Gene: Slc5a5 (solute carrier family 5 member 5) Rattus norvegicus
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Symbol:
Slc5a5
Name:
solute carrier family 5 member 5
Description:
Exhibits sodium:iodide symporter activity. Involved in iodide transport and sodium ion transport. Localizes to the plasma membrane. Human ortholog(s) of this gene implicated in congenital hypothyroidism. Orthologous to human SLC5A5 (solute carrier family 5 member 5); PARTICIPATES IN thyroid hormone biosynthetic pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3',4,4',5-Pentachlorobiphenyl.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
na(+)/I(-) cotransporter; na(+)/I(-) symporter; na(+)/I(-)-symporter; Na+/I- symporter; Nis; sodium-iodide symporter; sodium/iodide cotransporter; sodium/iodide symporter; solute carrier family 5 (sodium iodide symporter) member 5; solute carrier family 5 (sodium iodide symporter), member 5; solute carrier family 5 (sodium/iodide cotransporter), member 5; solute carrier family 5, member 5
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
SLC5A5 (solute carrier family 5 member 5) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Slc5a5 (solute carrier family 5 (sodium iodide symporter), member 5) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Slc5a5 (solute carrier family 5 member 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
SLC5A5 (solute carrier family 5 member 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SLC5A5 (solute carrier family 5 member 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Slc5a5 (solute carrier family 5 member 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
SLC5A5 (solute carrier family 5 member 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
SLC5A5 (solute carrier family 5 member 5)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Slc5a5 (solute carrier family 5 (sodium iodide symporter), member 5)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
slc5a5 (solute carrier family 5 member 5)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
CG10444
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Caenorhabditis elegans (roundworm):
ZK822.5
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER)
Drosophila melanogaster (fruit fly):
CG2187
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER)
Saccharomyces cerevisiae (baker's yeast):
DUR3
Alliance
DIOPT (InParanoid, PhylomeDB)
Drosophila melanogaster (fruit fly):
CG31262
Alliance
DIOPT (Ensembl Compara, Hieranoid, OrthoFinder, PANTHER)
Drosophila melanogaster (fruit fly):
CG31668
Alliance
DIOPT (Ensembl Compara, Hieranoid, OrthoFinder, PANTHER)
Drosophila melanogaster (fruit fly):
CG7720
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER)
Drosophila melanogaster (fruit fly):
CG32669
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Drosophila melanogaster (fruit fly):
CG33124
Alliance
DIOPT (Ensembl Compara, Hieranoid, OrthoFinder, PANTHER)
Drosophila melanogaster (fruit fly):
CG42235
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER)
Drosophila melanogaster (fruit fly):
CG5687
Alliance
DIOPT (Ensembl Compara, Hieranoid, OrthoFinder, PANTHER)
Drosophila melanogaster (fruit fly):
CG6723
Alliance
DIOPT (Ensembl Compara, Hieranoid, OrthoFinder, PANTHER)
Drosophila melanogaster (fruit fly):
CG9657
Alliance
DIOPT (Ensembl Compara, Hieranoid, OrthoFinder, PANTHER)
Drosophila melanogaster (fruit fly):
SLC5A11
Alliance
DIOPT (Ensembl Compara, Hieranoid, OrthoFinder, PANTHER)
Drosophila melanogaster (fruit fly):
Smvt
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER)
Drosophila melanogaster (fruit fly):
salt
