Car12 (carbonic anhydrase 12) - Rat Genome Database

Name: Car12
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Car12 (carbonic anhydrase 12) Rattus norvegicus

Analyze

Symbol:

Car12

Name:

carbonic anhydrase 12

RGD ID:

1306612

Description:

Predicted to enable carbonate dehydratase activity. Involved in estrous cycle. Located in apical plasma membrane and basolateral plasma membrane. Human ortholog(s) of this gene implicated in isolated hyperchlorhidrosis and lung non-small cell carcinoma. Orthologous to human CA12 (carbonic anhydrase 12); INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Ca12; carbonic anyhydrase 12; LOC363085; membrane-bound carbonic anhydrase 12

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CA12 (carbonic anhydrase 12)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Car12 (carbonic anhydrase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ca12 (carbonic anhydrase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CA12 (carbonic anhydrase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CA12 (carbonic anhydrase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ca12 (carbonic anhydrase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CA12 (carbonic anhydrase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CA12 (carbonic anhydrase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ca12 (carbonic anhydrase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	CA12 (carbonic anhydrase 12)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Car12 (carbonic anhydrase 12)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ca12 (carbonic anhydrase XII)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG18673	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG18672	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG3669	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG5379	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	caix	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ca12	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	76,169,723 - 76,225,465 (+)	NCBI		GRCr8
mRatBN7.2	8	67,274,739 - 67,330,428 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	67,274,359 - 67,330,440 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	72,787,939 - 72,840,890 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	71,060,751 - 71,113,710 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	68,930,478 - 68,983,460 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	72,405,770 - 72,461,425 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	72,405,748 - 72,460,240 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	72,071,988 - 72,127,646 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	71,017,732 - 71,070,729 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	8	66,660,144 - 66,713,076 (+)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

colon adenocarcinoma (ISO)

colorectal adenocarcinoma (ISO)

colorectal cancer (ISO)

colorectal carcinoma (ISO)

Colorectal Neoplasms (ISO)

esophagus squamous cell carcinoma (ISO)

fibrolamellar carcinoma (ISO)

hepatocellular carcinoma (ISO)

hypertrophic cardiomyopathy (ISO)

isolated hyperchlorhidrosis (ISO)

lung cancer (ISO)

lung metastasis (ISO)

Lung Neoplasms (ISO)

lung non-small cell carcinoma (ISO)

Lynch syndrome (ISO)

nemaline myopathy 6 (ISO)

oral squamous cell carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

14-Deoxy-11,12-didehydroandrographolide (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-palmitoylglycerol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3-methylcholanthrene (ISO)

4-hydroxynon-2-enal (ISO)

4-methylumbelliferyl beta-D-galactoside (ISO)

5-aza-2'-deoxycytidine (ISO)

5-fluorouracil (ISO)

acetazolamide (ISO)

acrylamide (ISO)

afimoxifene (ISO)

aflatoxin B1 (ISO)

amphotericin B (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

bosentan (ISO)

bromobenzene (EXP)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

CGP 52608 (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

clofibrate (ISO)

clomiphene (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

cyclophosphamide (ISO)

cyclosporin A (ISO)

cytarabine (ISO)

DDE (ISO)

decabromodiphenyl ether (EXP)

dexamethasone (ISO)

dibutyl phthalate (EXP)

diethylstilbestrol (ISO)

dimethylarsinic acid (ISO)

dioxygen (EXP,ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (ISO)

Enterolactone (ISO)

entinostat (ISO)

estrone (ISO)

famotidine (ISO)

fipronil (ISO)

fulvestrant (ISO)

genistein (ISO)

glyphosate (EXP)

hexestrol (ISO)

hydrogen peroxide (ISO)

hypochlorous acid (ISO)

indometacin (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

menadione (ISO)

mestranol (ISO)

mifepristone (ISO)

N,N-diethyl-m-toluamide (EXP,ISO)

N-Nitrosopyrrolidine (ISO)

nitrofen (EXP)

O-methyleugenol (ISO)

oryzalin (ISO)

ozone (ISO)

paclitaxel (ISO)

panobinostat (ISO)

paracetamol (EXP)

paraquat (EXP)

PCB138 (ISO)

perfluorooctanoic acid (EXP)

permethrin (EXP)

phenobarbital (ISO)

pirinixic acid (ISO)

progesterone (ISO)

raloxifene (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

temozolomide (ISO)

thiram (ISO)

topiramate (ISO)

trichostatin A (ISO)

triclosan (ISO)

tris(2-butoxyethyl) phosphate (ISO)

troglitazone (ISO)

trovafloxacin (ISO)

urethane (ISO)

valproic acid (ISO)

vancomycin (ISO)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chloride ion homeostasis (ISO)

estrous cycle (IEP)

one-carbon metabolic process (IBA)

