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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306612
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Car12
Name: carbonic anhydrase 12
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Car12decreases expressionISOCA12 (Homo sapiens)6480464CTDfulvestrant results in decreased expression of CA12 mRNAPMID:26865669
Car12multiple interactionsISOCA12 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in increased methylation of CA12 gene; Fulvestrant inhibits the reaction [Genistein results in increased expression of CA12 mRNA]; Fulvestrant promotes the reaction [Dexamethasone inhibits the reaction [Genistein results in increased expression of CA12 mRNA]]PMID:25136773 PMID:31601247
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