Cfi (complement factor I) - Rat Genome Database

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Gene: Cfi (complement factor I) Rattus norvegicus
Analyze
Symbol: Cfi
Name: complement factor I
RGD ID: 620429
Description: Predicted to enable metal ion binding activity; scavenger receptor activity; and serine-type endopeptidase activity. Involved in cellular response to interleukin-6. Located in extracellular space and nucleus. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; age related macular degeneration 13; atypical hemolytic-uremic syndrome; complement factor I deficiency; and macular degeneration. Orthologous to human CFI (complement factor I); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Staphylococcus aureus infection pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C3B/C4B inactivator; FI
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22218,389,079 - 218,430,565 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2218,387,990 - 218,430,561 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2226,074,156 - 226,108,943 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02223,973,845 - 224,008,640 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02218,831,494 - 218,866,282 (+)NCBIRnor_WKY
Rnor_6.02235,264,149 - 235,305,779 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2235,264,219 - 235,305,781 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0274,628,922 - 74,659,423 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42227,281,621 - 227,325,109 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12227,268,300 - 227,311,787 (+)NCBI
Celera2210,674,292 - 210,712,800 (+)NCBICelera
Cytogenetic Map2q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (EXP,ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
fenthion  (ISO)
flutamide  (EXP)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
L-ethionine  (EXP)
lansoprazole  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
methylmercury chloride  (ISO)
nickel atom  (ISO)
nitrofen  (EXP)
omeprazole  (EXP)
ozone  (ISO)
pantoprazole  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
quartz  (EXP)
quercetin  (ISO)
rabeprazole  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (EXP,ISO)
tacrolimus hydrate  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zearalenone  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Complement factor I: a susceptibility gene for atypical haemolytic uraemic syndrome. Fremeaux-Bacchi V, etal., J Med Genet. 2004 Jun;41(6):e84.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Complement mutation-associated de novo thrombotic microangiopathy following kidney transplantation. Le Quintrec M, etal., Am J Transplant. 2008 Aug;8(8):1694-701. doi: 10.1111/j.1600-6143.2008.02297.x. Epub 2008 Jun 28.
4. Genetic, behavioral, and sociodemographic risk factors for second eye progression in age-related macular degeneration. Lechanteur YT, etal., Invest Ophthalmol Vis Sci. 2012 Aug 24;53(9):5846-52. doi: 10.1167/iovs.11-7731.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Increased plasma concentrations of complement modulating proteins (C1 inhibitor, C4-binding protein, factor H and factor I) in psoriasis. Ohkohchi K, etal., Tohoku J Exp Med. 1988 Apr;154(4):315-21.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Transcriptome characterization by RNA-Seq reveals the involvement of the complement components in noise-traumatized rat cochleae. Patel M, etal., Neuroscience. 2013 May 30;248C:1-16. doi: 10.1016/j.neuroscience.2013.05.038.
10. Serum levels of C3 and factors I and B in minimal change disease. Patiroglu T, etal., Acta Paediatr Jpn. 1998 Aug;40(4):333-6. doi: 10.1111/j.1442-200x.1998.tb01942.x.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice. Rose KL, etal., J Clin Invest. 2008 Feb;118(2):608-18.
17. Complement factor I is upregulated in rat hepatocytes by interleukin-6 but not by interferon-gamma, interleukin-1beta, or tumor necrosis factor-alpha. Schlaf G, etal., Biol Chem. 2001 Jul;382(7):1089-94.
18. Rat complement factor I: molecular cloning, sequencing and expression in tissues and isolated cells. Schlaf G, etal., Immunology 1999 Nov;98(3):464-74.
19. A functional variant in the CFI gene confers a high risk of age-related macular degeneration. van de Ven JP, etal., Nat Genet. 2013 Jul;45(7):813-7. doi: 10.1038/ng.2640. Epub 2013 May 19.
20. Complement Factor H Serum Levels Determine Resistance to Pneumococcal Invasive Disease. van der Maten E, etal., J Infect Dis. 2016 Jun 1;213(11):1820-7. doi: 10.1093/infdis/jiw029. Epub 2016 Jan 21.