Cellular Component

apical plasma membrane (IDA)

basolateral plasma membrane (IDA)

plasma membrane (IBA)

Molecular Function

carbonate dehydratase activity (IBA,ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Prognostic value of carbonic anhydrase XII (CA XII) overexpression in hepatocellular carcinoma.	null
2.	Integrative Proteo-Genomic Analysis for Recurrent Survival Prognosis in Colon Adenocarcinoma.	Ai F, etal., Front Oncol. 2022 Jun 30;12:871568. doi: 10.3389/fonc.2022.871568. eCollection 2022.
3.	Comprehensive analysis of The Cancer Genome Atlas reveals a unique gene and non-coding RNA signature of fibrolamellar carcinoma.	Dinh TA, etal., Sci Rep. 2017 Mar 17;7:44653. doi: 10.1038/srep44653.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	In-vivo functional study on the involvement of CFTR, SLC26A6, NHE-1 and CA isoenzymes II and XII in uterine fluid pH, volume and electrolyte regulation in rats under different sex-steroid influence.	Gholami K, etal., Int J Med Sci. 2013 Jul 5;10(9):1121-34. doi: 10.7150/ijms.5918. Print 2013.
6.	Region- and cell-specific differences in the distribution of carbonic anhydrases II, III, XII, and XIV in the adult rat epididymis.	Hermo L, etal., J Histochem Cytochem. 2005 Jun;53(6):699-713. doi: 10.1369/jhc.4A6575.2005.
7.	Response of CAIX and CAXII to in vitro re-oxygenation and clinical significance of the combined expression in NSCLC patients.	Ilie M, etal., Lung Cancer. 2013 Oct;82(1):16-23. doi: 10.1016/j.lungcan.2013.07.005. Epub 2013 Jul 30.
8.	Expression of von Hippel-Lindau tumor suppressor and tumor-associated carbonic anhydrases IX and XII in normal and neoplastic colorectal mucosa.	Kivela AJ, etal., World J Gastroenterol. 2005 May 7;11(17):2616-25. doi: 10.3748/wjg.v11.i17.2616.
9.	Expression of a novel transmembrane carbonic anhydrase isozyme XII in normal human gut and colorectal tumors.	Kivelä A, etal., Am J Pathol. 2000 Feb;156(2):577-84. doi: 10.1016/S0002-9440(10)64762-1.
10.	CAXII Is a sero-diagnostic marker for lung cancer.	Kobayashi M, etal., PLoS One. 2012;7(3):e33952. doi: 10.1371/journal.pone.0033952. Epub 2012 Mar 16.
11.	pH regulators to target the tumor immune microenvironment in human hepatocellular carcinoma.	Kuchuk O, etal., Oncoimmunology. 2018 Mar 26;7(7):e1445452. doi: 10.1080/2162402X.2018.1445452. eCollection 2018.
12.	Localization of carbonic anhydrase XII to the basolateral membrane of H+-secreting cells of mouse and rat kidney.	Kyllönen MS, etal., J Histochem Cytochem. 2003 Sep;51(9):1217-24. doi: 10.1177/002215540305100912.
13.	Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer.	Niemelä AM, etal., Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1760-6. doi: 10.1158/1055-9965.EPI-07-0080.
14.	Carbonic anhydrase XII mediates the survival and prometastatic functions of macrophages in human hepatocellular carcinoma.	Ning WR, etal., J Clin Invest. 2022 Apr 1;132(7). pii: 153110. doi: 10.1172/JCI153110.
15.	Carbonic Anhydrase XII as an Independent Prognostic Factor in Advanced Esophageal Squamous Cell Carcinoma.	Ochi F, etal., J Cancer. 2015 Jul 29;6(10):922-9. doi: 10.7150/jca.11269. eCollection 2015.
16.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
17.	GOA pipeline	RGD automated data pipeline
18.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
20.	Carbonic anhydrase enzymes II, VII, IX and XII in colorectal carcinomas.	Viikilä P, etal., World J Gastroenterol. 2016 Sep 28;22(36):8168-77. doi: 10.3748/wjg.v22.i36.8168.
21.	An inhibitory antibody targeting carbonic anhydrase XII abrogates chemoresistance and significantly reduces lung metastases in an orthotopic breast cancer model in vivo.	von Neubeck B, etal., Int J Cancer. 2018 Oct 15;143(8):2065-2075. doi: 10.1002/ijc.31607. Epub 2018 Aug 10.

