solute carrier family 22 member 7 increases uptake
multiple interactions
ISO SLC22A7 protein results in increased uptake of Cimetidine
Cimetidine inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates]
CTD PMID:12065749 PMID:16006492 NCBI chr 9:22,044,672...22,052,051
Ensembl chr 9:14,547,849...14,553,921
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions
increases uptake
affects transport
ISO
EXP
Cimetidine inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Cimetidine]
SLC22A8 protein results in increased uptake of Cimetidine
Cimetidine inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]
estradiol-17 beta-glucuronide inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; estrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Famotidine inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; p-Aminohippuric Acid inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Penicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Cimetidine]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Ranitidine inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]
CTD PMID:10224140 PMID:11306713 PMID:15100168 PMID:15319347 PMID:15496291 More... NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slc47a1 solute carrier family 47 member 1 affects transport
multiple interactions
decreases activity
ISO SLC47A1 protein affects the transport of Cimetidine
Cimetidine inhibits the reaction [SLC47A1 protein results in increased uptake of Cadmium]
Cimetidine inhibits the reaction [SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Cimetidine inhibits the reaction [SLC47A1 protein results in increased uptake of Cadmium]
Cimetidine results in decreased activity of SLC47A1 protein
CTD PMID:16928787 PMID:21599003 PMID:27871888 NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Cimetidine inhibits the reaction [SLC47A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Cimetidine inhibits the reaction [SLC47A2 protein results in increased uptake of Cadmium] CTD PMID:21599003 PMID:27871888 NCBI chr10:46,490,262...46,532,954
Ensembl chr10:45,991,095...46,033,904
JBrowse link
G Slc9a3 solute carrier family 9 member A3 multiple interactions EXP [piperine co-treated with Cimetidine co-treated with Pyruvates] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of SLC9A3 protein] CTD PMID:12806184 NCBI chr 1:30,953,215...30,996,209
Ensembl chr 1:29,124,674...29,167,417
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Cimetidine inhibits the reaction [Dimaprit inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
Cimetidine inhibits the reaction [Cocaine results in increased expression of TNF protein]
CTD PMID:9088875 PMID:11856816 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
cinacalcet term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Cinacalcet results in decreased activity of CYP2D6 protein CTD PMID:16680561 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Cinacalcet results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Klf2 KLF transcription factor 2 increases expression
multiple interactions
decreases ubiquitination
ISO Cinacalcet results in increased expression of KLF2 protein
[Cinacalcet inhibits the reaction [Adenine results in increased expression of TRAF2 protein]] which results in decreased ubiquitination of and results in decreased degradation of KLF2 protein; [Cinacalcet results in decreased expression of TRAF2 protein] which results in decreased ubiquitination of KLF2 protein; Cinacalcet inhibits the reaction [Adenine results in decreased expression of KLF2 protein]; TRAF2 protein inhibits the reaction [Cinacalcet results in increased expression of KLF2 protein]
Cinacalcet results in decreased ubiquitination of KLF2 protein
CTD PMID:35635602 NCBI chr16:17,555,136...17,557,768
Ensembl chr16:17,514,552...17,523,944
JBrowse link
G Pth parathyroid hormone decreases expression
multiple interactions
decreases secretion
ISO Cinacalcet results in decreased expression of PTH protein
[Cinacalcet co-treated with Vitamin D] results in decreased expression of PTH protein
Cinacalcet results in decreased secretion of PTH protein
CTD PMID:17060004 PMID:18256372 PMID:21541686 PMID:22118402 NCBI chr 1:176,942,901...176,946,034
Ensembl chr 1:167,508,598...167,511,530
JBrowse link
G Traf2 Tnf receptor-associated factor 2 multiple interactions
decreases expression
ISO [Cinacalcet inhibits the reaction [Adenine results in increased expression of TRAF2 protein]] which results in decreased ubiquitination of and results in decreased degradation of KLF2 protein; [Cinacalcet results in decreased expression of TRAF2 protein] which results in decreased ubiquitination of KLF2 protein; Cinacalcet inhibits the reaction [Adenine results in increased expression of TRAF2 protein]; TRAF2 protein inhibits the reaction [Cinacalcet results in increased expression of KLF2 protein]
Cinacalcet results in decreased expression of TRAF2 mRNA; Cinacalcet results in decreased expression of TRAF2 protein
CTD PMID:35635602 NCBI chr 3:28,740,098...28,764,752
Ensembl chr 3:8,341,951...8,366,538
JBrowse link
co-trimoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ins2 insulin 2 increases secretion ISO Trimethoprim, Sulfamethoxazole Drug Combination results in increased secretion of INS protein modified form CTD PMID:14714756 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
cobicistat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf3 activating transcription factor 3 multiple interactions ISO [Rifampin co-treated with Cobicistat] results in increased expression of ATF3 mRNA CTD PMID:33629115 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Rifampin co-treated with Cobicistat] results in increased expression of BAX mRNA CTD PMID:33629115 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Cbr3 carbonyl reductase 3 multiple interactions ISO [Rifampin co-treated with Cobicistat] results in increased expression of CBR3 mRNA CTD PMID:33629115 NCBI chr11:46,478,295...46,486,555
Ensembl chr11:33,008,615...33,016,875
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [[Rifampin results in increased activity of NR1I2 protein] which results in increased activity of CYP3A4 protein] which results in increased metabolism of and results in increased activity of and results in increased susceptibility to Cobicistat CTD PMID:33629115 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Cobicistat] results in increased expression of DDIT3 mRNA; [Rifampin co-treated with Cobicistat] results in increased expression of DDIT3 mRNA CTD PMID:33629115 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO [Rifampin co-treated with Cobicistat] results in increased expression of GPX2 mRNA CTD PMID:33629115 NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:95,493,589...95,496,877
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Cobicistat] results in increased expression of HSPA5 mRNA; [Rifampin co-treated with Cobicistat] results in increased expression of HSPA5 mRNA CTD PMID:33629115 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Ngfr nerve growth factor receptor multiple interactions ISO [Rifampin co-treated with Cobicistat] results in increased expression of TNFRSF10B mRNA CTD PMID:33629115 NCBI chr10:81,012,077...81,030,305
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [[Rifampin results in increased activity of NR1I2 protein] which results in increased activity of CYP3A4 protein] which results in increased metabolism of and results in increased activity of and results in increased susceptibility to Cobicistat CTD PMID:33629115 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased activity of NR1I3 protein] which results in increased susceptibility to Cobicistat CTD PMID:33629115 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:83,632,899...83,637,906
JBrowse link
eupatorin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases response to substance
increases metabolic processing
decreases activity
increases expression
ISO CYP1A1 protein results in increased susceptibility to eupatorin
CYP1A1 protein results in increased metabolism of eupatorin analog
eupatorin analog results in decreased activity of CYP1A1 protein
eupatorin results in increased expression of CYP1A1 mRNA
CTD PMID:18454852 PMID:19601638 PMID:21482471 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
increases expression
decreases activity
ISO CYP1B1 protein results in increased metabolism of eupatorin analog
eupatorin results in increased expression of CYP1B1 mRNA
eupatorin results in decreased activity of CYP1B1 protein
CTD PMID:19601638 PMID:21482471 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO eupatorin results in decreased activity of CYP2C19 protein CTD PMID:21093571 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO eupatorin results in decreased activity of CYP2D6 protein CTD PMID:21276781 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO eupatorin results in decreased activity of CYP3A4 protein CTD PMID:21276781 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
exemestane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg4 ATP binding cassette subfamily G member 4 increases expression ISO exemestane results in increased expression of ABCG4 mRNA CTD PMID:17254854 NCBI chr 8:53,508,005...53,525,314
Ensembl chr 8:44,611,187...44,626,881
JBrowse link
G Adcyap1r1 ADCYAP receptor type I increases expression ISO exemestane results in increased expression of ADCYAP1R1 mRNA CTD PMID:17254854 NCBI chr 4:85,924,171...85,972,973
Ensembl chr 4:84,593,892...84,642,700
JBrowse link
G Ar androgen receptor multiple interactions
affects localization
ISO exemestane binds to and results in increased activity of AR protein
exemestane affects the localization of AR protein
CTD PMID:25752796 PMID:28478275 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Areg amphiregulin increases expression ISO exemestane results in increased expression of AREG mRNA CTD PMID:18677558 NCBI chr14:17,256,384...17,265,641
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G Cd83 CD83 molecule increases expression ISO exemestane results in increased expression of CD83 mRNA CTD PMID:17254854 NCBI chr17:21,093,281...21,113,223
Ensembl chr17:20,887,309...20,907,083
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO exemestane results in decreased activity of CYP19A1 protein CTD PMID:15837728 PMID:15909811 PMID:16034487 PMID:16054421 PMID:21341743 More... NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Dab2 DAB adaptor protein 2 increases expression ISO exemestane results in increased expression of DAB2 mRNA CTD PMID:17254854 NCBI chr 2:57,241,947...57,294,893
Ensembl chr 2:55,514,700...55,567,476
JBrowse link
G Dnaaf9 dynein axonemal assembly factor 9 increases expression ISO exemestane results in increased expression of DNAAF9 mRNA CTD PMID:17254854 NCBI chr 3:138,370,971...138,505,711
Ensembl chr 3:117,921,620...118,052,630
JBrowse link
G Ebf1 EBF transcription factor 1 increases expression ISO exemestane results in increased expression of EBF1 mRNA CTD PMID:17254854 NCBI chr10:29,597,221...29,990,571
Ensembl chr10:29,099,933...29,487,665
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [exemestane binds to and results in increased activity of ESR1 protein]; exemestane binds to and results in increased activity of ESR1 protein; Fulvestrant inhibits the reaction [exemestane binds to and results in increased activity of ESR1 protein] CTD PMID:18677558 PMID:25752796 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gpc2 glypican 2 increases expression ISO exemestane results in increased expression of GPC2 mRNA CTD PMID:17254854 NCBI chr12:22,391,489...22,397,822
Ensembl chr12:17,277,875...17,284,208
JBrowse link
G Hoxd11 homeobox D11 increases expression ISO exemestane results in increased expression of HOXD11 mRNA CTD PMID:17254854 NCBI chr 3:79,992,394...79,994,688
Ensembl chr 3:59,585,039...59,586,783
JBrowse link
G Inpp5k inositol polyphosphate-5-phosphatase K increases expression ISO exemestane results in increased expression of INPP5K mRNA CTD PMID:17254854 NCBI chr10:60,974,183...60,995,047
Ensembl chr10:60,475,897...60,496,773
JBrowse link
G Ints4 integrator complex subunit 4 increases expression ISO exemestane results in increased expression of INTS4 mRNA CTD PMID:17254854 NCBI chr 1:161,201,284...161,265,042
Ensembl chr 1:151,786,553...151,853,827
JBrowse link
G Kif13b kinesin family member 13B increases expression ISO exemestane results in increased expression of KIF13B mRNA CTD PMID:17254854 NCBI chr15:43,084,059...43,241,719
Ensembl chr15:38,924,624...39,084,879
JBrowse link
G Klk7 kallikrein-related peptidase 7 increases expression ISO exemestane results in increased expression of KLK7 mRNA CTD PMID:17254854 NCBI chr 1:103,403,206...103,407,907
Ensembl chr 1:94,266,605...94,271,332
JBrowse link
G Metrn meteorin, glial cell differentiation regulator increases expression ISO exemestane results in increased expression of METRN mRNA CTD PMID:17254854 NCBI chr10:15,321,200...15,323,218
Ensembl chr10:14,816,572...14,818,701
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO exemestane results in decreased expression of MKI67 protein CTD PMID:16002280 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mybl2 MYB proto-oncogene like 2 increases expression ISO exemestane results in increased expression of MYBL2 mRNA CTD PMID:17254854 NCBI chr 3:172,124,765...172,153,221
Ensembl chr 3:151,705,288...151,733,708
JBrowse link
G Myo9b myosin IXb increases expression ISO exemestane results in increased expression of MYO9B mRNA CTD PMID:17254854 NCBI chr16:17,979,374...18,064,100
Ensembl chr16:17,945,448...18,030,126
JBrowse link
G Ostm1 osteoclastogenesis associated transmembrane protein 1 increases expression ISO exemestane results in increased expression of OSTM1 mRNA CTD PMID:17254854 NCBI chr20:47,653,696...47,769,248
Ensembl chr20:46,153,075...46,187,023
JBrowse link
G Pgr progesterone receptor decreases expression
increases expression
ISO exemestane results in decreased expression of PGR protein
exemestane results in increased expression of PGR mRNA
CTD PMID:15909811 PMID:16002280 PMID:18677558 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Plcg2 phospholipase C, gamma 2 increases expression ISO exemestane results in increased expression of PLCG2 mRNA CTD PMID:17254854 NCBI chr19:62,456,196...62,592,684
Ensembl chr19:45,547,416...45,683,930
JBrowse link
G Rnf123 ring finger protein 123 increases expression ISO exemestane results in increased expression of RNF123 mRNA CTD PMID:17254854 NCBI chr 8:117,618,776...117,646,400
Ensembl chr 8:108,739,620...108,767,675
JBrowse link
G Rrp12 ribosomal RNA processing 12 increases expression ISO exemestane results in increased expression of RRP12 mRNA CTD PMID:17254854 NCBI chr 1:250,621,707...250,655,318
Ensembl chr 1:240,672,382...240,706,018
JBrowse link
G Slc13a4 solute carrier family 13 member 4 increases expression ISO exemestane results in increased expression of SLC13A4 mRNA CTD PMID:17254854 NCBI chr 4:64,910,505...64,955,986
Ensembl chr 4:63,943,395...63,988,857
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO exemestane inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Smim43 small integral membrane protein 43 increases expression ISO exemestane results in increased expression of SMIM43 mRNA CTD PMID:17254854 NCBI chr 2:121,304,262...121,314,779
Ensembl chr 2:119,385,754...119,385,945
JBrowse link
G Tbc1d17 TBC1 domain family, member 17 increases expression ISO exemestane results in increased expression of TBC1D17 mRNA CTD PMID:17254854 NCBI chr 1:104,461,266...104,469,615
Ensembl chr 1:95,322,737...95,333,005
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO exemestane results in increased expression of TFF1 mRNA CTD PMID:18677558 NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Tnfrsf14 TNF receptor superfamily member 14 increases expression ISO exemestane results in increased expression of TNFRSF14 mRNA CTD PMID:17254854 NCBI chr 5:170,768,413...170,776,749
Ensembl chr 5:165,484,262...165,493,703
JBrowse link
G Triobp TRIO and F-actin binding protein increases expression ISO exemestane results in increased expression of TRIOBP mRNA CTD PMID:17254854 NCBI chr 7:112,386,371...112,452,130
Ensembl chr 7:110,506,248...110,562,474
JBrowse link
G Xist X inactive specific transcript increases expression ISO exemestane results in increased expression of XIST mRNA CTD PMID:17254854 NCBI chr  X:72,540,753...72,558,266 JBrowse link
famotidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 multiple interactions ISO Famotidine inhibits the reaction [ADCYAP1 protein affects the secretion of Acids] CTD PMID:20388963 NCBI chr 9:120,550,236...120,569,096
Ensembl chr 9:113,103,718...113,109,773
JBrowse link
G Agt angiotensinogen multiple interactions EXP Famotidine inhibits the reaction [Indomethacin results in increased expression of AGT protein] CTD PMID:27645307 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases activity ISO Famotidine results in decreased activity of BRAF protein CTD PMID:20823850 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Car12 carbonic anhydrase 12 multiple interactions ISO Famotidine binds to and results in decreased activity of CA12 protein CTD PMID:30344913 NCBI chr 8:76,169,723...76,225,465
Ensembl chr 8:67,274,359...67,330,440
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO Famotidine binds to and results in decreased activity of CA2 protein CTD PMID:30344913 NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Car6 carbonic anhydrase 6 multiple interactions ISO Famotidine binds to and results in decreased activity of CA6 protein CTD PMID:30344913 NCBI chr 5:165,941,028...165,959,566
Ensembl chr 5:160,658,105...160,676,644
JBrowse link
G Car7 carbonic anhydrase 7 multiple interactions ISO Famotidine binds to and results in decreased activity of CA7 protein CTD PMID:30344913 NCBI chr19:435,520...444,927
Ensembl chr19:429,075...438,467
JBrowse link
G Cat catalase multiple interactions EXP
ISO
Famotidine inhibits the reaction [Indomethacin results in decreased activity of CAT protein]; Famotidine inhibits the reaction [Indomethacin results in increased activity of CAT protein]; Quercetin promotes the reaction [Famotidine inhibits the reaction [Indomethacin results in decreased activity of CAT protein]]
Famotidine inhibits the reaction [Indomethacin results in decreased expression of CAT protein]
CTD PMID:18726076 PMID:19034656 PMID:19497431 PMID:25926722 PMID:38447874 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]] CTD PMID:12538815 NCBI chr11:75,760,073...75,798,978
Ensembl chr11:62,254,624...62,292,030
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression
ISO Famotidine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CTNNB1 mRNA]
Famotidine results in increased expression of CTNNB1 mRNA
CTD PMID:31563592 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP Famotidine results in increased expression of CXCL1 protein CTD PMID:12023551 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions ISO Famotidine inhibits the reaction [CYP2C19 gene affects the susceptibility to Lansoprazole] CTD PMID:15963082 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO [Famotidine co-treated with Sucralfate] results in increased expression of FGF2 mRNA CTD PMID:17717918 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fgf21 fibroblast growth factor 21 increases expression ISO Famotidine results in increased expression of FGF21 protein CTD PMID:8774986 NCBI chr 1:105,219,825...105,221,376
Ensembl chr 1:96,083,441...96,090,454
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Famotidine inhibits the reaction [[Dimaprit binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA]; Famotidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA] CTD PMID:9187264 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions EXP Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein]] CTD PMID:15363660 NCBI chr10:27,096,731...27,152,563
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabra3 gamma-aminobutyric acid type A receptor subunit alpha 3 multiple interactions EXP Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15363660 NCBI chr  X:155,301,979...155,543,870
Ensembl chr  X:150,261,607...150,501,559
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions EXP Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15363660 NCBI chr10:27,438,127...27,657,680
Ensembl chr10:26,936,551...27,151,251
JBrowse link
G Gabrg1 gamma-aminobutyric acid type A receptor subunit gamma 1 multiple interactions EXP Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]] CTD PMID:15363660 NCBI chr14:37,750,292...37,821,651
Ensembl chr14:37,396,294...37,635,956
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions EXP Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15363660 NCBI chr10:26,876,926...26,965,523
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Gast gastrin affects expression
increases expression
ISO
EXP
Famotidine affects the expression of GAST protein
Famotidine results in increased expression of GAST protein
CTD PMID:12503773 PMID:17652263 NCBI chr10:85,765,216...85,767,881
Ensembl chr10:85,264,832...85,267,496
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide multiple interactions EXP Famotidine inhibits the reaction [GHRL protein results in increased secretion of Acids] CTD PMID:16838121 NCBI chr 4:148,421,315...148,431,128
Ensembl chr 4:146,865,712...146,869,621
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Famotidine inhibits the reaction [Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein]; Famotidine inhibits the reaction [Dizocilpine Maleate results in increased expression of GSK3B mRNA] CTD PMID:31563592 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions
decreases activity
increases expression
ISO
EXP
[Famotidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin; Famotidine binds to and results in decreased activity of HRH2 protein; Famotidine inhibits the reaction [[Dimaprit binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA]; Famotidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA]
Famotidine results in decreased activity of HRH2 protein
[Famotidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Histamine
Famotidine results in increased expression of HRH2 protein
CTD PMID:9187264 PMID:9681472 PMID:12832840 PMID:15961859 PMID:16632449 More... NCBI chr17:10,371,083...10,412,979
Ensembl chr17:10,368,298...10,407,631
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A decreases expression
multiple interactions
EXP Famotidine results in decreased expression of HSPA1A protein
Zinc Compounds analog inhibits the reaction [Famotidine results in decreased expression of HSPA1A protein]; Zinc Sulfate inhibits the reaction [Famotidine results in decreased expression of HSPA1A protein]
CTD PMID:16945336 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]] CTD PMID:11752121 PMID:12364868 PMID:12538815 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma multiple interactions ISO Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]
Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein]]
CTD PMID:11752121 PMID:12364868 PMID:19277450 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]] CTD PMID:11752121 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12a interleukin 12A multiple interactions ISO Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]] CTD PMID:11752121 PMID:12364868 NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]] CTD PMID:11752121 PMID:12364868 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il18 interleukin 18 multiple interactions ISO Famotidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]] CTD PMID:11752121 PMID:12364868 PMID:16723495 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
[Famotidine co-treated with Sucralfate] results in decreased expression of IL1B mRNA
Famotidine inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Famotidine inhibits the reaction [Indomethacin results in increased expression of IL1B mRNA]
CTD PMID:17717918 PMID:27474069 PMID:27645307 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions ISO Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]] CTD PMID:19277450 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein]] CTD PMID:19277450 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Famotidine inhibits the reaction [Ethanol results in increased expression of IL6 protein]; Famotidine inhibits the reaction [Ethanol results in increased secretion of IL6 protein] CTD PMID:17603938 PMID:27474069 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Famotidine inhibits the reaction [Histamine results in increased phosphorylation of MAPK1 protein] CTD PMID:17656145 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Famotidine inhibits the reaction [Histamine results in increased phosphorylation of MAPK3 protein] CTD PMID:17656145 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO Famotidine inhibits the reaction [Histamine results in increased expression of MMP1 mRNA]; Famotidine inhibits the reaction [Histamine results in increased secretion of MMP1 protein] CTD PMID:17656145 NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Famotidine inhibits the reaction [Ethanol results in increased expression of and results in increased activity of MMP9 protein]; Famotidine inhibits the reaction [Ethanol results in increased expression of MMP9 mRNA]; Famotidine inhibits the reaction [Ethanol results in increased secretion of and results in increased activity of MMP9 protein]; Famotidine inhibits the reaction [Ethanol results in increased secretion of MMP9 protein] CTD PMID:17603938 PMID:22257724 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases expression
ISO
EXP
Famotidine inhibits the reaction [Acids results in increased activity of MPO protein]
Famotidine results in increased expression of MPO protein
Famotidine inhibits the reaction [Ethanol results in increased activity of MPO protein]; Famotidine inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Famotidine promotes the reaction [Chlorpheniramine results in decreased activity of MPO protein]; Quercetin promotes the reaction [Famotidine inhibits the reaction [Indomethacin results in increased activity of MPO protein]]
CTD PMID:12023551 PMID:16091555 PMID:16437673 PMID:17603938 PMID:18726076 More... NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO Famotidine inhibits the reaction [Indomethacin results in increased expression of MYD88 protein] CTD PMID:38447874 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Famotidine inhibits the reaction [Indomethacin results in increased expression of NFKB1 protein] CTD PMID:38447874 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO Famotidine inhibits the reaction [Indomethacin results in increased expression of NFKB2 mRNA] CTD PMID:38447874 NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:245,165,950...245,173,213
JBrowse link
G Nppb natriuretic peptide B decreases expression EXP Famotidine results in decreased expression of NPPB protein CTD PMID:30310171 NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Ntf3 neurotrophin 3 multiple interactions EXP [Pyrilamine co-treated with Famotidine co-treated with ciproxifan] inhibits the reaction [Histamine results in increased expression of NTF3 protein]; [Pyrilamine co-treated with Famotidine] inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Famotidine inhibits the reaction [Histamine results in increased expression of NTF3 protein] CTD PMID:21276809 NCBI chr 4:160,601,161...160,670,623
Ensembl chr 4:158,914,957...158,984,596
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [Famotidine co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of PCNA protein]; Famotidine promotes the reaction [Acetic Acid results in increased expression of PCNA protein] CTD PMID:18853145 PMID:19251492 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha decreases expression EXP Famotidine results in decreased expression of PPP3CA protein CTD PMID:30310171 NCBI chr 2:227,839,058...228,113,560
Ensembl chr 2:225,165,766...225,438,974
JBrowse link
G Prdx3 peroxiredoxin 3 increases expression EXP Famotidine results in increased expression of PRDX3 protein CTD PMID:30310171 NCBI chr 1:269,987,691...270,000,111
Ensembl chr 1:260,001,637...260,014,111
JBrowse link
G Prl prolactin increases expression ISO Famotidine results in increased expression of PRL protein CTD PMID:8104296 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP Famotidine inhibits the reaction [Indomethacin results in increased expression of PTGS1 mRNA] CTD PMID:27645307 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO
Famotidine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]
Famotidine inhibits the reaction [Indomethacin results in decreased expression of PTGS2 mRNA]
CTD PMID:27645307 PMID:38447874 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Famotidine inhibits the reaction [Ethanol results in increased expression of RELA protein] CTD PMID:27474069 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G RT1-A2 RT1 class Ia, locus A2 affects expression ISO Famotidine affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:4,872,720...4,876,425 JBrowse link
G RT1-DMb RT1 class II, locus DMb affects expression ISO Famotidine affects the expression of HLA-DMB mRNA CTD PMID:25811541 NCBI chr20:4,695,009...4,702,560
Ensembl chr20:4,693,103...4,700,340
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP Heparin promotes the reaction [[Famotidine co-treated with Lipopolysaccharides] results in increased expression of SERPINE1 protein] CTD PMID:16401727 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Slc19a3 solute carrier family 19 member 3 multiple interactions
increases uptake
ISO Famotidine inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Famotidine inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine]
SLC19A3 protein results in increased uptake of Famotidine
CTD PMID:26528626 NCBI chr 9:91,723,799...91,747,499
Ensembl chr 9:84,277,024...84,299,337
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions
increases uptake
affects transport
ISO
EXP
Famotidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
SLC22A1 protein results in increased uptake of Famotidine
SLC22A1 protein affects the transport of Famotidine
CTD PMID:16006492 PMID:16141367 NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a2 solute carrier family 22 member 2 increases uptake
multiple interactions
ISO
EXP
SLC22A2 protein results in increased uptake of Famotidine
Famotidine inhibits the reaction [SLC22A2 protein affects the transport of Tetraethylammonium]; Famotidine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Famotidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD PMID:15496291 PMID:16006492 PMID:16141367 PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions
decreases activity
ISO Famotidine inhibits the reaction [SLC22A3 protein affects the transport of 1-Methyl-4-phenylpyridinium]; Famotidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
Famotidine results in decreased activity of SLC22A3 protein
CTD PMID:16141367 NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:48,235,476...48,324,612
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions
increases uptake
ISO
EXP
estrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Famotidine]; Famotidine inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Famotidine]
Famotidine inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Penicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of Famotidine]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Famotidine]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Famotidine]
Famotidine inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]
CTD PMID:15100168 PMID:15319347 PMID:15496291 PMID:16006492 NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Famotidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Famotidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,490,262...46,532,954
Ensembl chr10:45,991,095...46,033,904
JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions ISO Famotidine inhibits the reaction [Acids affects the localization of TACR1 protein] CTD PMID:16091555 NCBI chr 4:116,478,617...116,647,492
Ensembl chr 4:114,920,844...115,089,733
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Famotidine inhibits the reaction [Indomethacin results in increased expression of TLR4 protein] CTD PMID:38447874 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
ISO
EXP
Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
Famotidine results in increased secretion of TNF protein
Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNF protein]]
Famotidine inhibits the reaction [Ethanol results in increased expression of TNF protein]; Famotidine inhibits the reaction [Ethanol results in increased secretion of TNF protein]; Famotidine inhibits the reaction [Indomethacin results in increased expression of TNF mRNA]
CTD PMID:11752121 PMID:12538815 PMID:17603938 PMID:17698507 PMID:19277450 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
fluconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb9 ATP binding cassette subfamily B member 9 decreases expression EXP Fluconazole results in decreased expression of ABCB9 mRNA CTD PMID:16643972 NCBI chr12:38,146,659...38,192,862