21. [Association of single nucleotide polymorphism in complement factor I gene with age-related macular degeneration]. Wu PB, etal., Zhonghua Yan Ke Za Zhi. 2013 Apr;49(4):350-6.
Additional References at PubMed
PMID:12477932   PMID:16502470   PMID:19056867   PMID:19423168   PMID:23376485   PMID:23533145   PMID:24006456  


Genomics

Comparative Map Data
Cfi
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22218,389,079 - 218,430,565 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2218,387,990 - 218,430,561 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2226,074,156 - 226,108,943 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02223,973,845 - 224,008,640 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02218,831,494 - 218,866,282 (+)NCBIRnor_WKY
Rnor_6.02235,264,149 - 235,305,779 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2235,264,219 - 235,305,781 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0274,628,922 - 74,659,423 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42227,281,621 - 227,325,109 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12227,268,300 - 227,311,787 (+)NCBI
Celera2210,674,292 - 210,712,800 (+)NCBICelera
Cytogenetic Map2q43NCBI
CFI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384109,730,982 - 109,801,999 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4109,731,008 - 109,802,150 (-)EnsemblGRCh38hg38GRCh38
GRCh374110,652,138 - 110,723,155 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364110,881,297 - 110,942,783 (-)NCBINCBI36Build 36hg18NCBI36
Build 344111,019,455 - 111,080,745NCBI
Celera4107,955,508 - 108,016,895 (-)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4106,394,822 - 106,455,453 (-)NCBIHuRef
CHM1_14110,638,387 - 110,699,796 (-)NCBICHM1_1
T2T-CHM13v2.04113,032,911 - 113,104,052 (-)NCBIT2T-CHM13v2.0
Cfi
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393129,630,376 - 129,668,981 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3129,629,533 - 129,668,981 (+)EnsemblGRCm39 Ensembl
GRCm383129,836,727 - 129,875,332 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3129,835,884 - 129,875,332 (+)EnsemblGRCm38mm10GRCm38
MGSCv373129,539,657 - 129,578,246 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363129,828,759 - 129,867,354 (+)NCBIMGSCv36mm8
Celera3136,349,476 - 136,389,693 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map359.21NCBI
Cfi
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955496492,167 - 553,217 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955496492,217 - 553,398 (+)NCBIChiLan1.0ChiLan1.0
CFI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14112,804,645 - 112,865,581 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4112,804,645 - 112,865,581 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04102,236,868 - 102,311,359 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CFI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13229,936,447 - 29,986,755 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3229,936,393 - 29,985,724 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3212,034,262 - 12,093,545 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03230,155,997 - 30,216,527 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3230,155,943 - 30,206,594 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13230,150,126 - 30,210,801 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03229,894,695 - 29,953,963 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0329,895,138 - 9,954,756 (+)NCBIUU_Cfam_GSD_1.0
Cfi
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530110,952,721 - 10,990,319 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936563960,883 - 988,634 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936563960,883 - 998,136 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CFI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8112,433,633 - 112,470,832 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18112,430,824 - 112,470,844 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28120,517,180 - 120,554,319 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CFI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1757,641,363 - 57,713,209 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl757,640,141 - 57,700,805 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603736,292,740 - 36,365,937 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cfi
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624830111,004 - 151,514 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624830111,123 - 151,668 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cfi
382 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:122
Count of miRNA genes:97
Interacting mature miRNAs:102
Transcripts:ENSRNOT00000034706
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