Additional References at PubMed

PMID:14660577	PMID:16271802	PMID:16831598	PMID:21035102	PMID:28940640	PMID:36846718

Genomics

Comparative Map Data

Car12
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	76,169,723 - 76,225,465 (+)	NCBI		GRCr8
mRatBN7.2	8	67,274,739 - 67,330,428 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	67,274,359 - 67,330,440 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	72,787,939 - 72,840,890 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	71,060,751 - 71,113,710 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	68,930,478 - 68,983,460 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	72,405,770 - 72,461,425 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	72,405,748 - 72,460,240 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	72,071,988 - 72,127,646 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	71,017,732 - 71,070,729 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	8	66,660,144 - 66,713,076 (+)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

CA12
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	63,321,378 - 63,381,846 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	63,321,378 - 63,381,846 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	63,613,577 - 63,674,045 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	61,402,783 - 61,461,128 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	15	40,494,364 - 40,552,718 (-)	NCBI		Celera
Cytogenetic Map	15	q22.2	NCBI
HuRef	15	40,438,444 - 40,496,766 (-)	NCBI		HuRef
CHM1_1	15	63,734,781 - 63,793,114 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	61,126,049 - 61,186,532 (-)	NCBI		T2T-CHM13v2.0

Car12
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	66,619,026 - 66,674,127 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	66,620,968 - 66,674,127 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	66,712,296 - 66,766,845 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	66,713,686 - 66,766,845 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	66,561,493 - 66,614,652 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	66,512,886 - 66,565,989 (+)	NCBI		MGSCv36	mm8
Celera	9	63,948,029 - 64,000,964 (+)	NCBI		Celera
Cytogenetic Map	9	C	NCBI
cM Map	9	36.09	NCBI

Ca12
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	11,943,340 - 11,975,928 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	11,927,730 - 11,975,553 (+)	NCBI	ChiLan1.0	ChiLan1.0

CA12
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	52,571,690 - 52,630,424 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	56,747,752 - 56,806,529 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	42,270,188 - 42,328,952 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	60,565,592 - 60,624,008 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	60,565,592 - 60,624,008 (-)	Ensembl	panpan1.1		panPan2

CA12
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	27,903,460 - 27,957,162 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	27,905,837 - 27,957,742 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	27,822,431 - 27,876,096 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	28,075,321 - 28,129,041 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	28,077,699 - 28,129,047 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	28,012,749 - 28,066,343 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	28,074,625 - 28,128,260 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	28,311,867 - 28,365,995 (-)	NCBI		UU_Cfam_GSD_1.0