Ensembl chr12:32,499,225...32,531,931
JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide decreases expression EXP Fluconazole results in decreased expression of ADH1 mRNA CTD PMID:16643972 NCBI chr 2:229,470,703...229,482,291
Ensembl chr 2:226,797,303...226,808,892
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP Fluconazole results in increased expression of AKR7A3 mRNA CTD PMID:16643972 NCBI chr 5:156,876,721...156,884,599
Ensembl chr 5:151,584,479...151,601,394
JBrowse link
G Apoa4 apolipoprotein A4 decreases expression EXP Fluconazole results in decreased expression of APOA4 mRNA CTD PMID:16643972 NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:46,539,082...46,541,469
JBrowse link
G Ces2h carboxylesterase 2H increases expression EXP Fluconazole results in increased expression of CES2 mRNA CTD PMID:16643972 NCBI chr19:49,884,164...49,898,764
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 affects activity ISO Fluconazole affects the activity of CYP17A1 protein CTD PMID:31330226 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
decreases activity
ISO [Fluconazole results in decreased activity of CYP19A1 protein] which results in decreased chemical synthesis of Estrone; [Fluconazole results in decreased activity of CYP19A1 protein] which results in decreased metabolism of Androstenedione CTD PMID:31330226 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO Fluconazole results in increased expression of CYP1A2 mRNA CTD PMID:16730040 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression ISO Fluconazole results in increased expression of CYP26A1 mRNA CTD PMID:19429397 NCBI chr 1:244,883,822...244,887,657
Ensembl chr 1:235,471,298...235,475,204
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 increases expression ISO Fluconazole results in increased expression of CYP26B1 mRNA CTD PMID:19429397 NCBI chr 4:118,599,356...118,616,176
Ensembl chr 4:117,041,808...117,058,628
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression
ISO NR1I3 promotes the reaction [Fluconazole results in increased expression of CYP2B10 mRNA] CTD PMID:16730040 PMID:25656644 NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP Fluconazole results in decreased expression of CYP2C mRNA CTD PMID:16643972 NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 increases expression ISO Fluconazole results in increased expression of CYP2C55 mRNA CTD PMID:16730040 NCBI chr 1:246,286,341...246,348,607
Ensembl chr 1:236,873,967...236,936,238
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity
increases expression
multiple interactions
increases metabolic processing
ISO Fluconazole results in decreased activity of CYP2C19 protein
Fluconazole results in increased expression of CYP2C29 mRNA
[Fluconazole results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole
CYP2C19 protein results in increased metabolism of Fluconazole
CTD PMID:12464242 PMID:15843491 PMID:16730040 PMID:17702393 PMID:19328226 More... NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2g1 cytochrome P450, family 2, subfamily g, polypeptide 1 decreases expression EXP Fluconazole results in decreased expression of CYP2G1 mRNA CTD PMID:16643972 NCBI chr 1:91,273,309...91,284,499
Ensembl chr 1:82,145,073...82,156,828
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases expression ISO Fluconazole results in decreased expression of CYP2J9 mRNA CTD PMID:16730040 NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO Fluconazole results in decreased activity of CYP3A4 protein CTD PMID:15784650 PMID:15843491 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression
affects expression
EXP Fluconazole results in increased expression of CYP3A23-3A1 mRNA
Fluconazole affects the expression of CYP3A23-3A1 mRNA
CTD PMID:16643972 PMID:20623750 NCBI chr12:14,369,950...14,398,803
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression EXP Fluconazole results in increased expression of CYP3A13 mRNA CTD PMID:16643972 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp51 cytochrome P450, family 51 decreases activity
decreases response to substance
multiple interactions
ISO Fluconazole results in decreased activity of CYP51A1 protein
CYP51A1 gene results in decreased susceptibility to Fluconazole
CYP51A1 gene inhibits the reaction [Fluconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Fluconazole results in decreased metabolism of and results in increased abundance of 14-methylergosta-8,24(28)-dien-3,6-diol]; CYP51A1 gene inhibits the reaction [Fluconazole results in decreased metabolism of and results in increased abundance of Lanosterol]
CTD PMID:16989930 PMID:18694951 NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,036,865...30,055,410
Ensembl chr 6:30,036,865...30,055,410
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression ISO Fluconazole results in increased expression of GSTM1 mRNA CTD PMID:16730040 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Fluconazole results in decreased expression of JUND mRNA CTD PMID:16643972 NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,734,122...18,735,799
JBrowse link
G Lcn2 lipocalin 2 increases expression EXP Fluconazole results in increased expression of LCN2 mRNA CTD PMID:20623750 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Mark2 microtubule affinity regulating kinase 2 increases expression ISO Fluconazole results in increased expression of MARK2 mRNA CTD PMID:16730040 NCBI chr 1:213,890,213...213,955,417
Ensembl chr 1:204,461,030...204,525,652
JBrowse link
G Mpo myeloperoxidase increases expression EXP Fluconazole results in increased expression of MPO mRNA CTD PMID:20623750 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Fluconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein] CTD PMID:17438109 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects response to substance
increases response to substance
multiple interactions
ISO NR1I3 protein affects the susceptibility to Fluconazole
NR1I3 results in increased susceptibility to Fluconazole
NR1I3 promotes the reaction [Fluconazole results in increased expression of CYP2B10 mRNA]; NR1I3 promotes the reaction [Fluconazole results in increased expression of CYP3A11 mRNA]; NR1I3 promotes the reaction [Fluconazole results in increased expression of POR mRNA]
CTD PMID:23721867 PMID:25656644 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Por cytochrome p450 oxidoreductase decreases expression
multiple interactions
increases expression
EXP
ISO
Fluconazole results in decreased expression of POR mRNA
NR1I3 promotes the reaction [Fluconazole results in increased expression of POR mRNA]
CTD PMID:16643972 PMID:16730040 PMID:25656644 NCBI chr12:26,587,674...26,655,612
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression EXP Fluconazole results in increased expression of PPARG mRNA CTD PMID:20623750 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Slc13a2 solute carrier family 13 member 2 decreases expression ISO Fluconazole results in decreased expression of SLC13A2 mRNA CTD PMID:16730040 NCBI chr10:63,789,874...63,817,441
Ensembl chr10:63,291,815...63,319,127
JBrowse link
G Slc6a13 solute carrier family 6 member 13 decreases expression EXP Fluconazole results in decreased expression of SLC6A13 mRNA CTD PMID:16643972 NCBI chr 4:156,211,381...156,248,491
Ensembl chr 4:154,540,468...154,576,152
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases expression ISO Fluconazole results in increased expression of SLCO1A4 mRNA CTD PMID:16730040 NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 decreases expression EXP Fluconazole results in decreased expression of SRD5A1 mRNA CTD PMID:16643972 NCBI chr 1:35,514,914...35,548,898
Ensembl chr 1:33,686,391...33,720,461
JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO Fluconazole results in increased expression of STAR mRNA CTD PMID:23038793 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 affects expression EXP Fluconazole affects the expression of UGT1A9 mRNA CTD PMID:20623750 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases expression EXP Fluconazole results in increased expression of UGT2B1 mRNA CTD PMID:16643972 NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,024,006...21,035,986
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO Fluconazole inhibits the reaction [[Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol] CTD PMID:18098064 NCBI chr14:21,251,535...21,274,451
Ensembl chr14:20,896,682...20,919,604
JBrowse link
formestane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions
increases expression
ISO formestane metabolite inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]
formestane analog results in increased expression of AR mRNA; formestane metabolite results in increased expression of AR mRNA; formestane results in increased expression of AR mRNA
CTD PMID:29702199 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions EXP formestane promotes the reaction [Androstenedione results in increased expression of CYP11A1 mRNA]; formestane promotes the reaction [Testosterone results in increased expression of CYP11A1 mRNA] CTD PMID:21273442 NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
decreases activity
ISO
EXP
[formestane results in decreased activity of CYP19A1 protein] which results in decreased abundance of Estrone; formestane inhibits the reaction [Atrazine results in increased activity of CYP19A1 protein]; formestane inhibits the reaction [CYP19A1 protein affects the chemical synthesis of 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine]; formestane inhibits the reaction [CYP19A1 protein affects the metabolism of Methadone]; formestane inhibits the reaction [propazine results in increased activity of CYP19A1 protein]; formestane inhibits the reaction [Simazine results in increased activity of CYP19A1 protein]
formestane inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of CYP19A1 protein]; formestane inhibits the reaction [FSHB protein results in increased activity of CYP19A1 protein]; formestane promotes the reaction [Androstenedione results in increased expression of CYP19A1 mRNA]; formestane promotes the reaction [Testosterone results in increased expression of CYP19A1 mRNA]
CTD PMID:10746939 PMID:10806373 PMID:15242824 PMID:15319488 PMID:16177243 More... NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO formestane metabolite results in increased expression of ESR1 mRNA CTD PMID:29702199 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP formestane inhibits the reaction [FSHB protein results in increased activity of CYP19A1 protein] CTD PMID:22120136 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 decreases activity ISO formestane results in decreased activity of HSD17B1 protein CTD PMID:15876411 NCBI chr10:86,510,011...86,512,211
Ensembl chr10:86,009,728...86,011,927
JBrowse link
ginkgetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAX protein]
ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]
CTD PMID:25968939 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]
ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2 protein]
CTD PMID:25968939 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 multiple interactions ISO ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP3 protein] CTD PMID:25968939 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ftl1 ferritin light chain 1 decreases expression ISO ginkgetin results in decreased expression of FTL1 protein
ginkgetin results in decreased expression of FTL protein
CTD PMID:25968939 NCBI chr 1:105,072,858...105,074,705
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725
JBrowse link
G Tfrc transferrin receptor increases expression ISO ginkgetin results in increased expression of TFRC protein CTD PMID:25968939 NCBI chr11:81,668,478...81,690,318
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] CTD PMID:25968939 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
glycitein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ABCA1 mRNA CTD PMID:16963248 NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO glycitein inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; glycitein promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]; glycitein promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]] CTD PMID:34217736 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of ACSL3 mRNA CTD PMID:27424125 NCBI chr 9:87,563,601...87,613,078
Ensembl chr 9:80,115,112...80,164,627
JBrowse link
G Add2 adducin 2 multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ADD2 mRNA CTD PMID:16963248 NCBI chr 4:120,001,977...120,101,090
Ensembl chr 4:118,497,416...118,538,505
JBrowse link
G Ahr aryl hydrocarbon receptor increases activity ISO glycitein results in increased activity of AHR protein CTD PMID:17869316 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of ALDH1A2 mRNA CTD PMID:27424125 NCBI chr 8:80,758,641...80,837,891
Ensembl chr 8:71,877,850...71,957,107
JBrowse link
G Anpep alanyl aminopeptidase, membrane multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of ANPEP mRNA CTD PMID:27424125 NCBI chr 1:143,176,645...143,219,447
Ensembl chr 1:133,767,332...133,785,789
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha decreases expression ISO glycitein results in decreased expression of ARHGDIA mRNA CTD PMID:15757668 NCBI chr10:106,352,858...106,356,347
Ensembl chr10:105,854,533...105,858,023
JBrowse link
G Atoh8 atonal bHLH transcription factor 8 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of ATOH8 mRNA CTD PMID:27424125 NCBI chr 4:105,818,203...105,850,379
Ensembl chr 4:104,259,992...104,292,168
JBrowse link
G Atp6v0a2 ATPase H+ transporting V0 subunit a2 multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ATP6V0A2 mRNA CTD PMID:16963248 NCBI chr12:37,608,211...37,640,860
Ensembl chr12:31,822,733...32,007,069
JBrowse link
G Baz1a bromodomain adjacent to zinc finger domain, 1A multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of BAZ1A mRNA CTD PMID:16963248 NCBI chr 6:78,124,872...78,247,672
Ensembl chr 6:72,389,703...72,512,459
JBrowse link
G Bckdk branched chain ketoacid dehydrogenase kinase multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of BCKDK mRNA CTD PMID:27424125 NCBI chr 1:191,945,809...191,950,480
Ensembl chr 1:182,515,327...182,536,633
JBrowse link
G Bpgm bisphosphoglycerate mutase multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of BPGM mRNA CTD PMID:27424125 NCBI chr 4:64,106,809...64,135,749
Ensembl chr 4:63,140,018...63,168,581
JBrowse link
G Cabp5 calcium binding protein 5 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CABP5 mRNA CTD PMID:27424125 NCBI chr 1:83,486,396...83,499,421
Ensembl chr 1:74,350,811...74,363,830
JBrowse link
G Cacybp calcyclin binding protein multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of CACYBP mRNA CTD PMID:27424125 NCBI chr13:74,970,917...74,981,298
Ensembl chr13:72,437,490...72,450,177
JBrowse link
G Casp8ap2 caspase 8 associated protein 2 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CASP8AP2 mRNA CTD PMID:27424125 NCBI chr 5:51,809,366...51,848,633
Ensembl chr 5:47,014,667...47,052,275
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO glycitein results in decreased expression of CCNA2 CTD PMID:21161820 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO glycitein results in increased expression of CCND1 mRNA CTD PMID:19800779 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cd200r1 CD200 receptor 1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CD200R1 mRNA CTD PMID:27424125 NCBI chr11:69,392,943...69,427,213
Ensembl chr11:55,887,717...55,921,285
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases activity ISO glycitein results in decreased activity of CDK4 protein CTD PMID:21161820 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO ESR2 affects the reaction [glycitein results in increased expression of CDKN1A] CTD PMID:21161820 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cfap251 cilia and flagella associated protein 251 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of CFAP251 mRNA CTD PMID:27424125 NCBI chr12:38,923,154...38,997,881
Ensembl chr12:33,261,476...33,293,932
JBrowse link
G Cybrd1 cytochrome b reductase 1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CYBRD1 mRNA CTD PMID:27424125 NCBI chr 3:76,342,231...76,369,846
Ensembl chr 3:55,934,874...55,962,108
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions EXP [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of CYP11A1 mRNA CTD PMID:28964809 NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Dennd2d DENN domain containing 2D multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of DENND2D mRNA CTD PMID:27424125 NCBI chr 2:196,661,465...196,680,505
Ensembl chr 2:193,973,231...193,992,270
JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions EXP [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of DNMT1 mRNA CTD PMID:28964809 NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha multiple interactions EXP [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of DNMT3A mRNA CTD PMID:28964809 NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:26,822,609...26,896,687
JBrowse link
G Dock3 dedicator of cyto-kinesis 3 multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of DOCK3 mRNA CTD PMID:16963248 NCBI chr 8:116,431,158...116,782,218
Ensembl chr 8:107,552,463...107,903,514
JBrowse link
G Dpp9 dipeptidyl peptidase 9 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of DPP9 mRNA CTD PMID:27424125 NCBI chr 9:1,098,505...1,133,500
Ensembl chr 9:1,011,351...1,046,541
JBrowse link
G Edrf1 erythroid differentiation regulatory factor 1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of EDRF1 mRNA CTD PMID:27424125 NCBI chr 1:197,869,873...197,908,693
Ensembl chr 1:188,441,634...188,478,701
JBrowse link
G Efhd1 EF-hand domain family, member D1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of EFHD1 mRNA CTD PMID:27424125 NCBI chr 9:95,386,155...95,432,800
Ensembl chr 9:87,938,284...87,984,917
JBrowse link
G Epha1 Eph receptor A1 multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of EPHA1 mRNA CTD PMID:16963248 NCBI chr 4:72,213,022...72,227,543
Ensembl chr 4:71,246,409...71,260,846
JBrowse link
G Espn espin multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ESPN mRNA CTD PMID:16963248 NCBI chr 5:167,909,271...167,943,168
Ensembl chr 5:162,626,560...162,660,256
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
affects binding
ISO glycitein inhibits the reaction [Estradiol binds to ESR1 protein]
glycitein binds to ESR1 protein
CTD PMID:14579009 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects response to substance
ISO
EXP
ESR2 affects the reaction [glycitein results in increased expression of CDKN1A]
[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of ESR2 mRNA
ESR2 affects the susceptibility to glycitein
CTD PMID:21161820 PMID:28964809 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fam171a2 family with sequence similarity 171, member A2 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of FAM171A2 mRNA CTD PMID:27424125 NCBI chr10:87,894,049...87,904,213
Ensembl chr10:87,394,007...87,404,053
JBrowse link
G Fam180a family with sequence similarity 180, member A multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of FAM180A mRNA CTD PMID:27424125 NCBI chr 4:64,959,999...64,975,176
Ensembl chr 4:63,992,867...64,008,047
JBrowse link
G Fam210b family with sequence similarity 210, member B multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of FAM210B mRNA CTD PMID:27424125 NCBI chr 3:181,536,665...181,546,830
Ensembl chr 3:161,118,239...161,128,397
JBrowse link
G Fam241b family with sequence similarity 241 member B multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of FAM241B mRNA CTD PMID:27424125 NCBI chr20:30,595,082...30,598,007
Ensembl chr20:30,052,324...30,055,084
Ensembl chr 6:30,052,324...30,055,084
JBrowse link
G Fgd6 FYVE, RhoGEF and PH domain containing 6 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of FGD6 mRNA CTD PMID:27424125 NCBI chr 7:30,484,600...30,599,898
Ensembl chr 7:28,597,609...28,712,456
JBrowse link
G Fhl2 four and a half LIM domains 2 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of FHL2 mRNA CTD PMID:27424125 NCBI chr 9:52,881,091...52,954,540
Ensembl chr 9:45,388,981...45,431,192
JBrowse link
G Fmn2 formin 2 multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of FMN2 mRNA CTD PMID:16963248 NCBI chr13:88,986,863...89,303,789
Ensembl chr13:86,453,926...86,771,411
JBrowse link
G Galnt15 polypeptide N-acetylgalactosaminyltransferase 15 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of GALNT15 mRNA CTD PMID:27424125 NCBI chr16:7,233,524...7,273,290
Ensembl chr16:7,227,271...7,267,014
JBrowse link
G Gng5 G protein subunit gamma 5 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of GNG5 mRNA CTD PMID:27424125 NCBI chr 2:238,054,954...238,063,451
Ensembl chr 1:77,292,043...77,292,513
Ensembl chr11:77,292,043...77,292,513
JBrowse link
G Hipk4 homeodomain interacting protein kinase 4 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of HIPK4 mRNA CTD PMID:27424125 NCBI chr 1:91,938,308...91,948,680
Ensembl chr 1:82,810,708...82,821,077
JBrowse link
G Hmcn1 hemicentin 1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of HMCN1 mRNA CTD PMID:27424125 NCBI chr13:65,165,532...65,634,681
Ensembl chr13:62,615,461...63,084,524
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions EXP [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of HSD3B1 mRNA CTD PMID:28964809 NCBI chr 2:188,858,574...188,864,694
Ensembl chr 2:186,169,863...186,175,999
JBrowse link
G Ifrd2 interferon-related developmental regulator 2 multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of IFRD2 mRNA CTD PMID:16963248 NCBI chr 8:117,139,612...117,144,834
Ensembl chr 8:108,260,969...108,266,194
JBrowse link
G Il6r interleukin 6 receptor multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of IL6R mRNA CTD PMID:27424125 NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Irf2bp1 interferon regulatory factor 2 binding protein 1 multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of IRF2BP1 mRNA CTD PMID:16963248 NCBI chr 1:87,780,782...87,783,483
Ensembl chr 1:78,652,412...78,655,530
JBrowse link
G Isg20l2 interferon stimulated exonuclease gene 20-like 2 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of ISG20L2 mRNA CTD PMID:27424125 NCBI chr 2:175,694,638...175,704,125
Ensembl chr 2:173,396,780...173,406,614
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases activity ISO glycitein results in increased activity of JUN protein CTD PMID:17088408 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kcng2 potassium voltage-gated channel modifier subfamily G member 2 multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of KCNG2 mRNA CTD PMID:16963248 NCBI chr18:76,017,225...76,085,377
Ensembl chr18:73,743,074...73,808,723
JBrowse link
G Kdm5a lysine demethylase 5A multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of KDM5A mRNA CTD PMID:27424125 NCBI chr 4:155,238,124...155,316,121
Ensembl chr 4:153,565,846...153,642,422
JBrowse link
G Kitlg KIT ligand multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of KITLG mRNA CTD PMID:27424125 NCBI chr 7:36,782,621...36,863,796
Ensembl chr 7:34,896,053...34,977,214
JBrowse link
G Knstrn kinetochore-localized astrin/SPAG5 binding protein multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of KNSTRN mRNA CTD PMID:27424125 NCBI chr 3:126,254,633...126,274,412
Ensembl chr 3:105,800,954...105,820,715
JBrowse link
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of LDLRAP1 mRNA CTD PMID:27424125 NCBI chr 5:152,239,296...152,262,290
Ensembl chr 5:146,955,607...146,978,601
JBrowse link
G Lmod1 leiomodin 1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of LMOD1 mRNA CTD PMID:27424125 NCBI chr13:49,305,693...49,347,970
Ensembl chr13:46,754,033...46,794,900
JBrowse link
G Lrg1 leucine-rich alpha-2-glycoprotein 1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of LRG1 mRNA CTD PMID:27424125 NCBI chr 9:1,034,691...1,036,937
Ensembl chr 9:947,516...949,813
JBrowse link
G Lsr lipolysis stimulated lipoprotein receptor multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of LSR mRNA CTD PMID:27424125 NCBI chr 1:95,313,830...95,329,471
Ensembl chr 1:86,186,431...86,201,952
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO glycitein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
glycitein results in increased phosphorylation of MAPK1 protein
CTD PMID:17088408 PMID:20188714 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO glycitein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
glycitein results in increased phosphorylation of MAPK3 protein
CTD PMID:17088408 PMID:20188714 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases expression ISO glycitein results in decreased expression of MMP3 mRNA; glycitein results in decreased expression of MMP3 protein CTD PMID:20188714 NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO glycitein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]
glycitein results in decreased expression of MMP9 mRNA; glycitein results in decreased expression of MMP9 protein
CTD PMID:20188714 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mrpl33 mitochondrial ribosomal protein L33 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of MRPL33 mRNA CTD PMID:27424125 NCBI chr 6:30,545,794...30,553,987
Ensembl chr 6:24,825,827...24,833,834
JBrowse link
G Mtmr11 myotubularin related protein 11 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of MTMR11 mRNA CTD PMID:27424125 NCBI chr 2:186,410,851...186,421,024
Ensembl chr 2:183,723,530...183,732,148
JBrowse link
G Myof myoferlin multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of MYOF mRNA CTD PMID:27424125 NCBI chr 1:245,086,109...245,234,768
Ensembl chr 1:235,673,666...235,822,334
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases activity
ISO glycitein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; glycitein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
glycitein results in decreased activity of NOS2 protein
CTD PMID:11308324 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of NR4A1 mRNA CTD PMID:27424125 NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:132,374,840...132,389,297
JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 multiple interactions EXP [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 mRNA; [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 protein; [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased methylation of NR5A1 promoter; decitabine inhibits the reaction [[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 mRNA] CTD PMID:28964809 NCBI chr 3:42,874,505...42,896,109
Ensembl chr 3:22,465,502...22,486,328
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 increases expression ISO glycitein results in increased expression of NRIP1 mRNA CTD PMID:15757668 NCBI chr11:28,382,835...28,466,483
Ensembl chr11:14,895,553...14,981,761
JBrowse link
G Olfml3 olfactomedin-like 3 multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of OLFML3 mRNA CTD PMID:16963248 NCBI chr 2:193,932,665...193,935,494
Ensembl chr 2:191,244,221...191,247,050
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO glycitein results in decreased expression of PCNA CTD PMID:21161820 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pdlim2 PDZ and LIM domain 2 multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of PDLIM2 mRNA CTD PMID:16963248 NCBI chr15:51,647,195...51,659,904
Ensembl chr15:45,237,477...45,249,242
JBrowse link
G Pnn pinin, desmosome associated protein multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of PNN mRNA CTD PMID:16963248 NCBI chr 6:82,493,032...82,501,345
Ensembl chr 6:76,758,117...76,766,889
JBrowse link
G Pou4f2 POU class 4 homeobox 2 multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of POU4F2 mRNA CTD PMID:16963248 NCBI chr19:46,390,958...46,394,599
Ensembl chr19:29,486,686...29,490,327
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of PRKACA mRNA CTD PMID:27424125 NCBI chr19:41,059,843...41,083,189
Ensembl chr19:24,155,090...24,178,430
JBrowse link
G Prpf40a pre-mRNA processing factor 40 homolog A multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of PRPF40A mRNA CTD PMID:27424125 NCBI chr 3:58,036,779...58,098,996
Ensembl chr 3:37,627,690...37,690,886
JBrowse link
G Pspc1 paraspeckle component 1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of PSPC1 mRNA CTD PMID:27424125 NCBI chr15:34,941,445...35,027,460
Ensembl chr15:30,828,626...30,911,202
JBrowse link
G Pth1r parathyroid hormone 1 receptor multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of PTH1R mRNA CTD PMID:27424125 NCBI chr 8:119,572,295...119,597,405
Ensembl chr 8:110,697,485...110,719,729
JBrowse link
G Rassf5 Ras association domain family member 5 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of RASSF5 mRNA CTD PMID:27424125 NCBI chr13:45,189,768...45,255,277
Ensembl chr13:42,637,549...42,703,024
JBrowse link
G Rgs22 regulator of G-protein signaling 22 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of RGS22 mRNA CTD PMID:27424125 NCBI chr 7:69,073,681...69,194,041
Ensembl chr 7:67,188,519...67,308,875
JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 increases expression ISO glycitein results in increased expression of RPS6KA3 mRNA CTD PMID:15757668 NCBI chr  X:39,325,926...39,432,017
Ensembl chr  X:35,517,306...35,623,207
JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of S1PR3 mRNA CTD PMID:27424125 NCBI chr17:13,932,773...13,946,213
Ensembl chr17:13,781,050...13,794,505
JBrowse link
G Selplg selectin P ligand multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of SELPLG mRNA CTD PMID:27424125 NCBI chr12:48,457,102...48,470,444
Ensembl chr12:42,796,580...42,812,585
JBrowse link
G Sgpp1 sphingosine-1-phosphate phosphatase 1 multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of SGPP1 mRNA CTD PMID:16963248 NCBI chr 6:100,161,024...100,182,214
Ensembl chr 6:94,425,339...94,446,534
JBrowse link
G Siglec10 sialic acid binding Ig-like lectin 10 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of SIGLEC10 mRNA CTD PMID:27424125 NCBI chr 1:102,953,894...102,962,964
Ensembl chr 1:93,817,335...93,825,931
JBrowse link
G Slc12a2 solute carrier family 12 member 2 decreases expression ISO glycitein results in decreased expression of SLC12A2 mRNA CTD PMID:15757668 NCBI chr18:53,546,263...53,614,478
Ensembl chr18:51,348,302...51,416,440
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of SLC16A1 mRNA CTD PMID:27424125 NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:192,124,289...192,144,611
JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases uptake ISO SLC22A8 protein results in increased uptake of glycitein analog CTD PMID:21244849 NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Snx30 sorting nexin family member 30 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of SNX30 mRNA CTD PMID:27424125 NCBI chr 5:79,478,804...79,608,118
Ensembl chr 5:74,684,015...74,792,631
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions
increases activity
ISO glycitein promotes the reaction [SP1 protein binds to VDR promoter]; U 0126 inhibits the reaction [glycitein results in increased activity of SP1 protein] CTD PMID:17088408 NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Ssc5d scavenger receptor cysteine rich family member with 5 domains multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of SSC5D mRNA CTD PMID:27424125 NCBI chr 1:77,920,781...77,939,284
Ensembl chr 1:68,891,949...68,909,743
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of STAR mRNA; [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of STAR protein CTD PMID:28964809 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Stc1 stanniocalcin 1 multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of STC1 mRNA CTD PMID:16963248 NCBI chr15:50,709,439...50,720,093
Ensembl chr15:44,299,621...44,310,264
JBrowse link
G Styxl1 serine/threonine/tyrosine interacting-like 1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of STYXL1 mRNA CTD PMID:27424125 NCBI chr12:26,544,059...26,576,365
Ensembl chr12:20,907,435...20,939,752
JBrowse link
G Sumo1 small ubiquitin-like modifier 1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of SUMO1 mRNA CTD PMID:27424125 NCBI chr 9:68,572,901...68,602,803
Ensembl chr 9:61,077,435...61,108,761
JBrowse link
G Tacr3 tachykinin receptor 3 multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of TACR3 mRNA CTD PMID:16963248 NCBI chr 2:225,940,497...226,037,756
Ensembl chr 2:223,266,536...223,363,791
JBrowse link
G Tc2n tandem C2 domains, nuclear multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of TC2N mRNA CTD PMID:27424125 NCBI chr 6:126,526,006...126,622,163
Ensembl chr 6:120,761,119...120,849,326
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of TNFAIP6 mRNA CTD PMID:16963248 NCBI chr 3:56,911,398...56,930,797
Ensembl chr 3:36,502,188...36,521,649
JBrowse link
G Tp53 tumor protein p53 increases expression ISO glycitein results in increased expression of TP53 protein CTD PMID:19800779 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tp53i11 tumor protein p53 inducible protein 11 decreases expression
multiple interactions
