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Gene: Slc5a5 (solute carrier family 5 member 5) Rattus norvegicus
Symbol: Slc5a5
Name: solute carrier family 5 member 5
Description: Exhibits sodium:iodide symporter activity. Involved in iodide transport and sodium ion transport. Localizes to the plasma membrane. Human ortholog(s) of this gene implicated in congenital hypothyroidism. Orthologous to human SLC5A5 (solute carrier family 5 member 5); PARTICIPATES IN thyroid hormone biosynthetic pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3',4,4',5-Pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: na(+)/I(-) cotransporter; na(+)/I(-) symporter; na(+)/I(-)-symporter; Na+/I- symporter; Nis; sodium-iodide symporter; sodium/iodide cotransporter; sodium/iodide symporter; solute carrier family 5 (sodium iodide symporter) member 5; solute carrier family 5 (sodium iodide symporter), member 5; solute carrier family 5 (sodium/iodide cotransporter), member 5; solute carrier family 5, member 5
Homo sapiens (human) : SLC5A5 (solute carrier family 5 member 5)  HGNC  Alliance
Mus musculus (house mouse) : Slc5a5 (solute carrier family 5 (sodium iodide symporter), member 5)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc5a5 (solute carrier family 5 member 5)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC5A5 (solute carrier family 5 member 5)
Canis lupus familiaris (dog) : SLC5A5 (solute carrier family 5 member 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc5a5 (solute carrier family 5 member 5)
Sus scrofa (pig) : SLC5A5 (solute carrier family 5 member 5)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01620,297,414 - 20,307,401 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,297,414 - 20,307,400 (+)Ensembl
Rnor_5.01620,154,958 - 20,164,945 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,046,200 - 19,056,281 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11619,046,197 - 19,056,301 (+)NCBI
Celera1618,739,349 - 18,749,322 (+)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Slc5a5
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69267
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.