Ca12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	106,028,826 - 106,081,389 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	23,876,812 - 23,929,987 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	23,876,889 - 23,929,720 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CA12
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	108,649,271 - 108,710,651 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	108,649,277 - 108,710,658 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	119,822,275 - 119,904,112 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CA12
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	20,162,706 - 20,221,680 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	20,162,926 - 20,224,502 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	121,178,247 - 121,238,609 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ca12
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624781	9,140,837 - 9,196,400 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624781	9,140,753 - 9,195,651 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Car12
242 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	94
Count of miRNA genes:	73
Interacting mature miRNAs:	79
Transcripts:	ENSRNOT00000023952
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298065	Scl16	Serum cholesterol level QTL 16	3.8		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	30856404	75856404	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	30848154	101699754	Rat
1298079	Activ2	Activity QTL 2	9.5	0.000001	voluntary movement trait (VT:0003491)	rearing measurement (CMO:0001515)	8	41866876	86866876	Rat
70161	Bp62	Blood pressure QTL 62	2.9	0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	42692684	90165460	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	30848154	101699754	Rat
1582222	Epfw2	Epididymal fat weight QTL 2	3.2	0.0005	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	8	31737729	76737729	Rat
61464	Niddm11	Non-insulin dependent diabetes mellitus QTL 11	3.1	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	35582032	80582032	Rat
4889938	Bss89	Bone structure and strength QTL 89	3.8		tibia size trait (VT:0100001)	tibia cortical bone volume (CMO:0001725)	8	50095249	82460899	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	30848154	101699754	Rat
1300146	Rf17	Renal function QTL 17	2.9		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	8	28242912	73242912	Rat
8662823	Vetf5	Vascular elastic tissue fragility QTL 5	1.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	8	28242912	99525068	Rat
2313088	Bss75	Bone structure and strength QTL 75	3.1	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	8	30848154	82460899	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	27205715	99103503	Rat
731182	Uae24	Urinary albumin excretion QTL 24	6.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	19331152	93965294	Rat
724514	Uae15	Urinary albumin excretion QTL 15	2.9		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	29502665	70386295	Rat
631842	Inf1	Infertility severity QTL 1	4.1	0.001	seminal gland mass (VT:0010524)	seminal vesicle wet weight (CMO:0001603)	8	22662330	67662330	Rat
737824	Hcar10	Hepatocarcinoma resistance QTL 10	2.9		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	8	40713066	82925667	Rat
1331769	Rf39	Renal function QTL 39	3.871		urine output (VT:0003620)	timed urine volume (CMO:0000260)	8	41866876	75097878	Rat
61358	Bp39	Blood pressure QTL 39	2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	35551938	80551938	Rat
1358906	Bp253	Blood pressure QTL 253	4	0.0004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	40713066	93965294	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	27205715	99103503	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	46531639	119088626	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	30848259	105647037	Rat
1582254	Kidm31	Kidney mass QTL 31	3		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	8	54237644	85365202	Rat
10402857	Bp380	Blood pressure QTL 380		0.95	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	53968765	98968765	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	27205715	99103503	Rat
631216	Stl9	Serum triglyceride level QTL 9	4.71	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	8	41867010	70386132	Rat
5684973	Bss100	Bone structure and strength QTL 100	4.7		tibia area (VT:1000281)	tibia area measurement (CMO:0001382)	8	50095249	82460899	Rat
1582243	Bw66	Body weight QTL 66	3.4	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	8	54237644	85365202	Rat
2313057	Bss76	Bone structure and strength QTL 76	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	8	30848154	82460899	Rat
12879878	Bw183	Body weight QTL 183		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	43296169	98968765	Rat
1300177	Cm2	Cardiac mass QTL 2	3.65		heart mass (VT:0007028)	heart weight (CMO:0000017)	8	54259986	100382532	Rat
1549908	Neudeg1	Neurodegradation QTL 1	5.5	0	nervous system integrity trait (VT:0010566)	logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)	8	30188867	94457446	Rat
12879879	Cm99	Cardiac mass QTL 99		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	43296169	98968765	Rat
2313067	Bss77	Bone structure and strength QTL 77	3.1	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	8	30848154	82460899	Rat
12879880	Cm100	Cardiac mass QTL 100		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	43296169	98968765	Rat
12879881	Cm101	Cardiac mass QTL 101		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	8	43296169	98968765	Rat
12879882	Am8	Aortic mass QTL 8		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	43296169	98968765	Rat
12879883	Kidm65	Kidney mass QTL 65		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	43296169	98968765	Rat
1358912	Bw51	Body weight QTL 51	2.95		body mass (VT:0001259)	body weight (CMO:0000012)	8	51351728	107062046	Rat
2313086	Bss60	Bone structure and strength QTL 60	4.1	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	8	50095249	82460899	Rat
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	61290298	119084929	Rat
2293697	Bmd39	Bone mineral density QTL 39			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	8	54043744	98968765	Rat
1331837	Bw23	Body weight QTL 23	4.19	0.00007	body mass (VT:0001259)	body weight (CMO:0000012)	8	46531722	99083736	Rat
1331838	Niddm61	Non-insulin dependent diabetes mellitus QTL 61	3.53	0.0004	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	36469535	99083736	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
631653	Bp125	Blood pressure QTL 125	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	66142385	111142385	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
631271	Lecl1	Lens clarity QTL 1		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	8	18984168	84531599	Rat
2303564	Gluco43	Glucose level QTL 43	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	26130187	71130187	Rat
2303570	Gluco48	Glucose level QTL 48	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	49805831	94805831	Rat
2313046	Bss78	Bone structure and strength QTL 78	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	8	30848154	82460899	Rat
2303572	Insul13	Insulin level QTL 13	2		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	8	26130187	71130187	Rat
2301402	Bp316	Blood pressure QTL 316		0.005	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	53968765	98968765	Rat
631664	Hcar3	Hepatocarcinoma resistance QTL 3	2.9	0.0005	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	8	54237644	99103503	Rat

Markers in Region

BE121257

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	67,324,477 - 67,324,688 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	72,455,475 - 72,455,685	NCBI	Rnor6.0
Rnor_5.0	8	72,121,696 - 72,121,906	UniSTS	Rnor5.0
RGSC_v3.4	8	71,067,306 - 71,067,516	UniSTS	RGSC3.4
Celera	8	66,709,653 - 66,709,863	UniSTS
RH 3.4 Map	8	851.6	UniSTS
Cytogenetic Map	8	q24	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	6	15	9	1	9			23	31	23
Low		16	35	25	16	25	8	10	51	4	18	10	8
Below cutoff		20	7	7	2	7		1				1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001080756	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006243310	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006243311	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063265771	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063265772	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063265773	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063265774	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY952140	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EF187255	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000023952 ⟹ ENSRNOP00000023952

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	67,274,359 - 67,330,440 (+)	Ensembl
Rnor_6.0 Ensembl	8	72,405,748 - 72,460,240 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105264 ⟹ ENSRNOP00000091938

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	67,274,601 - 67,330,440 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000116915 ⟹ ENSRNOP00000087370

