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Gene: Lifr (LIF receptor subunit alpha) Rattus norvegicus
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Symbol: Lifr
Name: LIF receptor subunit alpha
Description: Exhibits cytokine binding activity and leukemia inhibitory factor receptor activity. Predicted to contribute to ciliary neurotrophic factor receptor activity and oncostatin-M receptor activity. Involved in several processes, including animal organ regeneration; negative regulation of muscle cell apoptotic process; and neuron projection morphogenesis. Predicted to localize to the external side of plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in osteochondrodysplasia. Orthologous to human LIFR (LIF receptor subunit alpha); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: leukemia inhibitor factor receptor alpha-chain; leukemia inhibitory factor receptor; leukemia inhibitory factor receptor alpha; LIF receptor; LIF receptor alpha; LIF-R
Orthologs:
Homo sapiens (human) : LIFR (LIF receptor subunit alpha)  HGNC  Alliance
Mus musculus (house mouse) : Lifr (LIF receptor alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lifr (LIF receptor subunit alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : LIFR (LIF receptor subunit alpha)
Canis lupus familiaris (dog) : LIFR (LIF receptor subunit alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lifr (LIF receptor subunit alpha)
Sus scrofa (pig) : LOC102167255 (leukemia inhibitory factor receptor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0256,424,910 - 56,489,346 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0276,165,154 - 76,229,631 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4256,426,058 - 56,477,198 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1256,354,290 - 56,405,431 (+)NCBI
Celera251,855,443 - 51,906,055 (+)NCBICelera
Cytogenetic Map2q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Lifr
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621431
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.