Lifr (LIF receptor subunit alpha) - Rat Genome Database

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Gene: Lifr (LIF receptor subunit alpha) Rattus norvegicus
Analyze
Symbol: Lifr
Name: LIF receptor subunit alpha
RGD ID: 621431
Description: Enables cytokine binding activity and leukemia inhibitory factor receptor activity. Involved in several processes, including animal organ regeneration; negative regulation of muscle cell apoptotic process; and neuron projection morphogenesis. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in osteochondrodysplasia. Orthologous to human LIFR (LIF receptor subunit alpha); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: leukemia inhibitor factor receptor alpha-chain; leukemia inhibitory factor receptor; leukemia inhibitory factor receptor alpha; LIF receptor; LIF receptor alpha; LIF-R
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8257,951,787 - 58,020,357 (+)NCBIGRCr8
mRatBN7.2256,224,393 - 56,292,988 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl256,250,120 - 56,286,699 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx263,340,495 - 63,390,488 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0261,410,670 - 61,461,110 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0256,411,932 - 56,462,624 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0256,424,910 - 56,489,346 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl256,426,367 - 56,489,415 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0276,165,154 - 76,229,631 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4256,426,058 - 56,477,198 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1256,354,290 - 56,405,431 (+)NCBI
Celera251,855,443 - 51,906,055 (+)NCBICelera
Cytogenetic Map2q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acetic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
asbestos  (ISO)
atrazine  (EXP)
belinostat  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromochloroacetic acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
folic acid  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
glyphosate  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
letrozole  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
mercury dibromide  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
nevirapine  (EXP)
nickel sulfate  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
pyridaben  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
rofecoxib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
starch  (EXP)
sulfadimethoxine  (EXP)
tamoxifen  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular cloning of rat leukemia inhibitory factor receptor alpha-chain gene and its expression during pregnancy. Aikawa J, etal., Biochim Biophys Acta 1997 Sep 12;1353(3):266-76.
2. Null leukemia inhibitory factor receptor (LIFR) mutations in Stuve-Wiedemann/Schwartz-Jampel type 2 syndrome. Dagoneau N, etal., Am J Hum Genet. 2004 Feb;74(2):298-305. Epub 2004 Jan 21.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Evidence that IL-6-type cytokine signaling in cardiomyocytes is inhibited by oxidative stress: parthenolide targets JAK1 activation by generating ROS. Kurdi M and Booz GW, J Cell Physiol. 2007 Aug;212(2):424-31.
5. Increased expression of IL-6 and LIF in the hypertrophied left ventricle of TGR(mRen2)27 and SHR rats. Kurdi M, etal., Mol Cell Biochem. 2005 Jan;269(1-2):95-101.
6. Characterization of the protective effects of cardiotrophin-1 against non-ischemic death stimuli in adult cardiomyocytes. Lopez N, etal., Cytokine. 2005 Jun 7;30(5):282-92. Epub 2005 Apr 2.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Leukemia inhibitory factor receptor signaling negatively modulates nerve growth factor-induced neurite outgrowth in PC12 cells and sympathetic neurons. Ng YP, etal., J Biol Chem. 2003 Oct 3;278(40):38731-9. Epub 2003 Jul 18.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Leukemia inhibitory factor is involved in tubular regeneration after experimental acute renal failure. Yoshino J, etal., J Am Soc Nephrol. 2003 Dec;14(12):3090-101.
16. Effect of tea polyphenol on cytokine gene expression in rats with alcoholic liver disease. Zhang XG, etal., Hepatobiliary Pancreat Dis Int. 2006 May;5(2):268-72.