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	67,274,899 - 67,330,440 (+)	Ensembl

RefSeq Acc Id:

NM_001080756 ⟹ NP_001074225

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	76,169,815 - 76,225,465 (+)	NCBI
mRatBN7.2	8	67,274,768 - 67,330,428 (+)	NCBI
Rnor_6.0	8	72,405,923 - 72,458,898 (+)	NCBI
Rnor_5.0	8	72,071,988 - 72,127,646 (+)	NCBI
RGSC_v3.4	8	71,017,732 - 71,070,729 (+)	RGD
Celera	8	66,660,144 - 66,713,076 (+)	RGD

Sequence:

show sequence

ATGCCTCACTGCAGCCTGCACGCTACTGTCGTCCTCCTATTGGTGATCCTTAAGGAGCAACCTT
CCAGCTCAGCCCCACTCAACGGATCCAAGTGGACCTACATTGGTCCTGCTGGGGAAAAGAACTG
GTCCAAGAAGTACCCGTCATGTGGGGGTCTCCTGCAGTCCCCGATAGACCTACACAGTGACATC
CTTCAATATGATGCCAGCCTTGCACCACTCCAGTTCCAAGGTTACAATGTGTCTGTTGAAAAGC
TATTGAACCTAACCAATGATGGCCATTCAGTGAGACTGAATCTGAACTCAGACATGTACATCCA
GGGACTCCAGCCTCACCAGTACAGAGCGGAGCAGCTGCACTTGCACTGGGGGAACCGCAATGAC
CCCCATGGCTCTGAACACACTGTGAGTGGGAAGCACTTTGCTGCTGAGCTGCACATCGTCCATT
ATAACTCAGACCTGTACTCCGACTTCGGCAGTGCCAGTGACAAGTCAGAAGGGCTCGCTGTCCT
TGCTGTTCTTATTGAGATAGGCTCTGTCAATCCGTCCTATGACAAGATCTTTAGTCATCTTCAA
CACGTCAAGTATAAAGGCCAACAAGTGCTCATCCCAGGCTTCAACATTGAAGAACTTCTGCCTG
AGAGCCCTGGCGAGTATTACCGCTATGAAGGGTCCCTGACTACACCTCCTTGCTACCCTACTGT
GCTCTGGACAGTTTTCCGAAACCCTGTGCAGATTTCCCAGGAGCAGCTGCTAGCTTTGGAGACA
GCTCTGTATTTCACACACATGGATGATCCTTCCCCCAGAGAAATGGTCAACAACTTCCGGCAAG
TCCAGAAGTTTGATGAGAGGCTGGTGTATATCTCCTTCCGACAAGGACTGCTTACCGACACAGG
ACTGAGTTTGGGTATCATCCTTTCAGTGGCCCTGGCTGGTGTCCTTGGGATCTCCATTGTTCTG
GCAGTGTCTGTTTGGCTCTTCAAAAGGAAGAAGAGCAAAAAAGGTGACAACAAGGGAGTCATTT
ATAAACCAGCCATCAAGAAGGAGGCTGAGGTCCACGCCTGA

hide sequence

RefSeq Acc Id:

XM_006243311 ⟹ XP_006243373

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	76,169,723 - 76,225,460 (+)	NCBI
mRatBN7.2	8	67,274,739 - 67,330,428 (+)	NCBI
Rnor_6.0	8	72,405,770 - 72,461,425 (+)	NCBI
Rnor_5.0	8	72,071,988 - 72,127,646 (+)	NCBI

Sequence:

