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Gene: Cfi (complement factor I) Rattus norvegicus
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Symbol: Cfi
Name: complement factor I
Description: Predicted to have metal ion binding activity; scavenger receptor activity; and serine-type endopeptidase activity. Involved in cellular response to interleukin-6. Localizes to the extracellular space and nucleus. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; age related macular degeneration 13; atypical hemolytic-uremic syndrome; complement factor I deficiency; and macular degeneration. Orthologous to human CFI (complement factor I); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Staphylococcus aureus infection pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: C3B/C4B inactivator; FI
Orthologs:
Homo sapiens (human) : CFI (complement factor I)  HGNC  Alliance
Mus musculus (house mouse) : Cfi (complement component factor i)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cfi (complement factor I)
Pan paniscus (bonobo/pygmy chimpanzee) : CFI (complement factor I)
Canis lupus familiaris (dog) : CFI (complement factor I)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cfi (complement factor I)
Sus scrofa (pig) : CFI (complement factor I)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02235,264,149 - 235,305,779 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0274,628,922 - 74,659,423 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42227,281,621 - 227,325,109 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12227,268,300 - 227,311,787 (+)NCBI
Celera2210,674,292 - 210,712,800 (+)NCBICelera
Cytogenetic Map2q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cfi
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620429
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.