ISO glycitein results in decreased expression of TP53I11 mRNA
[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of TP53I11 mRNA
CTD PMID:15757668 PMID:27424125 NCBI chr 3:99,600,213...99,615,462
Ensembl chr 3:79,144,895...79,160,050
JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of UCHL1 mRNA CTD PMID:16963248 NCBI chr14:41,838,859...41,849,743
Ensembl chr14:41,485,031...41,495,590
JBrowse link
G Vcpip1 valosin containing protein interacting protein 1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of VCPIP1 mRNA CTD PMID:27424125 NCBI chr 5:14,317,083...14,343,724
Ensembl chr 5:9,534,129...9,562,040
JBrowse link
G Vdr vitamin D receptor multiple interactions
increases expression
ISO fulvestrant inhibits the reaction [glycitein results in increased expression of VDR protein]; glycitein promotes the reaction [SP1 protein binds to VDR promoter]; U 0126 inhibits the reaction [glycitein results in increased expression of VDR protein]
glycitein results in increased expression of VDR mRNA; glycitein results in increased expression of VDR protein
CTD PMID:17088408 NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:128,987,981...129,037,677
JBrowse link
itraconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Itraconazole results in decreased activity of ABCB11 protein CTD PMID:20829430 PMID:23956101 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects activity
decreases activity
multiple interactions
affects transport
ISO Itraconazole affects the activity of ABCB1 protein
Itraconazole results in decreased activity of ABCB1 protein
Itraconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin]; Itraconazole promotes the reaction [ABCB1 gene SNP affects the susceptibility to fexofenadine]
ABCB1 protein affects the transport of Itraconazole
CTD PMID:15905803 PMID:15964336 PMID:15969931 PMID:16084853 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Acvr1c activin A receptor type 1C increases expression ISO Itraconazole results in increased expression of ACVR1C mRNA CTD PMID:31099283 NCBI chr 3:63,224,322...63,301,252
Ensembl chr 3:42,822,610...42,892,327
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO AHR promotes the reaction [Itraconazole results in increased expression of NQO1 mRNA]; AHR promotes the reaction [Itraconazole results in increased expression of NQO1 protein] CTD PMID:17923278 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Amdhd1 amidohydrolase domain containing 1 decreases expression ISO Itraconazole results in decreased expression of AMDHD1 mRNA CTD PMID:31099283 NCBI chr 7:29,930,966...29,946,199
Ensembl chr 7:28,043,716...28,059,156
JBrowse link
G Ar androgen receptor multiple interactions ISO Itraconazole binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bicc1 BicC family RNA binding protein 1 decreases expression ISO Itraconazole results in decreased expression of BICC1 mRNA CTD PMID:31099283 NCBI chr20:17,448,745...17,685,887
Ensembl chr20:17,449,560...17,686,776
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA] CTD PMID:23688403 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Cpn2 carboxypeptidase N subunit 2 decreases expression ISO Itraconazole results in decreased expression of CPN2 mRNA CTD PMID:31099283 NCBI chr11:83,990,943...84,000,821
Ensembl chr11:70,486,057...70,496,472
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Itraconazole inhibits the reaction [Biological Products results in increased expression of CXCL10 mRNA]; Itraconazole inhibits the reaction [Biological Products results in increased expression of CXCL10 protein] CTD PMID:24471457 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO Itraconazole results in increased expression of CXCL1 mRNA CTD PMID:31099283 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 multiple interactions ISO Itraconazole binds to and results in decreased activity of CYP11B1 protein CTD PMID:31982514 NCBI chr 7:108,719,349...108,726,024
Ensembl chr 7:106,838,590...106,845,004
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 multiple interactions ISO Itraconazole binds to and results in decreased activity of CYP11B2 protein CTD PMID:31982514 NCBI chr 7:108,689,319...108,694,808
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
decreases activity
ISO Dactinomycin inhibits the reaction [Itraconazole results in increased expression of CYP1A1 mRNA]; Itraconazole results in increased expression of and results in increased activity of CYP1A1 protein
Itraconazole results in increased expression of CYP1A1 mRNA; Itraconazole results in increased expression of CYP1A1 protein
Itraconazole results in decreased activity of CYP1A1 protein
CTD PMID:17283379 PMID:28390928 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 decreases activity ISO
EXP
Itraconazole results in decreased activity of CYP24A1 protein CTD PMID:15328084 NCBI chr 3:179,694,647...179,709,083
Ensembl chr 3:159,275,947...159,290,383
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases hydroxylation
affects activity
decreases activity
affects metabolic processing
increases metabolic processing
decreases expression
ISO Itraconazole binds to and results in decreased activity of CYP3A4 protein
CYP3A4 protein results in increased hydroxylation of Itraconazole
Itraconazole affects the activity of CYP3A4 protein
Itraconazole results in decreased activity of CYP3A4 protein
CYP3A4 protein affects the metabolism of Itraconazole
CYP3A4 protein results in increased metabolism of Itraconazole
Itraconazole results in decreased expression of CYP3A4 mRNA; Itraconazole results in decreased expression of CYP3A4 protein
CTD PMID:15328084 PMID:15383492 PMID:15447735 PMID:15684493 PMID:15784650 More... NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp51 cytochrome P450, family 51 decreases activity
decreases response to substance
multiple interactions
ISO Itraconazole results in decreased activity of CYP51A1 protein
CYP51A1 gene results in decreased susceptibility to Itraconazole
CYP51A1 gene inhibits the reaction [Itraconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Itraconazole results in decreased metabolism of and results in increased abundance of 14-methylergosta-8,24(28)-dien-3,6-diol]; CYP51A1 gene inhibits the reaction [Itraconazole results in decreased metabolism of and results in increased abundance of Lanosterol]
CTD PMID:16989930 PMID:18694951 NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,036,865...30,055,410
Ensembl chr 6:30,036,865...30,055,410
JBrowse link
G Dclre1c DNA cross-link repair 1C increases expression ISO Itraconazole results in increased expression of DCLRE1C mRNA CTD PMID:31099283 NCBI chr17:79,684,988...79,718,399
Ensembl chr17:74,776,935...74,809,186
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Itraconazole results in increased expression of DDIT3 mRNA CTD PMID:31099283 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dtna dystrobrevin, alpha decreases expression ISO Itraconazole results in decreased expression of DTNA mRNA CTD PMID:31099283 NCBI chr18:14,862,801...15,218,993
Ensembl chr18:14,587,852...14,944,261
JBrowse link
G Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 decreases expression ISO Itraconazole results in decreased expression of ENPP3 mRNA CTD PMID:31099283 NCBI chr 1:22,382,717...22,454,324
Ensembl chr 1:20,563,697...20,635,041
JBrowse link
G Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 decreases expression ISO Itraconazole results in decreased expression of ESCO2 mRNA CTD PMID:31099283 NCBI chr15:44,210,124...44,230,785
Ensembl chr15:40,034,568...40,055,306
Ensembl chr15:40,034,568...40,055,306
JBrowse link
G Esrra estrogen related receptor, alpha decreases expression ISO Itraconazole results in decreased expression of ESRRA mRNA CTD PMID:31099283 NCBI chr 1:213,533,309...213,543,432
Ensembl chr 1:204,104,101...204,114,268
JBrowse link
G Fabp5 fatty acid binding protein 5 increases expression ISO Itraconazole results in increased expression of FABP5 mRNA CTD PMID:31099283 NCBI chr 2:93,672,451...93,676,186
Ensembl chr 2:91,765,056...91,853,773
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Itraconazole results in increased expression of FOSL1 mRNA CTD PMID:31099283 NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Gfpt1 glutamine fructose-6-phosphate transaminase 1 decreases expression ISO Itraconazole results in decreased expression of GFPT1 mRNA CTD PMID:31099283 NCBI chr 4:121,054,023...121,103,799
Ensembl chr 4:119,496,714...119,546,471
JBrowse link
G Gjb1 gap junction protein, beta 1 decreases expression ISO Itraconazole results in decreased expression of GJB1 mRNA CTD PMID:31099283 NCBI chr  X:70,541,845...70,549,776
Ensembl chr  X:66,501,820...66,509,925
JBrowse link
G Gli1 GLI family zinc finger 1 decreases expression ISO
EXP
Itraconazole analog results in decreased expression of GLI1 mRNA; Itraconazole results in decreased expression of GLI1 mRNA CTD PMID:21936514 PMID:33905526 NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:63,156,926...63,169,251
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases expression ISO Itraconazole results in increased expression of GOT1 protein CTD PMID:31099283 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:242,357,306...242,380,633
JBrowse link
G Gpr6 G protein-coupled receptor 6 decreases expression ISO Itraconazole results in decreased expression of GPR6 mRNA CTD PMID:31099283 NCBI chr20:46,072,480...46,075,251
Ensembl chr20:44,489,853...44,492,624
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression ISO Itraconazole results in increased expression of GPT protein CTD PMID:31099283 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Itraconazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gulp1 GULP PTB domain containing engulfment adaptor 1 decreases expression ISO Itraconazole results in decreased expression of GULP1 mRNA CTD PMID:31099283 NCBI chr 9:54,114,823...54,391,058
Ensembl chr 9:46,622,669...46,899,005
JBrowse link
G Hmga2 high mobility group AT-hook 2 increases expression ISO Itraconazole results in increased expression of HMGA2 mRNA CTD PMID:31099283 NCBI chr 7:57,762,710...57,884,555
Ensembl chr 7:55,880,112...55,994,784
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Itraconazole results in increased expression of HMGCS1 mRNA CTD PMID:31099283 NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression ISO Itraconazole results in decreased expression of HMGCS2 mRNA CTD PMID:31099283 NCBI chr 2:188,564,348...188,590,872
Ensembl chr 2:185,875,616...185,902,130
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity ISO Itraconazole results in decreased activity of HSD11B2 protein CTD PMID:28131847 PMID:29385285 PMID:33387577 NCBI chr19:50,307,569...50,312,812
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Ihh Indian hedgehog signaling molecule decreases expression EXP Itraconazole results in decreased expression of IHH mRNA CTD PMID:33905526 NCBI chr 9:83,952,986...83,959,203
Ensembl chr 9:76,504,315...76,510,532
JBrowse link
G Il12b interleukin 12B increases expression ISO Itraconazole results in increased expression of IL12B mRNA CTD PMID:31099283 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
decreases secretion
ISO 1-Methyl-3-isobutylxanthine inhibits the reaction [Itraconazole results in decreased expression of IL4 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Itraconazole results in decreased secretion of IL4 protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Bucladesine inhibits the reaction [Itraconazole results in decreased expression of IL4 mRNA]; Bucladesine inhibits the reaction [Itraconazole results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Itraconazole results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Itraconazole results in decreased secretion of IL4 protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Itraconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone] CTD PMID:11886533 PMID:15284827 PMID:23688403 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 multiple interactions
decreases secretion
decreases expression
ISO 1-Methyl-3-isobutylxanthine inhibits the reaction [Itraconazole results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Itraconazole results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [Itraconazole results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [Itraconazole results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Itraconazole results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Itraconazole results in decreased secretion of IL5 protein] CTD PMID:11886533 PMID:15284827 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Madcam1 mucosal vascular addressin cell adhesion molecule 1 multiple interactions ISO Itraconazole inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein] CTD PMID:12388057 NCBI chr 7:10,686,920...10,690,322
Ensembl chr 7:10,036,301...10,039,703
JBrowse link
G Mbd1 methyl-CpG binding domain protein 1 increases expression ISO Itraconazole results in increased expression of MBD1 mRNA CTD PMID:31099283 NCBI chr18:70,145,093...70,159,744
Ensembl chr18:67,869,992...67,886,554
JBrowse link
G Myt1 myelin transcription factor 1 increases expression ISO Itraconazole results in increased expression of MYT1 mRNA CTD PMID:31099283 NCBI chr 3:189,263,569...189,327,844
Ensembl chr 3:168,886,089...168,950,341
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Itraconazole promotes the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]] CTD PMID:17998298 NCBI chr 6:32,952,090...33,229,829
Ensembl chr 6:27,232,611...27,475,664
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein] CTD PMID:23688403 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO AHR promotes the reaction [Itraconazole results in increased expression of NQO1 mRNA]; AHR promotes the reaction [Itraconazole results in increased expression of NQO1 protein]; Dactinomycin inhibits the reaction [Itraconazole results in increased expression of NQO1 mRNA]
Itraconazole results in increased expression of NQO1 mRNA; Itraconazole results in increased expression of NQO1 protein
CTD PMID:17923278 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases expression
ISO Itraconazole promotes the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Itraconazole promotes the reaction [Rifampin results in increased expression of NR1I2 mRNA]
Itraconazole results in increased expression of NR1I2 mRNA
CTD PMID:17998298 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Oaz3 ornithine decarboxylase antizyme 3 decreases expression ISO Itraconazole results in decreased expression of OAZ3 mRNA CTD PMID:31099283 NCBI chr 2:184,762,242...184,765,176
Ensembl chr 2:182,073,215...182,082,399
JBrowse link
G Pnma2 PNMA family member 2 increases expression ISO Itraconazole results in increased expression of PNMA2 mRNA CTD PMID:31099283 NCBI chr15:45,287,445...45,296,340
Ensembl chr15:41,112,009...41,121,427
JBrowse link
G Ptch1 patched 1 decreases expression EXP Itraconazole results in decreased expression of PTCH1 mRNA CTD PMID:33905526 NCBI chr17:1,548,449...1,613,461
Ensembl chr17:1,542,877...1,607,333
JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 decreases expression ISO Itraconazole results in decreased expression of RAPGEF4 mRNA CTD PMID:31099283 NCBI chr 3:77,217,024...77,509,933
Ensembl chr 3:56,809,270...57,102,316
JBrowse link
G Rgs16 regulator of G-protein signaling 16 decreases expression ISO Itraconazole results in decreased expression of RGS16 mRNA CTD PMID:31099283 NCBI chr13:68,421,480...68,443,312
Ensembl chr13:65,887,530...65,892,857
JBrowse link
G Rpp25 ribonuclease P and MRP subunit p25 increases expression ISO Itraconazole results in increased expression of RPP25 mRNA CTD PMID:31099283 NCBI chr 8:66,803,262...66,804,642
Ensembl chr 8:57,907,352...57,908,732
JBrowse link
G Sema3e semaphorin 3E increases expression ISO Itraconazole results in increased expression of SEMA3E mRNA CTD PMID:31099283 NCBI chr 4:21,252,686...21,510,449
Ensembl chr 4:20,299,718...20,555,229
JBrowse link
G Slc25a36 solute carrier family 25 member 36 increases expression ISO Itraconazole results in increased expression of SLC25A36 mRNA CTD PMID:31099283 NCBI chr 8:106,539,355...106,573,240
Ensembl chr 8:97,662,127...97,693,703
JBrowse link
G Smo smoothened, frizzled class receptor decreases expression EXP Itraconazole results in decreased expression of SMO mRNA CTD PMID:33905526 NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:58,343,529...58,373,829
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Itraconazole inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein] CTD PMID:24471457 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Stx8 syntaxin 8 increases expression ISO Itraconazole results in increased expression of STX8 mRNA CTD PMID:31099283 NCBI chr10:53,154,572...53,393,912
Ensembl chr10:52,654,990...52,894,993
JBrowse link
G Sycp3 synaptonemal complex protein 3 increases expression ISO Itraconazole results in increased expression of SYCP3 mRNA CTD PMID:31099283 NCBI chr 7:24,761,476...24,775,933
Ensembl chr 7:22,874,055...22,888,511
JBrowse link
G Tbc1d9 TBC1 domain family member 9 increases expression ISO Itraconazole results in increased expression of TBC1D9 mRNA CTD PMID:31099283 NCBI chr19:24,842,166...24,951,383
Ensembl chr19:24,842,205...24,943,129
JBrowse link
G Tmem138 transmembrane protein 138 decreases expression ISO Itraconazole results in decreased expression of TMEM138 mRNA CTD PMID:31099283 NCBI chr 1:216,644,047...216,651,091 JBrowse link
G Tmsb4x thymosin beta 4, X-linked decreases expression ISO Itraconazole results in decreased expression of TMSB4X mRNA CTD PMID:31099283 NCBI chr  X:30,761,611...30,763,612
Ensembl chr  X:27,128,610...27,146,667
Ensembl chr10:27,128,610...27,146,667
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Itraconazole inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein] CTD PMID:12388057 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein] CTD PMID:23688403 NCBI chr18:24,723,990...24,728,419
Ensembl chr18:24,449,844...24,453,548
JBrowse link
G Tspan8 tetraspanin 8 decreases expression ISO Itraconazole results in decreased expression of TSPAN8 mRNA CTD PMID:31099283 NCBI chr 7:53,331,019...53,365,402
Ensembl chr 7:51,445,074...51,479,356
JBrowse link
G Zfp451 zinc finger protein 451 increases expression ISO Itraconazole results in increased expression of ZFP451 mRNA CTD PMID:31099283 NCBI chr 9:43,481,395...43,546,103
Ensembl chr 9:35,985,443...36,040,652
JBrowse link
letrozole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression
multiple interactions
EXP Letrozole results in decreased expression of ADIPOQ protein
Spironolactone inhibits the reaction [Letrozole results in decreased expression of ADIPOQ protein]
CTD PMID:33359182 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Adm adrenomedullin increases expression
multiple interactions
EXP Letrozole results in increased expression of ADM protein
ADM protein inhibits the reaction [Letrozole results in decreased expression of AKT1 mRNA]; ADM protein inhibits the reaction [Letrozole results in decreased expression of BCL2 protein]; ADM protein inhibits the reaction [Letrozole results in decreased expression of FSHB protein]; ADM protein inhibits the reaction [Letrozole results in decreased expression of PIK3CG mRNA]; ADM protein inhibits the reaction [Letrozole results in decreased expression of PPARG mRNA]; ADM protein inhibits the reaction [Letrozole results in increased expression of ATF6 mRNA]; ADM protein inhibits the reaction [Letrozole results in increased expression of BAX protein]; ADM protein inhibits the reaction [Letrozole results in increased expression of CCN2 protein]; ADM protein inhibits the reaction [Letrozole results in increased expression of DDIT3 mRNA]; ADM protein inhibits the reaction [Letrozole results in increased expression of IL6 protein]; ADM protein inhibits the reaction [Letrozole results in increased expression of INS1 protein]; ADM protein inhibits the reaction [Letrozole results in increased expression of TGFB1 protein]; ADM protein inhibits the reaction [Letrozole results in increased expression of TNF protein]; ADM protein inhibits the reaction [Letrozole results in increased expression of XBP1 mRNA]; ADM protein promotes the reaction [Letrozole results in increased expression of ADM protein]
CTD PMID:33491863 NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression
multiple interactions
EXP Letrozole results in decreased expression of AKT1 mRNA
ADM protein inhibits the reaction [Letrozole results in decreased expression of AKT1 mRNA]
CTD PMID:33491863 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Angpt2 angiopoietin 2 multiple interactions ISO [letrozole results in decreased abundance of Estradiol] which results in decreased expression of ANGPT2 mRNA CTD PMID:19620711 NCBI chr16:77,790,760...77,841,241
Ensembl chr16:71,088,364...71,138,804
JBrowse link
G Angpt4 angiopoietin 4 multiple interactions ISO [letrozole results in decreased abundance of Estradiol] which results in decreased expression of ANGPT4 mRNA CTD PMID:19620711 NCBI chr 3:160,880,539...160,913,923
Ensembl chr 3:140,420,389...140,453,583
JBrowse link
G Ar androgen receptor multiple interactions
decreases expression
ISO diacerein inhibits the reaction [Letrozole results in decreased expression of AR mRNA] CTD PMID:37030623 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Atf6 activating transcription factor 6 increases expression
multiple interactions
EXP Letrozole results in increased expression of ATF6 mRNA
ADM protein inhibits the reaction [Letrozole results in increased expression of ATF6 mRNA]
CTD PMID:33491863 NCBI chr13:85,460,312...85,639,959
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP Letrozole results in increased expression of BAX protein
ADM protein inhibits the reaction [Letrozole results in increased expression of BAX protein]
CTD PMID:33491863 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
EXP ADM protein inhibits the reaction [Letrozole results in decreased expression of BCL2 protein] CTD PMID:33491863 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO [letrozole results in decreased abundance of Estradiol] which results in decreased expression of BMP2 mRNA CTD PMID:19620711 NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Cat catalase decreases activity
multiple interactions
ISO Letrozole results in decreased activity of CAT protein
diacerein inhibits the reaction [Letrozole results in decreased activity of CAT protein]
CTD PMID:37030623 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression
multiple interactions
EXP Letrozole results in increased expression of CCN2 protein
ADM protein inhibits the reaction [Letrozole results in increased expression of CCN2 protein]
CTD PMID:33491863 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO [Letrozole co-treated with Everolimus] results in decreased expression of CCND1 protein; [Sirolimus co-treated with Letrozole] results in decreased expression of CCND1 protein; [Sorafenib co-treated with Letrozole] results in decreased expression of CCND1 protein
letrozole results in decreased expression of CCND1 protein
CTD PMID:16033851 PMID:20054642 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd2 cyclin D2 multiple interactions
decreases expression
ISO [letrozole co-treated with Everolimus] results in decreased expression of CCND2 protein
letrozole results in decreased expression of CCND2 protein
CTD PMID:16033851 NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO letrozole results in increased expression of CDKN1A protein CTD PMID:20054642 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [Oleic Acid co-treated with letrozole] affects the localization of CYCS protein; [Olive Oil co-treated with letrozole] affects the localization of CYCS protein CTD PMID:24161488 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions
decreases expression
ISO diacerein inhibits the reaction [Letrozole results in decreased expression of CYP11A1 mRNA] CTD PMID:37030623 NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression
decreases expression
multiple interactions
EXP
ISO
Letrozole results in increased expression of CYP17A1 mRNA
Letrozole results in decreased expression of CYP17A1 mRNA
[Letrozole co-treated with tris(2,3-dibromopropyl)isocyanurate] results in decreased expression of CYP17A1 mRNA; diacerein inhibits the reaction [Letrozole results in increased expression of CYP17A1 mRNA]
Metformin inhibits the reaction [Letrozole results in increased expression of CYP17A1 mRNA]; N(1)-methylnicotinamide inhibits the reaction [Letrozole results in increased expression of CYP17A1 mRNA]; Niacinamide inhibits the reaction [Letrozole results in increased expression of CYP17A1 mRNA]
CTD PMID:32298659 PMID:37030623 PMID:37254606 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
decreases expression
decreases activity
increases activity
ISO
EXP
Letrozole inhibits the reaction [[sodium arsenite results in increased activity of CYP19A1 protein] which results in increased abundance of Estradiol]; Letrozole inhibits the reaction [sodium arsenite results in increased activity of CYP19A1 protein]; Letrozole inhibits the reaction [sodium arsenite results in increased expression of CYP19A1 mRNA]
diacerein inhibits the reaction [Letrozole results in decreased expression of CYP19A1 mRNA]
letrozole binds to and results in decreased activity of CYP19A1 protein
letrozole results in decreased activity of CYP19A1 protein
letrozole results in increased activity of CYP19A1 protein
Letrozole results in decreased activity of CYP19A1 protein
CTD PMID:15837728 PMID:15909811 PMID:15967659 PMID:16009161 PMID:16013988 More... NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases oxidation ISO CYP3A4 protein results in increased oxidation of Letrozole CTD PMID:19845430 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp51 cytochrome P450, family 51 decreases activity ISO letrozole results in decreased activity of CYP51A1 protein CTD PMID:16989930 NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,036,865...30,055,410
Ensembl chr 6:30,036,865...30,055,410
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
EXP Letrozole results in increased expression of DDIT3 mRNA
ADM protein inhibits the reaction [Letrozole results in increased expression of DDIT3 mRNA]
CTD PMID:33491863 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 increases expression ISO letrozole results in increased expression of DKK1 mRNA CTD PMID:21851939 NCBI chr 1:237,794,969...237,798,650
Ensembl chr 1:228,381,521...228,385,202
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [letrozole co-treated with Everolimus] results in increased phosphorylation of and results in decreased activity of EIF4EBP1 protein; letrozole results in increased phosphorylation of and results in decreased activity of EIF4EBP1 protein CTD PMID:16033851 NCBI chr16:71,495,457...71,508,845
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Elk1 ETS transcription factor ELK1 increases expression ISO letrozole results in increased expression of ELK1 protein CTD PMID:15967659 NCBI chr  X:3,692,367...3,709,252
Ensembl chr  X:1,139,756...1,155,713
JBrowse link
G Epas1 endothelial PAS domain protein 1 multiple interactions ISO [letrozole results in decreased abundance of Estradiol] which results in decreased expression of EPAS1 mRNA CTD PMID:19620711 NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:7,790,647...7,871,228
JBrowse link
G Esr1 estrogen receptor 1 decreases expression
multiple interactions
ISO Letrozole results in decreased expression of ESR1 mRNA
diacerein inhibits the reaction [Letrozole results in decreased expression of ESR1 mRNA]
CTD PMID:37030623 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Fgf22 fibroblast growth factor 22 increases expression ISO letrozole results in increased expression of FGF22 mRNA CTD PMID:21851939 NCBI chr 7:10,598,254...10,600,945
Ensembl chr 7:9,948,071...9,950,486
JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression
multiple interactions
decreases expression
decreases secretion
ISO
EXP
letrozole results in increased expression of FSHB protein
diacerein inhibits the reaction [Letrozole results in decreased expression of FSHB protein]
Letrozole results in decreased secretion of FSHB protein
ADM protein inhibits the reaction [Letrozole results in decreased expression of FSHB protein]; Spironolactone inhibits the reaction [Letrozole results in decreased secretion of FSHB protein]
CTD PMID:15123030 PMID:31295448 PMID:33491863 PMID:37030623 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Fshr follicle stimulating hormone receptor multiple interactions
decreases expression
ISO diacerein inhibits the reaction [Letrozole results in decreased expression of FSHR mRNA] CTD PMID:37030623 NCBI chr 6:10,952,329...11,160,288
Ensembl chr 6:5,198,825...5,406,785
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions
increases activity
EXP Spironolactone inhibits the reaction [Letrozole results in increased activity of GGT1 protein] CTD PMID:37328115 NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression ISO letrozole results in decreased expression of GJA1 protein CTD PMID:29180066 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Grb2 growth factor receptor bound protein 2 increases expression ISO letrozole results in increased expression of GRB2 protein CTD PMID:15967659 NCBI chr10:101,380,354...101,448,138
Ensembl chr10:100,869,718...100,949,309
JBrowse link
G Gsr glutathione-disulfide reductase decreases expression
multiple interactions
EXP Letrozole results in decreased expression of GSR protein
Spironolactone inhibits the reaction [Letrozole results in decreased expression of GSR protein]
CTD PMID:31295448 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
multiple interactions
EXP letrozole results in decreased expression of HMOX1 protein
indole-3-carbinol inhibits the reaction [Letrozole results in decreased expression of HMOX1 protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in decreased expression of HMOX1 protein]]; Linagliptin inhibits the reaction [Letrozole results in decreased expression of HMOX1 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in decreased expression of HMOX1 protein]]
CTD PMID:28619389 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 multiple interactions ISO [Letrozole co-treated with tris(2,3-dibromopropyl)isocyanurate] results in decreased expression of HSD17B4 mRNA CTD PMID:37254606 NCBI chr18:45,515,427...45,604,467
Ensembl chr18:43,328,824...43,417,952
JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions
EXP letrozole results in increased expression of IL10 protein
indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of IL10 protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in increased expression of IL10 protein]]; Linagliptin inhibits the reaction [Letrozole results in increased expression of IL10 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of IL10 protein]]
CTD PMID:28619389 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
EXP Letrozole results in increased expression of IL6 protein
ADM protein inhibits the reaction [Letrozole results in increased expression of IL6 protein]; Letrozole results in increased expression of and results in increased secretion of IL6 protein; Spironolactone inhibits the reaction [Letrozole results in increased expression of IL6 protein]; Spironolactone inhibits the reaction [Letrozole results in increased secretion of IL6 protein]
CTD PMID:33359182 PMID:33491863 PMID:37328115 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins1 insulin 1 multiple interactions
increases expression
EXP
ISO
ADM protein inhibits the reaction [Letrozole results in increased expression of INS1 protein]; indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of INS1 protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in increased expression of INS1 protein]]; Linagliptin inhibits the reaction [Letrozole results in increased expression of INS1 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of INS1 protein]]; Spironolactone inhibits the reaction [Letrozole results in increased expression of INS1 protein]
diacerein inhibits the reaction [Letrozole results in increased expression of INS1 protein]
CTD PMID:28619389 PMID:33359182 PMID:33491863 PMID:37030623 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Kitlg KIT ligand multiple interactions
decreases expression
ISO diacerein inhibits the reaction [Letrozole results in decreased expression of KITL mRNA] CTD PMID:37030623 NCBI chr 7:36,782,621...36,863,796
Ensembl chr 7:34,896,053...34,977,214
JBrowse link
G Ldha lactate dehydrogenase A increases activity
multiple interactions
EXP Letrozole results in increased activity of LDHA protein
Spironolactone inhibits the reaction [Letrozole results in increased activity of LDHA protein]
CTD PMID:37328115 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:97,366,021...97,433,472
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression
multiple interactions
increases secretion
ISO
EXP
letrozole results in increased expression of LHB protein
diacerein inhibits the reaction [Letrozole results in increased expression of LHB protein]
Letrozole results in increased secretion of LHB protein
indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of LHB protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in increased expression of LHB protein]]; LHB protein inhibits the reaction [Letrozole results in increased expression of LHB protein]; Linagliptin inhibits the reaction [Letrozole results in increased expression of LHB protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of LHB protein]]; Metformin inhibits the reaction [Letrozole results in increased secretion of LHB protein]; N(1)-methylnicotinamide inhibits the reaction [Letrozole results in increased secretion of LHB protein]; Niacinamide inhibits the reaction [Letrozole results in increased secretion of LHB protein]; Spironolactone inhibits the reaction [Letrozole results in increased secretion of LHB protein]
CTD PMID:15123030 PMID:16046582 PMID:28619389 PMID:31295448 PMID:32298659 More... NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor multiple interactions
decreases expression
ISO diacerein inhibits the reaction [Letrozole results in decreased expression of LHR mRNA] CTD PMID:37030623 NCBI chr 6:11,415,361...11,480,834
Ensembl chr 6:5,661,871...5,724,521
JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO letrozole results in increased expression of LIF mRNA; letrozole results in increased expression of LIF protein CTD PMID:21851939 NCBI chr14:83,354,602...83,364,053
Ensembl chr14:79,134,574...79,140,482
JBrowse link
G Lifr LIF receptor subunit alpha increases expression ISO letrozole results in increased expression of LIFR mRNA CTD PMID:21851939 NCBI chr 2:57,951,787...58,020,357
Ensembl chr 2:56,250,120...56,286,699
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases expression ISO letrozole results in increased expression of MAP2K1 protein CTD PMID:15967659 NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 increases expression ISO letrozole results in increased expression of MAP2K2 protein CTD PMID:15967659 NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:8,580,905...8,610,243
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO letrozole results in increased expression of and results in increased phosphorylation of MAPK1 protein CTD PMID:15967659 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO letrozole results in increased expression of and results in increased phosphorylation of MAPK3 protein CTD PMID:15967659 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO letrozole results in decreased expression of MKI67 protein CTD PMID:16002280 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO letrozole inhibits the reaction [sodium arsenite results in increased activity of and results in increased secretion of MMP2 protein] CTD PMID:24068038 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO letrozole inhibits the reaction [sodium arsenite results in increased activity of and results in increased secretion of MMP9 protein] CTD PMID:24068038 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO [Letrozole co-treated with Everolimus] inhibits the reaction [Androstenedione affects the activity of MTOR protein]; Letrozole inhibits the reaction [Androstenedione affects the activity of MTOR protein]; Letrozole inhibits the reaction [Estradiol affects the activity of MTOR protein] CTD PMID:16033851 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [Sirolimus co-treated with letrozole] results in decreased expression of MYC protein; [sorafenib co-treated with letrozole] results in decreased expression of MYC protein CTD PMID:20054642 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions
increases expression
EXP Metformin inhibits the reaction [Letrozole results in increased expression of NAMPT mRNA]; N(1)-methylnicotinamide inhibits the reaction [Letrozole results in increased expression of NAMPT mRNA]; Niacinamide inhibits the reaction [Letrozole results in increased expression of NAMPT mRNA] CTD PMID:32298659 NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:49,424,332...49,462,100
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases expression
EXP indole-3-carbinol inhibits the reaction [letrozole results in decreased expression of NFE2L2 protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [letrozole results in decreased expression of NFE2L2 protein]]; Linagliptin inhibits the reaction [letrozole results in decreased expression of NFE2L2 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [letrozole results in decreased expression of NFE2L2 protein]] CTD PMID:28619389 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
increases expression
EXP Spironolactone inhibits the reaction [Letrozole results in increased expression of NLRP3 protein] CTD PMID:37328115 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 multiple interactions EXP Letrozole results in increased expression of and results in increased secretion of PCSK9 protein; Spironolactone inhibits the reaction [Letrozole results in increased expression of and results in increased secretion of PCSK9 protein] CTD PMID:37328115 NCBI chr 5:126,440,102...126,462,507
Ensembl chr 5:121,211,278...121,233,688
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO [letrozole results in decreased abundance of Estradiol] which results in decreased expression of PECAM1 protein CTD PMID:19620711 NCBI chr10:92,090,263...92,152,002
Ensembl chr10:91,590,521...91,652,116
JBrowse link
G Pgr progesterone receptor decreases expression ISO letrozole results in decreased expression of PGR protein CTD PMID:16002280 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma decreases expression
multiple interactions
EXP Letrozole results in decreased expression of PIK3CG mRNA
ADM protein inhibits the reaction [Letrozole results in decreased expression of PIK3CG mRNA]
CTD PMID:33491863 NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:48,766,864...48,802,043
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
decreases expression
EXP ADM protein inhibits the reaction [Letrozole results in decreased expression of PPARG mRNA] CTD PMID:33491863 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Prl prolactin multiple interactions
increases expression
EXP Spironolactone inhibits the reaction [Letrozole results in increased expression of PRL protein] CTD PMID:33359182 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases expression ISO letrozole results in increased expression of RAF1 protein CTD PMID:15967659 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO [letrozole co-treated with Everolimus] results in decreased phosphorylation of and affects the activity of RB1 protein; [Sirolimus co-treated with letrozole] results in decreased expression of RB1 protein; [sorafenib co-treated with letrozole] results in decreased expression of RB1 protein; letrozole results in decreased phosphorylation of and affects the activity of RB1 protein CTD PMID:16033851 PMID:20054642 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
EXP indole-3-carbinol inhibits the reaction [letrozole affects the localization of RELA protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [letrozole affects the localization of RELA protein]]; Linagliptin inhibits the reaction [letrozole affects the localization of RELA protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [letrozole affects the localization of RELA protein]] CTD PMID:28619389 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Retn resistin increases expression
multiple interactions
EXP Letrozole results in increased expression of RETN mRNA
Metformin inhibits the reaction [Letrozole results in increased expression of RETN mRNA]; N(1)-methylnicotinamide inhibits the reaction [Letrozole results in increased expression of RETN mRNA]
CTD PMID:32298659 NCBI chr12:6,508,653...6,511,115
Ensembl chr12:1,710,881...1,712,620
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
decreases phosphorylation
ISO [letrozole co-treated with Everolimus] results in decreased phosphorylation of RPS6 protein
letrozole results in decreased phosphorylation of RPS6 protein
CTD PMID:16033851 NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 multiple interactions ISO letrozole results in increased expression of and results in increased phosphorylation of RPS6KA1 protein CTD PMID:15967659 NCBI chr 5:151,362,819...151,402,064
Ensembl chr 5:146,079,021...146,118,272
JBrowse link
G Shbg sex hormone binding globulin decreases secretion
multiple interactions
EXP Letrozole results in decreased secretion of SHBG protein
Spironolactone inhibits the reaction [Letrozole results in decreased secretion of SHBG protein]
CTD PMID:37328115 NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,332,941...54,351,057
JBrowse link
G Shc1 SHC adaptor protein 1 increases expression ISO letrozole results in increased expression of SHC1 protein CTD PMID:15967659 NCBI chr 2:177,135,649...177,147,257
Ensembl chr 2:174,837,930...174,849,536
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO letrozole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions
decreases expression
EXP Metformin inhibits the reaction [Letrozole results in decreased expression of SLC2A4 mRNA]; Niacinamide inhibits the reaction [Letrozole results in decreased expression of SLC2A4 mRNA] CTD PMID:32298659 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Tert telomerase reverse transcriptase multiple interactions ISO letrozole inhibits the reaction [Metribolone results in increased activity of TERT protein] CTD PMID:19561322 NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression
EXP ADM protein inhibits the reaction [Letrozole results in increased expression of TGFB1 protein]; indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of TGFB1 protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in increased expression of TGFB1 protein]]; Linagliptin inhibits the reaction [Letrozole results in increased expression of TGFB1 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of TGFB1 protein]] CTD PMID:28619389 PMID:33491863 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
EXP Letrozole results in increased expression of TNF protein
ADM protein inhibits the reaction [Letrozole results in increased expression of TNF protein]; indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of TNF protein]; indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in increased expression of TNF protein]]; Linagliptin inhibits the reaction [Letrozole results in increased expression of TNF protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of TNF protein]]; Spironolactone inhibits the reaction [Letrozole results in increased expression of TNF protein]
CTD PMID:28619389 PMID:33359182 PMID:33491863 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression
ISO diacerein inhibits the reaction [Letrozole results in increased expression of VEGFA protein] CTD PMID:37030623 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions
increases expression
EXP ADM protein inhibits the reaction [Letrozole results in increased expression of XBP1 mRNA] CTD PMID:33491863 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693
JBrowse link
nitrososulfamethoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO 4-nitrososulfamethoxazole results in increased expression of AKR1B10 mRNA CTD PMID:28444390 NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Hmgb1 high mobility group box 1 increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of HMGB1 protein CTD PMID:28444390 NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565
JBrowse link
G Ifng interferon gamma increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of IFNG protein CTD PMID:22331489 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il13 interleukin 13 increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of IL13 protein CTD PMID:22331489 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il1a interleukin 1 alpha increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of IL1A protein CTD PMID:28444390 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of IL1B protein CTD PMID:28444390 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il5 interleukin 5 increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of IL5 protein CTD PMID:22331489 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of IL6 protein CTD PMID:28444390 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mpo myeloperoxidase affects binding
multiple interactions
ISO 4-nitrososulfamethoxazole binds to MPO protein
[[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Sulfamethoxazole] which results in increased chemical synthesis of 4-nitrososulfamethoxazole
CTD PMID:25531135 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO 4-nitrososulfamethoxazole results in increased expression of NQO1 mRNA CTD PMID:28444390 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO 4-nitrososulfamethoxazole results in increased expression of SRXN1 mRNA CTD PMID:28444390 NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Tnf tumor necrosis factor increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of TNF protein CTD PMID:28444390 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO 4-nitrososulfamethoxazole results in increased expression of TXNRD1 mRNA CTD PMID:28444390 NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
omeprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO Omeprazole results in increased expression of ABCA1 mRNA CTD PMID:20060385 NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Omeprazole results in decreased activity of ABCB11 protein CTD PMID:20829430 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects expression
multiple interactions
EXP
ISO
Omeprazole affects the expression of ABCB1A mRNA
Omeprazole promotes the reaction [Cisplatin results in increased expression of ABCB1 protein]
Omeprazole promotes the reaction [Cisplatin results in increased expression of ABCB1A protein]
CTD PMID:19483382 PMID:30452898 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression ISO Omeprazole results in decreased expression of ABCB4 mRNA CTD PMID:12040753 NCBI chr 4:26,106,895...26,164,440
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [Omeprazole results in increased susceptibility to Cisplatin] which results in decreased expression of ABCC2 protein CTD PMID:35447140 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Omeprazole results in increased expression of ABCC3 mRNA CTD PMID:19118567 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 affects expression EXP Omeprazole affects the expression of ABCC6 mRNA CTD PMID:19483382 NCBI chr 1:105,583,681...105,637,895
Ensembl chr 1:96,447,251...96,501,464
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression
multiple interactions
ISO Omeprazole results in increased expression of ABCG2 mRNA alternative form; Omeprazole results in increased expression of ABCG2 protein
Omeprazole inhibits the reaction [ABCG2 protein results in increased transport of lucifer yellow]
CTD PMID:20804740 PMID:31348918 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 affects expression EXP Omeprazole affects the expression of ABCG5 mRNA CTD PMID:19483382 NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:9,965,118...9,990,563
JBrowse link
G Abhd1 abhydrolase domain containing 1 affects expression EXP Omeprazole affects the expression of ABHD1 mRNA CTD PMID:19483382 NCBI chr 6:31,142,476...31,147,464
Ensembl chr 6:25,422,526...25,427,514
JBrowse link
G Abhd14b abhydrolase domain containing 14b affects expression EXP Omeprazole affects the expression of ABHD14B mRNA CTD PMID:19483382 NCBI chr 8:115,966,792...115,970,829
Ensembl chr 8:107,088,069...107,092,119
JBrowse link
G Abhd17a abhydrolase domain containing 17A, depalmitoylase affects expression EXP Omeprazole affects the expression of ABHD17A mRNA CTD PMID:19483382 NCBI chr 7:9,775,016...9,781,447
Ensembl chr 7:9,124,332...9,130,762
JBrowse link
G Acaca acetyl-CoA carboxylase alpha affects expression EXP Omeprazole affects the expression of ACACA mRNA CTD PMID:19483382 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain affects expression EXP Omeprazole affects the expression of ACADL mRNA CTD PMID:19483382 NCBI chr 9:75,783,689...75,822,077
Ensembl chr 9:68,333,980...68,372,220
JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression EXP
ISO
Omeprazole results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Aco1 aconitase 1 affects expression EXP Omeprazole affects the expression of ACO1 mRNA CTD PMID:19483382 NCBI chr 5:60,055,895...60,111,920
Ensembl chr 5:55,259,827...55,316,391
JBrowse link
G Aco2 aconitase 2 affects expression EXP Omeprazole affects the expression of ACO2 mRNA CTD PMID:19483382 NCBI chr 7:115,265,816...115,308,931
Ensembl chr 7:113,385,646...113,428,261
JBrowse link
G Acot12 acyl-CoA thioesterase 12 affects expression EXP Omeprazole affects the expression of ACOT12 mRNA CTD PMID:19483382 NCBI chr 2:24,721,648...24,763,686
Ensembl chr 2:22,986,626...23,027,536
JBrowse link
G Acot4 acyl-CoA thioesterase 4 affects expression EXP Omeprazole affects the expression of ACOT4 mRNA CTD PMID:19483382 NCBI chr 6:109,399,032...109,405,138
Ensembl chr 6:103,668,753...103,673,917
JBrowse link
G Adam15 ADAM metallopeptidase domain 15 affects expression EXP Omeprazole affects the expression of ADAM15 mRNA CTD PMID:19483382 NCBI chr 2:177,052,363...177,062,879
Ensembl chr 2:174,754,633...174,765,113
JBrowse link
G Add1 adducin 1 affects expression EXP Omeprazole affects the expression of ADD1 mRNA CTD PMID:19483382 NCBI chr14:80,333,242...80,401,641
Ensembl chr14:76,108,654...76,167,182
JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide decreases expression ISO Omeprazole results in decreased expression of ADH1C mRNA CTD PMID:12040753 NCBI chr 2:229,470,703...229,482,291
Ensembl chr 2:226,797,303...226,808,892
JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide affects expression EXP Omeprazole affects the expression of ADH4 mRNA CTD PMID:19483382 NCBI chr 2:229,622,092...229,640,120
Ensembl chr 2:226,947,466...226,987,591
JBrowse link
G Adtrp androgen-dependent TFPI-regulating protein affects expression EXP Omeprazole affects the expression of ADTRP mRNA CTD PMID:19483382 NCBI chr17:23,113,578...23,199,616
Ensembl chr17:22,930,740...22,993,826
JBrowse link
G Afm afamin affects expression EXP Omeprazole affects the expression of AFM mRNA CTD PMID:19483382 NCBI chr14:17,815,194...17,848,042
Ensembl chr14:17,531,024...17,563,870
JBrowse link
G Agt angiotensinogen affects expression EXP Omeprazole affects the expression of AGT mRNA CTD PMID:19483382 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a affects expression EXP Omeprazole affects the expression of AGTR1A mRNA CTD PMID:19483382 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases response to substance
affects localization
decreases expression
increases expression
increases activity
decreases activity
ISO
EXP
AG-879 inhibits the reaction [Omeprazole results in increased activity of AHR protein]; AHR protein affects the reaction [Omeprazole results in decreased expression of CXCR4 mRNA]; AHR protein affects the reaction [Omeprazole results in increased expression of HAMP mRNA]; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A2 mRNA]; AHR protein mutant form inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of AHR mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of CYP1A1 mRNA]; BMX mRNA affects the reaction [Omeprazole results in increased activity of AHR protein]; Omeprazole binds to and results in increased activity of AHR protein; Omeprazole promotes the reaction [AHR protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [AHR protein binds to CYP1B1 promoter]; omeprazole sulfide inhibits the reaction [Omeprazole results in increased activity of AHR protein]; Puromycin inhibits the reaction [Omeprazole results in increased expression of AHR protein]
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of AHR mRNA; AHR protein promotes the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Omeprazole affects the localization of [ARNT protein co-treated with AHR protein]
AHR protein results in increased susceptibility to Omeprazole
Omeprazole affects the localization of AHR protein
Omeprazole results in decreased activity of AHR protein
CTD PMID:9139728 PMID:9395520 PMID:14742684 PMID:16109480 PMID:20171196 More... NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 affects expression EXP Omeprazole affects the expression of AKR1A1 mRNA CTD PMID:19483382 NCBI chr 5:135,329,605...135,367,037
Ensembl chr 5:130,092,732...130,113,674
JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 affects expression EXP Omeprazole affects the expression of AKR7A2 mRNA CTD PMID:19483382 NCBI chr 5:156,835,589...156,844,127
Ensembl chr 5:151,552,343...151,560,909
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 affects expression
multiple interactions
EXP Omeprazole affects the expression of AKR7A3 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of AKR7A3 mRNA
CTD PMID:19483382 PMID:22687989 NCBI chr 5:156,876,721...156,884,599
Ensembl chr 5:151,584,479...151,601,394
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 affects expression
multiple interactions
EXP Omeprazole affects the expression of ALDH1A1 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of ALDH1A1 mRNA
CTD PMID:19483382 PMID:22687989 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 increases expression ISO Omeprazole results in increased expression of ALDH1A3 mRNA CTD PMID:12040753 NCBI chr 1:129,392,516...129,436,552
Ensembl chr 1:119,982,277...120,017,436
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member affects expression EXP Omeprazole affects the expression of ALDH2 mRNA CTD PMID:19483382 NCBI chr12:40,610,244...40,643,220
Ensembl chr12:34,901,219...34,982,521
JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 increases expression ISO Omeprazole results in increased expression of ALDH3A1 mRNA CTD PMID:12040753 NCBI chr10:46,392,464...46,402,151
Ensembl chr10:45,892,924...45,902,681
JBrowse link
G Alkbh7 alkB homolog 7 affects expression EXP Omeprazole affects the expression of ALKBH7 mRNA CTD PMID:19483382 NCBI chr 9:1,925,896...1,928,048
Ensembl chr 9:1,838,811...1,841,044
JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 affects expression EXP Omeprazole affects the expression of AP2M1 mRNA CTD PMID:19483382 NCBI chr11:93,859,690...93,868,600
Ensembl chr11:80,328,041...80,364,140
JBrowse link
G Apcs amyloid P component, serum affects expression EXP Omeprazole affects the expression of APCS mRNA CTD PMID:19483382 NCBI chr13:87,905,532...87,906,508
Ensembl chr13:85,373,220...85,374,298
JBrowse link
G Apoa4 apolipoprotein A4 affects expression EXP Omeprazole affects the expression of APOA4 mRNA CTD PMID:19483382 NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:46,539,082...46,541,469
JBrowse link
G Apoh apolipoprotein H affects expression EXP Omeprazole affects the expression of APOH mRNA CTD PMID:19483382 NCBI chr10:93,841,992...93,855,897
Ensembl chr10:93,310,977...93,356,329
JBrowse link
G Apool apolipoprotein O-like affects expression EXP Omeprazole affects the expression of APOOL mRNA CTD PMID:19483382 NCBI chr  X:81,569,960...81,635,906
Ensembl chr  X:77,377,781...77,443,900
JBrowse link
G Arg1 arginase 1 affects expression EXP Omeprazole affects the expression of ARG1 mRNA CTD PMID:19483382 NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Arl6ip1 ARL6 interacting reticulophagy regulator 1 affects expression EXP Omeprazole affects the expression of ARL6IP1 mRNA CTD PMID:19483382 NCBI chr 1:181,864,717...181,874,232
Ensembl chr 1:172,430,489...172,439,994
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions
affects localization
ISO
EXP
Omeprazole promotes the reaction [ARNT protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1B1 promoter]
Omeprazole affects the localization of ARNT protein
Omeprazole affects the localization of [ARNT protein co-treated with AHR protein]
CTD PMID:9395520 PMID:21703235 PMID:25826687 NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Asgr2 asialoglycoprotein receptor 2 affects expression EXP Omeprazole affects the expression of ASGR2 mRNA CTD PMID:19483382 NCBI chr10:55,320,082...55,333,294
Ensembl chr10:54,821,438...54,834,617
JBrowse link
G Atf5 activating transcription factor 5 affects expression EXP Omeprazole affects the expression of ATF5 mRNA CTD PMID:19483382 NCBI chr 1:104,432,094...104,437,611
Ensembl chr 1:95,295,610...95,299,707
JBrowse link
G Atp5f1e ATP synthase F1 subunit epsilon affects expression EXP Omeprazole affects the expression of ATP5F1E mRNA CTD PMID:19483382 NCBI chr 3:183,677,270...183,680,172
Ensembl chr 3:163,260,476...163,261,450
JBrowse link
G Atp6ap2 ATPase H+ transporting accessory protein 2 affects expression EXP Omeprazole affects the expression of ATP6AP2 mRNA CTD PMID:19483382 NCBI chr  X:12,856,708...12,883,670
Ensembl chr  X:10,183,068...10,210,918
JBrowse link
G Atp6v1a ATPase H+ transporting V1 subunit A affects expression EXP Omeprazole affects the expression of ATP6V1A mRNA CTD PMID:19483382 NCBI chr11:70,066,800...70,120,603
Ensembl chr11:56,560,974...56,614,694
JBrowse link
G Atp6v1f ATPase H+ transporting V1 subunit F affects expression EXP Omeprazole affects the expression of ATP6V1F mRNA CTD PMID:19483382 NCBI chr 4:59,033,020...59,035,980 JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions ISO Omeprazole inhibits the reaction [ATP7A protein results in increased activity of TYR protein]
Omeprazole inhibits the reaction [Copper affects the localization of ATP7A protein]; Omeprazole inhibits the reaction [cupric chloride affects the localization of ATP7A protein]
CTD PMID:25337692 NCBI chr  X:75,159,635...75,267,094
Ensembl chr  X:71,094,202...71,198,354
JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase affects expression EXP Omeprazole affects the expression of BAAT mRNA CTD PMID:19483382 NCBI chr 5:68,647,166...68,656,137
Ensembl chr 5:63,850,705...63,860,685
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Omeprazole inhibits the reaction [Cisplatin results in increased expression of BAX protein] CTD PMID:30452898 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Omeprazole inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein] CTD PMID:30452898 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl6b BCL6B, transcription repressor affects expression EXP Omeprazole affects the expression of BCL6B mRNA CTD PMID:19483382 NCBI chr10:55,439,566...55,444,631
Ensembl chr10:54,940,909...54,945,974
JBrowse link
G Bltp3b bridge-like lipid transfer protein family member 3B affects expression EXP Omeprazole affects the expression of BLTP3B mRNA CTD PMID:19483382 NCBI chr 7:26,068,948...26,149,033
Ensembl chr 7:24,181,644...24,261,720
JBrowse link
G Bmf Bcl2 modifying factor affects expression EXP Omeprazole affects the expression of BMF mRNA CTD PMID:19483382 NCBI chr 3:125,953,466...125,974,087
Ensembl chr 3:105,499,538...105,520,145
JBrowse link
G Bmx BMX non-receptor tyrosine kinase multiple interactions ISO BMX mRNA affects the reaction [Omeprazole results in increased activity of AHR protein] CTD PMID:21861773 NCBI chr  X:33,859,128...33,921,876
Ensembl chr  X:30,227,251...30,289,993
JBrowse link
G Bnip3 BCL2 interacting protein 3 affects expression EXP Omeprazole affects the expression of BNIP3 mRNA CTD PMID:19483382 NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Btf3 basic transcription factor 3 affects expression EXP Omeprazole affects the expression of BTF3 mRNA CTD PMID:19483382 NCBI chr 2:31,394,010...31,401,138
Ensembl chr 2:29,659,231...29,666,879
Ensembl chr13:29,659,231...29,666,879
JBrowse link
G C1qa complement C1q A chain decreases expression EXP Omeprazole results in decreased expression of C1QA mRNA CTD PMID:25626140 NCBI chr 5:154,417,086...154,419,933
Ensembl chr 5:149,133,636...149,136,534
JBrowse link
G C1qbp complement C1q binding protein affects expression EXP Omeprazole affects the expression of C1QBP mRNA CTD PMID:19483382 NCBI chr10:56,198,534...56,203,185
Ensembl chr10:55,699,954...55,704,649
JBrowse link
G C1qc complement C1q C chain decreases expression EXP Omeprazole results in decreased expression of C1QC mRNA CTD PMID:25626140 NCBI chr 5:154,410,845...154,414,208
Ensembl chr 5:149,127,415...149,131,017
JBrowse link
G C1s complement C1s affects expression EXP Omeprazole affects the expression of C1S mRNA CTD PMID:19483382 NCBI chr 4:159,116,549...159,128,736
Ensembl chr 4:157,430,117...157,442,303
JBrowse link
G C2cd2 C2 calcium-dependent domain containing 2 affects expression EXP Omeprazole affects the expression of C2CD2 mRNA CTD PMID:19483382 NCBI chr11:50,694,680...50,759,096
Ensembl chr11:37,227,415...37,289,739
JBrowse link
G C4bpa complement component 4 binding protein, alpha affects expression
decreases expression
EXP Omeprazole affects the expression of C4BPA mRNA
Omeprazole results in decreased expression of C4BPA mRNA
CTD PMID:19483382 PMID:25626140 NCBI chr13:44,627,959...44,663,552
Ensembl chr13:42,075,717...42,111,205
JBrowse link
G C4bpb complement component 4 binding protein, beta decreases expression EXP Omeprazole results in decreased expression of C4BPB mRNA CTD PMID:25626140 NCBI chr13:44,673,064...44,683,781
Ensembl chr13:42,120,798...42,131,817
JBrowse link
G C7 complement C7 affects expression EXP Omeprazole affects the expression of C7 mRNA CTD PMID:19483382 NCBI chr 2:55,815,687...55,892,605
Ensembl chr 2:54,088,116...54,158,535
JBrowse link
G C8b complement C8 beta chain affects expression EXP Omeprazole affects the expression of C8B mRNA CTD PMID:19483382 NCBI chr 5:124,763,974...124,801,522
Ensembl chr 5:119,535,146...119,572,565
JBrowse link
G Cadps2 calcium dependent secretion activator 2 affects expression EXP Omeprazole affects the expression of CADPS2 mRNA CTD PMID:19483382 NCBI chr 4:52,746,054...53,275,252
Ensembl chr 4:51,781,053...52,309,829
JBrowse link
G Caprin1 cell cycle associated protein 1 affects expression EXP Omeprazole affects the expression of CAPRIN1 mRNA CTD PMID:19483382 NCBI chr 3:110,606,489...110,685,408
Ensembl chr 3:90,153,620...90,230,502
JBrowse link
G Car2 carbonic anhydrase 2 affects expression EXP Omeprazole affects the expression of CA2 mRNA CTD PMID:19483382 NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Car3 carbonic anhydrase 3 affects expression EXP Omeprazole affects the expression of CAR3 mRNA CTD PMID:19483382 NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
affects expression
increases cleavage
ISO
EXP
Omeprazole analog results in increased activity of CASP3 protein; Omeprazole results in increased activity of CASP3 protein
Omeprazole inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
Omeprazole inhibits the reaction [Ethanol results in increased activity of CASP3 protein]; Omeprazole inhibits the reaction [Ethanol results in increased expression of CASP3 mRNA]; Omeprazole inhibits the reaction [Indomethacin results in increased activity of CASP3 protein]
Omeprazole affects the expression of CASP3 mRNA
Omeprazole results in increased cleavage of CASP3 protein
CTD PMID:15461867 PMID:18336733 PMID:19251492 PMID:19483382 PMID:25637687 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases cleavage ISO Omeprazole analog results in increased cleavage of CASP8 protein CTD PMID:18336733 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cat catalase increases activity
multiple interactions
EXP
ISO
Omeprazole results in increased activity of CAT protein
Omeprazole inhibits the reaction [Ethanol results in decreased activity of CAT protein]
Omeprazole inhibits the reaction [Acetic Acid results in increased activity of CAT protein]
CTD PMID:18547560 PMID:28849987 PMID:33245926 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cbr1 carbonyl reductase 1 affects expression EXP Omeprazole affects the expression of CBR1 mRNA CTD PMID:19483382 NCBI chr11:46,346,405...46,348,815
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
JBrowse link
G Cckbr cholecystokinin B receptor multiple interactions ISO [Omeprazole co-treated with CCKBR protein] results in increased expression of IER3 CTD PMID:17704804 NCBI chr 1:169,183,578...169,193,583
Ensembl chr 1:159,771,733...159,814,881
JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP Omeprazole results in decreased expression of CCND1 mRNA CTD PMID:17202759 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Omeprazole results in increased expression of CDKN1A protein CTD PMID:27358234 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdo1 cysteine dioxygenase type 1 affects expression EXP Omeprazole affects the expression of CDO1 mRNA CTD PMID:19483382 NCBI chr18:41,619,076...41,633,719
Ensembl chr18:39,432,474...39,447,296
JBrowse link
G Cept1 choline/ethanolamine phosphotransferase 1 affects expression EXP Omeprazole affects the expression of CEPT1 mRNA CTD PMID:19483382 NCBI chr 2:196,682,455...196,724,430
Ensembl chr 2:193,993,447...194,035,578
JBrowse link
G Ces2h carboxylesterase 2H affects expression EXP Omeprazole affects the expression of CES2 mRNA CTD PMID:19483382 NCBI chr19:49,884,164...49,898,764
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Cfi complement factor I affects expression
decreases expression
EXP Omeprazole affects the expression of CFI mRNA
Omeprazole results in decreased expression of CFI mRNA
CTD PMID:19483382 PMID:25626140 NCBI chr 2:221,062,206...221,104,790
Ensembl chr 2:218,387,990...218,430,561