show sequence

AGCCTAGAGGCGGCCACGAGTCGACACAACCGACGTGCACGCTTTGGTCCCAGGCTACGTGCAC
GCTGTGCTGGTGTGCCGCTGCCAGCTCGGAGCGGAACAGAGCGCCCCACAGCTTAGAGCCAGCG
GCAGCTTTGAGTCGCCGGGACAAAGATGCCTCACTGCAGCCTGCACGCTACTGTCGTCCTCCTA
TTGGTGATCCTTAAGGAGCAACCTTCCAGCTCAGCCCCACTCAACGGATCCAAGTGGACCTACA
TTGGTCCTGCTGGGGAAAAGAACTGGTCCAAGAAGTACCCGTCATGTGGGGGTCTCCTGCAGTC
CCCGATAGACCTACACAGTGACATCCTTCAATATGATGCCAGCCTTGCACCACTCCAGTTCCAA
GGTTACAATGTGTCTGTTGAAAAGCTATTGAACCTAACCAATGATGGCCATTCAGTGAGACTGA
ATCTGAACTCAGACATGTACATCCAGGGACTCCAGCCTCACCAGTACAGAGCGGAGCAGCTGCA
CTTGCACTGGGGGAACCGCAATGACCCCCATGGCTCTGAACACACTGTGAGTGGGAAGCACTTT
GCTGCTGAGCTGCACATCGTCCATTATAACTCAGACCTGTACTCCGACTTCGGCAGTGCCAGTG
ACAAGTCAGAAGGGCTCGCTGTCCTTGCTGTTCTTATTGAGATAGGCTCTGTCAATCCGTCCTA
TGACAAGATCTTTAGTCATCTTCAACACGTCAAGTATAAAGGCCAACAAGTGCTCATCCCAGGC
TTCAACATTGAAGAACTTCTGCCTGAGAGCCCTGGCGAGTATTACCGCTATGAAGGGTCCCTGA
CTACACCTCCTTGCTACCCTACTGTGCTCTGGACAGTTTTCCGAAACCCTGTGCAGATTTCCCA
GGAGCAGCTGCTAGCTTTGGAGACAGCTCTGTATTTCACACACATGGATGATCCTTCCCCCAGA
GAAATGGTCAACAACTTCCGGCAAGTCCAGAAGTTTGATGAGAGGCTGGTGTATATCTCCTTCC
GACAAGGTATCATCCTTTCAGTGGCCCTGGCTGGTGTCCTTGGGATCTCCATTGTTCTGGCAGT
GTCTGTTTGGCTCTTCAAAAGGAAGAAGAGCAAAAAAGGTGACAACAAGGGAGTCATTTATAAA
CCAGCCATCAAGAAGGAGGCTGAGGTCCACGCCTGAGGTCCCTGGCAGTCTCAGACATCCAAGG
AAGGACCTTGCTTTGGATACTACATACTTTGGCTCTCTGGACACTTGAAATACCTCAAGGTGTT
CTCTTGAGCTCACCTGTATCCCCTTCCCCCAGACTCTTGTGAGGCTTCCAGCTGGGCCTCCCCT
GTTCTGCTGTCACATCCATCCCAGAATGACCAGTGAGTGGGATGAAGTGAACTAGGGGGCAGGA
GTTTTGAGTGGACTTCTCCAGCTGTGTGAGACGGCTAAAGATTCTGAATTCTGAGTCACAAAAC
CTAACTTGCTGGTGGACCATTCTGGTTTGGAAAACACTAGCATCCTGGTTCTTCCTGGTACATT
TCCAGAGTCCTGAAGGTTATTCTCCAACCTTCCAGACTACAACATGCACCCTTTGCTTAGGTGA
CACTTTTGAAACTCAGCTTCCTTCCTCAGGGAGCAGTTGTTTTCCTTGGATTTCCTTCTGCTCT
GACAGACCCACCAACCTGACCTCGCACCTACAGAGAAGAACTGAGACAGGAAGTACATATTATC
AGAAAGAAATGAAAACCATAATATACCAGGACATTTTTACAGTCCTATCTTTTGGGTTACAGAC
ATTGACCATGCCTTACAGCAAAGCAGGCTCACGTTTTATTCCTTAGTGGGGATGAAACGGAGAC
AGAGAAAGGAGAAGCAGAGGGAACGGGAAGGCATACATTGTCCAGGAGTCTGCCTTTGGAGCCA
GAACTGGACTCAAGATACAGTGTAGGGGAAAACAGTCTATGCTATCACCTACTTGGCCTCAGGA
GGACAGTTACACTTTACACTCCACTCCGTTATTTGGAAATGAATTACTTCCTCTGTCCTGGAAT
AATCTACTCTGTTTTGAACTCAGGGGAAGCAGACAGAATCAAGACTACTGGACAGTTTTGCCTC
CTTTGCCCAAATGTCCATTCTACCTTGTCTGATCTTCCTACTACCCACTCGGTGTCAGGACTGT
CTACTCCTCTGGCTGTGGGGAAGTCTAAATAATGTTTAGTGAAATGTATTTTCATATTATCAAA
GCAGGAAGCTATCCGTGTAGAGCTAAACCAGGTCTTGGTATTTAAGTACCGAAACCAATAGAAT
GTTTCTGAGATTCTCCCTGTTCTTCCCCTCAGTCCCATGGTTTCTGGGAATGCTTAATCCCTTC
TTCATGTTCTTTCCACCGAGGTGAGAACCCTGTGGAGAGCAGTCAGTTCATGGCTCTAAAGAAG
TCTCAGCCACCAGCCCCTGATTGCTAGTTCCTTGCAGTTCATAGGGAGTTCTCTGATTTAGTCT
CGTTTTGACAGCATGGAATGTCCTCTTGAAGAGCAGGTTTATATATTTTTTTCTTCTTCTATCC
TCCCTCCTGACTTGATAAAAATCTCTTCTGCTATTACAGTGTTTCACAGTGGCGGCCCTGTGTC
TTTGTAGCATAATTCACTGGGCAAAGTTACAGGTGATTAGATGGGGGCTCAGCTGTGTGTGCAG
TACCTGTGCATGCACTCCTTGGAGTCTGGGTGCCACCCTAGCCTTGGGACCAACATGCCTGATG
GTGTCATCAGAGTGAGGGCAAGCCTCAAGAAGAAGCAACCCAATTTAGGTGGCTTCCTGACCTT
GGTCCAGGATTGTCCTCCAGAAGCTATCATAAAGCAGTCCAGGGCAGCAAGTCTGTCTTAAAGA
AGTGTATACACTGACAAGTTATGTGAGAGTACAGCGAGGTCATCATGGCTGGCCTGAGGATTGG
TCAGAAAAGGAGAGATGCTAGGAGGCAAAAACAGTGGCATTTCTCCTTCCCTTTTCCCCTTCAG
CATGGTCCAGGCATTCAGTCCTCGCTCAATCCTCATGGCTGAGATGAAACAAAGCCAGGGAGGC
AGAAAGAGTGCTCCAAGAATCAGCGCTGTCAACCTTTAACTCCTGAAGATGCAGCTTTCTTCAG
ATTCAAAATCATTCTGTGGGACACCTGGCCACCACTGAGGGAAACCAGTGCTGTGGTATATGAT
ACACAGCCTTGCACTCCTTAACTCTGCTGTGTGAGGTGCAAGGTGGGTGCCTGGGAGAGCCTGG
GCTGGCACAGGGCTGGGCACATAGCAAGTGGAGATGACCTACACAATTCGTGGGTGGGCGGGGG
GCACACACCAGGGACCTGAGGAAGGCACTGGCTTCTGTAATATTTCCTCTGCCTCTAACAGGAA
AACTTGAGTCTCTCTGTTCTTTGTTAGTATCTGTCTTCTATTATAGCAAATCCTATATCCATGG
CTTTAATGGACATTCTAAAATTTGCTGCACTGACAGTCTTAATATTTCTATTCCTCTCCCTCTC
TATACTCTTTGAAGACCTCCTGATTGGCCCTGAGGAAGTACCAGGGGTAACAGTATCTCTGGGT
CCCTGTCCCTCAGCCCATAGGCCACTGTGATAATTGTCTGCTTAGCATTTCCATATTTATTGTA
CCAATGATTGTAATGAAGATATACACTGAAAGTTTGAGATTATAATAAAAACATTTTTCACATC
TGA