2299161Iddm33Insulin dependent diabetes mellitus QTL 332.98blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2206312063220876787Rat
631203Gluco14Glucose level QTL 140.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)2206665645219003804Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat

Markers in Region
D2Mgh29  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22218,414,747 - 218,414,891 (+)MAPPERmRatBN7.2
Rnor_6.02235,289,967 - 235,290,110NCBIRnor6.0
Rnor_5.0274,640,967 - 74,641,110UniSTSRnor5.0
RGSC_v3.42227,309,864 - 227,310,008RGDRGSC3.4
RGSC_v3.42227,309,865 - 227,310,008UniSTSRGSC3.4
RGSC_v3.12227,296,545 - 227,296,688RGD
Celera2210,697,016 - 210,697,159UniSTS
RH 3.4 Map21547.1UniSTS
RH 3.4 Map21547.1RGD
RH 2.0 Map21130.1RGD
Cytogenetic Map2q43UniSTS
RH128544  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22218,430,201 - 218,430,411 (+)MAPPERmRatBN7.2
Rnor_6.02235,305,416 - 235,305,625NCBIRnor6.0
Rnor_5.0274,629,076 - 74,629,285UniSTSRnor5.0
RGSC_v3.42227,324,746 - 227,324,955UniSTSRGSC3.4
Celera2210,712,437 - 210,712,646UniSTS
RH 3.4 Map21556.7UniSTS
Cytogenetic Map2q43UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 3 3 3
Medium 1 38 38 38 1 5 4
Low 1 2 16 14 8 8 11 24 22 7 8
Below cutoff 1 17 5 3 45 6 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000086245   ⟹   ENSRNOP00000071685
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2218,399,719 - 218,430,561 (+)Ensembl
Rnor_6.0 Ensembl2235,264,219 - 235,305,781 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113687   ⟹   ENSRNOP00000089885
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2218,387,990 - 218,430,561 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116911   ⟹   ENSRNOP00000089666
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2218,387,990 - 218,430,561 (+)Ensembl
RefSeq Acc Id: NM_024157   ⟹   NP_077071
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22218,389,079 - 218,430,565 (+)NCBI
Rnor_6.02235,264,298 - 235,305,779 (+)NCBI
Rnor_5.0274,628,922 - 74,659,423 (-)NCBI
RGSC_v3.42227,281,621 - 227,325,109 (+)RGD
Celera2210,674,292 - 210,712,800 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_077071 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH89798 (Get FASTA)   NCBI Sequence Viewer  
  CAB41688 (Get FASTA)   NCBI Sequence Viewer  
  EDL82188 (Get FASTA)   NCBI Sequence Viewer  
  Q9WUW3 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_077071   ⟸   NM_024157
- Peptide Label: precursor
- UniProtKB: Q5EBC4 (UniProtKB/Swiss-Prot),   Q9WUW3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071685   ⟸   ENSRNOT00000086245
RefSeq Acc Id: ENSRNOP00000089885   ⟸   ENSRNOT00000113687
RefSeq Acc Id: ENSRNOP00000089666   ⟸   ENSRNOT00000116911
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WUW3-F1-model_v2 AlphaFold Q9WUW3 1-604 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691751
Promoter ID:EPDNEW_R2276
Type:initiation region
Name:Cfi_1
Description:complement factor I
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02235,264,271 - 235,264,331EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620429 AgrOrtholog
BioCyc Gene G2FUF-51236 BioCyc
Ensembl Genes ENSRNOG00000053400 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000071685.2 UniProtKB/TrEMBL
  ENSRNOP00000089666.1 UniProtKB/TrEMBL
  ENSRNOP00000089885 ENTREZGENE
  ENSRNOP00000089885.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000086245.2 UniProtKB/TrEMBL
  ENSRNOT00000113687 ENTREZGENE
  ENSRNOT00000113687.1 UniProtKB/TrEMBL
  ENSRNOT00000116911.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.10.250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7321559 IMAGE-MGC_LOAD
InterPro FacI_MAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79126 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108679 IMAGE-MGC_LOAD
NCBI Gene 79126 ENTREZGENE
Pfam Kazal_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cfi PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE KAZAL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FIMAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KAZAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00202 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56487 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K135_RAT UniProtKB/TrEMBL
  A0A8I6AAQ9_RAT UniProtKB/TrEMBL
  A0A8I6AC86_RAT UniProtKB/TrEMBL
  CFAI_RAT UniProtKB/Swiss-Prot
  Q5EBC4 ENTREZGENE
  Q9WUW3 ENTREZGENE
UniProt Secondary Q5EBC4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Cfi  complement factor I      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Cfi  complement factor I      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the uterus and small intestine 634725
gene_homology shows identities of 87% to the mouse and of 78% to the human FI nucleotide sequence 634725