JBrowse link
G Cftr CF transmembrane conductance regulator affects metabolic processing ISO CFTR protein affects the metabolism of Omeprazole CTD PMID:15319328 NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Chp1 calcineurin-like EF-hand protein 1 affects expression EXP Omeprazole affects the expression of CHP1 mRNA CTD PMID:19483382 NCBI chr 3:126,989,800...127,025,071
Ensembl chr 3:106,536,004...106,571,251
JBrowse link
G Cisd1 CDGSH iron sulfur domain 1 affects expression EXP Omeprazole affects the expression of CISD1 mRNA CTD PMID:19483382 NCBI chr20:17,254,462...17,267,843
Ensembl chr20:17,255,151...17,284,924
JBrowse link
G Clcn4 chloride voltage-gated channel 4 affects expression EXP Omeprazole affects the expression of CLCN4 mRNA CTD PMID:19483382 NCBI chr  X:27,290,769...27,356,967
Ensembl chr  X:23,729,338...23,793,238
JBrowse link
G Clpp caseinolytic mitochondrial matrix peptidase proteolytic subunit affects expression EXP Omeprazole affects the expression of CLPP mRNA CTD PMID:19483382 NCBI chr 9:1,917,305...1,924,706
Ensembl chr 9:1,830,311...1,837,693
JBrowse link
G Clptm1l CLPTM1-like affects expression EXP Omeprazole affects the expression of CLPTM1L mRNA CTD PMID:19483382 NCBI chr 1:31,496,094...31,512,148
Ensembl chr 1:29,667,545...29,683,530
JBrowse link
G Cmbl carboxymethylenebutenolidase homolog affects expression EXP Omeprazole affects the expression of CMBL mRNA CTD PMID:19483382 NCBI chr 2:84,280,128...84,301,878
Ensembl chr 2:82,571,888...82,591,009
JBrowse link
G Cmpk1 cytidine/uridine monophosphate kinase 1 affects expression EXP Omeprazole affects the expression of CMPK1 mRNA CTD PMID:19483382 NCBI chr 5:133,717,073...133,744,623
Ensembl chr 5:128,480,301...128,507,830
JBrowse link
G Copg1 COPI coat complex subunit gamma 1 affects expression EXP Omeprazole affects the expression of COPG1 mRNA CTD PMID:19483382 NCBI chr 4:121,923,644...121,949,819
Ensembl chr 4:120,366,542...120,415,616
JBrowse link
G Cops4 COP9 signalosome subunit 4 affects expression EXP Omeprazole affects the expression of COPS4 mRNA CTD PMID:19483382 NCBI chr14:9,382,897...9,413,216
Ensembl chr14:9,078,576...9,108,887
JBrowse link
G Coq3 coenzyme Q3 methyltransferase affects expression EXP Omeprazole affects the expression of COQ3 mRNA CTD PMID:19483382 NCBI chr 5:40,226,313...40,257,383
Ensembl chr 5:35,429,574...35,460,607
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 affects expression EXP Omeprazole affects the expression of COX4I1 mRNA CTD PMID:19483382 NCBI chr19:65,630,383...65,636,623
Ensembl chr19:48,721,199...48,727,921
JBrowse link
G Cpn1 carboxypeptidase N subunit 1 affects expression EXP Omeprazole affects the expression of CPN1 mRNA CTD PMID:19483382 NCBI chr 1:252,793,786...252,822,675
Ensembl chr 1:242,844,212...242,873,465
JBrowse link
G Cpq carboxypeptidase Q affects expression EXP Omeprazole affects the expression of CPQ mRNA CTD PMID:19483382 NCBI chr 7:66,148,973...66,719,189
Ensembl chr 7:64,264,081...64,724,546
JBrowse link
G Crem cAMP responsive element modulator affects expression EXP Omeprazole affects the expression of CREM mRNA CTD PMID:19483382 NCBI chr17:58,932,011...59,001,160
Ensembl chr17:54,239,030...54,305,989
JBrowse link
G Csnk2b casein kinase 2 beta affects expression EXP Omeprazole affects the expression of CSNK2B mRNA CTD PMID:19483382 NCBI chr20:3,704,833...3,709,999
Ensembl chr20:3,698,733...3,707,133
JBrowse link
G Csrp1 cysteine and glycine-rich protein 1 affects expression EXP Omeprazole affects the expression of CSRP1 mRNA CTD PMID:19483382 NCBI chr13:49,709,928...49,731,141
Ensembl chr13:47,167,789...47,179,384
JBrowse link
G Ctnna1 catenin alpha 1 affects expression EXP Omeprazole affects the expression of CTNNA1 mRNA CTD PMID:19483382 NCBI chr18:27,002,330...27,135,009
Ensembl chr18:26,728,485...26,860,910
JBrowse link
G Ctsb cathepsin B decreases activity ISO Omeprazole results in decreased activity of CTSB protein CTD PMID:34871754 NCBI chr15:41,565,607...41,586,479
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Ctsd cathepsin D multiple interactions EXP Omeprazole inhibits the reaction [Cysteamine results in increased expression of CTSD protein] CTD PMID:20165931 NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Ctse cathepsin E decreases expression EXP Omeprazole results in decreased expression of CTSE CTD PMID:7575556 NCBI chr13:45,644,168...45,666,722
Ensembl chr13:43,092,128...43,114,502
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression
multiple interactions
ISO Omeprazole results in decreased expression of CXCR4 mRNA
AHR protein affects the reaction [Omeprazole results in decreased expression of CXCR4 mRNA]
CTD PMID:25826687 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
multiple interactions
decreases activity
increases expression
ISO
EXP
Omeprazole results in increased activity of CYP1A1 promoter
Omeprazole inhibits the reaction [Oxygen results in increased expression of CYP1A1 protein]; Omeprazole promotes the reaction [Oxygen results in decreased expression of CYP1A1 mRNA]
Omeprazole results in decreased activity of CYP1A1 protein
Omeprazole results in increased expression of CYP1A1 mRNA; Omeprazole results in increased expression of CYP1A1 protein
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA; AHR protein promotes the reaction [Omeprazole results in increased expression of CYP1A1 protein]; daidzein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; daidzein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Genistein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; Genistein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; herbimycin inhibits the reaction [Omeprazole results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; lavendustin A inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Staurosporine inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Tosyllysine Chloromethyl Ketone inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]
AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein mutant form inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; Omeprazole promotes the reaction [AHR protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [NCOA1 protein binds to CYP1A1 promoter]
CTD PMID:8647108 PMID:8900397 PMID:9041675 PMID:9139728 PMID:9152597 More... NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
increases expression
decreases activity
multiple interactions
ISO
EXP
Omeprazole results in increased activity of CYP1A2 promoter; Omeprazole results in increased activity of CYP1A2 protein
Omeprazole results in increased expression of CYP1A2 mRNA; Omeprazole results in increased expression of CYP1A2 protein
Omeprazole results in decreased activity of CYP1A2 protein
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A2 mRNA
[Omeprazole results in increased expression of CYP1A2 protein] which results in decreased alkylation of Phenacetin; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A2 mRNA]; Omeprazole results in increased expression of and results in increased activity of CYP1A2 protein
CTD PMID:9152597 PMID:9744552 PMID:12040753 PMID:12623754 PMID:12841937 More... NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
affects expression
decreases activity
increases expression
ISO Omeprazole promotes the reaction [AHR protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [NCOA1 protein binds to CYP1B1 promoter]
Omeprazole affects the expression of CYP1B1 mRNA
Omeprazole results in decreased activity of CYP1B1 protein
Omeprazole results in increased expression of CYP1B1 mRNA
CTD PMID:12040753 PMID:12623754 PMID:18420780 PMID:21703235 PMID:25826687 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 affects expression EXP Omeprazole affects the expression of CYP2A1 mRNA CTD PMID:19483382 NCBI chr 1:91,359,278...91,372,554
Ensembl chr 1:82,231,611...82,244,887
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Omeprazole results in increased expression of CYP2B1 mRNA; Omeprazole results in increased expression of CYP2B1 protein CTD PMID:9152597 PMID:19118567 NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression
affects expression
EXP Omeprazole results in increased expression of CYP2B2 protein
Omeprazole affects the expression of CYP2B2 mRNA
CTD PMID:9152597 PMID:19483382 NCBI chr 1:90,722,243...90,736,272
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 affects expression
decreases activity
increases expression
increases activity
EXP
ISO
Omeprazole affects the expression of CYP2B3 mRNA
Omeprazole results in decreased activity of CYP2B10 protein
Omeprazole results in increased expression of CYP2B6 mRNA
Omeprazole results in increased activity of CYP2B6 protein
CTD PMID:17954527 PMID:18420780 PMID:19118567 PMID:19483382 PMID:22524704 NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases metabolic processing
decreases activity
multiple interactions
increases hydroxylation
increases metabolic processing
affects metabolic processing
ISO CYP2C19 gene alternative form results in decreased metabolism of Omeprazole
Omeprazole results in decreased activity of CYP2C19 protein
[5-bromotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-chlorotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-fluoro-alpha-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-fluorotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [7-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Chloramphenicol results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Fluconazole results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [indopan results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Omeprazole results in decreased activity of CYP2C19 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine metabolite; [Omeprazole results in decreased activity of CYP2C19 protein] which results in decreased chemical synthesis of Aconitine metabolite; [Tryptamines analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; Omeprazole affects the reaction [CYP2C19 protein affects the metabolism of Warfarin]; Omeprazole inhibits the reaction [CYP2C19 protein results in decreased methylation of adinazolam]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased chemical synthesis of 4-hydroxymephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of auriculasin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of Fluoxetine]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased oxidation of 2-oxo-clopidogrel]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased oxidation of Clopidogrel]
CYP2C19 protein results in increased hydroxylation of Omeprazole
CYP2C19 protein results in increased metabolism of Omeprazole
CYP2C19 protein affects the metabolism of Omeprazole
CTD PMID:8930576 PMID:9600717 PMID:11752104 PMID:12464242 PMID:12467917 More... NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 affects expression EXP Omeprazole affects the expression of CYP2D3 mRNA CTD PMID:19483382 NCBI chr 7:115,797,785...115,802,142
Ensembl chr 7:113,908,947...113,922,084
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects expression
decreases activity
EXP
ISO
Omeprazole affects the expression of CYP2D4 mRNA
Omeprazole results in decreased activity of CYP2D6 protein
CTD PMID:18420780 PMID:19483382 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Omeprazole results in increased expression of and results in increased activity of CYP2E1 protein CTD PMID:15802389 PMID:36243147 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 affects expression EXP Omeprazole affects the expression of CYP2F4 mRNA CTD PMID:19483382 NCBI chr 1:91,543,768...91,557,553
Ensembl chr 1:82,416,130...82,429,896
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 affects expression EXP Omeprazole affects the expression of CYP2J4 mRNA CTD PMID:19483382 NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Cyp2t1 cytochrome P450, family 2, subfamily t, polypeptide 1 affects expression EXP Omeprazole affects the expression of CYP2T1 mRNA CTD PMID:19483382 NCBI chr 1:91,573,923...91,579,215
Ensembl chr 1:82,446,921...82,451,563
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
increases metabolic processing
multiple interactions
increases expression
ISO CYP3A4 protein affects the metabolism of Omeprazole
CYP3A4 protein results in increased metabolism of Omeprazole
[Omeprazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein affects the reaction [Omeprazole results in increased expression of CYP3A4 mRNA]; Omeprazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Omeprazole results in increased expression of and results in increased activity of CYP3A4 protein
Omeprazole results in increased expression of CYP3A4 mRNA; Omeprazole results in increased expression of CYP3A4 protein
CTD PMID:7870052 PMID:8930576 PMID:9744552 PMID:12235278 PMID:12485723 More... NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 affects expression
increases expression
EXP Omeprazole affects the expression of CYP3A23-3A1 mRNA
Omeprazole results in increased expression of CYP3A23-3A1 mRNA
CTD PMID:19118567 PMID:19483382 NCBI chr12:14,369,950...14,398,803
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects expression
increases expression
EXP
ISO
Omeprazole affects the expression of CYP3A9 mRNA
Omeprazole results in increased expression of CYP3A5 mRNA
CTD PMID:19118567 PMID:19483382 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 affects expression EXP Omeprazole affects the expression of CYP4A8 mRNA CTD PMID:19483382 NCBI chr 5:133,938,882...133,970,226
Ensembl chr 5:128,702,131...128,733,476
JBrowse link
G Cyp4f6 cytochrome P450, family 4, subfamily f, polypeptide 6 affects expression EXP Omeprazole affects the expression of CYP4F6 mRNA CTD PMID:19483382 NCBI chr 7:12,680,799...12,708,378
Ensembl chr 7:12,030,301...12,057,782
JBrowse link
G Dbi diazepam binding inhibitor affects expression EXP Omeprazole affects the expression of DBI mRNA CTD PMID:19483382 NCBI chr13:33,794,231...33,802,632
Ensembl chr13:31,206,988...31,268,693
JBrowse link
G Dcaf11 DDB1 and CUL4 associated factor 11 affects expression EXP Omeprazole affects the expression of DCAF11 mRNA CTD PMID:19483382 NCBI chr15:33,015,370...33,027,407
Ensembl chr15:29,046,826...29,057,669
JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase affects expression EXP Omeprazole affects the expression of DCXR mRNA CTD PMID:19483382 NCBI chr10:106,504,730...106,506,619 JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Omeprazole results in increased expression of DDIT3 protein CTD PMID:27358234 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Decr1 2,4-dienoyl-CoA reductase 1 affects expression EXP Omeprazole affects the expression of DECR1 mRNA CTD PMID:19483382 NCBI chr 5:34,208,195...34,236,074
Ensembl chr 5:29,411,172...29,439,018
JBrowse link
G Dexi Dexi homolog affects expression EXP Omeprazole affects the expression of DEXI mRNA CTD PMID:19483382 NCBI chr10:5,632,400...5,645,653
Ensembl chr10:5,137,288...5,138,738
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 affects expression EXP Omeprazole affects the expression of DGAT1 mRNA CTD PMID:19483382 NCBI chr 7:110,104,514...110,119,091
Ensembl chr 7:108,218,524...108,234,299
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase affects expression EXP Omeprazole affects the expression of DHCR24 mRNA CTD PMID:19483382 NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:121,344,575...121,371,137
JBrowse link
G Dhrs4 dehydrogenase/reductase 4 affects expression EXP Omeprazole affects the expression of DHRS4 mRNA CTD PMID:19483382 NCBI chr15:32,924,482...32,948,103
Ensembl chr15:28,966,553...28,978,127
JBrowse link
G Dhrs7b dehydrogenase/reductase 7B affects expression EXP Omeprazole affects the expression of DHRS7B mRNA CTD PMID:19483382 NCBI chr10:46,003,845...46,036,498
Ensembl chr10:45,504,426...45,537,076
JBrowse link
G Dhx16 DEAH-box helicase 16 affects expression EXP Omeprazole affects the expression of DHX16 mRNA CTD PMID:19483382 NCBI chr20:2,866,804...2,879,790
Ensembl chr20:2,862,000...2,874,948
JBrowse link
G Dmac2l distal membrane arm assembly component 2 like affects expression EXP Omeprazole affects the expression of DMAC2L mRNA CTD PMID:19483382 NCBI chr 6:93,941,605...93,959,932
Ensembl chr 6:88,205,700...88,223,933
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 affects expression EXP Omeprazole affects the expression of DNAJC3 mRNA CTD PMID:19483382 NCBI chr15:102,432,667...102,475,643
Ensembl chr15:96,025,624...96,065,181
JBrowse link
G Dpp4 dipeptidylpeptidase 4 affects expression EXP Omeprazole affects the expression of DPP4 mRNA CTD PMID:19483382 NCBI chr 3:67,370,794...67,452,422
Ensembl chr 3:46,962,243...47,043,901
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase affects expression EXP Omeprazole affects the expression of DPYD mRNA CTD PMID:19483382 NCBI chr 2:209,293,902...210,159,777
Ensembl chr 2:206,609,122...207,474,982
JBrowse link
G Ears2 glutamyl-tRNA synthetase 2, mitochondrial affects expression EXP Omeprazole affects the expression of EARS2 mRNA CTD PMID:19483382 NCBI chr 1:186,025,740...186,057,165
Ensembl chr 1:176,597,986...176,625,836
JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 affects expression EXP Omeprazole affects the expression of ECHS1 mRNA CTD PMID:19483382 NCBI chr 1:204,324,679...204,333,506
Ensembl chr 1:194,895,036...194,903,884
JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 affects expression EXP Omeprazole affects the expression of ECI1 mRNA CTD PMID:19483382 NCBI chr10:13,961,250...13,974,595
Ensembl chr10:13,456,563...13,470,061
JBrowse link
G Eci2 enoyl-CoA delta isomerase 2 affects expression EXP Omeprazole affects the expression of ECI2 mRNA CTD PMID:19483382 NCBI chr17:30,056,274...30,092,169
Ensembl chr17:29,870,391...29,886,781
JBrowse link
G Eef1g eukaryotic translation elongation factor 1 gamma affects expression EXP Omeprazole affects the expression of EEF1G mRNA CTD PMID:19483382 NCBI chr 1:215,289,815...215,300,421
Ensembl chr 1:205,860,698...205,872,382
JBrowse link
G Egf epidermal growth factor multiple interactions ISO Omeprazole promotes the reaction [Indomethacin results in increased expression of EGF protein] CTD PMID:18431645 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase affects expression EXP Omeprazole affects the expression of EHHADH mRNA CTD PMID:19483382 NCBI chr11:92,746,409...92,779,647
Ensembl chr11:79,241,938...79,275,188
JBrowse link
G Eif4a2 eukaryotic translation initiation factor 4A2 affects expression EXP Omeprazole affects the expression of EIF4A2 mRNA CTD PMID:19483382 NCBI chr11:91,268,730...91,276,738
Ensembl chr11:77,764,124...77,770,781
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 affects expression EXP Omeprazole affects the expression of EIF4EBP1 mRNA CTD PMID:19483382 NCBI chr16:71,495,457...71,508,845
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Eif4h eukaryotic translation initiation factor 4H affects expression EXP Omeprazole affects the expression of EIF4H mRNA CTD PMID:19483382 NCBI chr12:27,719,527...27,736,350
Ensembl chr12:22,082,835...22,099,876
JBrowse link
G Enc1 ectodermal-neural cortex 1 affects expression EXP Omeprazole affects the expression of ENC1 mRNA CTD PMID:19483382 NCBI chr 2:30,285,274...30,297,194
Ensembl chr 2:28,550,464...28,562,713
JBrowse link
G Eno1 enolase 1 affects expression EXP Omeprazole affects the expression of ENO1 mRNA CTD PMID:19483382 NCBI chr 5:166,002,867...166,014,252
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336
JBrowse link
G Enpep glutamyl aminopeptidase affects expression EXP Omeprazole affects the expression of ENPEP mRNA CTD PMID:19483382 NCBI chr 2:220,456,258...220,526,218
Ensembl chr 2:217,782,005...217,851,947
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 affects expression EXP Omeprazole affects the expression of ENPP1 mRNA CTD PMID:19483382 NCBI chr 1:22,518,051...22,583,044
Ensembl chr 1:20,698,764...20,763,715
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO Omeprazole promotes the reaction [EP300 protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1B1 promoter] CTD PMID:21703235 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Epcam epithelial cell adhesion molecule affects expression EXP Omeprazole affects the expression of EPCAM mRNA CTD PMID:19483382 NCBI chr 6:12,633,715...12,649,678
Ensembl chr 6:6,878,237...6,896,127
JBrowse link
G Erp29 endoplasmic reticulum protein 29 affects expression EXP Omeprazole affects the expression of ERP29 mRNA CTD PMID:19483382 NCBI chr12:40,750,177...40,756,607
Ensembl chr12:35,089,707...35,096,376
JBrowse link
G Esd esterase D affects expression EXP Omeprazole affects the expression of ESD mRNA CTD PMID:19483382 NCBI chr15:56,453,082...56,472,582
Ensembl chr15:50,043,632...50,063,144
JBrowse link
G Etfb electron transfer flavoprotein subunit beta affects expression EXP Omeprazole affects the expression of ETFB mRNA CTD PMID:19483382 NCBI chr 1:102,988,499...103,002,663
Ensembl chr 1:93,851,858...93,866,068
JBrowse link
G Faah fatty acid amide hydrolase affects expression EXP Omeprazole affects the expression of FAAH mRNA CTD PMID:19483382 NCBI chr 5:134,716,545...134,735,396
Ensembl chr 5:129,479,824...129,498,677
JBrowse link
G Fads2 fatty acid desaturase 2 affects expression EXP Omeprazole affects the expression of FADS2 mRNA CTD PMID:19483382 NCBI chr 1:216,132,277...216,172,190
Ensembl chr 1:206,708,783...206,748,789
JBrowse link
G Fbp1 fructose-bisphosphatase 1 affects expression EXP Omeprazole affects the expression of FBP1 mRNA CTD PMID:19483382 NCBI chr17:2,212,941...2,235,749
Ensembl chr17:2,208,031...2,230,071
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 affects expression EXP Omeprazole affects the expression of FDFT1 mRNA CTD PMID:19483382 NCBI chr15:41,588,114...41,616,168
Ensembl chr15:37,412,146...37,440,287
JBrowse link
G Fdps farnesyl diphosphate synthase affects expression EXP Omeprazole affects the expression of FDPS mRNA CTD PMID:19483382 NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:174,486,665...174,507,776
JBrowse link
G Fdx2 ferredoxin 2 affects expression EXP Omeprazole affects the expression of FDX2 mRNA CTD PMID:19483382 NCBI chr 8:27,881,091...27,886,230
Ensembl chr 8:19,604,916...19,609,849
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 affects expression EXP Omeprazole affects the expression of FMO1 mRNA CTD PMID:19483382 NCBI chr13:77,715,405...77,747,666
Ensembl chr13:75,182,176...75,214,647
JBrowse link
G Gamt guanidinoacetate N-methyltransferase affects expression EXP Omeprazole affects the expression of GAMT mRNA CTD PMID:19483382 NCBI chr 7:10,099,267...10,102,083
Ensembl chr 7:9,448,628...9,451,778
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase affects expression EXP Omeprazole affects the expression of GAPDH mRNA CTD PMID:19483382 NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gast gastrin increases expression ISO
EXP
Omeprazole results in increased expression of GAST protein CTD PMID:11422300 PMID:12189558 PMID:12763636 PMID:15223672 PMID:16618411 More... NCBI chr10:85,765,216...85,767,881
Ensembl chr10:85,264,832...85,267,496
JBrowse link
G Gbe1 1,4-alpha-glucan branching enzyme 1 affects expression EXP Omeprazole affects the expression of GBE1 mRNA CTD PMID:19483382 NCBI chr11:22,181,194...22,446,640
Ensembl chr11:8,734,820...9,000,210
JBrowse link
G Gchfr GTP cyclohydrolase I feedback regulator affects expression EXP Omeprazole affects the expression of GCHFR mRNA CTD PMID:19483382 NCBI chr 3:126,611,892...126,615,926
Ensembl chr 3:106,159,394...106,162,080
JBrowse link
G Ggh gamma-glutamyl hydrolase affects expression EXP Omeprazole affects the expression of GGH mRNA CTD PMID:19483382 NCBI chr 5:38,326,747...38,349,655
Ensembl chr 5:33,529,880...33,552,787
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP [Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GGT1 mRNA CTD PMID:22687989 NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Gjb1 gap junction protein, beta 1 affects expression EXP Omeprazole affects the expression of GJB1 mRNA CTD PMID:19483382 NCBI chr  X:70,541,845...70,549,776
Ensembl chr  X:66,501,820...66,509,925
JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 affects expression EXP Omeprazole affects the expression of GPLD1 mRNA CTD PMID:19483382 NCBI chr17:40,512,659...40,560,483
Ensembl chr17:40,084,617...40,126,939
JBrowse link
G Gpx1 glutathione peroxidase 1 affects expression EXP Omeprazole affects the expression of GPX1 mRNA CTD PMID:19483382 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions EXP [Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA CTD PMID:22687989 NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:95,493,589...95,496,877
JBrowse link
G Gpx4 glutathione peroxidase 4 affects expression EXP Omeprazole affects the expression of GPX4 mRNA CTD PMID:19483382 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Grina glutamate ionotropic receptor NMDA type subunit associated protein 1 affects expression EXP Omeprazole affects the expression of GRINA mRNA CTD PMID:19483382 NCBI chr 7:109,842,870...109,846,048
Ensembl chr 7:107,962,207...107,965,366
JBrowse link
G Grpel1 GrpE-like 1, mitochondrial affects expression EXP Omeprazole affects the expression of GRPEL1 mRNA CTD PMID:19483382 NCBI chr14:78,517,049...78,522,868
Ensembl chr14:74,292,023...74,298,200
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression
multiple interactions
EXP Omeprazole results in increased expression of GSTA5 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA
CTD PMID:17202759 PMID:22687989 NCBI chr 8:87,985,768...87,997,766
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP Omeprazole results in increased expression of GSTP1 mRNA CTD PMID:19118567 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects expression EXP Omeprazole affects the expression of GSTT1 mRNA CTD PMID:19483382 NCBI chr20:12,856,068...12,873,020
Ensembl chr20:12,856,669...12,873,585
JBrowse link
G Gtf2h5 general transcription factor IIH subunit 5 affects expression EXP Omeprazole affects the expression of GTF2H5 mRNA CTD PMID:19483382 NCBI chr 1:49,061,904...49,068,612
Ensembl chr 1:46,656,859...46,664,939
JBrowse link
G Gzma granzyme A affects expression EXP Omeprazole affects the expression of GZMA mRNA CTD PMID:19483382 NCBI chr 2:46,473,763...46,485,696
Ensembl chr 2:44,740,569...44,752,493
JBrowse link
G H3f3b H3.3 histone B affects expression EXP Omeprazole affects the expression of H3F3B mRNA CTD PMID:19483382 NCBI chr10:101,755,404...101,764,616
Ensembl chr10:101,256,480...101,258,709
Ensembl chr13:101,256,480...101,258,709
JBrowse link
G Hal histidine ammonia lyase affects expression EXP Omeprazole affects the expression of HAL mRNA CTD PMID:19483382 NCBI chr 7:29,894,495...29,924,744
Ensembl chr 7:28,006,972...28,037,701
JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression
multiple interactions
increases secretion
ISO Omeprazole results in increased expression of HAMP mRNA
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Omeprazole results in increased expression of HAMP mRNA]; AHR protein affects the reaction [Omeprazole results in increased expression of HAMP mRNA]
Omeprazole results in increased expression of HAMP mRNA; Omeprazole results in increased expression of HAMP protein
Omeprazole results in increased secretion of HAMP protein
CTD PMID:31669099 NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:86,170,901...86,172,891
JBrowse link
G Hao2 hydroxyacid oxidase 2 affects expression EXP Omeprazole affects the expression of HAO2 mRNA CTD PMID:19483382 NCBI chr 2:188,888,848...188,921,567
Ensembl chr 2:186,200,504...186,224,425
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 affects expression EXP Omeprazole affects the expression of HBA-A2 mRNA CTD PMID:19483382 NCBI chr10:15,828,291...15,829,138
Ensembl chr10:15,307,815...15,338,392
Ensembl chr10:15,307,815...15,338,392
JBrowse link
G Hbb hemoglobin subunit beta affects expression EXP Omeprazole affects the expression of HBB mRNA CTD PMID:19483382 NCBI chr 1:167,662,310...167,663,721
Ensembl chr 1:158,120,200...158,252,012
JBrowse link
G Hdc histidine decarboxylase affects expression
increases stability
increases expression
multiple interactions
EXP Omeprazole affects the expression of HDC mRNA
Omeprazole results in increased stability of HDC protein
Omeprazole results in increased expression of HDC mRNA
Omeprazole results in increased expression of and results in increased activity of HDC protein
CTD PMID:12763636 PMID:19483382 NCBI chr 3:134,300,628...134,318,704
Ensembl chr 3:113,847,260...113,865,341
JBrowse link
G Hgd homogentisate 1, 2-dioxygenase affects expression EXP Omeprazole affects the expression of HGD mRNA CTD PMID:19483382 NCBI chr11:76,592,202...76,643,776
Ensembl chr11:63,086,752...63,138,323
JBrowse link
G Hmgn1 high mobility group nucleosome binding domain 1 affects expression EXP Omeprazole affects the expression of HMGN1 mRNA CTD PMID:19483382 NCBI chr11:48,891,813...48,897,732
Ensembl chr11:35,422,328...35,428,254
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO Acetylcysteine promotes the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; Acetylcysteine promotes the reaction [Omeprazole results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 protein]; Omeprazole results in increased expression of and results in increased activity of HMOX1 protein
Omeprazole results in increased expression of HMOX1 mRNA; Omeprazole results in increased expression of HMOX1 protein
CTD PMID:16712795 PMID:27725188 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 affects expression EXP Omeprazole affects the expression of HPRT1 mRNA CTD PMID:19483382 NCBI chr  X:137,655,744...137,687,718
Ensembl chr  X:132,736,096...132,768,154
JBrowse link
G Hps5 HPS5, biogenesis of lysosomal organelles complex 2 subunit 2 affects expression EXP Omeprazole affects the expression of HPS5 mRNA CTD PMID:19483382 NCBI chr 1:106,417,902...106,457,220
Ensembl chr 1:97,247,598...97,321,019
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 affects expression EXP Omeprazole affects the expression of HSD17B4 mRNA CTD PMID:19483382 NCBI chr18:45,515,427...45,604,467
Ensembl chr18:43,328,824...43,417,952
JBrowse link
G Hsdl2 hydroxysteroid dehydrogenase like 2 affects expression EXP Omeprazole affects the expression of HSDL2 mRNA CTD PMID:19483382 NCBI chr 5:79,238,881...79,274,051
Ensembl chr 5:74,443,872...74,479,839
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A decreases expression
multiple interactions
EXP Omeprazole results in decreased expression of HSPA1A mRNA; Omeprazole results in decreased expression of HSPA1A protein
Zinc Compounds analog inhibits the reaction [Omeprazole results in decreased expression of HSPA1A protein]; Zinc Sulfate inhibits the reaction [Omeprazole results in decreased expression of HSPA1A protein]
CTD PMID:15223672 PMID:16945336 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like multiple interactions EXP Omeprazole inhibits the reaction [Ethanol results in increased expression of HSPA1L mRNA] CTD PMID:25637687 NCBI chr20:3,853,496...3,860,223
Ensembl chr20:3,848,843...3,855,571
JBrowse link
G Htra1 HtrA serine peptidase 1 affects expression EXP Omeprazole affects the expression of HTRA1 mRNA CTD PMID:19483382 NCBI chr 1:194,928,069...194,977,619
Ensembl chr 1:185,497,735...185,547,379
JBrowse link
G Ier3 immediate early response 3 multiple interactions ISO [Omeprazole co-treated with CCKBR protein] results in increased expression of IER3 CTD PMID:17704804 NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,928,378...2,929,583
JBrowse link
G Ifng interferon gamma multiple interactions ISO Omeprazole inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein] CTD PMID:19232345 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 affects expression EXP Omeprazole affects the expression of IGF1 mRNA CTD PMID:19483382 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igfals insulin-like growth factor binding protein, acid labile subunit affects expression EXP Omeprazole affects the expression of IGFALS mRNA CTD PMID:19483382 NCBI chr10:14,397,076...14,408,439
Ensembl chr10:13,898,395...13,902,677
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 affects expression EXP Omeprazole affects the expression of IGFBP2 mRNA CTD PMID:19483382 NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:74,415,546...74,442,937
JBrowse link
G Il10 interleukin 10 multiple interactions ISO
EXP
Omeprazole inhibits the reaction [Ethanol results in decreased expression of IL10 protein] CTD PMID:26970604 PMID:38341112 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il16 interleukin 16 multiple interactions EXP Omeprazole inhibits the reaction [Ethanol results in increased expression of IL16 protein] CTD PMID:38341112 NCBI chr 1:147,026,852...147,127,177
Ensembl chr 1:137,617,944...137,718,130
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Omeprazole inhibits the reaction [Cisplatin results in increased expression of IL1B protein] CTD PMID:32418911 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
Omeprazole inhibits the reaction [Cisplatin results in increased expression of IL6 protein]; Omeprazole inhibits the reaction [Ethanol results in decreased expression of IL6 protein]
Omeprazole inhibits the reaction [Ethanol results in increased expression of IL6 protein]
