Hba-a2 (hemoglobin alpha, adult chain 2) - Rat Genome Database

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Gene: Hba-a2 (hemoglobin alpha, adult chain 2) Rattus norvegicus
Analyze
Symbol: Hba-a2
Name: hemoglobin alpha, adult chain 2
RGD ID: 1359364
Description: Is predicted to contribute to haptoglobin binding activity and peroxidase activity. Involved in response to estradiol. Predicted to localize to several cellular components, including cytosolic small ribosomal subunit; haptoglobin-hemoglobin complex; and hemoglobin complex. Human ortholog(s) of this gene implicated in Heinz body anemia; alpha thalassemia; familial erythrocytosis 7; and hemoglobin H disease. Orthologous to several human genes including HBA2 (hemoglobin subunit alpha 2); INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2-alpha globin; 2-alpha-1 globin; Alpha-1/2-globin; Glnc2; Glnc3; globin c2; globin c3; Hba-a1; Hba1; Hba2; hemoglobin alpha 2 chain; Hemoglobin alpha-1/2 chain; Hemoglobin subunit alpha-1/2; hemoglobin, alpha 2; LOC360504
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21015,323,830 - 15,324,677 (-)NCBI
Rnor_6.0 Ensembl1015,589,364 - 15,590,220 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01015,589,364 - 15,590,207 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01015,484,459 - 15,485,302 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41015,570,930 - 15,571,773 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11015,571,977 - 15,572,821 (-)NCBI
Celera1014,991,420 - 14,992,263 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
aconitine  (EXP)
aldehydo-D-glucose  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
barium sulfate  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
biotin  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP)
buspirone  (EXP)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
ceric oxide  (EXP)
cetilistat  (ISO)
chromium atom  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
coumarin  (EXP)
cyanocob(III)alamin  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
DDE  (ISO)
dibromoacetic acid  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (EXP)
dioxygen  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
flutamide  (EXP)
furan  (EXP)
glucose  (ISO)
hydralazine  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
L-ethionine  (EXP)
linezolid  (EXP)
methotrexate  (EXP)
methyl methanesulfonate  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
nickel subsulfide  (EXP)
nicotinamide  (EXP)
nimesulide  (EXP)
omeprazole  (EXP)
orlistat  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (EXP)
PhIP  (EXP)
picolinic acid  (ISO)
pirinixic acid  (EXP)
potassium dichromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
sarin  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
streptozocin  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
toluene  (EXP)
tremolite asbestos  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
tris(picolinato)chromium  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:7550311   PMID:8706699   PMID:12477932   PMID:19740759   PMID:19946888   PMID:20458337   PMID:21805676   PMID:22516433   PMID:23012479   PMID:23376485   PMID:23533145   PMID:25002582  
PMID:26316108  