Additional References at PubMed
PMID:7957045   PMID:8385113   PMID:8999038   PMID:12643274   PMID:12707266   PMID:15051883   PMID:15716858   PMID:17873291   PMID:21446866   PMID:22291973   PMID:23064267   PMID:23533145  
PMID:24006456   PMID:30937308  


Genomics

Comparative Map Data
Lifr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8257,951,787 - 58,020,357 (+)NCBIGRCr8
mRatBN7.2256,224,393 - 56,292,988 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl256,250,120 - 56,286,699 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx263,340,495 - 63,390,488 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0261,410,670 - 61,461,110 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0256,411,932 - 56,462,624 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0256,424,910 - 56,489,346 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl256,426,367 - 56,489,415 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0276,165,154 - 76,229,631 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4256,426,058 - 56,477,198 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1256,354,290 - 56,405,431 (+)NCBI
Celera251,855,443 - 51,906,055 (+)NCBICelera
Cytogenetic Map2q16NCBI
LIFR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38538,474,668 - 38,608,403 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl538,474,668 - 38,608,354 (-)EnsemblGRCh38hg38GRCh38
GRCh37538,474,770 - 38,595,507 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36538,510,822 - 38,631,253 (-)NCBINCBI36Build 36hg18NCBI36
Build 34538,515,661 - 38,631,253NCBI
Celera538,361,644 - 38,482,099 (-)NCBICelera
Cytogenetic Map5p13.1NCBI
HuRef538,427,081 - 38,547,293 (-)NCBIHuRef
CHM1_1538,476,985 - 38,597,458 (-)NCBICHM1_1
T2T-CHM13v2.0538,723,737 - 38,857,447 (-)NCBIT2T-CHM13v2.0
Lifr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39157,120,091 - 7,226,970 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl157,120,095 - 7,226,970 (+)EnsemblGRCm39 Ensembl
GRCm38157,090,610 - 7,197,489 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl157,090,614 - 7,197,489 (+)EnsemblGRCm38mm10GRCm38
MGSCv37157,079,572 - 7,147,489 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36157,087,757 - 7,138,433 (+)NCBIMGSCv36mm8
Celera156,977,793 - 7,045,762 (+)NCBICelera
Cytogenetic Map15A1NCBI
cM Map153.46NCBI
Lifr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542623,047,167 - 23,116,891 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542623,045,867 - 23,093,694 (-)NCBIChiLan1.0ChiLan1.0
LIFR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2471,780,323 - 71,863,299 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1569,933,979 - 70,016,932 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0571,817,431 - 71,899,101 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1576,878,633 - 76,934,893 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl576,878,633 - 76,928,267 (+)Ensemblpanpan1.1panPan2
LIFR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1470,328,963 - 70,376,127 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl470,267,514 - 70,376,127 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha470,004,435 - 70,051,591 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0470,845,522 - 70,892,699 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl470,839,649 - 70,893,245 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1470,593,619 - 70,640,769 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0470,707,131 - 70,754,284 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0471,245,697 - 71,292,862 (+)NCBIUU_Cfam_GSD_1.0
Lifr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213227,678,883 - 227,719,656 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365183,652,152 - 3,693,078 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365183,651,630 - 3,693,072 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC102167255
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1623,634,298 - 23,804,854 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11623,627,700 - 23,672,724 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21624,852,896 - 24,857,618 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LIFR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1437,307,753 - 37,385,489 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl437,314,347 - 37,362,137 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607127,670,489 - 27,746,669 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lifr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475916,410,687 - 16,472,014 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475916,368,390 - 16,478,486 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lifr
573 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:42
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000016036
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22238462767384627Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)238573329122609194Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24280460760653831Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