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 16 20,297,414 - 20,307,401 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 16 20,297,414 - 20,307,400 (+) Ensembl Rnor_5.0 16 20,154,958 - 20,164,945 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 16 19,046,200 - 19,056,281 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 16 19,046,197 - 19,056,301 (+) NCBI Celera 16 18,739,349 - 18,749,322 (+) NCBI Celera Cytogenetic Map 16 p14 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
amenorrhea ISO RGD:731751 8554872 ClinVar Annotator: match by term: Primary amenorrhea ClinVar PMID:21681106 Thyroid Dyshormonogenesis ISO RGD:731751 8554872 ClinVar Annotator: match by term: Thyroid Hormonogenesis Defect ClinVar Thyroid Dyshormonogenesis ISO RGD:731751 8554872 ClinVar Annotator: match by term: Thyroid Hormonogenesis Defect ClinVar PMID:25741868 Thyroid Dyshormonogenesis 1 ISO RGD:731751 8554872 ClinVar Annotator: match by term: Thyroid dyshormonogenesis 1 ClinVar PMID:25741868 Thyroid Dyshormonogenesis 1 ISO RGD:731751 8554872 ClinVar Annotator: match by OMIM:274400 ClinVar PMID:12161518 , PMID:3451231 Thyroid Dyshormonogenesis 1 ISO RGD:731751 8554872 ClinVar Annotator: match by OMIM:274400 ClinVar PMID:9388506 Thyroid Dyshormonogenesis 1 ISO RGD:731751 8554872 ClinVar Annotator: match by OMIM:274400 ClinVar PMID:9745458 Thyroid Dyshormonogenesis 1 ISO RGD:731751 8554872 ClinVar Annotator: match by OMIM:274400 ClinVar PMID:9171822 more ... Thyroid Dyshormonogenesis 1 ISO RGD:731751 8554872 ClinVar Annotator: match by OMIM:274400 ClinVar PMID:10487695 , PMID:3998954 Thyroid Dyshormonogenesis 1 ISO RGD:731751 8554872 ClinVar Annotator: match by OMIM:274400 ClinVar PMID:9486973
Imported Annotations - CTD
Breast Neoplasms ISO RGD:731751 11554173 CTD Direct Evidence: therapeutic CTD PMID:12489024 cholangiocarcinoma ISO RGD:731751 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17408651 disease of cellular proliferation ISO RGD:731751 11554173 CTD Direct Evidence: therapeutic CTD PMID:15522214 hepatocellular carcinoma ISO RGD:731751 11554173 CTD Direct Evidence: therapeutic CTD PMID:15347726 , PMID:15520214 Kidney Neoplasms ISO RGD:731751 11554173 CTD Direct Evidence: therapeutic CTD PMID:12489024 malignant glioma ISO RGD:731751 11554173 CTD Direct Evidence: therapeutic CTD PMID:12489024 melanoma ISO RGD:731751 11554173 CTD Direct Evidence: therapeutic CTD PMID:12489024 Ovarian Neoplasms ISO RGD:731751 11554173 CTD Direct Evidence: therapeutic CTD PMID:12489024 Prostatic Neoplasms ISO RGD:731751 11554173 CTD Direct Evidence: therapeutic CTD PMID:12489024 , PMID:14633711 Thyroid Neoplasms ISO RGD:731751 11554173 CTD Direct Evidence: marker/mechanism, therapeutic CTD PMID:16954431 , PMID:17045167 Imported Annotations - OMIM
Thyroid Dyshormonogenesis 1 ISO RGD:731751 7240710 OMIM
1,3-benzothiazole-2-thiol multiple interactions ISO RGD:731751 6480464 captax inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine] CTD PMID:27979590 17beta-estradiol multiple interactions EXP 6480464 [Estradiol co-treated with OXT protein] results in increased expression of SLC5A5 mRNA CTD PMID:16954431 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of SLC5A5 protein CTD PMID:16954431 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:731752 6480464 [2 more ... CTD PMID:25510870 2,2',4,4'-Tetrabromodiphenyl ether decreases activity EXP 6480464 2 more ... CTD PMID:26827900 2,2',4,4'-Tetrabromodiphenyl ether multiple interactions ISO RGD:731751 6480464 2 more ... CTD PMID:27979590 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO RGD:731752 6480464 [2 more ... CTD PMID:25510870 2,3',4,4',5-Pentachlorobiphenyl multiple interactions EXP 6480464 alpha-naphthoflavone inhibits the reaction [2 more ... CTD PMID:26519956 2,3',4,4',5-Pentachlorobiphenyl decreases expression ISO RGD:731751 6480464 2 more ... CTD PMID:25644787 2,3',4,4',5-Pentachlorobiphenyl multiple interactions ISO RGD:731751 