hide sequence

RefSeq Acc Id:

XM_063265771 ⟹ XP_063121841

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	76,169,723 - 76,225,460 (+)	NCBI

RefSeq Acc Id:

XM_063265772 ⟹ XP_063121842

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	76,169,944 - 76,225,460 (+)	NCBI

RefSeq Acc Id:

XM_063265773 ⟹ XP_063121843

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	76,185,046 - 76,225,460 (+)	NCBI

RefSeq Acc Id:

XM_063265774 ⟹ XP_063121844

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	76,169,948 - 76,225,460 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001074225	(Get FASTA)	NCBI Sequence Viewer
	XP_006243373	(Get FASTA)	NCBI Sequence Viewer
	XP_063121841	(Get FASTA)	NCBI Sequence Viewer
	XP_063121842	(Get FASTA)	NCBI Sequence Viewer
	XP_063121843	(Get FASTA)	NCBI Sequence Viewer
	XP_063121844	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAX50191	(Get FASTA)	NCBI Sequence Viewer
	ABM64774	(Get FASTA)	NCBI Sequence Viewer
	EDL95857	(Get FASTA)	NCBI Sequence Viewer
	EDL95858	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000023952.6
	ENSRNOP00000087370.1
	ENSRNOP00000091938.1

RefSeq Acc Id:	NP_001074225 ⟸ NM_001080756
- Peptide Label:	precursor
- UniProtKB:	A2IBE2 (UniProtKB/TrEMBL), A0A8I6A5P9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPHCSLHATVVLLLVILKEQPSSSAPLNGSKWTYIGPAGEKNWSKKYPSCGGLLQSPIDLHSDI LQYDASLAPLQFQGYNVSVEKLLNLTNDGHSVRLNLNSDMYIQGLQPHQYRAEQLHLHWGNRND PHGSEHTVSGKHFAAELHIVHYNSDLYSDFGSASDKSEGLAVLAVLIEIGSVNPSYDKIFSHLQ HVKYKGQQVLIPGFNIEELLPESPGEYYRYEGSLTTPPCYPTVLWTVFRNPVQISQEQLLALET ALYFTHMDDPSPREMVNNFRQVQKFDERLVYISFRQGLLTDTGLSLGIILSVALAGVLGISIVL AVSVWLFKRKKSKKGDNKGVIYKPAIKKEAEVHA hide sequence