CTD PMID:25637687 PMID:32418911 PMID:38341112 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Impa1 inositol monophosphatase 1 affects expression EXP Omeprazole affects the expression of IMPA1 mRNA CTD PMID:19483382 NCBI chr 2:93,370,200...93,391,474
Ensembl chr 2:91,462,799...91,484,313
JBrowse link
G Inhbe inhibin subunit beta E affects expression EXP Omeprazole affects the expression of INHBE mRNA CTD PMID:19483382 NCBI chr 7:65,061,531...65,064,519
Ensembl chr 7:63,176,219...63,179,172
JBrowse link
G Isyna1 inositol-3-phosphate synthase 1 affects expression EXP Omeprazole affects the expression of ISYNA1 mRNA CTD PMID:19483382 NCBI chr16:18,873,119...18,876,116
Ensembl chr16:18,839,145...18,841,979
JBrowse link
G Itih4 inter-alpha-trypsin inhibitor heavy chain 4 affects expression EXP Omeprazole affects the expression of ITIH4 mRNA CTD PMID:19483382 NCBI chr16:6,086,985...6,102,162
Ensembl chr16:6,080,539...6,095,708
JBrowse link
G Jak1 Janus kinase 1 affects expression EXP Omeprazole affects the expression of JAK1 mRNA CTD PMID:19483382 NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:115,780,248...115,888,926
JBrowse link
G Kdelr2 KDEL endoplasmic reticulum protein retention receptor 2 affects expression EXP Omeprazole affects the expression of KDELR2 mRNA CTD PMID:19483382 NCBI chr12:16,252,424...16,270,737
Ensembl chr12:11,138,820...11,157,153
JBrowse link
G Kdr kinase insert domain receptor affects expression
multiple interactions
EXP
ISO
Omeprazole affects the expression of KDR mRNA
Omeprazole promotes the reaction [Oxygen results in decreased expression of KDR protein]
CTD PMID:19483382 PMID:26272953 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Krt8 keratin 8 affects expression EXP Omeprazole affects the expression of KRT8 mRNA CTD PMID:19483382 NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:133,124,203...133,131,728
JBrowse link
G Lcat lecithin cholesterol acyltransferase affects expression EXP Omeprazole affects the expression of LCAT mRNA CTD PMID:19483382 NCBI chr19:50,744,598...50,748,064
Ensembl chr19:33,834,403...33,838,231
JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 affects expression EXP Omeprazole affects the expression of LCMT1 mRNA CTD PMID:19483382 NCBI chr 1:187,335,173...187,391,195
Ensembl chr 1:177,904,139...177,960,112
JBrowse link
G Lipc lipase C, hepatic type affects expression EXP Omeprazole affects the expression of LIPC mRNA CTD PMID:19483382 NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:71,509,635...71,635,464
JBrowse link
G Lox lysyl oxidase affects expression EXP Omeprazole affects the expression of LOX mRNA CTD PMID:19483382 NCBI chr18:48,162,889...48,175,640
Ensembl chr18:45,967,343...46,041,477
JBrowse link
G Lrp3 LDL receptor related protein 3 affects expression EXP Omeprazole affects the expression of LRP3 mRNA CTD PMID:19483382 NCBI chr 1:96,980,762...96,996,157
Ensembl chr 1:87,844,868...87,859,110
JBrowse link
G Man2b1 mannosidase, alpha, class 2B, member 1 affects expression EXP Omeprazole affects the expression of MAN2B1 mRNA CTD PMID:19483382 NCBI chr19:39,959,964...39,979,299
Ensembl chr19:23,055,097...23,074,389
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 affects expression EXP Omeprazole affects the expression of MAP2K2 mRNA CTD PMID:19483382 NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:8,580,905...8,610,243
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Omeprazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK14 protein] CTD PMID:17406807 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Masp2 MBL associated serine protease 2 affects expression EXP Omeprazole affects the expression of MASP2 mRNA CTD PMID:19483382 NCBI chr 5:164,319,017...164,332,686
Ensembl chr 5:159,035,911...159,049,580
JBrowse link
G Me1 malic enzyme 1 affects expression
multiple interactions
EXP Omeprazole affects the expression of ME1 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA
CTD PMID:19483382 PMID:22687989 NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Mmp14 matrix metallopeptidase 14 multiple interactions EXP Omeprazole inhibits the reaction [Indomethacin results in decreased expression of MMP14 protein] CTD PMID:16934674 NCBI chr15:31,857,824...31,867,049
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP Omeprazole inhibits the reaction [Hydrogen Peroxide results in decreased activity of MMP2 protein] CTD PMID:16934674 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmut methylmalonyl-CoA mutase affects expression EXP Omeprazole affects the expression of MMUT mRNA CTD PMID:19483382 NCBI chr 9:27,425,935...27,454,202
Ensembl chr 9:19,928,727...19,957,046
JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity
ISO
EXP
Omeprazole inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Omeprazole inhibits the reaction [Acids results in increased activity of MPO protein]
Omeprazole results in decreased activity of MPO protein
Omeprazole inhibits the reaction [Acetic Acid results in increased activity of MPO protein]; Omeprazole inhibits the reaction [Cysteamine results in increased expression of MPO protein]; Omeprazole inhibits the reaction [Ethanol results in increased activity of MPO protein]; Omeprazole inhibits the reaction [Indomethacin results in increased activity of MPO protein]
CTD PMID:16091555 PMID:17151854 PMID:20165931 PMID:25637687 PMID:27780710 More... NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mro maestro affects expression EXP Omeprazole affects the expression of MRO mRNA CTD PMID:19483382 NCBI chr18:69,723,764...69,742,815
Ensembl chr18:67,450,595...67,467,044
JBrowse link
G Mrpl2 mitochondrial ribosomal protein L2 affects expression EXP Omeprazole affects the expression of MRPL2 mRNA CTD PMID:19483382 NCBI chr 9:21,830,834...21,834,607
Ensembl chr 9:14,333,234...14,337,040
JBrowse link
G Mrpl9 mitochondrial ribosomal protein L9 affects expression EXP Omeprazole affects the expression of MRPL9 mRNA CTD PMID:19483382 NCBI chr 2:184,768,837...184,775,787
Ensembl chr 2:182,076,369...182,087,095
JBrowse link
G Mug2 murinoglobulin 2 affects expression EXP Omeprazole affects the expression of PZP mRNA CTD PMID:19483382 NCBI chr 4:156,836,140...156,908,972
Ensembl chr 4:155,164,011...155,236,475
JBrowse link
G Myadm myeloid-associated differentiation marker affects expression EXP Omeprazole affects the expression of MYADM mRNA CTD PMID:19483382 NCBI chr 1:74,779,616...74,796,752
Ensembl chr 1:65,864,173...65,874,035
JBrowse link
G Mycbp2 MYC binding protein 2 affects expression EXP Omeprazole affects the expression of MYCBP2 mRNA CTD PMID:19483382 NCBI chr15:86,352,061...86,590,126
Ensembl chr15:79,937,354...80,175,498
JBrowse link
G Myo1d myosin ID affects expression EXP Omeprazole affects the expression of MYO1D mRNA CTD PMID:19483382 NCBI chr10:65,986,900...66,263,538
Ensembl chr10:65,489,154...65,766,349
JBrowse link
G Naa38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit affects expression EXP Omeprazole affects the expression of NAA38 mRNA CTD PMID:19483382 NCBI chr10:54,588,304...54,617,715
Ensembl chr10:54,117,163...54,119,494
JBrowse link
G Nap1l1 nucleosome assembly protein 1-like 1 affects expression EXP Omeprazole affects the expression of NAP1L1 mRNA CTD PMID:19483382 NCBI chr 7:48,819,464...48,844,108
Ensembl chr 7:46,933,356...46,956,593
JBrowse link
G Nat8 N-acetyltransferase 8 affects expression EXP Omeprazole affects the expression of NAT8 mRNA CTD PMID:19483382 NCBI chr 4:119,836,986...119,837,764
Ensembl chr 4:118,270,954...118,281,763
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Omeprazole promotes the reaction [NCOA1 protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [NCOA1 protein binds to CYP1B1 promoter] CTD PMID:21703235 NCBI chr 6:32,952,090...33,229,829
Ensembl chr 6:27,232,611...27,475,664
JBrowse link
G Ndrg2 NDRG family member 2 affects expression EXP Omeprazole affects the expression of NDRG2 mRNA CTD PMID:19483382 NCBI chr15:27,074,481...27,087,376
Ensembl chr15:24,600,982...24,609,626
JBrowse link
G Ndufs5 NADH:ubiquinone oxidoreductase subunit S5 affects expression EXP Omeprazole affects the expression of NDUFS5 mRNA CTD PMID:19483382 NCBI chr 5:141,258,828...141,264,552
Ensembl chr 5:135,974,034...135,979,603
Ensembl chr14:135,974,034...135,979,603
Ensembl chr 2:135,974,034...135,979,603
JBrowse link
G Ndufv3 NADH:ubiquinone oxidoreductase subunit V3 affects expression EXP Omeprazole affects the expression of NDUFV3 mRNA CTD PMID:19483382 NCBI chr20:9,613,786...9,622,941
Ensembl chr20:9,612,431...9,623,074
Ensembl chr13:9,612,431...9,623,074
JBrowse link
G Neu2 neuraminidase 2 affects expression EXP Omeprazole affects the expression of NEU2 mRNA CTD PMID:19483382 NCBI chr 9:95,666,338...95,715,209
Ensembl chr 9:88,249,135...88,267,355
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 protein] CTD PMID:27725188 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Omeprazole inhibits the reaction [Cisplatin results in decreased expression of NFKBIA protein] CTD PMID:32418911 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nfx1 nuclear transcription factor, X-box binding 1 affects expression EXP Omeprazole affects the expression of NFX1 mRNA CTD PMID:19483382 NCBI chr 5:60,900,140...60,958,889
Ensembl chr 5:56,105,234...56,162,912
JBrowse link
G Nipal2 NIPA-like domain containing 2 affects expression EXP Omeprazole affects the expression of NIPAL2 mRNA CTD PMID:19483382 NCBI chr 7:67,659,628...67,771,105
Ensembl chr 7:65,774,477...65,884,807
JBrowse link
G Nit1 nitrilase 1 affects expression EXP Omeprazole affects the expression of NIT1 mRNA CTD PMID:19483382 NCBI chr13:86,302,334...86,305,770
Ensembl chr13:83,765,941...83,773,332
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP Lipopolysaccharides inhibits the reaction [Omeprazole inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]]; Omeprazole inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein] CTD PMID:32418911 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 affects expression EXP Omeprazole affects the expression of NME2 mRNA CTD PMID:19483382 NCBI chr10:79,394,999...79,400,418
Ensembl chr10:78,897,770...78,903,538
Ensembl chr20:78,897,770...78,903,538
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
EXP
ISO
Omeprazole results in increased expression of NQO1 mRNA
Omeprazole inhibits the reaction [Oxygen results in increased expression of NQO1 mRNA]; Omeprazole inhibits the reaction [Oxygen results in increased expression of NQO1 protein]
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of NQO1 mRNA
CTD PMID:17202759 PMID:22687989 PMID:26272953 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO
EXP
[Omeprazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein affects the reaction [Omeprazole results in increased expression of CYP3A4 mRNA] CTD PMID:12695340 PMID:17041008 PMID:25680588 PMID:26187274 PMID:27732639 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects expression
decreases metabolic processing
increases expression
EXP
ISO
Omeprazole affects the expression of NR1I3 mRNA
NR1I3 gene mutant form results in decreased metabolism of Omeprazole
Omeprazole results in increased expression of NR1I3 mRNA
CTD PMID:19118567 PMID:19483382 PMID:27434302 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects expression EXP Omeprazole affects the expression of NR3C1 mRNA CTD PMID:19483382 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Oaf out at first homolog affects expression EXP Omeprazole affects the expression of OAF mRNA CTD PMID:19483382 NCBI chr 8:52,491,314...52,509,285
Ensembl chr 8:43,594,363...43,612,334
JBrowse link
G Obp3 alpha-2u globulin PGCL4 affects expression EXP Omeprazole affects the expression of OBP3 mRNA CTD PMID:19483382 NCBI chr 5:79,637,234...79,640,810
Ensembl chr 5:74,842,316...74,845,757
JBrowse link
G Ogdh oxoglutarate dehydrogenase affects expression EXP Omeprazole affects the expression of OGDH mRNA CTD PMID:19483382 NCBI chr14:85,363,949...85,431,405
Ensembl chr14:81,150,091...81,217,479
JBrowse link
G Olr59 olfactory receptor 59 affects expression EXP Omeprazole affects the expression of OLR59 mRNA CTD PMID:19483382 NCBI chr 1:166,604,972...166,639,634
Ensembl chr 1:157,193,080...157,211,179
JBrowse link
G Ostc oligosaccharyltransferase complex non-catalytic subunit affects expression EXP Omeprazole affects the expression of OSTC mRNA CTD PMID:19483382 NCBI chr 2:221,924,727...221,940,253
Ensembl chr 2:219,236,952...219,266,107
JBrowse link
G Otc ornithine transcarbamylase affects expression EXP Omeprazole affects the expression of OTC mRNA CTD PMID:19483382 NCBI chr  X:15,126,358...15,202,473
Ensembl chr  X:12,453,834...12,566,918
JBrowse link
G Pabpc4 poly(A) binding protein, cytoplasmic 4 affects expression EXP Omeprazole affects the expression of PABPC4 mRNA CTD PMID:19483382 NCBI chr 5:140,847,835...140,864,089
Ensembl chr 5:135,563,562...135,578,979
JBrowse link
G Paics phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase affects expression EXP Omeprazole affects the expression of PAICS mRNA CTD PMID:19483382 NCBI chr14:31,553,355...31,586,843
Ensembl chr14:31,173,541...31,232,635
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Omeprazole results in increased cleavage of PARP1 protein CTD PMID:15461867 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pc pyruvate carboxylase affects expression EXP Omeprazole affects the expression of PCX mRNA CTD PMID:19483382 NCBI chr 1:211,228,708...211,327,792
Ensembl chr 1:201,804,267...201,898,380
JBrowse link
G Pccb propionyl-CoA carboxylase subunit beta affects expression EXP Omeprazole affects the expression of PCCB mRNA CTD PMID:19483382 NCBI chr 8:110,470,197...110,520,222
Ensembl chr 8:101,590,737...101,641,234
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP
ISO
[Omeprazole co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of PCNA protein]; Omeprazole promotes the reaction [Acetic Acid results in increased expression of PCNA protein]
Omeprazole inhibits the reaction [Ethanol results in decreased expression of PCNA protein]
CTD PMID:19251492 PMID:26970604 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pcsk6 proprotein convertase subtilisin/kexin type 6 affects expression EXP Omeprazole affects the expression of PCSK6 mRNA CTD PMID:19483382 NCBI chr 1:128,839,742...129,038,087
Ensembl chr 1:119,429,265...119,627,596
JBrowse link
G Pctp phosphatidylcholine transfer protein affects expression EXP Omeprazole affects the expression of PCTP mRNA CTD PMID:19483382 NCBI chr10:75,305,999...75,351,919
Ensembl chr10:74,808,887...74,849,867
JBrowse link
G Pdcl3 phosducin-like 3 affects expression EXP Omeprazole affects the expression of PDCL3 mRNA CTD PMID:19483382 NCBI chr 9:48,730,083...48,738,554
Ensembl chr 9:41,234,234...41,243,735
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 affects expression EXP Omeprazole affects the expression of PDIA3 mRNA CTD PMID:19483382 NCBI chr 3:128,841,781...128,865,733
Ensembl chr 3:108,388,245...108,413,236
JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 affects expression EXP Omeprazole affects the expression of PDIA6 mRNA CTD PMID:19483382 NCBI chr 6:45,791,704...45,808,947
Ensembl chr 6:40,062,926...40,080,613
JBrowse link
G Pex19 peroxisomal biogenesis factor 19 affects expression EXP Omeprazole affects the expression of PEX19 mRNA CTD PMID:19483382 NCBI chr13:87,124,654...87,141,170
Ensembl chr13:84,592,312...84,608,608
JBrowse link
G Pgam1 phosphoglycerate mutase 1 affects expression EXP Omeprazole affects the expression of PGAM1 mRNA CTD PMID:19483382 NCBI chr 1:250,673,152...250,680,762
Ensembl chr 1:240,723,920...240,738,452
JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 affects expression EXP Omeprazole affects the expression of PGRMC1 mRNA CTD PMID:19483382 NCBI chr  X:120,698,610...120,706,805
Ensembl chr  X:115,832,884...115,888,682
JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase affects expression EXP Omeprazole affects the expression of PHYH mRNA CTD PMID:19483382 NCBI chr17:78,238,747...78,255,645
Ensembl chr17:73,329,082...73,346,409
JBrowse link
G Pigp phosphatidylinositol glycan anchor biosynthesis, class P affects expression EXP Omeprazole affects the expression of PIGP mRNA CTD PMID:19483382 NCBI chr11:47,152,601...47,158,766
Ensembl chr11:33,682,948...33,689,321
JBrowse link
G Pklr pyruvate kinase L/R affects expression EXP Omeprazole affects the expression of PKLR mRNA CTD PMID:19483382 NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:174,543,039...174,551,870
JBrowse link
G Pla2g4a phospholipase A2 group 4A increases phosphorylation
multiple interactions
ISO Omeprazole results in increased phosphorylation of PLA2G4A protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Omeprazole results in increased phosphorylation of PLA2G4A protein]
CTD PMID:25797602 NCBI chr13:64,427,921...64,572,352
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Plbd1 phospholipase B domain containing 1 affects expression EXP Omeprazole affects the expression of PLBD1 mRNA CTD PMID:19483382 NCBI chr 4:171,204,198...171,260,488
Ensembl chr 4:169,472,983...169,529,277
JBrowse link
G Plg plasminogen affects expression EXP Omeprazole affects the expression of PLG mRNA CTD PMID:19483382 NCBI chr 1:50,872,927...50,915,406
Ensembl chr 1:48,325,185...48,367,786
JBrowse link
G Pls3 plastin 3 affects expression EXP Omeprazole affects the expression of PLS3 mRNA CTD PMID:19483382 NCBI chr  X:116,401,247...116,495,898
Ensembl chr  X:111,589,254...111,683,891
JBrowse link
G Pon2 paraoxonase 2 affects expression EXP Omeprazole affects the expression of PON2 mRNA CTD PMID:19483382 NCBI chr 4:34,356,270...34,391,684
Ensembl chr 4:33,389,714...33,425,248
JBrowse link
G Pou2f2 POU class 2 homeobox 2 multiple interactions EXP
ISO
Omeprazole inhibits the reaction [Cisplatin results in increased expression of POU2F2 protein] CTD PMID:30452898 NCBI chr 1:89,810,153...89,897,560
Ensembl chr 1:80,685,741...80,724,261
JBrowse link
G Ppdpf pancreatic progenitor cell differentiation and proliferation factor affects expression EXP Omeprazole affects the expression of PPDPF mRNA CTD PMID:19483382 NCBI chr 3:188,676,821...188,678,599
Ensembl chr 3:168,299,791...168,301,036
JBrowse link
G Prdx2 peroxiredoxin 2 affects expression EXP Omeprazole affects the expression of PRDX2 mRNA CTD PMID:19483382 NCBI chr19:40,085,788...40,091,083
Ensembl chr19:23,180,930...23,186,194
JBrowse link
G Prdx6 peroxiredoxin 6 affects expression EXP Omeprazole affects the expression of PRDX6 mRNA CTD PMID:19483382 NCBI chr13:76,062,082...76,072,631
Ensembl chr13:73,528,210...73,539,355
JBrowse link
G Prl prolactin increases expression ISO Omeprazole results in increased expression of PRL protein CTD PMID:20726208 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa affects expression EXP Omeprazole affects the expression of PROC mRNA CTD PMID:19483382 NCBI chr18:24,038,596...24,049,061
Ensembl chr18:23,764,368...23,775,133
JBrowse link
G Prpsap1 phosphoribosyl pyrophosphate synthetase-associated protein 1 affects expression EXP Omeprazole affects the expression of PRPSAP1 mRNA CTD PMID:19483382 NCBI chr10:102,199,949...102,221,642
Ensembl chr10:101,701,096...101,750,751
JBrowse link
G Psma6 proteasome 20S subunit alpha 6 affects expression EXP Omeprazole affects the expression of PSMA6 mRNA CTD PMID:19483382 NCBI chr 6:78,500,676...78,531,693
Ensembl chr 6:72,765,473...72,796,554
JBrowse link
G Psmb1 proteasome 20S subunit beta 1 affects expression EXP Omeprazole affects the expression of PSMB1 mRNA CTD PMID:19483382 NCBI chr 1:65,115,770...65,136,516
Ensembl chr 1:56,420,618...56,463,560
JBrowse link
G Psmb3 proteasome 20S subunit beta 3 affects expression EXP Omeprazole affects the expression of PSMB3 mRNA CTD PMID:19483382 NCBI chr10:83,193,787...83,200,883
Ensembl chr10:82,697,425...82,704,521
JBrowse link
G Psmc1 proteasome 26S subunit, ATPase 1 affects expression EXP Omeprazole affects the expression of PSMC1 mRNA CTD PMID:19483382 NCBI chr 6:125,122,497...125,134,859
Ensembl chr 6:119,392,855...119,410,123
JBrowse link
G Psmc3 proteasome 26S subunit, ATPase 3 affects expression EXP Omeprazole affects the expression of PSMC3 mRNA CTD PMID:19483382 NCBI chr 3:97,487,643...97,493,025
Ensembl chr 3:77,031,825...77,043,358
JBrowse link
G Psmc5 proteasome 26S subunit, ATPase 5 affects expression EXP Omeprazole affects the expression of PSMC5 mRNA CTD PMID:19483382 NCBI chr10:91,687,553...91,693,487
Ensembl chr10:91,187,743...91,213,135
JBrowse link
G Psmd1 proteasome 26S subunit, non-ATPase 1 affects expression EXP Omeprazole affects the expression of PSMD1 mRNA CTD PMID:19483382 NCBI chr 9:94,157,971...94,233,218
Ensembl chr 9:86,709,947...86,785,211
JBrowse link
G Psmd4 proteasome 26S subunit ubiquitin receptor, non-ATPase 4 affects expression EXP Omeprazole affects the expression of PSMD4 mRNA CTD PMID:19483382 NCBI chr 2:185,287,941...185,297,238
Ensembl chr 2:182,598,934...182,608,194
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO
[Omeprazole co-treated with beta-Naphthoflavone] results in increased expression of PTGS2 mRNA; [Omeprazole co-treated with beta-Naphthoflavone] results in increased expression of PTGS2 protein
Omeprazole inhibits the reaction [Ethanol results in increased expression of PTGS2 protein]
CTD PMID:23038005 PMID:26970604 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptms parathymosin affects expression EXP Omeprazole affects the expression of PTMS mRNA CTD PMID:19483382 NCBI chr 4:159,408,647...159,412,837
Ensembl chr 4:157,722,386...157,727,009
JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F affects expression EXP Omeprazole affects the expression of PTPRF mRNA CTD PMID:19483382 NCBI chr 5:137,027,376...137,109,405
Ensembl chr 5:131,742,754...131,810,023
JBrowse link
G Pttg1ip PTTG1 interacting protein affects expression EXP Omeprazole affects the expression of PTTG1IP mRNA CTD PMID:19483382 NCBI chr20:11,029,608...11,047,395
Ensembl chr20:11,030,015...11,047,316
JBrowse link
G Pygl glycogen phosphorylase L affects expression EXP Omeprazole affects the expression of PYGL mRNA CTD PMID:19483382 NCBI chr 6:94,433,558...94,476,219
Ensembl chr 6:88,697,593...88,740,310
JBrowse link
G Rab5if RAB5 interacting factor affects expression EXP Omeprazole affects the expression of RAB5IF mRNA CTD PMID:19483382 NCBI chr 3:165,818,060...165,828,071
Ensembl chr 3:145,357,861...145,368,012
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
[Omeprazole co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of RELA protein]; Lipopolysaccharides inhibits the reaction [Omeprazole inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]]; Omeprazole inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]
Omeprazole inhibits the reaction [Cisplatin affects the localization of RELA protein]
CTD PMID:19251492 PMID:30452898 PMID:32418911 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Retsat retinol saturase increases expression EXP Omeprazole results in increased expression of RETSAT mRNA CTD PMID:25626140 NCBI chr 4:106,211,459...106,220,222
Ensembl chr 4:104,653,155...104,668,310
JBrowse link
G Rida reactive intermediate imine deaminase A homolog affects expression EXP Omeprazole affects the expression of RIDA mRNA CTD PMID:19483382 NCBI chr 7:67,576,586...67,590,493
Ensembl chr 7:65,691,435...65,705,716
JBrowse link
G Rnase4 ribonuclease A family member 4 affects expression EXP Omeprazole affects the expression of RNASE4 mRNA CTD PMID:19483382 NCBI chr15:26,786,287...26,803,634
Ensembl chr15:24,312,464...24,330,117
JBrowse link
G Rnf103 ring finger protein 103 affects expression EXP Omeprazole affects the expression of RNF103 mRNA CTD PMID:19483382 NCBI chr 4:105,084,762...105,100,839
Ensembl chr 4:103,526,502...103,555,919
JBrowse link
G Rnps1 RNA binding protein with serine rich domain 1 affects expression EXP Omeprazole affects the expression of RNPS1 mRNA CTD PMID:19483382 NCBI chr10:13,950,151...13,960,396
Ensembl chr10:13,445,653...13,455,858
JBrowse link
G Rpl11 ribosomal protein L11 affects expression EXP Omeprazole affects the expression of RPL11 mRNA CTD PMID:19483382 NCBI chr 5:153,557,592...153,561,230
Ensembl chr 5:148,274,069...148,277,599
JBrowse link
G Rpl13 ribosomal protein L13 affects expression EXP Omeprazole affects the expression of RPL13 mRNA CTD PMID:19483382 NCBI chr19:68,062,442...68,065,065
Ensembl chr19:51,153,924...51,163,014
Ensembl chr 3:51,153,924...51,163,014
JBrowse link
G Rpl15 ribosomal protein L15 affects expression EXP Omeprazole affects the expression of RPL15 mRNA CTD PMID:19483382 NCBI chr15:9,934,663...9,937,946
Ensembl chr15:7,503,883...7,507,165
Ensembl chr12:7,503,883...7,507,165
JBrowse link
G Rpl17 ribosomal protein L17 affects expression EXP Omeprazole affects the expression of RPL17 mRNA CTD PMID:19483382 NCBI chr18:70,856,275...70,859,388
Ensembl chr18:68,581,098...68,584,253
Ensembl chr 3:68,581,098...68,584,253
JBrowse link
G Rpl23 ribosomal protein L23 affects expression EXP Omeprazole affects the expression of RPL23 mRNA CTD PMID:19483382 NCBI chr10:83,268,223...83,272,184
Ensembl chr10:82,771,538...82,775,870
JBrowse link
G Rpl3 ribosomal protein L3 affects expression EXP Omeprazole affects the expression of RPL3 mRNA CTD PMID:19483382 NCBI chr 7:113,491,943...113,508,115
Ensembl chr 7:111,621,610...111,636,468
JBrowse link
G Rpl32 ribosomal protein L32 affects expression EXP Omeprazole affects the expression of RPL32 mRNA CTD PMID:19483382 NCBI chr 4:150,536,650...150,540,214
Ensembl chr 4:148,864,044...148,867,612
Ensembl chr 3:148,864,044...148,867,612
JBrowse link
G Rpl4 ribosomal protein L4 affects expression EXP Omeprazole affects the expression of RPL4 mRNA CTD PMID:19483382 NCBI chr 8:73,566,477...73,571,600
Ensembl chr 8:64,671,160...64,676,306
JBrowse link
G Rpn2 ribophorin II affects expression EXP Omeprazole affects the expression of RPN2 mRNA CTD PMID:19483382 NCBI chr 3:166,361,955...166,409,272
Ensembl chr 3:145,941,839...145,989,543
JBrowse link
G Rps14 ribosomal protein S14 affects expression EXP Omeprazole affects the expression of RPS14 mRNA CTD PMID:19483382 NCBI chr18:56,492,010...56,503,092
Ensembl chr18:54,227,854...54,233,166
JBrowse link
G Rps18 ribosomal protein S18 affects expression EXP Omeprazole affects the expression of RPS18 mRNA CTD PMID:19483382 NCBI chr20:4,933,741...4,937,423
Ensembl chr20:4,931,768...4,938,315
JBrowse link
G Rps19 ribosomal protein S19 affects expression EXP Omeprazole affects the expression of RPS19 mRNA CTD PMID:19483382 NCBI chr 1:89,608,408...89,614,390
Ensembl chr 1:80,480,951...80,486,508
Ensembl chr 7:80,480,951...80,486,508
JBrowse link
G Rps20 ribosomal protein S20 affects expression EXP Omeprazole affects the expression of RPS20 mRNA CTD PMID:19483382 NCBI chr 5:21,616,687...21,618,068
Ensembl chr 5:16,819,304...16,820,475
Ensembl chr 9:16,819,304...16,820,475
Ensembl chr 3:16,819,304...16,820,475
Ensembl chr 5:16,819,304...16,820,475
JBrowse link
G Rps3a ribosomal protein S3a affects expression EXP Omeprazole affects the expression of RPS3A mRNA CTD PMID:19483382 NCBI chr 2:173,822,673...173,827,042
Ensembl chr 2:171,524,500...171,529,055
JBrowse link
G Rps6 ribosomal protein S6 affects expression EXP Omeprazole affects the expression of RPS6 mRNA CTD PMID:19483382 NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Rps8 ribosomal protein S8 affects expression EXP Omeprazole affects the expression of RPS8 mRNA CTD PMID:19483382 NCBI chr 5:135,866,941...135,869,511
Ensembl chr 5:130,629,716...130,633,268
JBrowse link
G Rras2 RAS related 2 affects expression EXP Omeprazole affects the expression of RRAS2 mRNA CTD PMID:19483382 NCBI chr 1:177,668,143...177,737,551
Ensembl chr 1:168,233,693...168,303,111
JBrowse link
G RT1-DMa RT1 class II, locus DMa affects expression ISO Omeprazole affects the expression of HLA-DMA mRNA CTD PMID:25811541 NCBI chr20:4,708,932...4,712,335
Ensembl chr20:4,707,028...4,710,432
JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 affects expression ISO Omeprazole affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr20:1,329,227...1,333,394
Ensembl chr20:1,287,521...1,328,117
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression EXP Omeprazole affects the expression of RT1-S3 mRNA CTD PMID:19483382 NCBI chr20:2,675,463...2,680,229
Ensembl chr20:2,670,709...2,675,411
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 affects expression EXP Omeprazole affects the expression of S1PR1 mRNA CTD PMID:19483382 NCBI chr 2:206,309,715...206,314,070
Ensembl chr 2:203,621,587...203,629,681
JBrowse link
G Sbspon somatomedin B and thrombospondin, type 1 domain containing affects expression EXP Omeprazole affects the expression of SBSPON mRNA CTD PMID:19483382 NCBI chr 5:8,186,004...8,216,576
Ensembl chr 5:3,402,648...3,435,420
JBrowse link
G Sdc2 syndecan 2 affects expression EXP Omeprazole affects the expression of SDC2 mRNA CTD PMID:19483382 NCBI chr 7:66,012,405...66,125,101
Ensembl chr 7:64,127,110...64,241,081
JBrowse link
G Sdhc succinate dehydrogenase complex subunit C affects expression EXP Omeprazole affects the expression of SDHC mRNA CTD PMID:19483382 NCBI chr13:86,077,133...86,098,025
Ensembl chr13:83,544,652...83,566,253
JBrowse link
G Sdhd succinate dehydrogenase complex subunit D affects expression EXP Omeprazole affects the expression of SDHD mRNA CTD PMID:19483382 NCBI chr 8:59,841,090...59,850,641
Ensembl chr 8:50,944,704...50,954,238
JBrowse link
G Sell selectin L decreases expression EXP Omeprazole results in decreased expression of SELL protein CTD PMID:17652263 NCBI chr13:78,950,100...78,969,604
Ensembl chr13:76,416,915...76,436,456
JBrowse link
G Serinc3 serine incorporator 3 affects expression EXP Omeprazole affects the expression of SERINC3 mRNA CTD PMID:19483382 NCBI chr 3:172,721,208...172,749,853
Ensembl chr 3:152,301,772...152,321,808
JBrowse link
G Serpina1 serpin family A member 1 affects expression EXP Omeprazole affects the expression of SERPINA1 mRNA CTD PMID:19483382 NCBI chr 6:128,631,101...128,653,125
Ensembl chr 6:122,866,312...122,888,339
JBrowse link
G Serpina10 serpin family A member 10 affects expression EXP Omeprazole affects the expression of SERPINA10 mRNA CTD PMID:19483382 NCBI chr 6:128,520,894...128,529,332
Ensembl chr 6:122,756,108...122,764,544
JBrowse link
G Serpina4 serpin family A member 4 affects expression EXP Omeprazole affects the expression of SERPINA4 mRNA CTD PMID:19483382 NCBI chr 6:128,764,738...128,773,858
Ensembl chr 6:122,999,900...123,009,082
JBrowse link
G Serpinf2 serpin family F member 2 affects expression EXP Omeprazole affects the expression of SERPINF2 mRNA CTD PMID:19483382 NCBI chr10:60,770,698...60,778,782
Ensembl chr10:60,272,400...60,281,243
JBrowse link
G Serping1 serpin family G member 1 decreases expression EXP Omeprazole results in decreased expression of SERPING1 mRNA CTD PMID:25626140 NCBI chr 3:90,249,410...90,259,299
Ensembl chr 3:69,842,739...69,852,034
JBrowse link
G Sfxn1 sideroflexin 1 affects expression EXP Omeprazole affects the expression of SFXN1 mRNA CTD PMID:19483382 NCBI chr17:10,491,315...10,527,793
Ensembl chr17:10,486,271...10,522,529
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 affects expression EXP Omeprazole affects the expression of SHMT2 mRNA CTD PMID:19483382 NCBI chr 7:65,244,247...65,249,580
Ensembl chr 7:63,358,961...63,364,236
JBrowse link
G Slc22a1 solute carrier family 22 member 1 affects expression EXP Omeprazole affects the expression of SLC22A1 mRNA CTD PMID:19483382 NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Omeprazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions EXP Dithioerythritol inhibits the reaction [Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]]; Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine] CTD PMID:19041296 NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,008,311...38,035,309
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions ISO [Omeprazole results in decreased activity of SLC22A8 protein] which results in decreased uptake of Indican CTD PMID:36243147 NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slc23a1 solute carrier family 23 member 1 affects expression EXP Omeprazole affects the expression of SLC23A1 mRNA CTD PMID:19483382 NCBI chr18:27,490,549...27,504,563
Ensembl chr18:27,216,281...27,230,697
JBrowse link
G Slc25a13 solute carrier family 25 member 13 affects expression EXP Omeprazole affects the expression of SLC25A13 mRNA CTD PMID:19483382 NCBI chr 4:35,145,721...35,328,403
Ensembl chr 4:34,179,224...34,361,902
JBrowse link
G Slc25a3 solute carrier family 25 member 3 affects expression EXP Omeprazole affects the expression of SLC25A3 mRNA CTD PMID:19483382 NCBI chr 7:27,499,164...27,506,685
Ensembl chr 7:25,586,725...25,667,727
JBrowse link
G Slc27a2 solute carrier family 27 member 2 affects expression EXP Omeprazole affects the expression of SLC27A2 mRNA CTD PMID:19483382 NCBI chr 3:134,258,101...134,295,581
Ensembl chr 3:113,804,728...113,842,208
JBrowse link
G Slc39a8 solute carrier family 39 member 8 affects expression EXP Omeprazole affects the expression of SLC39A8 mRNA CTD PMID:19483382 NCBI chr 2:226,845,686...226,992,668
Ensembl chr 2:224,256,654...224,319,129
JBrowse link