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2 more ... CTD PMID:25644787 2,3',4,4',5-Pentachlorobiphenyl decreases expression EXP 6480464 2 more ... CTD PMID:26519956 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:731752 6480464 Tetrachlorodibenzodioxin affects the expression of SLC5A5 mRNA CTD PMID:21570461 3,7-dihydropurine-6-thione decreases expression EXP 6480464 Mercaptopurine results in decreased expression of SLC5A5 mRNA CTD PMID:23358152 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:731751 6480464 1-Methyl-3-isobutylxanthine promotes the reaction [[Tretinoin co-treated with Hydrocortisone] affects the localization of SLC5A5 protein], 1-Methyl-3-isobutylxanthine promotes the reaction [[Tretinoin co-treated with Hydrocortisone] results in increased expression of SLC5A5 protein] CTD PMID:16439463 4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid multiple interactions ISO RGD:731751 6480464 4 more ... CTD PMID:12541134 5-aza-2'-deoxycytidine multiple interactions ISO RGD:731751 6480464 [[Butyrates co-treated with Decitabine] results in increased expression of SLC5A5 mRNA] which results in increased uptake of Iodine more ... CTD PMID:17967635 , PMID:19524134 5-aza-2'-deoxycytidine increases expression ISO RGD:731751 6480464 Decitabine results in increased expression of SLC5A5 mRNA CTD PMID:17967635 5-azacytidine multiple interactions ISO RGD:731751 6480464 [Azacitidine co-treated with Butyrates] affects the expression of SLC5A5 mRNA CTD PMID:17164311 5-azacytidine increases expression ISO RGD:731751 6480464 Azacitidine results in increased expression of SLC5A5 mRNA CTD PMID:16954431 5-Nitro-2-(3-phenylpropylamino)benzoic acid multiple interactions ISO RGD:731751 6480464 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine] CTD PMID:27979590 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of SLC5A5 mRNA CTD PMID:22342233 9-cis-retinoic acid increases expression ISO RGD:731751 6480464 Alitretinoin results in increased expression of SLC5A5 mRNA CTD PMID:16954431 acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of SLC5A5 mRNA CTD PMID:28959563 adenosine increases expression EXP 6480464 Adenosine results in increased expression of SLC5A5 mRNA, Adenosine results in increased expression of SLC5A5 protein CTD PMID:16954431 aflatoxin B1 decreases methylation ISO RGD:731751 6480464 Aflatoxin B1 results in decreased methylation of SLC5A5 intron CTD PMID:30157460 all-trans-retinoic acid multiple interactions ISO RGD:731751 6480464 1-Methyl-3-isobutylxanthine promotes the reaction [[Tretinoin co-treated with Hydrocortisone] affects the localization of SLC5A5 protein] more ... CTD PMID:16234306 more ... all-trans-retinoic acid decreases expression ISO RGD:731751 6480464 Tretinoin results in decreased expression of SLC5A5 mRNA CTD PMID:21924320 all-trans-retinoic acid increases expression ISO RGD:731751 6480464 Tretinoin results in increased expression of SLC5A5 mRNA, Tretinoin results in increased expression of SLC5A5 protein CTD PMID:16234306 more ... all-trans-retinoic acid affects localization ISO RGD:731751 6480464 Tretinoin affects the localization of SLC5A5 protein CTD PMID:16439463 alpha-naphthoflavone multiple interactions EXP 6480464 alpha-naphthoflavone inhibits the reaction [2 more ... CTD PMID:26519956 amiodarone decreases expression ISO RGD:731751 6480464 Amiodarone results in decreased expression of SLC5A5 mRNA CTD PMID:18020914 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of SLC5A5 mRNA CTD PMID:16483693 ATP multiple interactions ISO RGD:731751 6480464 Adenosine Triphosphate inhibits the reaction [TSHB protein results in increased expression of SLC5A5 protein] CTD PMID:16439463 benzo[a]pyrene diol epoxide I increases expression ISO RGD:731751 6480464 7 more ... CTD PMID:19150397 