RefSeq Acc Id:	XP_006243373 ⟸ XM_006243311
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6AH35 (UniProtKB/TrEMBL), A0A8I6A5P9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPHCSLHATVVLLLVILKEQPSSSAPLNGSKWTYIGPAGEKNWSKKYPSCGGLLQSPIDLHSDI LQYDASLAPLQFQGYNVSVEKLLNLTNDGHSVRLNLNSDMYIQGLQPHQYRAEQLHLHWGNRND PHGSEHTVSGKHFAAELHIVHYNSDLYSDFGSASDKSEGLAVLAVLIEIGSVNPSYDKIFSHLQ HVKYKGQQVLIPGFNIEELLPESPGEYYRYEGSLTTPPCYPTVLWTVFRNPVQISQEQLLALET ALYFTHMDDPSPREMVNNFRQVQKFDERLVYISFRQGIILSVALAGVLGISIVLAVSVWLFKRK KSKKGDNKGVIYKPAIKKEAEVHA hide sequence

Ensembl Acc Id:

ENSRNOP00000023952 ⟸ ENSRNOT00000023952

Ensembl Acc Id:

ENSRNOP00000091938 ⟸ ENSRNOT00000105264

Ensembl Acc Id:

ENSRNOP00000087370 ⟸ ENSRNOT00000116915

RefSeq Acc Id:	XP_063121841 ⟸ XM_063265771
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A5P9 (UniProtKB/TrEMBL), F7FAJ9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063121842 ⟸ XM_063265772
- Peptide Label:	isoform X3
- UniProtKB:	A6J5I5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063121844 ⟸ XM_063265774
- Peptide Label:	isoform X4
- UniProtKB:	A6J5I5 (UniProtKB/TrEMBL), A6J5I4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063121843 ⟸ XM_063265773
- Peptide Label:	isoform X3
- UniProtKB:	A6J5I5 (UniProtKB/TrEMBL)

Protein Domains

Alpha-carbonic anhydrase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A2IBE2-F1-model_v2	AlphaFold	A2IBE2	1-354	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696090

Promoter ID:

EPDNEW_R6614

Type:

single initiation site

Name:

Car12_1

Description:

carbonic anhydrase 12

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	72,405,792 - 72,405,852	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306612	AgrOrtholog
BioCyc Gene	G2FUF-30015	BioCyc
Ensembl Genes	ENSRNOG00000017766	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000023952.7	UniProtKB/TrEMBL
	ENSRNOT00000105264.1	UniProtKB/TrEMBL
	ENSRNOT00000116915.1	UniProtKB/TrEMBL
Gene3D-CATH	3.10.200.10	UniProtKB/TrEMBL
InterPro	Carbonic_anhydrase_a-class	UniProtKB/TrEMBL
	Carbonic_anhydrase_a-class_cat	UniProtKB/TrEMBL
	Carbonic_anhydrase_a-class_CS	UniProtKB/TrEMBL
	Carbonic_anhydrase_a_sf	UniProtKB/TrEMBL
KEGG Report	rno:363085	UniProtKB/TrEMBL
NCBI Gene	363085	ENTREZGENE
PANTHER	Euk_COanhd	UniProtKB/TrEMBL
	PTHR18952:SF19	UniProtKB/TrEMBL
Pfam	Carb_anhydrase	UniProtKB/TrEMBL
PhenoGen	Car12	PhenoGen
PROSITE	ALPHA_CA_1	UniProtKB/TrEMBL
	ALPHA_CA_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000017766	RatGTEx
SMART	Carb_anhydrase	UniProtKB/TrEMBL
Superfamily-SCOP	Euk_COanhd	UniProtKB/TrEMBL
UniProt	A0A8I6A5P9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AH35	ENTREZGENE, UniProtKB/TrEMBL
	A2IBE2	ENTREZGENE, UniProtKB/TrEMBL
	A6J5I4	ENTREZGENE, UniProtKB/TrEMBL
	A6J5I5	ENTREZGENE, UniProtKB/TrEMBL
	F7FAJ9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-04-18	Car12	carbonic anhydrase 12	Ca12	carbonic anhydrase 12	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2019-04-16	Ca12	carbonic anhydrase 12	Car12	carbonic anhydrase 12	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-02-01	Car12	carbonic anhydrase 12	Car12	carbonic anyhydrase 12	Name changed	629549	APPROVED
2005-12-06	Car12	carbonic anyhydrase 12	Car12_predicted	carbonic anyhydrase 12 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Car12_predicted	carbonic anyhydrase 12 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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