G Slc40a1 solute carrier family 40 member 1 decreases expression ISO Omeprazole results in decreased expression of SLC40A1 protein CTD PMID:31669099 NCBI chr 9:55,525,457...55,633,463
Ensembl chr 9:48,033,526...48,051,481
JBrowse link
G Slc46a1 solute carrier family 46 member 1 affects expression EXP Omeprazole affects the expression of SLC46A1 mRNA CTD PMID:19483382 NCBI chr10:63,859,551...63,865,987
Ensembl chr10:63,361,486...63,368,848
JBrowse link
G Slc66a2 solute carrier family 66 member 2 affects expression EXP Omeprazole affects the expression of SLC66A2 mRNA CTD PMID:19483382 NCBI chr18:75,976,000...76,014,651
Ensembl chr18:73,702,564...73,739,676
JBrowse link
G Slc6a6 solute carrier family 6 member 6 affects expression EXP Omeprazole affects the expression of SLC6A6 mRNA CTD PMID:19483382 NCBI chr 4:125,752,340...125,826,033
Ensembl chr 4:124,195,218...124,268,875
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases expression ISO Omeprazole results in increased expression of SLCO1A2 mRNA CTD PMID:19118567 NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO Omeprazole inhibits the reaction [Ethanol results in decreased activity of SOD1 protein] CTD PMID:28849987 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sppl2a signal peptide peptidase-like 2A affects expression EXP Omeprazole affects the expression of SPPL2A mRNA CTD PMID:19483382 NCBI chr 3:134,602,684...134,646,752
Ensembl chr 3:114,151,069...114,193,264
JBrowse link
G Srm spermidine synthase affects expression EXP Omeprazole affects the expression of SRM mRNA CTD PMID:19483382 NCBI chr 5:164,309,002...164,312,203
Ensembl chr 5:159,025,873...159,029,405
JBrowse link
G Srprb SRP receptor subunit beta affects expression EXP Omeprazole affects the expression of SRPRB mRNA CTD PMID:19483382 NCBI chr 8:112,647,577...112,661,524 JBrowse link
G Ssx2ip SSX family member 2 interacting protein affects expression EXP Omeprazole affects the expression of SSX2IP mRNA CTD PMID:19483382 NCBI chr 2:237,958,286...237,991,026
Ensembl chr 2:235,298,088...235,330,745
JBrowse link
G St3gal6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 affects expression EXP Omeprazole affects the expression of ST3GAL6 mRNA CTD PMID:19483382 NCBI chr11:55,530,120...55,590,950
Ensembl chr11:42,077,621...42,121,776
JBrowse link
G St6gal1 ST6 beta-galactoside alpha-2,6-sialyltransferase 1 affects expression EXP Omeprazole affects the expression of ST6GAL1 mRNA CTD PMID:19483382 NCBI chr11:91,031,481...91,158,111
Ensembl chr11:77,526,837...77,653,310
JBrowse link
G Suclg1 succinate-CoA ligase GDP/ADP-forming subunit alpha affects expression EXP Omeprazole affects the expression of SUCLG1 mRNA CTD PMID:19483382 NCBI chr 4:106,866,329...106,895,686
Ensembl chr 4:105,308,039...105,337,600
JBrowse link
G Surf4 surfeit 4 affects expression EXP Omeprazole affects the expression of SURF4 mRNA CTD PMID:19483382 NCBI chr 3:30,646,435...30,659,641
Ensembl chr 3:10,241,837...10,263,315
JBrowse link
G Synj2bp synaptojanin 2 binding protein affects expression EXP Omeprazole affects the expression of SYNJ2BP mRNA CTD PMID:19483382 NCBI chr 6:106,920,970...106,958,653
Ensembl chr 6:101,189,714...101,227,406
JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions ISO Omeprazole inhibits the reaction [Acids affects the localization of TACR1 protein] CTD PMID:16091555 NCBI chr 4:116,478,617...116,647,492
Ensembl chr 4:114,920,844...115,089,733
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO Omeprazole results in increased expression of TGFB1 protein CTD PMID:36243147 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbi transforming growth factor, beta induced affects expression EXP Omeprazole affects the expression of TGFBI mRNA CTD PMID:19483382 NCBI chr17:7,960,885...7,990,234
Ensembl chr17:7,955,603...7,985,240
JBrowse link
G Thnsl2 threonine synthase-like 2 affects expression EXP Omeprazole affects the expression of THNSL2 mRNA CTD PMID:19483382 NCBI chr 4:104,671,305...104,691,084
Ensembl chr 4:103,112,963...103,132,017
JBrowse link
G Timm21 translocase of inner mitochondrial membrane 21 affects expression EXP Omeprazole affects the expression of TIMM21 mRNA CTD PMID:19483382 NCBI chr18:80,589,775...80,594,237
Ensembl chr18:78,314,909...78,319,454
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP Omeprazole inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein] CTD PMID:16934674 NCBI chr10:104,041,604...104,089,214
Ensembl chr10:103,531,505...103,590,611
JBrowse link
G Tkfc triokinase and FMN cyclase affects expression EXP Omeprazole affects the expression of TKFC mRNA CTD PMID:19483382 NCBI chr 1:216,664,446...216,677,815
Ensembl chr 1:207,236,557...207,252,737
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Lipopolysaccharides inhibits the reaction [Omeprazole inhibits the reaction [Cisplatin results in increased expression of TLR4 protein]]; Omeprazole inhibits the reaction [Cisplatin results in increased expression of TLR4 protein] CTD PMID:32418911 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tmbim1 transmembrane BAX inhibitor motif containing 1 affects expression EXP Omeprazole affects the expression of TMBIM1 mRNA CTD PMID:19483382 NCBI chr 9:83,320,972...83,338,469
Ensembl chr 9:75,871,835...75,889,069
JBrowse link
G Tmco1 transmembrane and coiled-coil domains 1 affects expression EXP Omeprazole affects the expression of TMCO1 mRNA CTD PMID:19483382 NCBI chr13:81,993,172...82,016,496
Ensembl chr13:79,460,135...79,483,555
JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 affects expression EXP Omeprazole affects the expression of TMED2 mRNA CTD PMID:19483382 NCBI chr12:37,713,522...37,722,606
Ensembl chr12:32,052,543...32,071,903
JBrowse link
G Tmed7 transmembrane p24 trafficking protein 7 affects expression EXP Omeprazole affects the expression of TMED7 mRNA CTD PMID:19483382 NCBI chr18:41,505,167...41,512,243
Ensembl chr18:39,297,351...39,325,640
JBrowse link
G Tmem123 transmembrane protein 123 affects expression EXP Omeprazole affects the expression of TMEM123 mRNA CTD PMID:19483382 NCBI chr 8:13,206,907...13,237,069
Ensembl chr 8:4,922,098...4,952,224
JBrowse link
G Tmem97 transmembrane protein 97 affects expression EXP Omeprazole affects the expression of TMEM97 mRNA CTD PMID:19483382 NCBI chr10:63,936,276...63,945,359
Ensembl chr10:63,438,222...63,589,730
JBrowse link
G Tmprss2 transmembrane serine protease 2 increases expression EXP Omeprazole results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr11:50,403,707...50,443,224
Ensembl chr11:36,934,306...36,973,715
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Omeprazole inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]; Omeprazole inhibits the reaction [Ethanol results in increased expression of TNF protein]
Omeprazole inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Omeprazole inhibits the reaction [Ethanol results in decreased expression of TNF protein]; Omeprazole inhibits the reaction [Ethanol results in increased expression of TNF protein]
CTD PMID:19232345 PMID:25637687 PMID:26970604 PMID:30452898 PMID:32418911 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Txn1 thioredoxin 1 affects expression EXP Omeprazole affects the expression of TXN1 mRNA CTD PMID:19483382 NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Txnl1 thioredoxin-like 1 affects expression EXP Omeprazole affects the expression of TXNL1 mRNA CTD PMID:19483382 NCBI chr18:59,397,275...59,428,072
Ensembl chr18:57,125,369...57,165,266
JBrowse link
G Tyr tyrosinase multiple interactions
decreases expression
ISO Omeprazole affects the N-linked glycosylation of and results in increased degradation of TYR protein; Omeprazole inhibits the reaction [ATP7A protein results in increased activity of TYR protein]
Omeprazole results in decreased expression of TYR protein
CTD PMID:25337692 NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:141,115,036...141,210,207
JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 affects expression EXP Omeprazole affects the expression of UBA52 mRNA CTD PMID:19483382 NCBI chr16:18,952,583...18,954,780
Ensembl chr16:18,900,616...18,920,807
JBrowse link
G Ube2n ubiquitin-conjugating enzyme E2N affects expression EXP Omeprazole affects the expression of UBE2N mRNA CTD PMID:19483382 NCBI chr 7:32,041,190...32,071,252
Ensembl chr 7:30,154,616...30,184,355
JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 affects expression EXP Omeprazole affects the expression of UFD1 mRNA CTD PMID:19483382 NCBI chr11:95,665,971...95,689,423
Ensembl chr11:82,161,619...82,185,087
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
affects expression
ISO
EXP
Omeprazole results in increased expression of UGT1A1 mRNA
Omeprazole affects the expression of UGT1A1 mRNA
CTD PMID:19118567 PMID:19483382 PMID:25626140 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression ISO Omeprazole results in increased expression of UGT1A2 mRNA; Omeprazole results in increased expression of UGT1A3 mRNA CTD PMID:19118567 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 increases expression ISO Omeprazole results in increased expression of UGT1A5 mRNA CTD PMID:19118567 NCBI chr 9:96,228,134...96,256,264
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases expression ISO Omeprazole results in increased expression of UGT1A4 mRNA CTD PMID:19118567 NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression
multiple interactions
EXP
ISO
Omeprazole results in increased expression of UGT1A6 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA
CTD PMID:19118567 PMID:22687989 NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases expression ISO Omeprazole results in increased expression of UGT1A9 mRNA CTD PMID:19118567 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases expression EXP Omeprazole results in increased expression of UGT2B1 mRNA CTD PMID:25626140 NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,024,006...21,035,986
JBrowse link
G Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI affects expression EXP Omeprazole affects the expression of UQCR11 mRNA CTD PMID:19483382 NCBI chr 7:9,955,717...9,960,432
Ensembl chr 7:9,305,058...9,309,750
JBrowse link
G Vnn1 vanin 1 affects expression EXP Omeprazole affects the expression of VNN1 mRNA CTD PMID:19483382 NCBI chr 1:23,356,324...23,366,629
Ensembl chr 1:21,537,094...21,547,395
JBrowse link
G Wdr26 WD repeat domain 26 affects expression EXP Omeprazole affects the expression of WDR26 mRNA CTD PMID:19483382 NCBI chr13:95,462,017...95,503,826
Ensembl chr13:92,930,285...92,977,295
JBrowse link
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma affects expression EXP Omeprazole affects the expression of YWHAG mRNA CTD PMID:19483382 NCBI chr12:26,381,106...26,409,466
Ensembl chr12:20,744,535...20,772,827
JBrowse link
G Zdhhc23 zinc finger DHHC-type palmitoyltransferase 23 affects expression EXP Omeprazole affects the expression of ZDHHC23 mRNA CTD PMID:19483382 NCBI chr11:70,224,581...70,240,971
Ensembl chr11:56,718,826...56,734,194
JBrowse link
G Zwint ZW10 interacting kinetochore protein affects expression EXP Omeprazole affects the expression of ZWINT mRNA CTD PMID:19483382 NCBI chr20:15,502,559...15,953,701
Ensembl chr20:15,938,157...15,953,957
JBrowse link
paroxetine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases export ISO ABCB1 protein results in increased export of Paroxetine CTD PMID:14550684 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO Paroxetine results in increased expression of ABCC2 protein CTD PMID:12524417 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [Paroxetine binds to APP 5' UTR] which results in decreased secretion of APP protein modified form CTD PMID:15681799 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Ar androgen receptor multiple interactions ISO Paroxetine binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein increases expression EXP Paroxetine results in increased expression of ARC mRNA CTD PMID:14580947 NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:106,555,785...106,559,378
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression ISO Paroxetine results in increased expression of BDNF mRNA; Paroxetine results in increased expression of BDNF protein CTD PMID:21301813 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Paroxetine results in increased activity of and results in increased cleavage of CASP3 protein
Paroxetine results in increased activity of CASP3 protein
CTD PMID:17174998 PMID:28482088 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO Paroxetine results in increased activity of CASP8 protein CTD PMID:28482088 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO Paroxetine results in increased activity of CASP9 protein CTD PMID:28482088 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cat catalase multiple interactions
decreases activity
ISO isoliquiritigenin inhibits the reaction [Paroxetine results in decreased activity of CAT protein]; Sildenafil Citrate inhibits the reaction [Paroxetine results in decreased activity of CAT protein] CTD PMID:36740106 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Chl1 cell adhesion molecule L1-like affects response to substance ISO CHL1 affects the susceptibility to Paroxetine CTD PMID:21332311 NCBI chr 4:137,847,648...138,062,077
Ensembl chr 4:136,291,463...136,503,265
JBrowse link
G Cs citrate synthase increases activity EXP Paroxetine results in increased activity of CS protein CTD PMID:20347017 NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:758,345...791,421
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Paroxetine results in decreased activity of CYP19A1 protein CTD PMID:26162595 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
decreases activity
ISO Paroxetine inhibits the reaction [CYP2B6 protein results in increased chemical synthesis of hydroxybupropion]; Paroxetine inhibits the reaction [CYP2B6 protein results in increased metabolism of Bupropion]
Paroxetine results in decreased activity of CYP2B6 protein
CTD PMID:21915887 NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases metabolic processing
decreases activity
multiple interactions
increases metabolic processing
increases response to substance
ISO CYP2D6 gene mutant form results in decreased metabolism of Paroxetine
Paroxetine results in decreased activity of CYP2D6 protein
[Paroxetine results in decreased activity of CYP2D6 protein] which results in decreased abundance of 4-hydroxy-N-desmethyltamoxifen; [Paroxetine results in decreased activity of CYP2D6 protein] which results in decreased degradation of Metoprolol; [Paroxetine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [Paroxetine results in decreased activity of CYP2D6 protein] which results in increased susceptibility to Metoprolol; Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in decreased susceptibility to Debrisoquin]; Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in decreased susceptibility to Nortriptyline]; Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in increased abundance of 10-hydroxynortriptyline]; Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in increased abundance of Debrisoquin metabolite]; Paroxetine inhibits the reaction [CYP2D6 protein results in increased chemical synthesis of Dextrorphan]; Paroxetine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; Paroxetine inhibits the reaction [CYP2D6 protein results in increased oxidation of dimemorfan]
CYP2D6 protein results in increased metabolism of Paroxetine
CYP2D6 gene mutant form results in increased susceptibility to Paroxetine
CTD PMID:10470702 PMID:11673748 PMID:12173784 PMID:12378847 PMID:14639062 More... NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Dbh dopamine beta-hydroxylase increases response to substance ISO DBH protein results in increased susceptibility to Paroxetine CTD PMID:15148402 NCBI chr 3:30,886,313...30,903,313
Ensembl chr 3:10,488,260...10,505,248
JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 multiple interactions ISO Paroxetine inhibits the reaction [Manganese deficiency results in decreased expression of DDAH1 protein] CTD PMID:21312047 NCBI chr 2:237,327,812...237,460,624
Ensembl chr 2:234,667,491...234,799,339
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [[Paroxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [[Paroxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Paroxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein CTD PMID:19662385 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Glud1 glutamate dehydrogenase 1 multiple interactions ISO Paroxetine inhibits the reaction [Manganese deficiency results in decreased expression of GLUD1 protein] CTD PMID:21312047 NCBI chr16:9,646,569...9,680,215
Ensembl chr16:9,640,312...9,673,957
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity
multiple interactions
ISO Paroxetine results in increased activity of GPT protein
isoliquiritigenin inhibits the reaction [Paroxetine results in increased activity of GPT protein]; Sildenafil Citrate inhibits the reaction [Paroxetine results in increased activity of GPT protein]
CTD PMID:36740106 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Hcrtr1 hypocretin receptor 1 increases expression ISO Paroxetine results in increased expression of HCRTR1 mRNA CTD PMID:21157932 NCBI chr 5:147,761,392...147,771,846
Ensembl chr 5:142,477,214...142,486,674
JBrowse link
G Hcrtr2 hypocretin receptor 2 increases expression ISO Paroxetine results in increased expression of HCRTR2 mRNA CTD PMID:21157932 NCBI chr 8:85,870,279...85,986,405
Ensembl chr 8:76,989,834...77,105,893
JBrowse link
G Hrh1 histamine receptor H 1 increases expression ISO Paroxetine results in increased expression of HRH1 mRNA CTD PMID:21157932 NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B decreases expression EXP Paroxetine results in decreased expression of HTR1B mRNA CTD PMID:10861803 NCBI chr 8:91,395,405...91,414,815
Ensembl chr 8:82,517,360...82,534,549
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A affects response to substance ISO HTR2A gene polymorphism affects the susceptibility to Paroxetine CTD PMID:17503984 NCBI chr15:56,360,647...56,428,703
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C multiple interactions ISO [[Paroxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [[Paroxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Paroxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein; Paroxetine binds to and results in increased activity of HTR2C protein CTD PMID:19662385 NCBI chr  X:115,453,190...115,682,325
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions
ISO Paroxetine results in increased expression of IL10 mRNA; Paroxetine results in increased expression of IL10 protein
LY 215840 inhibits the reaction [Paroxetine results in increased expression of IL10 mRNA]; LY 215840 inhibits the reaction [Paroxetine results in increased expression of IL10 protein]
CTD PMID:32020710 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il17a interleukin 17A multiple interactions
decreases expression
ISO LY 215840 inhibits the reaction [Paroxetine results in decreased expression of IL17A protein] CTD PMID:32020710 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il1b interleukin 1 beta affects expression ISO Paroxetine affects the expression of IL1B protein CTD PMID:32020710 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Ins2 insulin 2 multiple interactions EXP Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein]; pyrazolanthrone inhibits the reaction [Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein]] CTD PMID:17728140 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions
decreases activity
EXP Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein]; pyrazolanthrone inhibits the reaction [Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein]]
Paroxetine results in decreased activity of IRS1 protein
CTD PMID:17728140 NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Jak2 Janus kinase 2 multiple interactions
increases expression
ISO LY 215840 promotes the reaction [Paroxetine results in increased expression of JAK2 mRNA] CTD PMID:32020710 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO Paroxetine results in decreased activity of [KCNJ3 protein binds to KCNJ6 protein] CTD PMID:17072103 NCBI chr 3:60,353,990...60,518,110
Ensembl chr 3:39,945,351...40,109,124
JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions ISO Paroxetine results in decreased activity of [KCNJ6 protein binds to KCNJ5 protein] CTD PMID:17072103 NCBI chr 8:38,981,598...39,011,197
Ensembl chr 8:30,724,925...30,753,518
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 multiple interactions ISO Paroxetine results in decreased activity of [KCNJ3 protein binds to KCNJ6 protein]; Paroxetine results in decreased activity of [KCNJ6 protein binds to KCNJ5 protein]; Paroxetine results in decreased activity of [KCNJ6 protein binds to KCNJ6 protein] CTD PMID:17072103 NCBI chr11:47,531,312...47,778,348
Ensembl chr11:34,061,708...34,308,758
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [[Paroxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:19662385 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [[Paroxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:19662385 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity
multiple interactions
EXP Paroxetine results in increased activity of MAPK8 protein
pyrazolanthrone inhibits the reaction [Paroxetine results in increased phosphorylation of and results in increased activity of MAPK8 protein]
CTD PMID:17728140 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Pf4 platelet factor 4 decreases expression ISO Paroxetine results in decreased expression of PF4 protein CTD PMID:10770450 NCBI chr14:17,582,477...17,583,392
Ensembl chr14:17,298,308...17,299,365
JBrowse link
G Ppbp pro-platelet basic protein decreases expression ISO Paroxetine results in decreased expression of PPBP protein CTD PMID:10770450 NCBI chr14:17,586,495...17,587,299
Ensembl chr14:17,302,326...17,303,130
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Paroxetine results in decreased expression of PTGS2 mRNA; Paroxetine results in decreased expression of PTGS2 protein CTD PMID:17499975 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Paroxetine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc6a15 solute carrier family 6 member 15 multiple interactions ISO Paroxetine inhibits the reaction [Corticosterone results in decreased expression of SLC6A15 mRNA] CTD PMID:31344373 NCBI chr 7:40,439,607...40,493,788
Ensembl chr 7:38,553,196...38,607,239
JBrowse link
G Slc6a4 solute carrier family 6 member 4 decreases expression
multiple interactions
affects expression
ISO
EXP
Paroxetine results in decreased expression of SLC6A4 mRNA
Paroxetine binds to and results in decreased activity of SLC6A4 protein
Paroxetine affects the expression of SLC6A4 mRNA
CTD PMID:10575045 PMID:16055263 PMID:16272152 NCBI chr10:62,322,688...62,357,060
Ensembl chr10:61,826,123...61,858,384
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Paroxetine inhibits the reaction [Manganese deficiency results in increased expression of SOD2 protein] CTD PMID:21312047 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases expression
increases expression
multiple interactions
ISO Paroxetine results in decreased expression of STAT3 mRNA; Paroxetine results in decreased expression of STAT3 protein
Paroxetine results in increased expression of STAT3 mRNA
LY 215840 promotes the reaction [Paroxetine results in increased expression of STAT3 mRNA]
CTD PMID:17499975 PMID:32020710 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tfap2a transcription factor AP-2 alpha increases expression ISO Paroxetine results in increased expression of TFAP2A protein CTD PMID:28844482 NCBI chr17:24,230,064...24,253,219
Ensembl chr17:24,024,432...24,047,507
JBrowse link
G Tnf tumor necrosis factor decreases secretion
multiple interactions
decreases expression
ISO Paroxetine results in decreased secretion of TNF protein
LY 215840 inhibits the reaction [Paroxetine results in decreased expression of TNF protein]
CTD PMID:17499975 PMID:32020710 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Paroxetine results in increased expression of VEGFA mRNA CTD PMID:21301813 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vgf VGF nerve growth factor inducible increases expression ISO Paroxetine results in increased expression of VGF mRNA CTD PMID:21301813 NCBI chr12:25,274,004...25,281,803
Ensembl chr12:19,637,320...19,640,341
JBrowse link
quinidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
affects response to substance
decreases expression
affects transport
affects binding
multiple interactions
ISO ABCB1 protein results in increased transport of Quinidine
ABCB1A protein affects the susceptibility to Quinidine
Quinidine results in decreased expression of ABCB1 protein
ABCB1 protein affects the transport of Quinidine
Quinidine binds to ABCB1 protein
methoxyfenozide inhibits the reaction [ABCB1 protein results in increased transport of Quinidine]; Quinidine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Docetaxel]; Quinidine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; tebufenozide inhibits the reaction [ABCB1 protein results in increased transport of Quinidine]
CTD PMID:15502009 PMID:15616150 PMID:20196146 PMID:23976943 PMID:26995013 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects response to substance
affects activity
ISO
EXP
ABCB1B protein affects the susceptibility to Quinidine
Quinidine affects the activity of ABCB1B protein
CTD PMID:12626638 PMID:15502009 NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain decreases expression EXP Quinidine results in decreased expression of ACADM mRNA CTD PMID:17522070 NCBI chr 2:245,518,693...245,542,864
Ensembl chr 2:242,858,865...242,883,147
JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Quinidine results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Adra1a adrenoceptor alpha 1A affects binding
multiple interactions
ISO Quinidine binds to ADRA1A protein
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]
CTD PMID:9570190 NCBI chr15:45,005,648...45,111,416
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Adra1b adrenoceptor alpha 1B affects binding
multiple interactions
ISO Quinidine binds to ADRA1B protein
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]
CTD PMID:9570190 NCBI chr10:28,756,461...28,874,831
Ensembl chr10:28,255,025...28,312,919
JBrowse link
G Adra1d adrenoceptor alpha 1D affects binding
multiple interactions
ISO Quinidine binds to ADRA1D protein
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]
CTD PMID:9570190 NCBI chr 3:139,246,333...139,262,331
Ensembl chr 3:118,793,346...118,809,354
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP Quinidine results in increased expression of ALDOA mRNA CTD PMID:17522070 NCBI chr 1:190,832,820...190,838,021
Ensembl chr 1:181,402,275...181,406,182
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Quinidine results in increased expression of ASNS mRNA CTD PMID:15342952 NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Cat catalase increases expression ISO Quinidine results in increased expression of CAT protein CTD PMID:12708743 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Quinidine results in increased expression of CDKN1A protein CTD PMID:12243503 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 increases expression EXP Quinidine results in increased expression of CEACAM1 mRNA CTD PMID:17522070 NCBI chr 1:90,171,401...90,187,810
Ensembl chr 1:81,043,595...81,059,992
JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 decreases expression EXP Quinidine results in decreased expression of CYB5R3 mRNA CTD PMID:17522070 NCBI chr 7:116,186,729...116,204,290
Ensembl chr 7:114,306,685...114,324,298
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
ISO Quinidine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Quinidine results in decreased activity of CYP1A1 protein
CTD PMID:18420780 PMID:18493746 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO Quinidine affects the reaction [CYP1A2 protein results in increased oxidation of 4-amino-2-phenoxymethanesulfonanilide]
Quinidine results in decreased activity of CYP1A2 protein
CTD PMID:15916432 PMID:19053182 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Quinidine results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 decreases activity ISO Quinidine results in decreased activity of CYP2A4 protein CTD PMID:18420780 NCBI chr 1:91,299,584...91,307,650
Ensembl chr 1:82,169,949...82,179,979
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity ISO Quinidine results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity
multiple interactions
EXP
ISO
Quinidine results in decreased activity of CYP2C6 protein
Quinidine results in decreased activity of CYP2C29 protein
Quinidine affects the reaction [CYP2C19 protein results in increased oxidation of 4-amino-2-phenoxymethanesulfonanilide]
CTD PMID:12814958 PMID:18420780 PMID:19053182 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 multiple interactions EXP Quinidine inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin] CTD PMID:19858067 NCBI chr 7:115,815,212...115,819,281
Ensembl chr 7:113,935,138...113,939,209
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
decreases activity
multiple interactions
ISO
EXP
CYP2D6 protein results in increased metabolism of Quinidine
Quinidine results in decreased activity of CYP2D6 protein
[Quinidine results in decreased activity of CYP2D6 protein] which results in decreased glutathionylation of Duloxetine Hydrochloride
Quinidine results in decreased activity of CYP2D6 gene mutant form; Quinidine results in decreased activity of CYP2D6 protein
[Quinidine results in decreased activity of CYP2D6 protein] which affects the susceptibility to Oxycodone; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of 4-hydroxy-N-desmethyltamoxifen; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of Aconitine metabolite; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased hydroxylation of N-desmethyltamoxifen; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; Quinidine affects the reaction [CYP2D6 protein polymorphism affects the metabolism of dacomitinib]; Quinidine binds to and results in decreased activity of CYP2D6 protein; Quinidine inhibits the reaction [3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin results in increased metabolism of CYP2D6 protein]; Quinidine inhibits the reaction [[CYP2D6 protein results in increased metabolism of 7-methoxy-4-(aminomethyl)coumarin] which results in increased chemical synthesis of Coumarins]; Quinidine inhibits the reaction [CYP2D6 protein affects the metabolism of 1-(3-chlorophenyl)piperazine]; Quinidine inhibits the reaction [CYP2D6 protein results in increased chemical synthesis of Dextrorphan]; Quinidine inhibits the reaction [CYP2D6 protein results in increased hydrolysis of bufuralol]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Atomoxetine Hydrochloride]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of auriculasin]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of bufuralol]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of tegaserod]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of YM 758]; Quinidine inhibits the reaction [notopterol results in decreased activity of CYP2D6 protein]
CTD PMID:8819299 PMID:11377097 PMID:11560869 PMID:11673748 PMID:12464242 More... NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Quinidine results in decreased activity of CYP2E1 protein CTD PMID:18420780 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
affects metabolic processing
ISO Quinidine inhibits the reaction [CYP3A4 protein results in increased metabolism of YM 758]; Quinidine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]
CYP3A4 protein affects the metabolism of Quinidine
CTD PMID:2271712 PMID:15784650 PMID:19230594 PMID:19299527 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Depp1 DEPP autophagy regulator 1 increases expression ISO Quinidine results in increased expression of DEPP1 mRNA CTD PMID:17567588 NCBI chr 4:151,583,105...151,585,455
Ensembl chr 4:149,910,779...149,914,542
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Quinidine results in increased expression of FABP1 mRNA CTD PMID:17567588 NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fga fibrinogen alpha chain increases expression EXP Quinidine results in increased expression of FGA mRNA CTD PMID:17522070 NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:168,374,120...168,381,528
JBrowse link
G Fgb fibrinogen beta chain increases expression EXP Quinidine results in increased expression of FGB mRNA CTD PMID:17522070 NCBI chr 2:170,693,966...170,700,875
Ensembl chr 2:168,394,916...168,405,979
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity ISO Quinidine results in decreased activity of GSTM1 protein CTD PMID:11807801 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression EXP Quinidine results in decreased expression of GSTM3 mRNA CTD PMID:17522070 NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
decreases activity
ISO Quinidine inhibits the reaction [GSTP1 protein affects the metabolism of and results in decreased activity of Ethacrynic Acid]
Quinidine results in decreased activity of GSTP1 protein