Benzo[ghi]perylene increases expression ISO RGD:731752 6480464 1, 12-benzoperylene results in increased expression of SLC5A5 mRNA CTD PMID:26377693 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SLC5A5 mRNA CTD PMID:26827900 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of SLC5A5 mRNA CTD PMID:23238275 more ... bisphenol A decreases activity EXP 6480464 bisphenol A results in decreased activity of SLC5A5 protein CTD PMID:26827900 Butylbenzyl phthalate increases expression ISO RGD:731751 6480464 butylbenzyl phthalate results in increased expression of SLC5A5 mRNA CTD PMID:16257484 Butylbenzyl phthalate increases expression EXP 6480464 butylbenzyl phthalate results in increased expression of SLC5A5 mRNA CTD PMID:16257484 carbamazepine multiple interactions ISO RGD:731751 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbamazepine promotes the reaction [Tretinoin results in increased expression of SLC5A5 protein]] more ... CTD PMID:20300827 cisplatin increases phosphorylation ISO RGD:731752 6480464 Cisplatin results in increased phosphorylation of SLC5A5 protein CTD PMID:22006019 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of SLC5A5 mRNA CTD PMID:24386269 Colforsin dapropate hydrochloride multiple interactions ISO RGD:731751 6480464 Colforsin inhibits the reaction [[Tretinoin co-treated with Hydrocortisone] results in increased activity of SLC5A5 protein] CTD PMID:16439463 Colforsin dapropate hydrochloride increases expression EXP 6480464 Colforsin results in increased expression of SLC5A5 mRNA, Colforsin results in increased expression of SLC5A5 protein CTD PMID:16954431 Colforsin dapropate hydrochloride increases expression ISO RGD:731751 6480464 Colforsin results in increased expression of SLC5A5 mRNA, Colforsin results in increased expression of SLC5A5 protein CTD PMID:16954431 cortisol multiple interactions ISO RGD:731751 6480464 1-Methyl-3-isobutylxanthine promotes the reaction [[Tretinoin co-treated with Hydrocortisone] affects the localization of SLC5A5 protein] more ... CTD PMID:16439463 cycloheximide increases expression ISO RGD:731751 6480464 Cycloheximide results in increased expression of SLC5A5 mRNA CTD PMID:17164311 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of SLC5A5 mRNA CTD PMID:21865292 cypermethrin multiple interactions ISO RGD:731751 6480464 cypermethrin inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine] CTD PMID:27979590 depsipeptide increases expression ISO RGD:731751 6480464 Depsipeptides results in increased expression of SLC5A5 mRNA, Depsipeptides results in increased expression of SLC5A5 protein CTD PMID:16954431 dexamethasone multiple interactions ISO RGD:731751 6480464 [Dexamethasone co-treated with Tretinoin] results in increased expression of SLC5A5 mRNA more ... CTD PMID:16234306 , PMID:16954431 dexamethasone decreases expression ISO RGD:731752 6480464 Dexamethasone results in decreased expression of SLC5A5 mRNA CTD PMID:22733784 Di-n-octyl phthalate increases expression EXP 6480464 di-n-octyl phthalate results in increased expression of SLC5A5 mRNA CTD PMID:16257484 Di-n-octyl phthalate increases expression ISO RGD:731751 6480464 di-n-octyl phthalate results in increased expression of SLC5A5 mRNA CTD PMID:16257484 dibutyl phthalate decreases expression ISO RGD:731751 6480464 Dibutyl Phthalate results in decreased expression of SLC5A5 mRNA CTD PMID:16257484 dibutyl phthalate multiple interactions ISO RGD:731751 6480464 Dibutyl Phthalate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine] CTD PMID:27979590 diiodine multiple interactions ISO RGD:731751 6480464 2 more ... CTD PMID:17967635 , PMID:27979590 diiodine increases uptake ISO RGD:731751 6480464 SLC5A5 protein results in increased uptake of Iodine CTD PMID:17332617 , PMID:27979590 diiodine increases