12879863Bp402Blood pressure QTL 4020.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24112578956532139Rat
1354592Rf50Renal function QTL 503.5urine output (VT:0003620)timed urine volume (CMO:0000260)25382274774786777Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)228484589169504100Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)228484589169504100Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000016036   ⟹   ENSRNOP00000016036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl256,250,120 - 56,286,699 (+)Ensembl
Rnor_6.0 Ensembl256,426,367 - 56,489,415 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102098   ⟹   ENSRNOP00000081114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl256,250,120 - 56,280,422 (+)Ensembl
RefSeq Acc Id: NM_031048   ⟹   NP_112310
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8257,963,389 - 58,014,068 (+)NCBI
mRatBN7.2256,236,013 - 56,286,699 (+)NCBI
Rnor_6.0256,436,726 - 56,487,589 (+)NCBI
Rnor_5.0276,165,154 - 76,229,631 (+)NCBI
RGSC_v3.4256,426,058 - 56,477,198 (+)RGD
Celera251,855,443 - 51,906,055 (+)RGD
Sequence:
RefSeq Acc Id: XM_006232027   ⟹   XP_006232089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8257,952,973 - 58,020,357 (+)NCBI
mRatBN7.2256,225,598 - 56,292,988 (+)NCBI
Rnor_6.0256,426,445 - 56,489,346 (+)NCBI
Rnor_5.0276,165,154 - 76,229,631 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006232029   ⟹   XP_006232091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8257,951,787 - 58,020,357 (+)NCBI
mRatBN7.2256,224,393 - 56,292,988 (+)NCBI
Rnor_6.0256,424,910 - 56,489,346 (+)NCBI
Rnor_5.0276,165,154 - 76,229,631 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039103223   ⟹   XP_038959151
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8257,951,791 - 58,020,357 (+)NCBI
mRatBN7.2256,224,393 - 56,292,988 (+)NCBI
RefSeq Acc Id: XM_063282627   ⟹   XP_063138697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8257,952,973 - 58,020,357 (+)NCBI
RefSeq Acc Id: NP_112310   ⟸   NM_031048
- Peptide Label: precursor
- UniProtKB: O70535 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006232091   ⟸   XM_006232029
- Peptide Label: isoform X1
- UniProtKB: G3V7K2 (UniProtKB/TrEMBL),   A6KGG5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232089   ⟸   XM_006232027
- Peptide Label: isoform X1
- UniProtKB: G3V7K2 (UniProtKB/TrEMBL),   A6KGG5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016036   ⟸   ENSRNOT00000016036
RefSeq Acc Id: XP_038959151   ⟸   XM_039103223
- Peptide Label: isoform X1
- UniProtKB: G3V7K2 (UniProtKB/TrEMBL),   A6KGG5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000081114   ⟸   ENSRNOT00000102098
RefSeq Acc Id: XP_063138697   ⟸   XM_063282627
- Peptide Label: isoform X1
- UniProtKB: A6KGG5 (UniProtKB/TrEMBL),   G3V7K2 (UniProtKB/TrEMBL)
Protein Domains
Fibronectin type-III

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70535-F1-model_v2 AlphaFold O70535 1-1093 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691172
Promoter ID:EPDNEW_R1697
Type:initiation region
Name:Lifr_1
Description:LIF receptor alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0256,426,337 - 56,426,397EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621431 AgrOrtholog
BioCyc Gene G2FUF-54147 BioCyc
Ensembl Genes ENSRNOG00000011696 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016036.5 UniProtKB/TrEMBL
  ENSRNOT00000102098.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hematopoietin_rcpt_Gp130_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIF-R-like_Ig-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIFR_D2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIFR_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Type-I_Cytokine_Rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81680 UniProtKB/Swiss-Prot
NCBI Gene 81680 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LEUKEMIA INHIBITORY FACTOR RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIF-R_Ig-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIFR_D2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIFR_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lifr PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMATOPO_REC_L_F2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011696 RatGTEx
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZRS1_RAT UniProtKB/TrEMBL
  A6KGG5 ENTREZGENE, UniProtKB/TrEMBL
  G3V7K2 ENTREZGENE, UniProtKB/TrEMBL
  LIFR_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-29 Lifr  LIF receptor subunit alpha  Lifr  LIF receptor alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-03-27 Lifr  LIF receptor alpha  Lifr  leukemia inhibitory factor receptor alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Lifr  leukemia inhibitory factor receptor alpha  Lifr  leukemia inhibitory factor receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Lifr  leukemia inhibitory factor receptor    leukemia inhibitor factor receptor alpha-chain  Name updated 1299863 APPROVED
2002-08-07 Lifr  leukemia inhibitor factor receptor alpha-chain      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver and placenta 633290