CTD PMID:11807801 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hibadh 3-hydroxyisobutyrate dehydrogenase increases expression EXP Quinidine results in increased expression of HIBADH mRNA CTD PMID:17522070 NCBI chr 4:82,979,759...83,077,819
Ensembl chr 4:81,649,175...81,780,617
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Quinidine inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein] CTD PMID:17520698 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Quinidine results in increased expression of INHBE mRNA CTD PMID:15342952 NCBI chr 7:65,061,531...65,064,519
Ensembl chr 7:63,176,219...63,179,172
JBrowse link
G Kcnh1 potassium voltage-gated channel subfamily H member 1 multiple interactions ISO Quinidine inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein] CTD PMID:17520698 NCBI chr13:106,253,101...106,555,712
Ensembl chr13:103,722,245...104,024,740
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
affects activity
affects binding
affects localization
affects response to substance
decreases response to substance
ISO [Quinidine results in decreased activity of KCNH2 protein] which results in decreased import of Thallium; Acids inhibits the reaction [Quinidine results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [Quinidine results in decreased activity of KCNH2 protein]; Potassium inhibits the reaction [Quinidine results in decreased activity of KCNH2 protein]; Quinidine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Quinidine promotes the reaction [naringenin results in decreased activity of KCNH2 protein]
Quinidine affects the activity of KCNH2 protein
Quinidine binds to KCNH2 protein
Quinidine affects the localization of KCNH2 protein mutant form
KCNH2 gene SNP affects the susceptibility to Quinidine
KCNH2 gene mutant form results in decreased susceptibility to Quinidine
CTD PMID:11741928 PMID:12695533 PMID:15671647 PMID:15673388 PMID:15821840 More... NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kcnk1 potassium two pore domain channel subfamily K member 1 multiple interactions ISO Quinidine affects the reaction [KCNK1 protein results in increased transport of Potassium]; Quinidine inhibits the reaction [KCNK1 protein results in increased transport of Sodium] CTD PMID:16847696 NCBI chr19:70,856,985...70,895,053
Ensembl chr19:53,959,657...53,997,724
JBrowse link
G Kcnk18 potassium two pore domain channel subfamily K member 18 multiple interactions ISO Quinidine inhibits the reaction [KCNK18 protein results in increased transport of Potassium] CTD PMID:12754259 NCBI chr 1:268,360,738...268,375,012
Ensembl chr 1:258,374,671...258,388,945
JBrowse link
G Kcnk9 potassium two pore domain channel subfamily K member 9 multiple interactions EXP Quinidine inhibits the reaction [KCNK9 protein results in increased transport of Potassium] CTD PMID:10734076 NCBI chr 7:106,316,783...106,362,452
Ensembl chr 7:104,437,934...104,473,175
JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP Quinidine results in increased expression of LBP mRNA CTD PMID:17522070 NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:146,954,015...146,981,586
JBrowse link
G Lipc lipase C, hepatic type decreases expression EXP Quinidine results in decreased expression of LIPC mRNA CTD PMID:17522070 NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:71,509,635...71,635,464
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression EXP Quinidine results in decreased expression of MYC mRNA CTD PMID:17522070 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Quinidine results in increased expression of NUPR1 mRNA CTD PMID:17567588 NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:181,213,368...181,215,281
JBrowse link
G Otc ornithine transcarbamylase decreases expression EXP Quinidine results in decreased expression of OTC mRNA CTD PMID:17522070 NCBI chr  X:15,126,358...15,202,473
Ensembl chr  X:12,453,834...12,566,918
JBrowse link
G Pklr pyruvate kinase L/R decreases expression EXP Quinidine results in decreased expression of PKLR mRNA CTD PMID:17522070 NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:174,543,039...174,551,870
JBrowse link
G Ptma prothymosin alpha decreases expression EXP Quinidine results in decreased expression of PTMA mRNA CTD PMID:17522070 NCBI chr 9:94,624,194...94,628,276
Ensembl chr 9:87,176,230...87,180,333
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression EXP Quinidine results in increased expression of S100A9 mRNA CTD PMID:17522070 NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 affects response to substance ISO SCN5A gene mutant form affects the susceptibility to Quinidine CTD PMID:17805561 NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions EXP
ISO
[Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Phenylephrine; [Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Synephrine
Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of Monocrotaline]; Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of Quercetin]; Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of retrorsine]
CTD PMID:16141367 PMID:21140131 PMID:23831208 PMID:24799337 PMID:24947867 NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Quinidine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:16141367 PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Quinidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16141367 NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:48,235,476...48,324,612
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Quinidine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:155,960,946...156,025,472
JBrowse link
G Slc47a1 solute carrier family 47 member 1 decreases activity
multiple interactions
ISO Quinidine results in decreased activity of SLC47A1 protein
Quinidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD PMID:16928787 PMID:22419765 NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Quinidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,490,262...46,532,954
Ensembl chr10:45,991,095...46,033,904
JBrowse link
G Tagln transgelin decreases expression ISO Quinidine results in decreased expression of TAGLN mRNA CTD PMID:17567588 NCBI chr 8:55,121,647...55,127,121
Ensembl chr 8:46,222,472...46,230,668
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Quinidine results in increased expression of TIMP1 mRNA CTD PMID:17522070 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A decreases expression EXP Quinidine results in decreased expression of TNFRSF1A mRNA CTD PMID:17522070 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tnfrsf8 TNF receptor superfamily member 8 decreases expression ISO Quinidine results in decreased expression of TNFRSF8 protein CTD PMID:12441127 NCBI chr 5:162,406,387...162,451,620
Ensembl chr 5:157,123,185...157,168,421
JBrowse link
G Tp53 tumor protein p53 decreases expression EXP Quinidine results in decreased expression of TP53 mRNA CTD PMID:17522070 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
JBrowse link
rhapontigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 increases activity ISO rhapontigenin analog results in increased activity of ESR1 protein CTD PMID:17935960 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 increases activity
multiple interactions
ISO rhapontigenin analog results in increased activity of ESR2 protein
Fulvestrant inhibits the reaction [rhapontigenin analog results in increased activity of ESR2 protein]
CTD PMID:17692514 PMID:17935960 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Tf transferrin multiple interactions ISO rhapontigenin analog inhibits the reaction [Lipopolysaccharides results in increased activity of TF protein] CTD PMID:16507316 NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
sciadopitysin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
multiple interactions
ISO sciadopitysin results in decreased activity of ABCB1 protein
sciadopitysin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]
CTD PMID:30790579 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression
multiple interactions
ISO sciadopitysin results in increased expression of BGLAP protein
sciadopitysin inhibits the reaction [Antimycin A results in increased expression of BGLAP protein]
CTD PMID:23624148 NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO sciadopitysin inhibits the reaction [Antimycin A results in increased expression of TNF protein] CTD PMID:23624148 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
sulfamethoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO Sulfamethoxazole results in decreased activity of ABCB11 protein
Sulfamethoxazole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:24014644 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Acan aggrecan decreases expression EXP Sulfamethoxazole results in decreased expression of ACAN mRNA CTD PMID:26107568 NCBI chr 1:142,390,951...142,453,779
Ensembl chr 1:132,981,582...133,043,627
JBrowse link
G Alb albumin multiple interactions ISO Sulfamethoxazole metabolite binds to and results in increased metabolism of ALB protein CTD PMID:19358516 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Col2a1 collagen type II alpha 1 chain decreases expression EXP Sulfamethoxazole results in decreased expression of COL2A1 mRNA CTD PMID:26107568 NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP [SOD2 co-treated with CYP3A4] affects the susceptibility to Sulfamethoxazole CTD PMID:19501153 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Sulfamethoxazole metabolite binds to and results in increased metabolism of GSTP1 protein CTD PMID:19358516 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Ifng interferon gamma increases secretion ISO Sulfamethoxazole analog results in increased secretion of IFNG protein CTD PMID:15588915 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il5 interleukin 5 increases secretion ISO Sulfamethoxazole analog results in increased secretion of IL5 protein CTD PMID:15588915 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Mir155 microRNA 155 increases expression ISO Sulfamethoxazole results in increased expression of MIR155 mRNA CTD PMID:29644860 NCBI chr11:37,261,114...37,261,178
Ensembl chr11:23,774,654...23,774,718
JBrowse link
G Mir18a microRNA 18a increases expression ISO Sulfamethoxazole results in increased expression of MIR18A mRNA CTD PMID:29644860 NCBI chr15:98,587,984...98,588,079
Ensembl chr15:92,180,765...92,180,860
JBrowse link
G Mir21 microRNA 21 increases expression ISO Sulfamethoxazole results in increased expression of MIR21 mRNA CTD PMID:29644860 NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Sulfamethoxazole] which results in increased chemical synthesis of 4-nitrososulfamethoxazole; [MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Sulfamethoxazole CTD PMID:25531135 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nat2 N-acetyltransferase 2 increases metabolic processing ISO NAT2 protein results in increased metabolism of Sulfamethoxazole CTD PMID:16847467 NCBI chr16:26,974,874...27,005,191
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase decreases expression ISO Sulfamethoxazole results in decreased expression of PHYH mRNA CTD PMID:15342952 NCBI chr17:78,238,747...78,255,645
Ensembl chr17:73,329,082...73,346,409
JBrowse link
G Pir pirin increases expression ISO Sulfamethoxazole results in increased expression of PIR mRNA CTD PMID:22609641 NCBI chr  X:33,740,428...33,851,049
Ensembl chr  X:30,108,538...30,219,218
JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 affects expression ISO Sulfamethoxazole affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr20:1,329,227...1,333,394
Ensembl chr20:1,287,521...1,328,117
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP [SOD2 co-treated with CYP3A4] affects the susceptibility to Sulfamethoxazole CTD PMID:19501153 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression EXP Sulfamethoxazole results in decreased expression of SOX9 mRNA CTD PMID:26107568 NCBI chr10:98,305,744...98,311,250
Ensembl chr10:97,806,485...97,811,994
JBrowse link
sulfamethoxazole hydroxylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyb5b cytochrome b5 type B multiple interactions ISO [MTARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine; [MTARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 NCBI chr19:51,972,611...52,006,477
Ensembl chr19:35,062,813...35,098,249
JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 multiple interactions ISO [MTARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine; [MTARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 NCBI chr 7:116,186,729...116,204,290
Ensembl chr 7:114,306,685...114,324,298
JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 multiple interactions ISO [MTARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 NCBI chr13:98,854,235...98,894,208
Ensembl chr13:96,339,757...96,397,796
JBrowse link
G Mtarc2 mitochondrial amidoxime reducing component 2 multiple interactions ISO [MTARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 NCBI chr13:98,894,347...98,928,754 JBrowse link
sulfaphenazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Butyric Acid co-treated with Sulfaphenazole] inhibits the reaction [Oxalic Acid results in increased expression of BAX mRNA]; Sulfaphenazole inhibits the reaction [Oxalic Acid results in increased expression of BAX mRNA] CTD PMID:37414240 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Butyric Acid co-treated with Sulfaphenazole] inhibits the reaction [Oxalic Acid results in decreased expression of BCL2 mRNA]; Sulfaphenazole inhibits the reaction [Oxalic Acid results in decreased expression of BCL2 mRNA] CTD PMID:37414240 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Butyric Acid co-treated with Sulfaphenazole] inhibits the reaction [Oxalic Acid results in increased expression of CASP3 mRNA]; Sulfaphenazole inhibits the reaction [Oxalic Acid results in increased expression of CASP3 mRNA] CTD PMID:37414240 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [Butyric Acid co-treated with Sulfaphenazole] inhibits the reaction [Oxalic Acid results in increased expression of CCL2 mRNA]; Sulfaphenazole inhibits the reaction [Oxalic Acid results in increased expression of CCL2 mRNA] CTD PMID:37414240 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cd44 CD44 molecule multiple interactions ISO [Butyric Acid co-treated with Sulfaphenazole] inhibits the reaction [Oxalic Acid results in increased expression of CD44 mRNA]; Sulfaphenazole inhibits the reaction [Oxalic Acid results in increased expression of CD44 mRNA] CTD PMID:37414240 NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Sulfaphenazole results in decreased activity of CYP1A2 protein CTD PMID:15916432 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP Sulfaphenazole results in decreased expression of CYP2C11 CTD PMID:15890479 NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity
multiple interactions
EXP
ISO
Sulfaphenazole results in decreased activity of CYP2C6 protein
Sulfaphenazole inhibits the reaction [CYP2C19 protein results in increased metabolism of triflumuron]
CTD PMID:12814958 PMID:31082524 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO Sulfaphenazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] CTD PMID:31102695 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO Sulfaphenazole inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone] CTD PMID:31102695 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Sulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac] CTD PMID:24246759 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Sulfaphenazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA] CTD PMID:12763371 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO Sulfaphenazole affects the reaction [nimesulide affects the localization of NFE2L2 protein] CTD PMID:20405857 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO [Butyric Acid co-treated with Sulfaphenazole] inhibits the reaction [Oxalic Acid results in increased expression of SPP1 mRNA]; Sulfaphenazole inhibits the reaction [Oxalic Acid results in increased expression of SPP1 mRNA] CTD PMID:37414240 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162
JBrowse link
terbinafine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER2 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein] CTD PMID:16784723 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl27 C-C motif chemokine ligand 27 multiple interactions ISO Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER2 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]; Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein] CTD PMID:16784723 NCBI chr 5:61,737,261...61,744,375
Ensembl chr 5:56,941,402...56,948,506
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER2 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein] CTD PMID:16784723 PMID:23688403 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Terbinafine inhibits the reaction [Biological Products results in increased expression of CXCL10 mRNA]; Terbinafine inhibits the reaction [Biological Products results in increased expression of CXCL10 protein] CTD PMID:24471457 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Terbinafine results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Terbinafine results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
decreases activity
ISO [terbinafine results in decreased activity of CYP2D6 protein] inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol] CTD PMID:24894748 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases response to substance
increases expression
ISO CYP3A4 protein results in increased susceptibility to Terbinafine
Terbinafine results in increased expression of CYP3A4 mRNA
CTD PMID:21540358 PMID:36356836 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO terbinafine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases secretion
decreases expression
ISO 1-Methyl-3-isobutylxanthine inhibits the reaction [terbinafine results in decreased expression of IL4 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [terbinafine results in decreased secretion of IL4 protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Bucladesine inhibits the reaction [terbinafine results in decreased expression of IL4 mRNA]; Bucladesine inhibits the reaction [terbinafine results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [terbinafine results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [terbinafine results in decreased secretion of IL4 protein]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; terbinafine promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone] CTD PMID:11886533 PMID:15284827 PMID:23688403 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 multiple interactions
decreases expression
decreases secretion
ISO 1-Methyl-3-isobutylxanthine inhibits the reaction [Terbinafine results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Terbinafine results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [Terbinafine results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [Terbinafine results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Terbinafine results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Terbinafine results in decreased secretion of IL5 protein]
terbinafine results in decreased expression of IL5 mRNA
terbinafine results in decreased secretion of IL5 protein
CTD PMID:11886533 PMID:15284827 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO terbinafine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO terbinafine results in increased phosphorylation of MAPK1 protein CTD PMID:20816994 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO terbinafine results in increased phosphorylation of MAPK3 protein CTD PMID:20816994 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO terbinafine results in decreased expression of MMP2 mRNA CTD PMID:17172416 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO terbinafine results in decreased expression of MMP9 mRNA CTD PMID:17172416 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects response to substance ISO NFE2L2 protein affects the susceptibility to terbinafine CTD PMID:21540358 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein] CTD PMID:23688403 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ptger2 prostaglandin E receptor 2 multiple interactions
increases response to substance
ISO PTGER2 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER2 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER2 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]
PTGER2 protein results in increased susceptibility to terbinafine
CTD PMID:16784723 NCBI chr15:20,694,765...20,708,475
Ensembl chr15:18,217,285...18,228,714
JBrowse link
G Ptger3 prostaglandin E receptor 3 multiple interactions
increases response to substance
ISO PTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]
PTGER3 protein results in increased susceptibility to terbinafine
CTD PMID:16784723 NCBI chr 2:249,264,985...249,409,966
Ensembl chr 2:246,606,183...246,684,434
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO terbinafine results in decreased phosphorylation of PTK2 protein CTD PMID:17172416 NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Pxn paxillin decreases phosphorylation ISO terbinafine results in decreased phosphorylation of PXN protein CTD PMID:17172416 NCBI chr12:46,721,546...46,768,706
Ensembl chr12:41,060,791...41,107,931
JBrowse link
G Rhoa ras homolog family member A increases localization ISO terbinafine results in increased localization of RHOA protein CTD PMID:17172416 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rhob ras homolog family member B decreases expression ISO terbinafine results in decreased expression of RHOB protein CTD PMID:17172416 NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:31,363,548...31,366,108
JBrowse link
G Rhoc ras homolog family member C increases localization ISO terbinafine results in increased localization of RHOC protein CTD PMID:17172416 NCBI chr 2:194,975,586...194,981,637
Ensembl chr 2:192,287,130...192,295,306
JBrowse link
G RT1-CE16 RT1 class I, locus CE16 affects response to substance ISO HLA-A gene polymorphism affects the susceptibility to Terbinafine CTD PMID:28043905 NCBI chr20:3,261,656...3,265,548
Ensembl chr20:3,257,123...3,279,563
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO terbinafine inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein] CTD PMID:24471457 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER2 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER2 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER2 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER3 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]; Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]; Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; Terbinafine inhibits the reaction [TNF protein results in increased secretion of Thromboxane B2]; Terbinafine promotes the reaction [TNF protein results in increased secretion of Dinoprostone]; U 0126 inhibits the reaction [Terbinafine results in increased expression of TNF protein]
terbinafine results in increased expression of TNF protein
CTD PMID:16784723 PMID:20816994 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein] CTD PMID:23688403 NCBI chr18:24,723,990...24,728,419
Ensembl chr18:24,449,844...24,453,548
JBrowse link
trans-rhaponticin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions EXP rhapontin inhibits the reaction [Streptozocin results in decreased activity of CAT protein] CTD PMID:32662907 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP rhapontin inhibits the reaction [Streptozocin results in decreased expression of HMOX1 mRNA]; rhapontin inhibits the reaction [Streptozocin results in decreased expression of HMOX1 protein] CTD PMID:32662907 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il10 interleukin 10 multiple interactions EXP rhapontin inhibits the reaction [Streptozocin results in decreased expression of IL10 mRNA]; rhapontin inhibits the reaction [Streptozocin results in decreased expression of IL10 protein] CTD PMID:32662907 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Ins1 insulin 1 multiple interactions EXP rhapontin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] CTD PMID:32662907 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP rhapontin inhibits the reaction [Streptozocin results in increased expression of KEAP1 mRNA]; rhapontin inhibits the reaction [Streptozocin results in increased expression of KEAP1 protein] CTD PMID:32662907 NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP rhapontin inhibits the reaction [Streptozocin results in increased expression of MMP2 mRNA] CTD PMID:32662907 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP rhapontin inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 mRNA]; rhapontin inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 protein] CTD PMID:32662907 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP rhapontin inhibits the reaction [Streptozocin results in decreased expression of NQO1 mRNA] CTD PMID:32662907 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP rhapontin inhibits the reaction [Streptozocin results in decreased expression of TIMP1 mRNA] CTD PMID:32662907 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP rhapontin inhibits the reaction [Streptozocin results in increased expression of TNF mRNA] CTD PMID:32662907 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
tranylcypromine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arc activity-regulated cytoskeleton-associated protein increases expression EXP Tranylcypromine results in increased expression of ARC mRNA CTD PMID:14580947 NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:106,555,785...106,559,378
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Tranylcypromine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein] CTD PMID:19135049 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Tranylcypromine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein] CTD PMID:19135049 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Tranylcypromine results in increased expression of BDNF mRNA CTD PMID:8601816 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Tranylcypromine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein] CTD PMID:19135049 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression EXP Tranylcypromine results in increased expression of CREB1 mRNA CTD PMID:8601816 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]
Tranylcypromine results in decreased activity of CYP1A2 protein
CTD PMID:15916432 PMID:24120545 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 multiple interactions ISO Tranylcypromine inhibits the reaction [CYP2A13 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] CTD PMID:18669584 NCBI chr 1:91,359,278...91,372,554
Ensembl chr 1:82,231,611...82,244,887
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
decreases activity
ISO Tranylcypromine inhibits the reaction [[CYP2B6 protein results in increased metabolism of 7-ethoxy-4-trifluoromethylcoumarin] which results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]; Tranylcypromine inhibits the reaction [CYP2B6 protein results in increased metabolism of Bupropion]
Tranylcypromine results in decreased activity of CYP2B6 protein
CTD PMID:23850985 PMID:28119166 NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions
decreases activity
ISO Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Tranylcypromine inhibits the reaction [[CYP2C19 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein]; Tranylcypromine inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]
Tranylcypromine results in decreased activity of CYP2C19 protein
CTD PMID:12569440 PMID:15306208 PMID:23850985 PMID:24120545 PMID:28119166 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Tranylcypromine results in decreased activity of CYP2E1 protein CTD PMID:15155557 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO Tranylcypromine results in decreased activity of CYP2J2 protein CTD PMID:12851038 NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Egr1 early growth response 1 decreases expression EXP Tranylcypromine results in decreased expression of EGR1 mRNA CTD PMID:7612155 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Tranylcypromine results in decreased expression of FOS mRNA CTD PMID:7612155 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Tranylcypromine inhibits the reaction [[Methimazole co-treated with Buthionine Sulfoximine] results in increased activity of GPT protein] CTD PMID:34788025 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Tranylcypromine inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA] CTD PMID:12763371 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression EXP Tranylcypromine results in increased expression of NTRK2 mRNA CTD PMID:8601816 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr12:26,587,674...26,655,612
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions
ISO Tranylcypromine results in increased activity of TAAR1 protein
[Tranylcypromine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD PMID:19725810 NCBI chr 1:23,336,978...23,337,976
Ensembl chr 1:21,517,258...21,532,084
JBrowse link
voriconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apob apolipoprotein B increases expression EXP Voriconazole results in increased expression of APOB protein CTD PMID:37659626 NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO Voriconazole results in decreased activity of CA1 protein CTD PMID:31478295 NCBI chr 2:88,550,681...88,593,454
Ensembl chr 2:86,861,897...86,872,208
JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Voriconazole results in decreased activity of CA2 protein CTD PMID:31478295 NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression EXP Voriconazole results in decreased expression of CPT1A protein CTD PMID:37659626 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Voriconazole results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 affects metabolic processing
decreases activity
ISO CYP2C19 protein affects the metabolism of Voriconazole
Voriconazole results in decreased activity of CYP2C19 protein
CTD PMID:15328084 PMID:15914520 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
decreases activity
ISO CYP3A4 protein affects the metabolism of Voriconazole
Voriconazole results in decreased activity of CYP3A4 protein
CTD PMID:15328084 PMID:15914520 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp51 cytochrome P450, family 51 multiple interactions
decreases response to substance
ISO CYP51A1 gene inhibits the reaction [Voriconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Voriconazole results in decreased metabolism of and results in increased abundance of 14-methylergosta-8,24(28)-dien-3,6-diol]; CYP51A1 gene inhibits the reaction [Voriconazole results in decreased metabolism of and results in increased abundance of Lanosterol]
CYP51A1 gene results in decreased susceptibility to Voriconazole
CTD PMID:18694951 NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,036,865...30,055,410
Ensembl chr 6:30,036,865...30,055,410
JBrowse link
G Fasn fatty acid synthase decreases expression EXP Voriconazole results in decreased expression of FASN protein CTD PMID:37659626 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP Voriconazole results in increased activity of GPT protein CTD PMID:37659626 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Mttp microsomal triglyceride transfer protein increases expression EXP Voriconazole results in increased expression of MTTP protein CTD PMID:37659626 NCBI chr 2:229,286,501...229,327,650
Ensembl chr 2:226,613,090...226,654,239
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
decreases expression
ISO
EXP
[NR1I2 protein co-treated with NR1I3 protein] affects the metabolism of Voriconazole
Voriconazole results in decreased expression of NR1I2 protein
CTD PMID:23274663 PMID:37659626 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [NR1I2 protein co-treated with NR1I3 protein] affects the metabolism of Voriconazole CTD PMID:23274663 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression EXP Voriconazole results in increased expression of PPARA protein CTD PMID:37659626 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP Voriconazole results in decreased expression of SCD protein CTD PMID:37659626 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562
JBrowse link

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  CHEBI ontology 19904
    role 19875
      biological role 19873
        biochemical role 19583
          enzyme inhibitor 18780
            EC 1.* (oxidoreductase) inhibitor 17562
              EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor 16001
                EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor 1256
                  EC 1.14.14.1 (unspecific monooxygenase) inhibitor + 1007
                  EC 1.14.14.14 (aromatase) inhibitor + 356
                  EC 1.14.14.154 (sterol 14alpha-demethylase) inhibitor + 0
                  EC 1.14.14.91 ( trans-cinnamate 4-monooxygenase) inhibitor + 0
                  EC 1.14.14.94 (leukotriene-B4 20-monooxygenase) inhibitor + 0
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