uptake EXP 6480464 SLC5A5 protein results in increased uptake of Iodine CTD PMID:17408651 diiodine affects transport ISO RGD:731751 6480464 SLC5A5 protein affects the transport of Iodine CTD PMID:12602914 Diisodecyl phthalate increases expression ISO RGD:731751 6480464 diisodecyl phthalate results in increased expression of SLC5A5 mRNA CTD PMID:16257484 Diisodecyl phthalate increases expression EXP 6480464 diisodecyl phthalate results in increased expression of SLC5A5 mRNA CTD PMID:16257484 doxorubicin multiple interactions ISO RGD:731751 6480464 SLC5A5 protein promotes the reaction [Doxorubicin results in increased uptake of Sodium Pertechnetate Tc 99m] CTD PMID:15671536 efavirenz multiple interactions ISO RGD:731751 6480464 [efavirenz co-treated with TSHB protein] results in increased expression of SLC5A5 mRNA, [efavirenz co-treated with TSHB protein] results in increased expression of SLC5A5 protein CTD PMID:16030158 fipronil decreases expression EXP 6480464 fipronil results in decreased expression of SLC5A5 mRNA CTD PMID:23962444 furan increases expression EXP 6480464 furan results in increased expression of SLC5A5 mRNA CTD PMID:25539665 genistein increases expression ISO RGD:731751 6480464 Genistein results in increased expression of SLC5A5 mRNA CTD PMID:21738342 indometacin multiple interactions ISO RGD:731751 6480464 Indomethacin inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine] CTD PMID:27979590 iodide salt multiple interactions ISO RGD:731751 6480464 Dexamethasone promotes the reaction [SLC5A5 protein results in increased uptake of Iodides] more ... CTD PMID:15671536 more ... iodide salt affects expression EXP 6480464 Iodides deficiency affects the expression of SLC5A5 mRNA CTD PMID:21623536 iodide salt increases uptake ISO RGD:731751 6480464 SLC5A5 protein results in increased uptake of Iodides CTD PMID:15671536 more ... lead diacetate affects expression EXP 6480464 lead acetate affects the expression of SLC5A5 mRNA CTD PMID:21864555 LY294002 multiple interactions ISO RGD:731751 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2 more ... CTD PMID:20300827 , PMID:25644787 mancozeb multiple interactions ISO RGD:731751 6480464 mancozeb inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine] CTD PMID:27979590 masoprocol multiple interactions EXP 6480464 Masoprocol inhibits the reaction [TSHB protein results in increased expression of SLC5A5 mRNA] CTD PMID:17962351 mercaptopurine decreases expression EXP 6480464 Mercaptopurine results in decreased expression of SLC5A5 mRNA CTD PMID:23358152 methimazole increases expression ISO RGD:731752 6480464 Methimazole results in increased expression of SLC5A5 protein CTD PMID:17332529 methimazole increases expression ISO RGD:731751 6480464 Methimazole results in increased expression of SLC5A5 mRNA CTD PMID:22342233 methimazole increases expression EXP 6480464 Methimazole results in increased expression of SLC5A5 mRNA CTD PMID:22342233 metiram multiple interactions ISO RGD:731751 6480464 polymarcine inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine] CTD PMID:27979590 mibolerone multiple interactions ISO RGD:731751 6480464 mibolerone promotes the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide], perchlorate inhibits the reaction [mibolerone promotes the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]] CTD PMID:14633711 N-Vinyl-2-pyrrolidone multiple interactions EXP 6480464 [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which affects the expression of SLC5A5 mRNA CTD PMID:22037397 nevirapine multiple interactions ISO RGD:731751 6480464 [Nevirapine co-treated with TSHB protein] results in increased expression of SLC5A5 mRNA, [Nevirapine co-treated with TSHB protein] results in increased expression of SLC5A5 protein CTD PMID:16030158 ouabain