Genomics

Comparative Map Data
Hba-a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21015,323,830 - 15,324,677 (-)NCBI
Rnor_6.0 Ensembl1015,589,364 - 15,590,220 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01015,589,364 - 15,590,207 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01015,484,459 - 15,485,302 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41015,570,930 - 15,571,773 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11015,571,977 - 15,572,821 (-)NCBI
Celera1014,991,420 - 14,992,263 (-)NCBICelera
Cytogenetic Map10q12NCBI
HBA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl16176,680 - 177,522 (+)EnsemblGRCh38hg38GRCh38
GRCh3816176,680 - 177,522 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3716226,679 - 227,521 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3616166,679 - 167,520 (+)NCBINCBI36hg18NCBI36
Build 3416166,678 - 167,520NCBI
Celera16426,194 - 427,035 (+)NCBI
Cytogenetic Map16p13.3NCBI
HuRef16144,721 - 145,562 (+)NCBIHuRef
CHM1_116226,657 - 227,528 (+)NCBICHM1_1
Hba-a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391132,246,492 - 32,247,310 (+)NCBIGRCm39mm39
GRCm39 Ensembl1132,246,489 - 32,247,298 (+)Ensembl
GRCm381132,296,492 - 32,297,310 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1132,296,489 - 32,297,298 (+)EnsemblGRCm38mm10GRCm38
MGSCv371132,196,492 - 32,197,310 (+)NCBIGRCm37mm9NCBIm37
Celera1134,701,680 - 34,701,823 (+)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1118.87NCBI
LOC100855540
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1640,324,378 - 40,325,427 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha641,588,015 - 41,589,066 (-)NCBI
ROS_Cfam_1.0640,667,527 - 40,668,582 (-)NCBI
UMICH_Zoey_3.1640,355,646 - 40,356,696 (-)NCBI
UNSW_CanFamBas_1.0640,316,610 - 40,317,658 (-)NCBI
UU_Cfam_GSD_1.0640,795,235 - 40,796,286 (-)NCBI
LOC110259958
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1341,482,353 - 41,483,564 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Position Markers
BI278462  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21015,323,916 - 15,324,261 (+)MAPPER
mRatBN7.21015,337,360 - 15,337,705 (+)MAPPER
Rnor_6.01015,602,889 - 15,603,233NCBIRnor6.0
Rnor_6.01015,589,447 - 15,589,791NCBIRnor6.0
Rnor_5.01015,497,984 - 15,498,328UniSTSRnor5.0
Rnor_5.01015,484,542 - 15,484,886UniSTSRnor5.0
RGSC_v3.41015,571,013 - 15,571,357UniSTSRGSC3.4
RGSC_v3.41015,584,455 - 15,584,799UniSTSRGSC3.4
Celera1015,004,952 - 15,005,296UniSTS
Celera1014,991,503 - 14,991,847UniSTS
Cytogenetic Map10q12UniSTS
BI282742  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21015,324,396 - 15,324,668 (+)MAPPER
Rnor_6.01015,589,927 - 15,590,198NCBIRnor6.0
Rnor_5.01015,485,022 - 15,485,293UniSTSRnor5.0
RGSC_v3.41015,571,493 - 15,571,764UniSTSRGSC3.4
Celera1014,991,983 - 14,992,254UniSTS
RH 3.4 Map10151.46UniSTS
Cytogenetic Map10q12UniSTS
UniSTS:465391  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21015,324,015 - 15,324,388 (+)MAPPER
mRatBN7.21015,337,459 - 15,337,832 (+)MAPPER
Rnor_6.01015,602,988 - 15,603,360NCBIRnor6.0
Rnor_6.01015,589,546 - 15,589,918NCBIRnor6.0
Rnor_5.01015,498,083 - 15,498,455UniSTSRnor5.0
Rnor_5.01015,484,641 - 15,485,013UniSTSRnor5.0
RGSC_v3.41015,571,112 - 15,571,484UniSTSRGSC3.4
RGSC_v3.41015,584,554 - 15,584,926UniSTSRGSC3.4
Celera1015,005,051 - 15,005,423UniSTS
Celera1014,991,602 - 14,991,974UniSTS
Cytogenetic Map10q12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10129592136Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135538813Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138594330Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142669970Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)10144902893Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1076442166221621Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10483563820170031Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10521719917555534Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10521719919591669Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10546011921524070Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10546011921524070Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10546011921524070Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10546011921524070Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10546011921524070Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10587753664401490Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10622909575983805Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10622928936185929Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10642907599492409Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10752145052521450Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109841807108540162Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101263951357639513Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101263951357639513Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101263951357639513Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101482789492423564Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014827894107857673Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014827894110992275Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101537547462469074Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:34
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000048977, ENSRNOT00000051483
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 41 26 24 11 24 41 16 19 10
Medium 3 5 33 17 8 17 8 11 33 19 22 1 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001007722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC096051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC091567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT548169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT548170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U29528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X56325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X65495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000048977   ⟹   ENSRNOP00000044081
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1015,589,364 - 15,590,220 (-)Ensembl
RefSeq Acc Id: NM_001007722   ⟹   NP_001007723
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21015,323,830 - 15,324,677 (-)NCBI
Rnor_6.01015,589,364 - 15,590,207 (-)NCBI
Rnor_5.01015,484,459 - 15,485,302 (-)NCBI
RGSC_v3.41015,570,930 - 15,571,773 (-)RGD
Celera1014,991,420 - 14,992,263 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001007723   ⟸   NM_001007722
- UniProtKB: P01946 (UniProtKB/Swiss-Prot),   A0A0G2JSV6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000044081   ⟸   ENSRNOT00000048977
Protein Domains
GLOBIN

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697074
Promoter ID:EPDNEW_R7599
Type:multiple initiation site
Name:Hba-a2_1
Description:hemoglobin alpha, adult chain 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7601  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01015,590,205 - 15,590,265EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359364 AgrOrtholog
Ensembl Genes ENSRNOG00000029886 UniProtKB/Swiss-Prot
  ENSRNOG00000047321 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000044081 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000044233 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000048977 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000051483 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.490.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Globin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Globin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Globin/Proto UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haemoglobin_a-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haemoglobin_pi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25632 UniProtKB/Swiss-Prot
  rno:360504 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 360504 ENTREZGENE
Pfam Globin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hba-a2 PhenoGen
PRINTS ALPHAHAEM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIHAEM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLOBIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46458 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSV6 ENTREZGENE, UniProtKB/TrEMBL
  HBA_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P33583 UniProtKB/Swiss-Prot
  Q63243 UniProtKB/Swiss-Prot
  Q80XV2 UniProtKB/Swiss-Prot
  Q91V15 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-31 Hba-a1  hemoglobin alpha, adult chain 1  Hba-a2  hemoglobin alpha, adult chain 2  Name and Symbol changed 629549 APPROVED
2015-12-31 Hba-a2  hemoglobin alpha, adult chain 2  Hba-a1  hemoglobin alpha, adult chain 1  Name and Symbol changed 629549 APPROVED
2015-10-06 Hba-a2  hemoglobin alpha, adult chain 2  Hba2  hemoglobin, alpha 2  Name and Symbol changed 629549 APPROVED
2010-05-05 Hba2  hemoglobin, alpha 2  LOC360504  hemoglobin alpha 2 chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 LOC360504  hemoglobin alpha 2 chain      Symbol and Name updated 1559027 APPROVED
2005-07-29 LOC360504  hemoglobin alpha 2 chain      Symbol and Name status set to provisional 70820 PROVISIONAL