multiple interactions ISO RGD:731751 6480464 Ouabain inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide] CTD PMID:12541134 perchlorate multiple interactions ISO RGD:731751 6480464 perchlorate inhibits the reaction [mibolerone promotes the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]] more ... CTD PMID:12601449 more ... perchlorate decreases activity EXP 6480464 perchlorate results in decreased activity of SLC5A5 protein CTD PMID:16987991 perchlorate affects expression EXP 6480464 perchlorate affects the expression of SLC5A5 mRNA CTD PMID:21623536 perchlorate increases expression ISO RGD:731752 6480464 perchlorate results in increased expression of SLC5A5 protein CTD PMID:17332529 phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of SLC5A5 mRNA CTD PMID:22037397 purine-6-thiol decreases expression EXP 6480464 Mercaptopurine results in decreased expression of SLC5A5 mRNA CTD PMID:23358152 quercetin affects expression ISO RGD:731751 6480464 Quercetin affects the expression of SLC5A5 mRNA CTD PMID:21738342 quercetin decreases expression EXP 6480464 Quercetin results in decreased expression of SLC5A5 mRNA, Quercetin results in decreased expression of SLC5A5 protein CTD PMID:24447974 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [TSHB protein results in increased expression of SLC5A5 mRNA] CTD PMID:17962351 resveratrol multiple interactions ISO RGD:731751 6480464 NOTCH1 mutant form inhibits the reaction [resveratrol results in increased expression of SLC5A5 mRNA] CTD PMID:23594881 resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of SLC5A5, resveratrol results in decreased expression of SLC5A5 protein CTD PMID:28668442 resveratrol increases expression ISO RGD:731751 6480464 resveratrol results in increased expression of SLC5A5 mRNA CTD PMID:21738342 , PMID:23594881 sodium bromide multiple interactions ISO RGD:731751 6480464 sodium bromide inhibits the reaction [SLC5A5 protein results in increased uptake of perrhenate analog] more ... CTD PMID:12488351 sodium chlorate multiple interactions ISO RGD:731751 6480464 sodium chlorate inhibits the reaction [SLC5A5 protein results in increased uptake of perrhenate analog] more ... CTD PMID:12488351 sodium iodide decreases export ISO RGD:731751 6480464 SLC5A5 protein results in decreased export of Sodium Iodide CTD PMID:15347726 , PMID:15522214 sodium iodide increases uptake ISO RGD:731751 6480464 SLC5A5 protein results in increased uptake of Sodium Iodide CTD PMID:12488351 more ... sodium iodide increases uptake EXP 6480464 SLC5A5 protein results in increased uptake of Sodium Iodide CTD PMID:12489024 , PMID:15520214 sodium iodide multiple interactions ISO RGD:731751 6480464 4 more ... CTD PMID:12488351 more ... sodium iodide multiple interactions EXP 6480464 sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide] CTD PMID:12489024 , PMID:15520214 sodium iodide increases activity EXP 6480464 Sodium Iodide results in increased activity of SLC5A5 protein CTD PMID:16987991 sodium iodide increases abundance ISO RGD:731751 6480464 SLC5A5 protein results in increased abundance of Sodium Iodide CTD PMID:15347726 sodium perchlorate multiple interactions EXP 6480464 sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide] CTD PMID:12489024 , PMID:15520214 sodium perchlorate increases expression EXP 6480464 sodium perchlorate results in increased expression of SLC5A5 mRNA, sodium perchlorate results in increased expression of SLC5A5 protein CTD PMID:29139221 sodium perchlorate multiple interactions ISO RGD:731751 6480464 sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine] more ... CTD PMID:12488351 more ... sodium perchlorate decreases activity EXP 6480464 sodium perchlorate results in decreased activity of SLC5A5 protein CTD PMID:26827900 sodium thiocyanate multiple interactions ISO RGD:731751 6480464 sodium thiocyanate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine] more ... CTD PMID:12488351 , PMID:27979590 tazarotene increases expression ISO RGD:731751 6480464 tazarotene results in increased expression of SLC5A5 mRNA CTD PMID:16954431 tebuconazole decreases expression ISO RGD:731751 6480464 tebuconazole results in decreased expression of SLC5A5 mRNA CTD PMID:30458266 technetium atom increases uptake ISO RGD:731751 6480464 SLC5A5 protein results in increased uptake of Technetium CTD PMID:15221289 technetium atom multiple interactions ISO RGD:731751 6480464 sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Technetium] CTD PMID:15221289 tetraoxorhenate(1-) multiple interactions ISO RGD:731751 6480464 dysidenin inhibits the reaction [SLC5A5 protein results in increased uptake of perrhenate analog] more ... CTD PMID:12488351 tetraoxorhenate(1-) increases uptake ISO RGD:731751 6480464 SLC5A5 protein results in increased uptake of perrhenate, SLC5A5 protein results in increased uptake of perrhenate analog CTD PMID:12488351 , PMID:15347726 theophylline increases expression ISO RGD:731751 6480464 Theophylline results in increased expression of SLC5A5 protein CTD PMID:19409042 thiocyanate multiple interactions ISO RGD:731751 6480464 thiocyanate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodides] CTD PMID:15850642 thiocyanate affects transport ISO RGD:731751 6480464 SLC5A5 protein affects the transport of thiocyanate CTD PMID:15345749 thyroxine decreases expression ISO RGD:731752 6480464 Thyroxine results in decreased expression of SLC5A5 protein CTD PMID:17332529 trichostatin A increases expression ISO RGD:731751 6480464 trichostatin A results in increased expression of SLC5A5 mRNA, trichostatin A results in increased expression of SLC5A5 protein CTD PMID:16954431 triclocarban decreases activity EXP 6480464 triclocarban results in decreased activity of SLC5A5 protein CTD PMID:26827900 triclocarban multiple interactions ISO RGD:731751 6480464 triclocarban inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine] CTD PMID:27979590 triclosan decreases activity EXP 6480464 Triclosan results in decreased activity of SLC5A5 protein CTD PMID:26827900 triphenyl phosphate increases expression EXP 6480464 triphenyl phosphate results in increased expression of SLC5A5 mRNA CTD PMID:25646720 troglitazone multiple interactions ISO RGD:731751 6480464 [troglitazone co-treated with Tretinoin] results in increased expression of SLC5A5 mRNA CTD PMID:16954431 troglitazone increases expression ISO RGD:731751 6480464 troglitazone results in increased expression of SLC5A5 mRNA CTD PMID:15785241 , PMID:16954431 valproic acid increases expression ISO RGD:731751 6480464 Valproic Acid results in increased expression of SLC5A5 mRNA, Valproic Acid results in increased expression of SLC5A5 protein CTD PMID:16954431 valproic acid increases expression ISO RGD:731752 6480464 Valproic Acid results in increased expression of SLC5A5 mRNA CTD PMID:19136453 , PMID:21427059 vemurafenib multiple interactions ISO RGD:731751 6480464 [BRAF protein mutant form affects the susceptibility to vemurafenib] which affects the expression of SLC5A5 mRNA more ... CTD PMID:26751190 vorinostat multiple interactions ISO RGD:731751 6480464 [vemurafenib co-treated with vorinostat] results in increased expression of SLC5A5 protein more ... CTD PMID:26751190 vorinostat increases expression ISO RGD:731751 6480464 vorinostat results in increased expression of SLC5A5 mRNA CTD PMID:26751190 wortmannin multiple interactions ISO RGD:731751 6480464 wortmannin inhibits the reaction [Carbamazepine promotes the reaction [Tretinoin results in increased expression of SLC5A5 protein]] CTD PMID:20300827
Gene-Chemical Interaction Annotations
